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FLASH GENE

Symbol

BEX2

contributors: mct/npt - updated : 20-03-2018

HGNC name	brain expressed X-linked 2
HGNC id	30933

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in a subset of primary breast cancers, mediating nerve growth factor/nuclear factor-kappaB inhibition of apoptosis in breast cancer cell lines (Naderi 2007) tumoral     --over   in glioma tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma contributes to glioma development by regulating the JUN NH2-terminal kinase pathway cancer digestive colon BEX2 as a potential candidate target for the treatment of colorectal cancer (CRC) cancer brain   potential target for novel therapies for ependymoma in children

ANIMAL & CELL MODELS

Bex2-deficient mice were viable and fertile under laboratory growth conditions showing no obvious phenotypic abnormalities 3)