| 1 | ZBTB16
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| Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis.
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| Yu W, Xie Z, Li J, Lin J, Su Z, Che Y, Ye F, Zhang Z, Xu P, Zeng Y, Xu X, Li Z, Feng P, Mi R, Wu Y, Shen H.
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| Bone Res. Jun 7;11(1):30. doi: 10.1038/s41413-023-00267-8. Erratum in: Bone Res. 2023 Jun 26;11(1):33. 2023
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| 2 | KAT2A, ZBTB16
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| GCN5 regulates ZBTB16 through acetylation, mediates osteogenic differentiation, and affects orthodontic tooth movement.
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| Shi SM, Liu TT, Wei XQ, Sun GH, Yang L, Zhu JF
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| Biochem Cell Biol. Jun 1;101(3):235-245. doi: 10.1139/bcb-2022-0080. Epub 2023 Feb 14 2023
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| 3 | SP7, ZBTB16
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| The role of ZBTB16 in odontogenic differentiation of dental pulp stem cells.
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| Zhu X, Niu C, Chen J, Yuan K, Jin Q, Hou L, Huang Z.
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| Arch Oral Biol. Mar;135:105366. doi: 10.1016/j.archoralbio.2022.105366. Epub 2022 Feb 2. 2022
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| 4 | ZBTB16
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| PLZF suppresses differentiation of mouse spermatogonial progenitor cells via binding of differentiation associated genes
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| Song W, Shi X, Xia Q, Yuan M, Liu J, Hao K, Qian Y, Zhao X, Zou K.
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| J Cell Physiol. Mar;235(3):3033-3042. doi: 10.1002/jcp.29208. Epub 2019 Sep 20 2020
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| 5 | ZBTB16
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| PLZF limits enhancer activity during hematopoietic progenitor aging.
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| Poplineau M, Vernerey J, Platet N, N'guyen L, Hérault L, Esposito M, Saurin AJ, Guilouf C, Iwama A, Duprez E.
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| Nucleic Acids Res. May 21;47(9):4509-4520. doi: 10.1093/nar/gkz174 2019
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| 6 | ZBTB16
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| PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2. 2018
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| Shen H, Zhan M, Zhang Y, Huang S, Xu S, Huang X, He M, Yao Y, Man M, Wang J.
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| Cell Death Dis. Jan 22;9(2):71. doi: 10.1038/s41419-017-0107-3 2018
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| 7 | ZBTB16
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| ZBTB16 and metabolic syndrome: a network perspective.
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| Šeda O, Šedová L, Včelák J, Vaňková M, Liška F, Bendlová B.
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| Physiol Res. Sep 26;66(Suppl 3):S357-S365. doi: 10.33549/physiolres.933730 2017
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| 8 | ZBTB16
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| Role of PLZF as a tumor suppressor in prostate cancer.
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| Jin Y, Nenseth HZ, Saatcioglu F.
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| Oncotarget. Aug 2;8(41):71317-71324. doi: 10.18632/oncotarget.19813. 2017
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| 9 | SP7, ZBTB16
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| ZBTB16 as a Downstream Target Gene of Osterix Regulates Osteoblastogenesis of Human Multipotent Mesenchymal Stromal Cells
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| Onizuka S, Iwata T, Park SJ, Nakai K, Yamato M, Okano T, Izumi Y.
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| J Cell Biochem. 2 016 Oct;117(10):2423-34. doi: 10.1002/jcb.25634. Epub 2016 Jun 29. 2016
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| 10 | HYDM, NLRP7, ZBTB16
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| NLRP7, Involved in Hydatidiform Molar Pregnancy (HYDM1), Interacts with the Transcriptional Repressor ZBTB16
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| Singer H, Biswas A, Nuesgen N, Oldenburg J, El-Maarri O.
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| PLoS One Jun 29;10(6):e0130416. doi: 10.1371/journal.pone.0130416. 2015
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| 11 | ZBTB16
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| Zbtb16 (PLZF) is stably suppressed and not inducible in non-innate T cells via T cell receptor-mediated signaling
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| Zhang S, Laouar A, Denzin LK, Sant'Angelo DB.
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| Sci Rep. Jul 16;5:12113. doi: 10.1038/srep12113. 2015
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| 12 | RARA, USP37, ZBTB16
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| The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability.
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| Yang WC, Shih HM.
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| Oncogene 32(43):5167-75. doi: 10.1038/onc.2012.537. Epub 2012 Dec 3.
2013
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| 13 | CEBPA, RARA, ZBTB16
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| RARα-PLZF oncogene inhibits C/EBPα function in myeloid cells.
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| Girard N, Tremblay M, Humbert M, Grondin B, Haman A, Labrecque J, Chen B, Chen Z, Chen SJ, Hoang T.
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| Proc Natl Acad Sci U S A 110(33):13522-7. doi: 10.1073/pnas.1310067110. Epub 2013 Jul 29. 2013
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| 14 | HOXA5, HOXB5, HOXC5, ZBTB16
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| Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb.
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| Xu B, Hrycaj SM, McIntyre DC, Baker NC, Takeuchi JK, Jeannotte L, Gaber ZB, Novitch BG, Wellik DM.
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| Proc Natl Acad Sci U S A 110(48):19438-43. doi: 10.1073/pnas.1315075110. Epub 2013 Nov 11.
2013
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| 15 | SLAMF6, ZBTB16
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| A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes.
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| Dutta M, Kraus ZJ, Gomez-Rodriguez J, Hwang SH, Cannons JL, Cheng J, Lee SY, Wiest DL, Wakeland EK, Schwartzberg PL.
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| J Immunol 190(5):2121-8. doi: 10.4049/jimmunol.1202145. Epub 2013 Jan 25.
2013
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| 16 | ZBTB16
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| Zbtb16 has a role in brown adipocyte bioenergetics.
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| Plaisier CL, Bennett BJ, He A, Guan B, Lusis AJ, Reue K, Vergnes L.
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| Nutr Diabetes 2:e46. doi: 10.1038/nutd.2012.21.
2012
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| 17 | ZBTB16
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| PLZF Controls the Expression of a Limited Number of Genes Essential for NKT Cell Function.
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| Gleimer M, von Boehmer H, Kreslavsky T.
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| Front Immunol 3:374. doi: 10.3389/fimmu.2012.00374. Epub 2012 Dec 21.
2012
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| 18 | SALL4, ZBTB16
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| Functional antagonism between Sall4 and Plzf defines germline progenitors.
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| Hobbs RM, Fagoonee S, Papa A, Webster K, Altruda F, Nishinakamura R, Chai L, Pandolfi PP.
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| Cell Stem Cell 10(3):284-98. doi: 10.1016/j.stem.2012.02.004.
2012
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| 19 | ATP6, CUL3, ZBTB16
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| BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
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| Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
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| Nature 491(7425):618-21. doi: 10.1038/nature11548. Epub 2012 Oct 21.
2012
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| 20 | ZBTB16
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| Promyelocytic leukemia zinc finger turns on the effector T cell program without requirement for agonist TCR signaling.
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| Savage AK, Constantinides MG, Bendelac A.
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| J Immunol 186(10):5801-6. doi: 10.4049/jimmunol.1100119. Epub 2011 Apr 8.
2011
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| 21 | ZBTB16
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| A corticosteroid-responsive transcription factor, promyelocytic leukemia zinc finger protein, mediates protection of the cochlea from acoustic trauma.
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| Peppi M, Kujawa SG, Sewell WF.
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| J Neurosci 31(2):735-41. doi: 10.1523/JNEUROSCI.3955-10.2011.
2011
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| 22 | MTOR, ZBTB16
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| Plzf regulates germline progenitor self-renewal by opposing mTORC1.
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| Hobbs RM, Seandel M, Falciatori I, Rafii S, Pandolfi PP.
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| Cell 142(3):468-79.PMID: 20691905 2010
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| 23 | CUX1, ZBTB16
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| The Promyelocytic Leukemia Zinc Finger (PLZF ) gene is a novel transcriptional target of the CCAAT-Displacement-protein (CUX1) repressor.
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| Fréchette I, Darsigny M, Brochu-Gaudreau K, Jones C, Boudreau F.
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| FEBS J 277(20):4241-53.
2010
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| 24 | ZBTB16
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| T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells.
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| Weinreich MA, Odumade OA, Jameson SC, Hogquist KA.
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| Nat Immunol 11(8):709-16. doi: 10.1038/ni.1898. Epub 2010 Jul 4.
2010
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| 25 | ZBTB16
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| PLZF induces the spontaneous acquisition of memory/effector functions in T cells independently of NKT cell-related signals.
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| Kovalovsky D, Alonzo ES, Uche OU, Eidson M, Nichols KE, Sant'Angelo DB.
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| J Immunol 184(12):6746-55. doi: 10.4049/jimmunol.1000776. Epub 2010 May 21.
2010
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| 26 | ZBTB16
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| The role of PLZF in human myeloid development.
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| Dick JE, Doulatov S.
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| Ann N Y Acad Sci 1176:150-3.PMID: 19796243 2009
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| 27 | CEBPA, ZBTB16
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| PLZF is a regulator of homeostatic and cytokine-induced myeloid development.
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| Doulatov S, Notta F, Rice KL, Howell L, Zelent A, Licht JD, Dick JE.
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| Genes Dev 23(17):2076-87.PMID: 19723763 2009
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| 28 | MTDH, ZBTB16
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| Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression.
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| Thirkettle HJ, Mills IG, Whitaker HC, Neal DE.
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| Oncogene 28(41):3663-70. Epub 2009 Aug 3.PMID: 19648967 2009
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| 29 | CD34, KIT, ZBTB16
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| PLZF-mediated control on c-kit expression in CD34(+) cells and early erythropoiesis.
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| Spinello I, Quaranta MT, Pasquini L, Pelosi E, Petrucci E, Pagliuca A, Castelli G, Mariani G, Diverio D, Foŕ R, Testa U, Labbaye C.
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| Oncogene 28(23):2276-88. doi: 10.1038/onc.2009.87. Epub 2009 May 4.
2009
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| 30 | CX3CR1, GZMB, IGFBP7, IL2RB, KIR3DL2, PAM, PRF1, S1PR5, SH2D1B, SPON2, ZBTB16
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| Gene expression changes in children with autism.
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| Gregg JP, Lit L, Baron CA, Hertz-Picciotto I, Walker W, Davis RA, Croen LA, Ozonoff S, Hansen R, Pessah IN, Sharp FR.
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| Genomics 91(1):22-9. Epub 2007 Nov 14. 2008
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| 31 | CXCR4, ZBTB16
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| A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis.
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| Labbaye C, Spinello I, Quaranta MT, Pelosi E, Pasquini L, Petrucci E, Biffoni M, Nuzzolo ER, Billi M, FoĂ R, Brunetti E, Grignani F, Testa U, Peschle C.
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| Nat Cell Biol 10(7):788-801. Epub 2008 Jun 22.
2008
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| 32 | ZBTB16
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| Biallelic loss of function of the promyelocytic leukaemia zinc finger (PLZF) gene causes severe skeletal defects and genital hypoplasia.
|
| Fischer S, Kohlhase J, Böhm D, Schweiger B, Hoffmann D, Heitmann M, Horsthemke B, Wieczorek D.
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| J Med Genet 45(11):731-7. Epub 2008 Jul 8.
2008
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| 33 | ZBTB16
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| The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions.
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| Kovalovsky D, Uche OU, Eladad S, Hobbs RM, Yi W, Alonzo E, Chua K, Eidson M, Kim HJ, Im JS, Pandolfi PP, Sant'Angelo DB.
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| Nat Immunol 9(9):1055-64. Epub 2008 Jul 27.
2008
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| 34 | RB1, ZBTB16
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| Retinoblastoma protein and the leukemia-associated PLZF transcription factor interact to repress target gene promoters.
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| Petrie K, Guidez F, Zhu J, Howell L, Owen G, Chew YP, Parks S, Waxman S, Licht J, Mittnacht S, Zelent A.
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| Oncogene 27(39):5260-6. Epub 2008 May 26.
2008
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| 35 | GNAO1, ZBTB16
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| The alpha subunit of Go interacts with promyelocytic leukemia zinc finger protein and modulates its functions.
|
| Won JH, Park JS, Ju HH, Kim S, Suh-Kim H, Ghil SH.
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| Cell Signal 20(5):884-91. doi: 10.1016/j.cellsig.2007.12.022. Epub 2008 Jan 12.
2008
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| 36 | TIMP1,ZBTB16
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| TIMP-1 regulates cell proliferation by interacting with the ninth zinc finger domain of PLZF.
|
| Rho SB, Chung BM, Lee JH.
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| J Cell Biochem 101(1):57-67. 2007
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| 37 | ZBTB16, TP53INP1, TERT, ID3, ID1
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| Identification of apoptosis-related PLZF target genes.
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| Bernardo MV, Yelo E, Gimeno L, Campillo JA, Parrado A.
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| Biochem Biophys Res Commun 359(2):317-22. Epub 2007 May 24. 2007
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| 38 | CRABP1, ZBTB16
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| RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia.
|
| Guidez F, Parks S, Wong H, Jovanovic JV, Mays A, Gilkes AF, Mills KI, Guillemin MC, Hobbs RM, Pandolfi PP, de ThŽ H, Solomon E, Grimwade D.
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| Proc Natl Acad Sci U S A 104(47):18694-9. Epub 2007 Nov 13. 2007
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| 39 | ZBTB16, ZBTB32
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| Identification of FAZF as a novel BMP2-induced transcription factor during osteoblastic differentiation.
|
| Ikeda R, Yoshida K, Inoue I.
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| J Cell Biochem 101(1):147-54.
2007
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| 40 | EEF1A1,ZBTB16
|
| A novel cervical cancer suppressor 3 (CCS-3) interacts with the BTB domain of PLZF and inhibits the cell growth by inducing apoptosis.
|
| Rho SB, Park YG, Park K, Lee SH, Lee JH.
|
| FEBS Lett 580(17):4073-80. Epub 2006 Jun 30. 2006
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| 41 | CRMP1, GNE, ZBTB16
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| The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis.
|
| Weidemann W, Stelzl U, Lisewski U, Bork K, Wanker EE, Hinderlich S, Horstkorte R.
|
| FEBS Lett 580(28-29):6649-54. Epub 2006 Nov 14.
2006
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| 42 | GLI3, ZBTB16
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| Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development.
|
| Barna M, Pandolfi PP, Niswander L.
|
| Nature 436(7048):277-81. 2005
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| 43 | ZBTB16
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| Plzf is required in adult male germ cells for stem cell self-renewal.
|
| Buaas FW, Kirsh AL, Sharma M, McLean DJ, Morris JL, Griswold MD, de Rooij DG, Braun RE.
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| Nat Genet 36(6):647-52. Epub 2004 May 23. 2004
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| 44 | ZBTB16
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| Essential role of Plzf in maintenance of spermatogonial stem cells.
|
| Costoya JA, Hobbs RM, Barna M, Cattoretti G, Manova K, Sukhwani M, Orwig KE, Wolgemuth DJ, Pandolfi PP.
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| Nat Genet 36(6):653-9. Epub 2004 May 23. 2004
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| 45 | HOXB2, ZBTB16
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| Regulation of Hoxb2 by APL-associated PLZF protein.
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| Ivins S, Pemberton K, Guidez F, Howell L, Krumlauf R, Zelent A.
|
| Oncogene 22(24):3685-97. 2003
|
| 46 | ZBTB16
|
| PLZF induces megakaryocytic development, activates Tpo receptor expression and interacts with GATA1 protein.
|
| Labbaye C, Quaranta MT, Pagliuca A, Militi S, Licht JD, Testa U, Peschle C.
|
| Oncogene 21(43):6669-79. 2002
|
| 47 | GATA2, ZBTB32, ZBTB16
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| Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein.
|
| Tsuzuki S, Enver T.
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| Blood 99(9):3404-10. 2002
|
| 48 | FHL2, ZBTB16
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| The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein.
|
| McLoughlin P, Ehler E, Carlile G, Licht JD, Schafer BW.
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| J Biol Chem 277(40):37045-53. 2002
|
| 49 | ZBTB16
|
| Down-stream regions of the POZ-domain influence the interaction of the t(11;17)-associated PLZF/RARalpha fusion protein with the histone-deacetylase recruiting co-repressor complex.
|
| Puccetti E, Sennewald B, Fosca-Ferrara F, Boehrer S, Bianchini A, Hoelzer D, Ottmann OG, Nervi C, Ruthardt M.
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| Hematol J 2(6):385-92. 2001
|
| 50 | APLZF, ZBTB16
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| Plzf regulates limb and axial skeletal patterning.
|
| Barna M, Hawe N, Niswander L, Pandolfi PP.
|
| Nat Genet 25(2):166-72. 2000
|
| 51 | ZBTB32, ZBTB16, APLZF
|
| Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene.
|
| Zhang T, et al.
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| Proc Natl Acad Sci U S A 96(20):11422-7 1999
|
| 52 | ZBTB16
|
| Genomic structure of the human PLZF gene.
|
| van Schothorst EM, Prins DE, Baysal BE, Beekman M, Licht JD, Waxman S, Zelent A, Cornelisse CJ, van Ommen GJ, Richard CW 3rd, Devilee P.
|
| Gene 236(1):21-4 1999
|
| 53 | PML, RARA, ZBTB16
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| Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.
|
| He LZ, Guidez F, Tribioli C, Peruzzi D, Ruthardt M, Zelent A, Pandolfi PP.
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| Nat Genet 18(2):126-35. 1998
|
| 54 | PML, RARA, ZBTB16
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| Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia.
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| Grignani F, De Matteis S, Nervi C, Tomassoni L, Gelmetti V, Cioce M, Fanelli M, Ruthardt M, Ferrara FF, Zamir I, Seiser C, Grignani F, Lazar MA, Minucci S, Pelicci PG.
|
| Nature 391(6669):815-8. 1998
|
| 55 | HDAC1, HDAC2, PML, RARA, ZBTB16
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| Role of the histone deacetylase complex in acute promyelocytic leukaemia.
|
| Lin RJ, et al.
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| Nature 391 : 811-814. 1998
|
| 56 | ZBTB16, RARA
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| The RARalpha-PLZF chimera associated with acute promyelocytic leukemia has retained a sequence-specific DNA-binding domain.
|
| Sitterlin D, et al.
|
| Oncogene 14 : 1067-1074. 1997
|
| 57 | PGL1, ZBTB16
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| A high-resolution STS, EST, and gene-based physical map of the hereditary paraganglioma region on chromosome 11q23.
|
| Baysal BE, van Schothorst EM, Farr JE, James MR, Devilee P, Richard CW 3rd.
|
| Genomics 44(2):214-21. 1997
|
| 58 | ZBTB16
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| Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17).
|
| Licht JD, et al.
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| Blood 85 : 1083-1094. 1995
|
| 59 | ZBTB16
|
| PLZF-RARalpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors.
|
| Chen Z, et al.
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| Proc Natl Acad Sci U S A 91 : 1178-1182. 1994
|
| 60 | ZBTB16
|
| Fusion between a novel Krźppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11:17) translocation associated with acute promyelocytic leukaemia.
|
| Chen Z, et al.
|
| EMBO J 12 : 1161-1167. 1993
|
| 61 | BCL6, ZBTB16, ZBTB25
|
| Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger protein.
|
| Numoto M, et al.
|
| Nucleic Acids Res 21 : 3767-3775. 1993
|
| 62 | APLZF, ZBTB16
|
| Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia.
|
| Chen SJ, Zelent A, Tong JH, Yu HQ, Wang ZY, Derre J, Berger R, Waxman S, Chen Z.
|
| J Clin Invest 91(5):2260-7. 1993
|