Citations for
The phenotypic spectrum of ZIC3 mutations includes isolated d-transposition of the great arteries and double outlet right ventricle.
D'Alessandro LC, Latney BC, Paluru PC, Goldmuntz E.
Am J Med Genet A m J Med Genet A. 2013 Feb 20. doi: 10.1002/ajmg.a.35849. [Epub ahead of print] 2013
Zic3 is required in the migrating primitive streak for node morphogenesis and left-right patterning.
Sutherland MJ, Wang S, Quinn ME, Haaning A, Ware SM.
Hum Mol Genet um Mol Genet. 2013 Jan 8. [Epub ahead of print] 2013
Zic3 is required in the extra-cardiac perinodal region of the lateral plate mesoderm for left-right patterning and heart development.
Jiang Z, Zhu L, Hu L, Slesnick TC, Pautler RG, Justice MJ, Belmont JW.
Hum Mol Genet 22(5):879-89. doi: 10.1093/hmg/dds494. Epub 2012 Nov 25. 2013
Zic3 induces conversion of human fibroblasts to stable neural progenitor-like cells.
Kumar A, Declercq J, Eggermont K, Agirre X, Prosper F, Verfaillie CM.
J Mol Cell Biol 4(4):252-5. doi: 10.1093/jmcb/mjs015. Epub 2012 Apr 15. No abstract available. 2012
Situs Inversus Totalis and a Novel ZIC3 Mutation in a Family with X-linked Heterotaxy.
D'Alessandro LC, Casey B, Siu VM.
Congenit Heart Dis ongenit Heart Dis. 2011 Dec 16. doi: 10.1111/j.1747-0803.2011.00602.x. [Epub ahead of print] 2011
Identification of a novel ZIC3 isoform and mutation screening in patients with heterotaxy and congenital heart disease.
Bedard JE, Haaning AM, Ware SM.
PLoS One 6(8):e23755. doi: 10.1371/journal.pone.0023755. Epub 2011 Aug 17. 2011
From VACTERL-H to heterotaxy: variable expressivity of ZIC3-related disorders.
Chung B, Shaffer LG, Keating S, Johnson J, Casey B, Chitayat D.
Am J Med Genet A 155A(5):1123-8. doi: 10.1002/ajmg.a.33859. Epub 2011 Apr 4. 2011
The pluripotency regulator Zic3 is a direct activator of the Nanog promoter in ESCs.
Lim LS, Hong FH, Kunarso G, Stanton LW.
Stem Cells 28(11):1961-9. doi: 10.1002/stem.527. 2010
Characterization of the interactions of human ZIC3 mutants with GLI3.
Zhu L, Zhou G, Poole S, Belmont JW.
Hum Mutat 29(1):99-105. 2008
10ZIC3, HTX1
Nuclear import and export signals are essential for proper cellular trafficking and function of ZIC3.
Bedard JE, Purnell JD, Ware SM.
Hum Mol Genet 16(2):187-98. Epub 2006 Dec 21. 2007
Identification of a novel role of ZIC3 in regulating cardiac development.
Zhu L, Harutyunyan KG, Peng JL, Wang J, Schwartz RJ, Belmont JW.
Hum Mol Genet 16(14):1649-60. Epub 2007 Apr 27. 2007
Zic3 is required for maintenance of pluripotency in embryonic stem cells.
Lim LS, Loh YH, Zhang W, Li Y, Chen X, Wang Y, Bakre M, Ng HH, Stanton LW.
Mol Biol Cell 18(4):1348-58. Epub 2007 Jan 31. 2007
13DWS1, ZIC1, ZIC2, ZIC3, ZIC4
The ZIC gene family in development and disease.
Grinberg I, Millen KJ.
Clin Genet 67(4):290-6. 2005
14HTX1, ZIC3
Identification and functional analysis of ZIC3 mutations in heterotaxy and related congenital heart defects.
Ware SM, Peng J, Zhu L, Fernbach S, Colicos S, Casey B, Towbin J, Belmont JW.
Am J Hum Genet 74(1):93-105. Epub 2003 Dec 16. 2004
15ZIC1, ZIC2, ZIC3, ZIC4, ZIC5
Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family.
Ishiguro A, Inoue T, Mikoshiba K, Aruga J.
Biochem Biophys Res Commun 324(1):302-7. 2004
16HTX1, ZIC3
X-linked transposition of the great arteries and incomplete penetrance among males with a nonsense mutation in ZIC3.
Megarbane A, Salem N, Stephan E, Ashoush R, Lenoir D, Delague V, Kassab R, Loiselet J, Bouvagnet P.
Eur J Hum Genet 8(9):704-8. 2000
17HTX1, ZIC3
A deletion encompassing Zic3 in bent tail, a mouse model for X-linked neural tube defects.
Klootwijk R, Franke B, van der Zee CE, de Boer RT, Wilms W, Hol FA, Mariman EC.
Hum Mol Genet 9(11):1615-22. 2000
18HTX1, ZIC1, ZIC3
X-linked situs abnormalities result from mutations in ZIC3.
Gebbia M, Ferrero GB, Pilia G, Bassi MT, Aylsworth A, Penman-Splitt M, Bird LM, Bamforth JS, Burn J, Schlessinger D, Nelson DL, Casey B.
Nat Genet 17(3):305-8. 1997