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FLASH GENE

Symbol

BEX2

contributors: mct/npt - updated : 20-03-2018

HGNC name	brain expressed X-linked 2
HGNC id	30933

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland           neuroendocrine pituitary     highly Homo sapiens Nervous brain diencephalon hypothalamus     Homo sapiens   brain forebrain cerebral lobe temporal lobe highly Homo sapiens   brain hindbrain cerebellum   highly Homo sapiens Reproductive male system testis

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	highly in brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

ortholog to murine Bex2

intraspecies

paralog to BEX1

Homologene

FAMILY

Brain Expressed X-linked gene family

CATEGORY

regulatory , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	may be a signaling adaptor molecule
	can enhance the transcriptional activity of LMO2
	may act as a specific regulator during embryonic development by modulating the transcriptional activity of a novel E-box sequence-binding complex that contains BEX2, LM2, NSCL2 and LDB1
	is implicated in oligodendroglioma biology
	has a functional interplay with JUN/JNK and RELA in breast cancer
	may be an important player during the development of glioma
	contributes to glioma development by regulating the JUN NH2-terminal kinase pathway
	regulates the invasion/migration ability of glioma cells
	increased BEX2 expression led to enhanced NFKB1 signaling as well as cell proliferation
	while BEX1 and NGFRAP1 act as tumor suppressors, BEX2 seems to act as an oncogene
	BEX2 promotes colorectal cancer cell proliferation via the JNK/JUN pathway

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of a DNA-binding protein complex

INTERACTION

DNA

RNA

small molecule

protein	interacting with LMO2
	BEX2 promoted the progression of glioma by promoting cell migration and invasion, and these effects might be mediated by CDH2 and MMP2
	BEX2 promotes proliferation of human glioblastoma cells via NFKB1 signaling pathway and BEX2 nuclear location is critical for RELA expression
	BEX2 affects the invasion and migration ability of glioma cells by regulating CTNNB1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in a subset of primary breast cancers, mediating nerve growth factor/nuclear factor-kappaB inhibition of apoptosis in breast cancer cell lines (Naderi 2007) tumoral     --over   in glioma tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma contributes to glioma development by regulating the JUN NH2-terminal kinase pathway cancer digestive colon BEX2 as a potential candidate target for the treatment of colorectal cancer (CRC) cancer brain   potential target for novel therapies for ependymoma in children

ANIMAL & CELL MODELS

Bex2-deficient mice were viable and fertile under laboratory growth conditions showing no obvious phenotypic abnormalities 3)