| 1 | KLK10, KLK13, KLK7, KLK9
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| Kallikrein-related peptidases protein expression in lymphoid tissues suggests potential implications in immune response.
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| Filippou PS, Ren AH, Soosaipillai A, Safar R, Prassas I, Diamandis EP, Conner JR.
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| Clin Biochem 77:41-47. doi: 10.1016/j.clinbiochem.2019.12.015. Epub 2020 Jan 2.
2020
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| 2 | KLK10, KLK15, KLK2, KLK3, KLK6, KLK7, KLK8
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| Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types.
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| Tailor PD, Kodeboyina SK, Bai S, Patel N, Sharma S, Ratnani A, Copland JA, She JX, Sharma A.
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| Oncotarget 9(25):17876-17888. doi: 10.18632/oncotarget.24947. eCollection 2018 Apr 3.
2018
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| 3 | KLK5, KLK7, SPINK5
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| Toll-like receptor signaling induces the expression of lympho-epithelial Kazal-type inhibitor in epidermal keratinocytes.
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| Sugimoto S, Morizane S, Nomura H, Kobashi M, Sugihara S, Iwatsuki K.
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| J Dermatol Sci 92(2):181-187. doi: 10.1016/j.jdermsci.2018.09.001. Epub 2018 Sep 15.
2018
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| 4 | KLK14, KLK5, KLK7, SERPINA12
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| Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin.
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| Ulbricht D, Tindall CA, Oertwig K, Hanke S, Sträter N, Heiker JT.
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| Biol Chem 399(9):1079-1084. doi: 10.1515/hsz-2018-0108.
2018
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| 5 | KLK5, KLK7
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| KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype.
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| Kasparek P, Ileninova Z, Zbodakova O, Kanchev I, Benada O, Chalupsky K, Brattsand M, Beck IM, Sedlacek R.
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| PLoS Genet 13(1):e1006566. doi: 10.1371/journal.pgen.1006566. eCollection 2017 Jan.
2017
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| 6 | KLK5, KLK7, PI3, SPINK5
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| Attenuated kallikrein-related peptidase activity disrupts desquamation and leads to stratum corneum thickening in human skin equivalent models.
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| McGovern JA, Meinert C, de Veer SJ, Hollier BG, Parker TJ, Upton Z.
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| Br J Dermatol 176(1):145-158. doi: 10.1111/bjd.14879. Epub 2016 Dec 22.
2017
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| 7 | KLK5, KLK6, KLK7, KLK8, KLK9
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| Molecular cloning of novel transcripts of human kallikrein-related peptidases 5, 6, 7, 8 and 9 (KLK5 - KLK9), using Next-generation sequencing.
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| Adamopoulos PG, Kontos CK, Scorilas A.
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| Sci Rep 7(1):17299. doi: 10.1038/s41598-017-16269-6.
2017
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| 8 | KLK5, kLK7
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| Attenuated kallikrein-related peptidase activity disrupts desquamation and leads to stratum corneum thickening in human skin equivalent models.
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| McGovern JA, Meinert C, de Veer SJ, Hollier BG, Parker TJ, Upton Z.
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| Br J Dermatol 176(1):145-158. doi: 10.1111/bjd.14879. Epub 2016 Dec 22.
2017
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| 9 | KLK14, KLK5, KLK7
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| Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7) Shed Light on KLK Proteolytic Activity in the Stratum Corneum.
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| de Veer SJ, Furio L, Swedberg JE, Munro CA, Brattsand M, Clements JA, Hovnanian A, Harris JM.
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| J Invest Dermatol 137(2):430-439. doi: 10.1016/j.jid.2016.09.017. Epub 2016 Sep 30.
2017
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| 10 | KLK7
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| Epigenetic regulation of KLK7 gene expression in pancreatic and cervical cancer cells.
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| Raju I, Kaushal GP, Haun RS.
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| Biol Chem 397(11):1135-1146. doi: 10.1515/hsz-2015-0307.
2016
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| 11 | KLK6, KLK7, KLK9
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| Prognostic significance of multiple kallikreins in high-grade astrocytoma.
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| Drucker KL, Gianinni C, Decker PA, Diamandis EP, Scarisbrick IA.
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| BMC Cancer 15:565. doi: 10.1186/s12885-015-1566-5.
2015
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| 12 | KLK7
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| Kallikrein-related peptidase 7 (KLK7) is a proliferative factor that is aberrantly expressed in human colon cancer.
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| Walker F, Nicole P, Jallane A, Soosaipillai A, Mosbach V, Oikonomopoulou K, Diamandis EP, Magdolen V, Darmoul D.
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| Biol Chem 395(9):1075-86. doi: 10.1515/hsz-2014-0142.
2014
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| 13 | KLK7, SERPINA12
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| Vaspin inhibits kallikrein 7 by serpin mechanism.
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| Heiker JT, Klöting N, Kovacs P, Kuettner EB, Sträter N, Schultz S, Kern M, Stumvoll M, Blüher M, Beck-Sickinger AG.
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| Cell Mol Life Sci 70(14):2569-83. doi: 10.1007/s00018-013-1258-8. Epub 2013 Jan 31.
2013
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| 14 | CMKLR1, KLK7
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| Proteolytic activation of prochemerin by kallikrein 7 breaks an ionic linkage and results in C-terminal rearrangement.
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| Schultz S, Saalbach A, Heiker JT, Meier R, Zellmann T, Simon JC, Beck-Sickinger AG.
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| Biochem J 452(2):271-80. doi: 10.1042/BJ20121880.
2013
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| 15 | KLK14, KLK7
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| Parallel overexpression and clinical significance of kallikrein-related peptidases 7 and 14 (KLK7KLK14) in colon cancer.
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| Devetzi M, Trangas T, Scorilas A, Xynopoulos D, Talieri M.
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| Thromb Haemost 109(4):716-25. doi: 10.1160/TH12-07-0518. Epub 2012 Dec 6.
2013
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| 16 | CASP14, KLK7
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| Kallikrein-related peptidase-7 regulates caspase-14 maturation during keratinocyte terminal differentiation by generating an intermediate form.
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| Yamamoto M, Miyai M, Matsumoto Y, Tsuboi R, Hibino T.
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| J Biol Chem 287(39):32825-34. Epub 2012 Jul 23.
2012
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| 17 | KLK7
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| Proteolytic action of kallikrein-related peptidase 7 produces unique active matrix metalloproteinase-9 lacking the C-terminal hemopexin domains.
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| Ramani VC, Kaushal GP, Haun RS.
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| Biochim Biophys Acta 1813(8):1525-31. doi: 10.1016/j.bbamcr.2011.05.007. Epub 2011 May 17.
2011
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| 18 | KLK11, KLK7
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| Immunohistochemical localization and analysis of kallikrein-related peptidase 7 and 11 expression in paired cancer and benign foci in prostate cancer patients.
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| Jamaspishvili T, Scorilas A, Kral M, Khomeriki I, Kurfurstova D, Kolar Z, Bouchal J.
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| Neoplasma 58(4):298-303.
2011
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| 19 | KLK1, KLK15, KLK6, KLK7
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| Immunohistochemical analysis of kallikrein-related peptidases in the normal kidney and renal tumors: potential clinical implications.
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| Gabril M, White NM, Moussa M, Chow TF, Metias SM, Fatoohi E, Yousef GM.
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| Biol Chem iol Chem. 2010 Feb 3. [Epub ahead of print]PMID: 20128686 2010
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| 20 | KLK10, KLK5, KLK7, KLK8
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| Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity.
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| Pettus JR, Johnson JJ, Shi Z, Davis JW, Koblinski J, Ghosh S, Liu Y, Ravosa MJ, Frazier S, Stack MS.
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| Histol Histopathol 24(2):197-207.
2009
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| 21 | KLK5, KLK7
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| Parallel underexpression of kallikrein 5 and kallikrein 7 mRNA in breast malignancies.
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| Li X, Liu J, Wang Y, Zhang L, Ning L, Feng Y.
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| Cancer Sci 100(4):601-7.PMID: 19453546 2009
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| 22 | KLK7
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| Clinical significance of kallikrein-related peptidase 7 (KLK7) in colorectal cancer.
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| Talieri M, Mathioudaki K, Prezas P, Alexopoulou DK, Diamandis EP, Xynopoulos D, Ardavanis A, Arnogiannaki N, Scorilas A.
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| Thromb Haemost 101(4):741-7.PMID: 19350120 2009
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| 23 | KLK7
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| The extracellular matrix protein fibronectin is a substrate for kallikrein 7.
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| Ramani VC, Haun RS.
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| Biochem Biophys Res Commun 369(4):1169-73. Epub 2008 Mar 14. 2008
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| 24 | KLK4, KLK5, KLK6, KLK7
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| Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7.
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| Debela M, Beaufort N, Magdolen V, Schechter NM, Craik CS, Schmitt M, Bode W, Goettig P.
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| Biol Chem 389(6):623-32. Review.PMID: 18627343 2008
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| 25 | KLK7, SLPI
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| Expression of the serine protease kallikrein 7 and its inhibitor antileukoprotease is decreased in prostate cancer.
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| Xuan Q, Yang X, Mo L, Huang F, Pang Y, Qin M, Chen Z, He M, Wang Q, Mo ZN.
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| Arch Pathol Lab Med 132(11):1796-801.PMID: 18976018 2008
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| 26 | KLK13, KLK2, KLK3, KLK5, KLK6, KLK7, KLK8
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| Distribution of 15 human kallikreins in tissues and biological fluids.
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| Shaw JL, Diamandis EP.
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| Clin Chem 53(8):1423-32. Epub 2007 Jun 15.PMID: 17573418 2007
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| 27 | KLK5, KLK7, KLK14
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| Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum.
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| Stefansson K, Brattsand M, Ny A, Glas B, Egelrud T.
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| Biol Chem 387(6):761-8. 2006
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| 28 | SPINK5, KLK5, KLK7
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| LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum.
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| Ishida-Yamamoto A, Deraison C, Bonnart C, Bitoun E, Robinson R, O'Brien TJ, Wakamatsu K, Ohtsubo S, Takahashi H, Hashimoto Y, Dopping-Hepenstal PJ, McGrath JA, Iizuka H, Richard G, Hovnanian A.
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| J Invest Dermatol 124(2):360-6. 2005
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| 29 | KLK5, KLK7
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| KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancer.
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| Planque C, de Monte M, Guyetant S, Rollin J, Desmazes C, Panel V, Lemarie E, Courty Y.
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| Biochem Biophys Res Commun 329(4):1260-6. 2005
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| 30 | KLK7
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| Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma.
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| Talieri M, Diamandis EP, Gourgiotis D, Mathioudaki K, Scorilas A.
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| Thromb Haemost 91(1):180-6. 2004
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| 31 | KLK7
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| Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers.
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| Dong Y, Kaushal A, Brattsand M, Nicklin J, Clements JA.
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| Clin Cancer Res 9(5):1710-20. 2003
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| 32 | KLK10, KLK11, KLK12, KLK13, KLK14, KLK4, KLK5, KLK6, KLK7, KLK8, KLK9
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| The New Human Kallikrein Gene Family: Implications in Carcinogenesis.
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| Diamandis EP, Yousef GM, Luo I, Magklara I, Obiezu CV.
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| Trends Endocrinol Metab 11(2):54-60. 2000
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| 33 | KLK1, KLK10, KLK11, KLK12, KLK13, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK8, KLK9
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| Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4.
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| Harvey TJ, Hooper JD, Myers SA, Stephenson SA, Ashworth LK, Clements JA.
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| J Biol Chem 275(48):37397-406.
2000
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| 34 | KLK7
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| Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase.
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| Hansson L, Stromqvist M, Backman A, Wallbrandt P, Carlstein A, Egelrud T.
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| J Biol Chem 269(30):19420-6. 1994
|