| 1 | CRS12, ZIC1
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| Gain-of-Function Mutations in ZIC1 Are Associated with Coronal Craniosynostosis and Learning Disability.
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| Twigg SR, Forecki J, Goos JA, Richardson IC, Hoogeboom AJ, van den Ouweland AM, Swagemakers SM, Lequin MH, Van Antwerp D, McGowan SJ, Westbury I, Miller KA, Wall SA; WGS500 Consortium, van der Spek PJ, Mathijssen IM, Pauws E, Merzdorf CS, Wilkie AO.
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| Am J Hum Genet 97(3):378-88. doi: 10.1016/j.ajhg.2015.07.007.
2015
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| 2 | ZIC1
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| Zic1 Promoter Hypermethylation in Plasma DNA Is a Potential Biomarker for Gastric Cancer and Intraepithelial Neoplasia.
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| Chen X, Lin Z, Xue M, Si J, Chen S.
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| PLoS One 10(7):e0133906. doi: 10.1371/journal.pone.0133906. eCollection 2015.
2015
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| 3 | ZIC1, ZIC2
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| Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum.
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| Frank CL, Liu F, Wijayatunge R, Song L, Biegler MT, Yang MG, Vockley CM, Safi A, Gersbach CA, Crawford GE, West AE.
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| Nat Neurosci 18(5):647-56. doi: 10.1038/nn.3995. Epub 2015 Apr 6.
2015
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| 4 | ZIC1
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| Role of ZIC1 methylation in hepatocellular carcinoma and its clinical significance.
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| Wang YY, Jiang JX, Ma H, Han J, Sun ZY, Liu ZM, Xu ZG.
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| Tumour Biol 35(8):7429-33. doi: 10.1007/s13277-014-1971-4. Epub 2014 Apr 30.
2014
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| 5 | ZIC1
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| ZIC1 is a putative tumor suppressor in thyroid cancer by modulating major signaling pathways and transcription factor FOXO3a.
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| Qiang W, Zhao Y, Yang Q, Liu W, Guan H, Lv S, Ji M, Shi B, Hou P.
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| J Clin Endocrinol Metab 99(7):E1163-72. doi: 10.1210/jc.2013-3729. Epub 2014 Mar 31.
2014
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| 6 | ZIC1, ZIC2
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| The role of Zic transcription factors in regulating hindbrain retinoic acid signaling.
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| Drummond DL, Cheng CS, Selland LG, Hocking JC, Prichard LB, Waskiewicz AJ.
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| BMC Dev Biol 13:31. doi: 10.1186/1471-213X-13-31.
2013
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| 7 | ZIC1
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| ZIC1 modulates cell-cycle distributions and cell migration through regulation of sonic hedgehog, PI(3)K and MAPK signaling pathways in gastric cancer.
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| Zhong J, Chen S, Xue M, Du Q, Cai J, Jin H, Si J, Wang L.
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| BMC Cancer 12:290. doi: 10.1186/1471-2407-12-290.
2012
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| 8 | FOXD3, MSX1, MSX2, PAX7, ZIC1
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| Dynamic and differential regulation of stem cell factor FoxD3 in the neural crest is Encrypted in the genome.
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| Simões-Costa MS, McKeown SJ, Tan-Cabugao J, Sauka-Spengler T, Bronner ME.
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| PLoS Genet 8(12):e1003142. doi: 10.1371/journal.pgen.1003142. Epub 2012 Dec 20.
2012
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| 9 | ZIC1, ZIC4
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| Multiple developmental programs are altered by loss of Zic1 and Zic4 to cause Dandy-Walker malformation cerebellar pathogenesis.
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| Blank MC, Grinberg I, Aryee E, Laliberte C, Chizhikov VV, Henkelman RM, Millen KJ.
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| Development 138(6):1207-16. Epub 2011 Feb 9.
2011
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| 10 | MYF5, ZIC1, ZIC2
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| A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis.
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| Pan H, Gustafsson MK, Aruga J, Tiedken JJ, Chen JC, Emerson CP Jr.
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| Dev Biol 351(1):120-7. Epub 2011 Jan 4.
2011
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| 11 | ATR, DEL3Q2, FOXL2, ZIC1, ZIC4
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| De novo interstitial deletion of 3q22.3-q25.2 encompassing FOXL2, ATR, ZIC1, and ZIC4 in a patient with blepharophimosis/ptosis/epicanthus inversus syndrome, Dandy-Walker malformation, and global developmental delay.
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| Lim BC, Park WY, Seo EJ, Kim KJ, Hwang YS, Chae JH.
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| J Child Neurol 26(5):615-8. Epub 2011 Apr 6.
2011
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| 12 | ATR, DEL3Q2, FOXL2, ZIC1, ZIC4
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| Dandy-Walker malformation associated with heterozygous ZIC1 and ZIC4 deletion: Report of a new patient.
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| Tohyama J, Kato M, Kawasaki S, Harada N, Kawara H, Matsui T, Akasaka N, Ohashi T, Kobayashi Y, Matsumoto N.
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| Am J Med Genet A 155A(1):130-3. doi: 10.1002/ajmg.a.33652. Epub 2010 Dec 10.
2011
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| 13 | ZIC1
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| ZIC1 overexpression is oncogenic in liposarcoma.
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| Brill E, Gobble R, Angeles C, Lagos-Quintana M, Crago A, Laxa B, Decarolis P, Zhang L, Antonescu C, Socci ND, Taylor BS, Sander C, Koff A, Singer S.
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| Cancer Res 70(17):6891-901. Epub 2010 Aug 16.
2010
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| 14 | ZIC1
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| Zic1 transcription factor in bone: neural developmental protein regulates mechanotransduction in osteocytes.
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| Kalogeropoulos M, Varanasi SS, Olstad OK, Sanderson P, Gautvik VT, Reppe S, Francis RM, Gautvik KM, Birch MA, Datta HK.
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| FASEB J 24(8):2893-903. Epub 2010 Mar 30.
2010
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| 15 | ZIC1, ZIC2, ZIC4, ZIC5
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| Expression of ZIC family genes in meningiomas and other brain tumors.
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| Aruga J, Nozaki Y, Hatayama M, Odaka YS, Yokota N.
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| BMC Cancer 10:79.
2010
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| 16 | ZIC1
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| ZIC1 is downregulated through promoter hypermethylation in gastric cancer.
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| Wang LJ, Jin HC, Wang X, Lam EK, Zhang JB, Liu X, Chan FK, Si JM, Sung JJ.
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| Biochem Biophys Res Commun 379(4):959-63. Epub 2009 Jan 9.
2009
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| 17 | GBX2, SIX1, ZIC1
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| The posteriorizing gene Gbx2 is a direct target of Wnt signalling and the earliest factor in neural crest induction.
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| Li B, Kuriyama S, Moreno M, Mayor R.
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| Development 136(19):3267-78.
2009
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| 18 | ZIC1, ZIC4
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| Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis.
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| Elsen GE, Choi LY, Millen KJ, Grinblat Y, Prince VE.
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| Dev Biol 314(2):376-92. Epub 2007 Dec 15. 2008
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| 19 | ZIC1
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| ZIC1 gene expression is controlled by DNA and histone methylation in mesenchymal proliferations.
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| Pourebrahim R, Van Dam K, Bauters M, De Wever I, Sciot R, Cassiman JJ, Tejpar S.
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| FEBS Lett 581(26):5122-6. Epub 2007 Oct 8. 2007
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| 20 | DWS1, ZIC1, ZIC2, ZIC3, ZIC4
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| The ZIC gene family in development and disease.
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| Grinberg I, Millen KJ.
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| Clin Genet 67(4):290-6. 2005
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| 21 | DWS1, ZIC1, ZIC4
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| Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation.
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| Grinberg I, Northrup H, Ardinger H, Prasad C, Dobyns WB, Millen KJ.
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| Nat Genet 36(10):1053-5. Epub 2004 Aug 29. 2004
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| 22 | ZIC1, ZIC2, ZIC3, ZIC4, ZIC5
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| Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family.
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| Ishiguro A, Inoue T, Mikoshiba K, Aruga J.
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| Biochem Biophys Res Commun 324(1):302-7. 2004
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| 23 | APOE, ZIC1, ZIC2
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| Transcription factors Zic1 and Zic2 bind and transactivate the apolipoprotein E gene promoter.
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| Salero E, Perez-Sen R, Aruga J, Gimenez C, Zafra F.
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| J Biol Chem 276(3):1881-8. 2001
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| 24 | HTX1, ZIC1, ZIC3
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| X-linked situs abnormalities result from mutations in ZIC3.
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| Gebbia M, Ferrero GB, Pilia G, Bassi MT, Aylsworth A, Penman-Splitt M, Bird LM, Bamforth JS, Burn J, Schlessinger D, Nelson DL, Casey B.
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| Nat Genet 17(3):305-8. 1997
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| 25 | ZIC1
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| Xenopus Zic3, a primary regulator both in neural and neural crest development.
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| Nakata K, Nagai T, Aruga J, Mikoshiba K.
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| Proc Natl Acad Sci U S A 94(22):11980-5. 1997
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| 26 | DWS1, ZIC1
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| Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma.
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| Yokota N, et al.
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| Cancer Res 56 : 377-383. 1996
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