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FLASH GENE
Symbol KLK7 contributors: mct/npt - updated : 10-07-2018
HGNC name kallikrein-related peptidase 7
HGNC id 6368
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in adenocarcinoma of the lung
tumoral     --over  
in pancreatic adenocarcinomas as well as other cancers
tumoral     --over  
in oral squamous cell carcinoma and may be implicated in malignant progression (Pettus 2009)
tumoral     --over  
in papillary renal cell carcinoma (Gabril 2010)
tumoral     --low  
in prostate and breast cancers (Li 2009)
tumoral     --over  
in colon cancer and its expression predicts poor prognosis for colon cancer patients (Galieri 2009)
tumoral     --low  
significantly decreased in prostate cancers compared with that in benign prostate epithelial cells (Xuan 2008)
constitutional     --other  
unregulated activities of KLK5 and KLK7 are responsible for Netherton syndrome (NS) development
tumoral     --over  
in human pancreatic ductal adenocarcinomas (PDACs)
Susceptibility
Variant & Polymorphism
Candidate gene potential biomarkers for breast cancer (Li 2009)
Marker
  • elevations in glioblastoma KLK6, KLK7 and KLK9 protein have utility as prognostic markers of patient survival
  • biomarker potential for chromophobe renal cell carcinoma
  • potential biomarker in colon adenocarcinoma
  • KLK7 and KLK14 gene expression can be regarded as markers of poor prognosis for Colon cancer (CC) patients with discriminating power between CC and adenoma patients
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    may represent a potential therapeutic target for human colon tumorigenesis
    ANIMAL & CELL MODELS