| 1 | SCA4, ZFHX3
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| Exonic trinucleotide repeat expansions in ZFHX3 cause spinocerebellar ataxia type 4: A poly-glycine disease
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| Wallenius J, Kafantari E, Jhaveri E, Gorcenco S, Ameur A, Karremo C, Dobloug S, Karrman K, de Koning T, Ilinca A, Landqvist Waldö M, Arvidsson A, Persson S, Englund E, Ehrencrona H, Puschmann A.
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| Am J Hum Genet. Jan 4;111(1):82-95. doi: 10.1016/j.ajhg.2023.11.008. Epub 2023 Nov 29. 2024
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| 2 | ZFHX3
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| Myeloid Zfhx3 deficiency protects against hypercapnia-induced suppression of host defense against influenza A virus.
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| Casalino-Matsuda SM, Chen F, Gonzalez-Gonzalez FJ, Matsuda H, Nair A, Abdala-Valencia H, Budinger GRS, Dong JT, Beitel GJ, Sporn PH.
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| JCI Insight. Jan 16;9(4):e170316. doi: 10.1172/jci.insight.170316. 2024
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| 3 | SCA4, ZFHX3
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| Adaptive Long-Read Sequencing Reveals GGC Repeat Expansion in ZFHX3 Associated with Spinocerebellar Ataxia Type 4.
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| Chen Z, Gustavsson EK, Macpherson H, Anderson C, Clarkson C, Rocca C, Self E, Alvarez Jerez P, Scardamaglia A, Pellerin D, Montgomery K, Lee J, Gagliardi D, Luo H; Genomics England Research Consortium; Hardy J, Polke J, Singleton AB, Blauwendraat C, Mathews KD, Tucci A, Fu YH, Houlden H, Ryten M, Ptáček LJ.
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| Mov Disord. Jan 10. doi: 10.1002/mds.29704. Epub ahead of print 2024
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| 4 | IDASDB, ZFHX3
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| Haploinsufficiency of ZFHX3, encoding a key player in neuronal development, causes syndromic intellectual disability.
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| Pérez Baca MDR, Jacobs EZ, Vantomme L, Leblanc P, Bogaert E, Dheedene A, De Cock L, Haghshenas S, Foroutan A, Levy MA, Kerkhof J, McConkey H, Chen CA, Batzir NA, Wang X, Palomares M, Carels M; ZFHX3 consortium; Dermaut B, Sadikovic B, Menten B, Yuan B, Vergult S, Callewaert B.
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| Am J Hum Genet. Mar 7;111(3):509-528. doi: 10.1016/j.ajhg.2024.01.013. Epub 2024 Feb 26. 2024
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| 5 | ATFB8, ZFHX3
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| Loss of the Atrial Fibrillation-Related Gene, Zfhx3, Results in Atrial Dilation and Arrhythmias
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| Jameson HS, Hanley A, Hill MC, Xiao L, Ye J, Bapat A, Ronzier E, Hall AW, Hucker WJ, Clauss S, Barazza M, Silber E, Mina JA, Tucker NR, Mills RW, Dong JT, Milan DJ, Ellinor PT.
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| Circ Res. Aug 4;133(4):313-329. doi: 10.1161/CIRCRESAHA.123.323029. Epub 2023 Jul 14. 2023
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| 6 | ZFHX3
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| Zfhx3 modulates retinal sensitivity and circadian responses to light
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| Hughes S, Edwards JK, Wilcox AG, Pothecary CA, Barnard AR, Joynson R, Joynson G, Hankins MW, Peirson SN, Banks G, Nolan PM.
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| FASEB J. Sep;35(9):e21802. doi: 10.1096/fj.202100563R. 2021
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| 7 | IRF6, MACF1, RBM15, SETD2, TFAP2A, ZFHX3, ZFHX4
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| Genome-wide Enrichment of De Novo Coding Mutations in Orofacial Cleft Trios
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| Bishop MR, Diaz Perez KK, Sun M, Ho S, Chopra P, Mukhopadhyay N, Hetmanski JB, Taub MA, Moreno-Uribe LM, Valencia-Ramirez LC, Restrepo Muñeton CP, Wehby G, Hecht JT, Deleyiannis F, Weinberg SM, Wu-Chou YH, Chen PK, Brand H, Epstein MP, Ruczinski I, Murray JC, Beaty TH, Feingold E, Lipinski RJ, Cutler DJ, Marazita ML, Leslie EJ
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| Am J Hum Genet. Jul 2;107(1):124-136. doi: 10.1016/j.ajhg.2020.05.018. Epub 2020 Jun 22. 2020
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| 8 | HIF1A, ZFHX3
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| The transcription factor ZFHX3 is crucial for the angiogenic function of hypoxia-inducible factor 1α in liver cancer cells.
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| Fu C, An N, Liu J, A J, Zhang B, Liu M, Zhang Z, Fu L, Tian X, Wang D, Dong JT.
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| J Biol Chem. May 15;295(20):7060-7074. doi: 10.1074/jbc.RA119.012131. Epub 2020 Apr 10 2020
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| 9 | PGR, ZFHX3
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| Zfhx3 is essential for progesterone/progesterone receptor signaling to drive ductal side-branching and alveologenesis in mouse mammary glands
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| Ma G, Gao A, Yang Y, He Y, Zhang X, Zhang B, Zhang Z, Li M, Fu X, Zhao D, Wu R, Qi L, Hu Q, Li J, Fu L, Zhu Z, Dong JT.
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| J Genet Genomics. Mar 20;46(3):119-131. doi: 10.1016/j.jgg.2019.03.003. Epub 2019 Mar 22. 2019
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| 10 | TRPV6, ZFHX3
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| Transcription factor ZFHX3 regulates calcium influx in mammary epithelial cells in part via the TRPV6 calcium channel
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| Zhao D, Han X, Huang L, Wang J, Zhang X, Jeon JH, Zhao Q, Dong JT.
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| Biochem Biophys Res Commun. Nov 5;519(2):366-371. doi: 10.1016/j.bbrc.2019.08.148. Epub 2019 Sep 10 2019
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| 11 | ZFHX3
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| Cellular localization of ATBF1 protein and its functional implication in breast epithelial cells.
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| Li M, Zhang C, Zhong Y, Zhao J.
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| Biochem Biophys Res Commun 7 Aug 19;490(2):492-498. doi: 10.1016/j.bbrc.2017.06.068. Epub 2017 Jun 15. 2017
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| 12 | ZFHX3
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| ZFHX3 knockdown increases arrhythmogenesis and dysregulates calcium homeostasis in HL-1 atrial myocytes.
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| Kao YH, Hsu JC, Chen YC, Lin YK, Lkhagva B, Chen SA, Chen YJ.
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| Int J Cardiol. May 1;210:85-92. doi: 10.1016/j.ijcard.2016.02.091. Epub 2016 Feb 17. 2016
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| 13 | PRLR, ZFHX3
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| Zinc Finger Homeodomain Factor Zfhx3 Is Essential for Mammary Lactogenic Differentiation by Maintaining Prolactin Signaling Activity
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| Zhao D, Ma G, Zhang X, He Y, Li M, Han X, Fu L, Dong XY, Nagy T, Zhao Q, Fu L, Dong JT.
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| J Biol Chem. Jun 10;291(24):12809-12820. doi: 10.1074/jbc.M116.719377. Epub 2016 Apr 20 2016
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| 14 | ZFHX3
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| Genetic polymorphisms in ZFHX3 are associated with atrial fibrillation in a Chinese Han population.
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| Liu Y, Ni B, Lin Y, Chen XG, Fang Z, Zhao L, Hu Z, Zhang F.
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| PLoS One 9(7):e101318. doi: 10.1371/journal.pone.0101318. eCollection 2014.
2014
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| 15 | ZFHX3
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| Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells.
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| Sun X, Li J, Dong FN, Dong JT.
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| PLoS One 9(3):e92746. doi: 10.1371/journal.pone.0092746. eCollection 2014.
2014
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| 16 | ZFHX3
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| Upregulation of ATBF1 by progesterone-PR signaling and its functional implication in mammary epithelial cells.
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| Li M, Zhao D, Ma G, Zhang B, Fu X, Zhu Z, Fu L, Sun X, Dong JT.
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| Biochem Biophys Res Commun 430(1):358-63. doi: 10.1016/j.bbrc.2012.11.009. Epub 2012 Nov 15.
2013
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| 17 | ZFHX3
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| Atbf1 regulates pubertal mammary gland development likely by inhibiting the pro-proliferative function of estrogen-ER signaling.
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| Li M, Fu X, Ma G, Sun X, Dong X, Nagy T, Xing C, Li J, Dong JT.
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| PLoS One 7(12):e51283. doi: 10.1371/journal.pone.0051283. Epub 2012 Dec 12.
2012
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| 18 | TRIM25, ZFHX3
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| Oestrogen causes ATBF1 protein degradation through the oestrogen-responsive E3 ubiquitin ligase EFP.
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| Dong XY, Fu X, Fan S, Guo P, Su D, Dong JT.
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| Biochem J 444(3):581-90. doi: 10.1042/BJ20111890.
2012
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| 19 | CAPN1, ZFHX3
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| AT motif binding factor 1 (ATBF1) is highly phosphorylated in embryonic brain and protected from cleavage by calpain-1.
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| Zhang S, Kim TS, Dong Y, Kanazawa S, Kawaguchi M, Gao N, Minato H, Takegami T, Nojima T, Asai K, Miura Y.
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| Biochem Biophys Res Commun 427(3):537-41. doi: 10.1016/j.bbrc.2012.09.092. Epub 2012 Sep 26.
2012
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| 20 | ESR1, ZFHX3
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| Estrogen up-regulates ATBF1 transcription but causes its protein degradation in estrogen receptor-alpha-positive breast cancer cells.
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| Dong XY, Guo P, Sun X, Li Q, Dong JT.
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| J Biol Chem 286(16):13879-90. Epub 2011 Mar 2.
2011
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| 21 | ZFHX3
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| Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GeneID population.
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| Li C, Wang F, Yang Y, Fu F, Xu C, Shi L, Li S, Xia Y, Wu G, Cheng X, Liu H, Wang C, Wang P, Hao J, Ke Y, Zhao Y, Liu M, Zhang R, Gao L, Yu B, Zeng Q, Liao Y, Yang B, Tu X, Wang QK.
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| Hum Genet 129(3):239-46. Epub 2010 Nov 25.
2011
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| 22 | RUNX3, ZFHX3
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| Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction.
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| Mabuchi M, Kataoka H, Miura Y, Kim TS, Kawaguchi M, Ebi M, Tanaka M, Mori Y, Kubota E, Mizushima T, Shimura T, Mizoshita T, Tanida S, Kamiya T, Asai K, Joh T.
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| Biochem Biophys Res Commun 398(2):321-5. doi: 10.1016/j.bbrc.2010.06.090. Epub 2010 Jun 25.
2010
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| 23 | ATFB8, ZFHX3
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| Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.
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| Benjamin EJ, Rice KM, Arking DE, Pfeufer A, van Noord C, Smith AV, Schnabel RB, Bis JC, Boerwinkle E, Sinner MF, Dehghan A, Lubitz SA, D'Agostino RB Sr, Lumley T, Ehret GB, Heeringa J, Aspelund T, Newton-Cheh C, Larson MG, Marciante KD, Soliman EZ, Rivadeneira F, Wang TJ, Eiríksdottir G, Levy D, Psaty BM, Li M, Chamberlain AM, Hofman A, Vasan RS, Harris TB, Rotter JI, Kao WH, Agarwal SK, Stricker BH, Wang K, Launer LJ, Smith NL, Chakravarti A, Uitterlinden AG, Wolf PA, Sotoodehnia N, Köttgen A, van Duijn CM, Meitinger T, Mueller M, Perz S, Steinbeck G, Wichmann HE, Lunetta KL, Heckbert SR, Gudnason V, Alonso A, Kääb S, Ellinor PT, Witteman JC.
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| Nat Genet 41(8):879-81. Epub 2009 Jul 13.PMID: 19597492 2009
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| 24 | ATFB8, ZFHX3
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| A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.
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| Gudbjartsson DF, Holm H, Gretarsdottir S, Thorleifsson G, Walters GB, Thorgeirsson G, Gulcher J, Mathiesen EB, Njølstad I, Nyrnes A, Wilsgaard T, Hald EM, Hveem K, Stoltenberg C, Kucera G, Stubblefield T, Carter S, Roden D, Ng MC, Baum L, So WY, Wong KS, Chan JC, Gieger C, Wichmann HE, Gschwendtner A, Dichgans M, Kuhlenbäumer G, Berger K, Ringelstein EB, Bevan S, Markus HS, Kostulas K, Hillert J, Sveinbjörnsdóttir S, Valdimarsson EM, Løchen ML, Ma RC, Darbar D, Kong A, Arnar DO, Thorsteinsdottir U, Stefansson K.
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| Nat Genet 41(8):876-8. Epub 2009 Jul 13.PMID: 19597491 2009
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| 25 | ZFHX3
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| Genome-wide linkage scan for prostate cancer susceptibility from the University of Michigan Prostate Cancer Genetics Project: suggestive evidence for linkage at 16q23.
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| Lange EM, Beebe-Dimmer JL, Ray AM, Zuhlke KA, Ellis J, Wang Y, Walters S, Cooney KA.
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| Prostate 69(4):385-91.PMID: 19035517 2009
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| 26 | NAALADL2, ZFHX3
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| A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease.
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| Burgner D, Davila S, Breunis WB, Ng SB, Li Y, Bonnard C, Ling L, Wright VJ, Thalamuthu A, Odam M, Shimizu C, Burns JC, Levin M, Kuijpers TW, Hibberd ML; International Kawasaki Disease Genetics Consortium.
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| PLoS Genet 5(1):e1000319. Epub 2009 Jan 9.
2009
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| 27 | POU1F1, ZFHX3
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| Atbf1 is required for the Pit1 gene early activation.
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| Qi Y, Ranish JA, Zhu X, Krones A, Zhang J, Aebersold R, Rose DW, Rosenfeld MG, Carrière C.
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| Proc Natl Acad Sci U S A 105(7):2481-6. Epub 2008 Feb 13. 2008
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| 28 | ZFHX3
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| Loss of heterozygosity at the ATBF1-A locus located in the 16q22 minimal region in breast cancer.
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| Kai K, Zhang Z, Yamashita H, Yamamoto Y, Miura Y, Iwase H.
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| BMC Cancer 8:262.PMID: 18796146 2008
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| 29 | ZFHX3
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| Infrequent mutation of ATBF1 in human breast cancer.
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| Sun X, Zhou Y, Otto KB, Wang M, Chen C, Zhou W, Subramanian K, Vertino PM, Dong JT.
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| J Cancer Res Clin Oncol 133(2):103-5. Epub 2006 Aug 24.PMID: 16932943 2007
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| 30 | ZFHX3
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| Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer.
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| Sun X, Frierson HF, Chen C, Li C, Ran Q, Otto KB, Cantarel BM, Vessella RL, Gao AC, Petros J, Miura Y, Simons JW, Dong JT.
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| Nat Genet 37(4):407-12. Epub 2005 Mar 6. 2005
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| 31 | ZFHX3, PIAS3
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| ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3.
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| Nojiri S, Joh T, Miura Y, Sakata N, Nomura T, Nakao H, Sobue S, Ohara H, Asai K, Ito M.
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| Biochem Biophys Res Commun 314(1):97-103. 2004
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| 32 | ZFHX3
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| DNA/RNA-dependent ATPase activity is associated with ATBF1, a multiple homeodomain-zinc finger protein.
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| Kawaguchi M, Miura Y, Ido A, Morinaga T, Sakata N, Oya T, Hashimoto-Tamaoki T, Sasahara M, Koizumi F, Tamaoki T.
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| Biochim Biophys Acta 1550(2):164-74. 2001
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| 33 | ZFHX3
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| The SRm160/300 splicing coactivator subunits.
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| Blencowe BJ, Bauren G, Eldridge AG, Issner R, Nickerson JA, Rosonina E, Sharp PA.
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| RNA 6(1):111-20. 2000
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| 34 | ZFHX3, SRRM2
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| Cloning and characterization of a novel RNA-binding protein SRL300 with RS domains.
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| Sawada Y, Miura Y, Umeki K, Tamaoki T, Fujinaga K, Ohtaki S.
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| Biochim Biophys Acta 1492(1):191-5. 2000
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| 35 | ZFHX3, SRRM1, SRRM2
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| A coactivator of pre-mRNA splicing.
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| Blencowe BJ, Issner R, Nickerson JA, Sharp PA.
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| Genes Dev 12(7):996-1009. 1998
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| 36 | ADRBK1, AR, ZFHX3, CACNA1A, CAPNS1, FOXE1, FOXF1, FMR1, AFF2, HCN1, NRXN1, CA10
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| CCG repeats in cDNAs from human brain.
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| Kleiderlein JJ, Nisson PE, Jessee J, Li WB, Becker KG, Derby ML, Ross CA, Margolis RL.
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| Hum Genet 103(6):666-73. 1998
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| 37 | ZFHX3
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| Assignment of the human ATBF1 transcription factor gene to chromosome 16q22.3-q23.1.
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| Yamada K, et al.
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| Genomics 29 : 552-553. 1995
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| 38 | ZFHX3
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| Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner.
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| Miura Y, Tam T, Ido A, Morinaga T, Miki T, Hashimoto T, Tamaoki T.
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| J Biol Chem 270(45):26840-8. 1995
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| 39 | ZFHX3
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| ATBF1, a multiple-homeodomain zinc finger protein, selectively down-regulates AT-rich elements of the human alpha-fetoprotein gene.
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| Yasuda H, et al.
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| Mol Cell Biol 14 : 1395-1401. 1994
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| 40 | ZFHX3
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| A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains fourhomeodomains and seventeen zinc fingers.
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| Morinaga T, et al.
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| Mol Cell Biol 11 : 6041-6049. 1991
|