Citations for
1RARA, USP37, ZBTB16
The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability.
Yang WC, Shih HM.
Oncogene 32(43):5167-75. doi: 10.1038/onc.2012.537. Epub 2012 Dec 3. 2013
2CEBPA, RARA, ZBTB16
RARα-PLZF oncogene inhibits C/EBPα function in myeloid cells.
Girard N, Tremblay M, Humbert M, Grondin B, Haman A, Labrecque J, Chen B, Chen Z, Chen SJ, Hoang T.
Proc Natl Acad Sci U S A 110(33):13522-7. doi: 10.1073/pnas.1310067110. Epub 2013 Jul 29. 2013
3HOXA5, HOXB5, HOXC5, ZBTB16
Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb.
Xu B, Hrycaj SM, McIntyre DC, Baker NC, Takeuchi JK, Jeannotte L, Gaber ZB, Novitch BG, Wellik DM.
Proc Natl Acad Sci U S A 110(48):19438-43. doi: 10.1073/pnas.1315075110. Epub 2013 Nov 11. 2013
4SLAMF6, ZBTB16
A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes.
Dutta M, Kraus ZJ, Gomez-Rodriguez J, Hwang SH, Cannons JL, Cheng J, Lee SY, Wiest DL, Wakeland EK, Schwartzberg PL.
J Immunol 190(5):2121-8. doi: 10.4049/jimmunol.1202145. Epub 2013 Jan 25. 2013
5ZBTB16
Zbtb16 has a role in brown adipocyte bioenergetics.
Plaisier CL, Bennett BJ, He A, Guan B, Lusis AJ, Reue K, Vergnes L.
Nutr Diabetes 2:e46. doi: 10.1038/nutd.2012.21. 2012
6ZBTB16
PLZF Controls the Expression of a Limited Number of Genes Essential for NKT Cell Function.
Gleimer M, von Boehmer H, Kreslavsky T.
Front Immunol 3:374. doi: 10.3389/fimmu.2012.00374. Epub 2012 Dec 21. 2012
7SALL4, ZBTB16
Functional antagonism between Sall4 and Plzf defines germline progenitors.
Hobbs RM, Fagoonee S, Papa A, Webster K, Altruda F, Nishinakamura R, Chai L, Pandolfi PP.
Cell Stem Cell 10(3):284-98. doi: 10.1016/j.stem.2012.02.004. 2012
8ATP6, CUL3, ZBTB16
BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
Nature 491(7425):618-21. doi: 10.1038/nature11548. Epub 2012 Oct 21. 2012
9ZBTB16
Promyelocytic leukemia zinc finger turns on the effector T cell program without requirement for agonist TCR signaling.
Savage AK, Constantinides MG, Bendelac A.
J Immunol 186(10):5801-6. doi: 10.4049/jimmunol.1100119. Epub 2011 Apr 8. 2011
10ZBTB16
A corticosteroid-responsive transcription factor, promyelocytic leukemia zinc finger protein, mediates protection of the cochlea from acoustic trauma.
Peppi M, Kujawa SG, Sewell WF.
J Neurosci 31(2):735-41. doi: 10.1523/JNEUROSCI.3955-10.2011. 2011
11MTOR, ZBTB16
Plzf regulates germline progenitor self-renewal by opposing mTORC1.
Hobbs RM, Seandel M, Falciatori I, Rafii S, Pandolfi PP.
Cell 142(3):468-79.PMID: 20691905 2010
12CUX1, ZBTB16
The Promyelocytic Leukemia Zinc Finger (PLZF ) gene is a novel transcriptional target of the CCAAT-Displacement-protein (CUX1) repressor.
Fréchette I, Darsigny M, Brochu-Gaudreau K, Jones C, Boudreau F.
FEBS J 277(20):4241-53. 2010
13ZBTB16
T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells.
Weinreich MA, Odumade OA, Jameson SC, Hogquist KA.
Nat Immunol 11(8):709-16. doi: 10.1038/ni.1898. Epub 2010 Jul 4. 2010
14ZBTB16
PLZF induces the spontaneous acquisition of memory/effector functions in T cells independently of NKT cell-related signals.
Kovalovsky D, Alonzo ES, Uche OU, Eidson M, Nichols KE, Sant'Angelo DB.
J Immunol 184(12):6746-55. doi: 10.4049/jimmunol.1000776. Epub 2010 May 21. 2010
15ZBTB16
The role of PLZF in human myeloid development.
Dick JE, Doulatov S.
Ann N Y Acad Sci 1176:150-3.PMID: 19796243 2009
16CEBPA, ZBTB16
PLZF is a regulator of homeostatic and cytokine-induced myeloid development.
Doulatov S, Notta F, Rice KL, Howell L, Zelent A, Licht JD, Dick JE.
Genes Dev 23(17):2076-87.PMID: 19723763 2009
17MTDH, ZBTB16
Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression.
Thirkettle HJ, Mills IG, Whitaker HC, Neal DE.
Oncogene 28(41):3663-70. Epub 2009 Aug 3.PMID: 19648967 2009
18CD34, KIT, ZBTB16
PLZF-mediated control on c-kit expression in CD34(+) cells and early erythropoiesis.
Spinello I, Quaranta MT, Pasquini L, Pelosi E, Petrucci E, Pagliuca A, Castelli G, Mariani G, Diverio D, Foà R, Testa U, Labbaye C.
Oncogene 28(23):2276-88. doi: 10.1038/onc.2009.87. Epub 2009 May 4. 2009
19CX3CR1, GZMB, IGFBP7, IL2RB, KIR3DL2, PAM, PRF1, S1PR5, SH2D1B, SPON2, ZBTB16
Gene expression changes in children with autism.
Gregg JP, Lit L, Baron CA, Hertz-Picciotto I, Walker W, Davis RA, Croen LA, Ozonoff S, Hansen R, Pessah IN, Sharp FR.
Genomics 91(1):22-9. Epub 2007 Nov 14. 2008
20CXCR4, ZBTB16
A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis.
Labbaye C, Spinello I, Quaranta MT, Pelosi E, Pasquini L, Petrucci E, Biffoni M, Nuzzolo ER, Billi M, Foà R, Brunetti E, Grignani F, Testa U, Peschle C.
Nat Cell Biol 10(7):788-801. Epub 2008 Jun 22. 2008
21ZBTB16
Biallelic loss of function of the promyelocytic leukaemia zinc finger (PLZF) gene causes severe skeletal defects and genital hypoplasia.
Fischer S, Kohlhase J, Böhm D, Schweiger B, Hoffmann D, Heitmann M, Horsthemke B, Wieczorek D.
J Med Genet 45(11):731-7. Epub 2008 Jul 8. 2008
22ZBTB16
The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions.
Kovalovsky D, Uche OU, Eladad S, Hobbs RM, Yi W, Alonzo E, Chua K, Eidson M, Kim HJ, Im JS, Pandolfi PP, Sant'Angelo DB.
Nat Immunol 9(9):1055-64. Epub 2008 Jul 27. 2008
23RB1, ZBTB16
Retinoblastoma protein and the leukemia-associated PLZF transcription factor interact to repress target gene promoters.
Petrie K, Guidez F, Zhu J, Howell L, Owen G, Chew YP, Parks S, Waxman S, Licht J, Mittnacht S, Zelent A.
Oncogene 27(39):5260-6. Epub 2008 May 26. 2008
24GNAO1, ZBTB16
The alpha subunit of Go interacts with promyelocytic leukemia zinc finger protein and modulates its functions.
Won JH, Park JS, Ju HH, Kim S, Suh-Kim H, Ghil SH.
Cell Signal 20(5):884-91. doi: 10.1016/j.cellsig.2007.12.022. Epub 2008 Jan 12. 2008
25TIMP1,ZBTB16
TIMP-1 regulates cell proliferation by interacting with the ninth zinc finger domain of PLZF.
Rho SB, Chung BM, Lee JH.
J Cell Biochem 101(1):57-67. 2007
26ZBTB16, TP53INP1, TERT, ID3, ID1
Identification of apoptosis-related PLZF target genes.
Bernardo MV, Yelo E, Gimeno L, Campillo JA, Parrado A.
Biochem Biophys Res Commun 359(2):317-22. Epub 2007 May 24. 2007
27CRABP1, ZBTB16
RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia.
Guidez F, Parks S, Wong H, Jovanovic JV, Mays A, Gilkes AF, Mills KI, Guillemin MC, Hobbs RM, Pandolfi PP, de ThŽ H, Solomon E, Grimwade D.
Proc Natl Acad Sci U S A 104(47):18694-9. Epub 2007 Nov 13. 2007
28ZBTB16, ZBTB32
Identification of FAZF as a novel BMP2-induced transcription factor during osteoblastic differentiation.
Ikeda R, Yoshida K, Inoue I.
J Cell Biochem 101(1):147-54. 2007
29EEF1A1,ZBTB16
A novel cervical cancer suppressor 3 (CCS-3) interacts with the BTB domain of PLZF and inhibits the cell growth by inducing apoptosis.
Rho SB, Park YG, Park K, Lee SH, Lee JH.
FEBS Lett 580(17):4073-80. Epub 2006 Jun 30. 2006
30CRMP1, GNE, ZBTB16
The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis.
Weidemann W, Stelzl U, Lisewski U, Bork K, Wanker EE, Hinderlich S, Horstkorte R.
FEBS Lett 580(28-29):6649-54. Epub 2006 Nov 14. 2006
31GLI3, ZBTB16
Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development.
Barna M, Pandolfi PP, Niswander L.
Nature 436(7048):277-81. 2005
32ZBTB16
Plzf is required in adult male germ cells for stem cell self-renewal.
Buaas FW, Kirsh AL, Sharma M, McLean DJ, Morris JL, Griswold MD, de Rooij DG, Braun RE.
Nat Genet 36(6):647-52. Epub 2004 May 23. 2004
33ZBTB16
Essential role of Plzf in maintenance of spermatogonial stem cells.
Costoya JA, Hobbs RM, Barna M, Cattoretti G, Manova K, Sukhwani M, Orwig KE, Wolgemuth DJ, Pandolfi PP.
Nat Genet 36(6):653-9. Epub 2004 May 23. 2004
34HOXB2, ZBTB16
Regulation of Hoxb2 by APL-associated PLZF protein.
Ivins S, Pemberton K, Guidez F, Howell L, Krumlauf R, Zelent A.
Oncogene 22(24):3685-97. 2003
35ZBTB16
PLZF induces megakaryocytic development, activates Tpo receptor expression and interacts with GATA1 protein.
Labbaye C, Quaranta MT, Pagliuca A, Militi S, Licht JD, Testa U, Peschle C.
Oncogene 21(43):6669-79. 2002
36GATA2, ZBTB32, ZBTB16
Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein.
Tsuzuki S, Enver T.
Blood 99(9):3404-10. 2002
37FHL2, ZBTB16
The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein.
McLoughlin P, Ehler E, Carlile G, Licht JD, Schafer BW.
J Biol Chem 277(40):37045-53. 2002
38ZBTB16
Down-stream regions of the POZ-domain influence the interaction of the t(11;17)-associated PLZF/RARalpha fusion protein with the histone-deacetylase recruiting co-repressor complex.
Puccetti E, Sennewald B, Fosca-Ferrara F, Boehrer S, Bianchini A, Hoelzer D, Ottmann OG, Nervi C, Ruthardt M.
Hematol J 2(6):385-92. 2001
39APLZF, ZBTB16
Plzf regulates limb and axial skeletal patterning.
Barna M, Hawe N, Niswander L, Pandolfi PP.
Nat Genet 25(2):166-72. 2000
40ZBTB32, ZBTB16, APLZF
Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene.
Zhang T, et al.
Proc Natl Acad Sci U S A 96(20):11422-7 1999
41ZBTB16
Genomic structure of the human PLZF gene.
van Schothorst EM, Prins DE, Baysal BE, Beekman M, Licht JD, Waxman S, Zelent A, Cornelisse CJ, van Ommen GJ, Richard CW 3rd, Devilee P.
Gene 236(1):21-4 1999
42PML, RARA, ZBTB16
Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.
He LZ, Guidez F, Tribioli C, Peruzzi D, Ruthardt M, Zelent A, Pandolfi PP.
Nat Genet 18(2):126-35. 1998
43PML, RARA, ZBTB16
Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia.
Grignani F, De Matteis S, Nervi C, Tomassoni L, Gelmetti V, Cioce M, Fanelli M, Ruthardt M, Ferrara FF, Zamir I, Seiser C, Grignani F, Lazar MA, Minucci S, Pelicci PG.
Nature 391(6669):815-8. 1998
44HDAC1, HDAC2, PML, RARA, ZBTB16
Role of the histone deacetylase complex in acute promyelocytic leukaemia.
Lin RJ, et al.
Nature 391 : 811-814. 1998
45ZBTB16, RARA
The RARalpha-PLZF chimera associated with acute promyelocytic leukemia has retained a sequence-specific DNA-binding domain.
Sitterlin D, et al.
Oncogene 14 : 1067-1074. 1997
46PGL1, ZBTB16
A high-resolution STS, EST, and gene-based physical map of the hereditary paraganglioma region on chromosome 11q23.
Baysal BE, van Schothorst EM, Farr JE, James MR, Devilee P, Richard CW 3rd.
Genomics 44(2):214-21. 1997
47ZBTB16
Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17).
Licht JD, et al.
Blood 85 : 1083-1094. 1995
48ZBTB16
PLZF-RARalpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors.
Chen Z, et al.
Proc Natl Acad Sci U S A 91 : 1178-1182. 1994
49ZBTB16
Fusion between a novel KrŸppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11:17) translocation associated with acute promyelocytic leukaemia.
Chen Z, et al.
EMBO J 12 : 1161-1167. 1993
50BCL6, ZBTB16, ZBTB25
Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger protein.
Numoto M, et al.
Nucleic Acids Res 21 : 3767-3775. 1993
51APLZF, ZBTB16
Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia.
Chen SJ, Zelent A, Tong JH, Yu HQ, Wang ZY, Derre J, Berger R, Waxman S, Chen Z.
J Clin Invest 91(5):2260-7. 1993