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FLASH GENE

Symbol

KLK7

contributors: mct/npt - updated : 10-07-2018

HGNC name	kallikrein-related peptidase 7
HGNC id	6368

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	tightly clustered multigene family on chromosome 19q13.4
STRUCTURE	7.59 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

clustered with kallikrein gene family

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005046 6 splicing 1927 NP_005037 27.4 253 - 2008 18627343 6 exons differing in the 5' UTR compared to variant 2 both variants encode the same protein NM_139277 6 splicing 1927 NP_644806 27.4 253 - 2008 18627343 6 exons differing in the 5' UTR compared to variant 1 both variants encode the same protein NM_001243126 5 - 1956 NP_001230055 - 246 - 2008 18627343 NM_001207053 5 - 1973 NP_001193982 - 161 - 2008 18627343

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Homo sapiens Digestive esophagus         Homo sapiens   liver         Homo sapiens Lymphoid/Immune tonsils       highly Homo sapiens Skin/Tegument skin appendages hair follicle     Homo sapiens Urinary kidney tubule     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining epidermis stratum corneum highly Homo sapiens skin tegument dermis

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	active site of serine proteinase
	a potential N glycosylation site
	a peptidase S1 domain

HOMOLOGY

Homologene

FAMILY	peptidase S1 family
	kallikrein subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
text	suprabasal keratinocytes
	in the skin, SPINK5, KLK7, and KLK5 were all found in the lamellar granule (LG) system, but were separately localized

basic FUNCTION	may catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface
	chymostatin-like serine protease, involved in desquamation cascade of the skin
	playing a role in aiding tumor invasion via degradation of ECM proteins like fibronectin
	participate in normal desquamation by facilitating cell shedding at the skin surface (Ramani 2008)
	its aberrant expression and secretion in tumors may facilitate metastasis by directly degrading components of the extracellular matrix and may thus play an important role in tumorigenesis (Ramani 2008)
	displays a unique chymotrypsin-like specificity for Tyr, which is also preferred at P2 (Debela 2008)
	chymotryptic-like serine protease, that may play an important role in the activation of MMP9 in tumors that express high levels of both these proteases
	KLK5, KLK7 and KLK14 are important proteases in skin desquamation

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	regulation of procaspase-14 maturation during keratinocyte terminal differentiation is a unique two-step process involving KLK7 and an activation intermediate of CASP14
	proteolytic activation of CMKLR1 by KLK7 breaks an ionic linkage and results in C-terminal rearrangement
	the actions of KLK7 are tightly controlled by PI3 and SPINK5, which also inhibits KLK5, localizing protease activity to the stratum corneum
	KLK7 is the first protease target of vaspin (SERPINA12)
	SPINK5 tightly controls the activities of serine proteases such as kallikrein-related peptidase KLK5 and KLK7 in the epidermis

cell & other

REGULATION

induced by

estrogens and glucocorticoids in a breast carcinoma cell line

inhibited by

SERPINA12

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in adenocarcinoma of the lung tumoral     --over   in pancreatic adenocarcinomas as well as other cancers tumoral     --over   in oral squamous cell carcinoma and may be implicated in malignant progression (Pettus 2009) tumoral     --over   in papillary renal cell carcinoma (Gabril 2010) tumoral     --low   in prostate and breast cancers (Li 2009) tumoral     --over   in colon cancer and its expression predicts poor prognosis for colon cancer patients (Galieri 2009) tumoral     --low   significantly decreased in prostate cancers compared with that in benign prostate epithelial cells (Xuan 2008) constitutional     --other   unregulated activities of KLK5 and KLK7 are responsible for Netherton syndrome (NS) development tumoral     --over   in human pancreatic ductal adenocarcinomas (PDACs)

Susceptibility

Variant & Polymorphism

Candidate gene	potential biomarkers for breast cancer (Li 2009)
Marker	elevations in glioblastoma KLK6, KLK7 and KLK9 protein have utility as prognostic markers of patient survival
	biomarker potential for chromophobe renal cell carcinoma
	potential biomarker in colon adenocarcinoma
	KLK7 and KLK14 gene expression can be regarded as markers of poor prognosis for Colon cancer (CC) patients with discriminating power between CC and adenoma patients
Therapy target
	System Type Disorder Pubmed cancer digestive colon may represent a potential therapeutic target for human colon tumorigenesis

ANIMAL & CELL MODELS