| 1 | CD247, LAT, ZAP70
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| The Immune Signaling Adaptor LAT Contributes to the Neuroanatomical Phenotype of 16p11.2 BP2-BP3 CNVs.
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| Loviglio MN, Arbogast T, Jønch AE, Collins SC, Popadin K, Bonnet CS, Giannuzzi G, Maillard AM, Jacquemont S; 16p11.
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| Am J Hum Genet 101(4):564-577. doi: 10.1016/j.ajhg.2017.08.016. Epub 2017 Sep 28.
2017
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| 2 | PRKCB, USP9X, ZAP70
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| Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity.
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| Naik E, Dixit VM.
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| J Immunol 196(8):3438-51. doi: 10.4049/jimmunol.1403165. Epub 2016 Mar 2.
2016
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| 3 | OTUD7B, ZAP70
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| Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination.
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| Hu H, Wang H, Xiao Y, Jin J, Chang JH, Zou Q, Xie X, Cheng X, Sun SC.
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| J Exp Med 213(3):399-414. doi: 10.1084/jem.20151426. Epub 2016 Feb 22.
2016
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| 4 | ADMIO2, ZAP70
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| A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.
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| Chan AY, Punwani D, Kadlecek TA, Cowan MJ, Olson JL, Mathes EF, Sunderam U, Fu SM, Srinivasan R, Kuriyan J, Brenner SE, Weiss A, Puck JM.
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| J Exp Med 213(2):155-65. doi: 10.1084/jem.20150888. Epub 2016 Jan 18.
2016
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| 5 | SYK, ZAP70
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| SYK expression endows human ZAP70-deficient CD8 T cells with residual TCR signaling.
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| Hauck F, Blumenthal B, Fuchs S, Lenoir C, Martin E, Speckmann C, Vraetz T, Mannhardt-Laakmann W, Lambert N, Gil M, Borte S, Audrain M, Schwarz K, Lim A, Schamel WW, Fischer A, Ehl S, Rensing-Ehl A, Picard C, Latour S.
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| Clin Immunol 161(2):103-9. doi: 10.1016/j.clim.2015.07.002. Epub 2015 Jul 14.
2015
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| 6 | CD27, ZAP70
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| Differential expression and function of CD27 in chronic lymphocytic leukemia cells expressing ZAP-70.
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| Lafarge ST, Hou S, Pauls SD, Johnston JB, Gibson SB, Marshall AJ.
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| Leuk Res 39(7):773-8. doi: 10.1016/j.leukres.2015.04.016. Epub 2015 May 2.
2015
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| 7 | LCK, ZAP70
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| The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.
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| Sjölin-Goodfellow H, Frushicheva MP, Ji Q, Cheng DA, Kadlecek TA, Cantor AJ, Kuriyan J, Chakraborty AK, Salomon AR, Weiss A.
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| Sci Signal 8(377):ra49. doi: 10.1126/scisignal.2005596.
2015
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| 8 | FYB1, ZAP70
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| Analysis of Phosphorylation-dependent Protein Interactions of Adhesion and Degranulation Promoting Adaptor Protein (ADAP) Reveals Novel Interaction Partners Required for Chemokine-directed T cell Migration.
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| Kuropka B, Witte A, Sticht J, Waldt N, Majkut P, Hackenberger CP, Schraven B, Krause E, Kliche S, Freund C.
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| Mol Cell Proteomics 14(11):2961-72. doi: 10.1074/mcp.M115.048249. Epub 2015 Aug 5.
2015
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| 9 | CD74, CXCR4, MIF, ZAP70
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| MIF promotes B cell chemotaxis through the receptors CXCR4 and CD74 and ZAP-70 signaling.
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| Klasen C, Ohl K, Sternkopf M, Shachar I, Schmitz C, Heussen N, Hobeika E, Levit-Zerdoun E, Tenbrock K, Reth M, Bernhagen J, El Bounkari O.
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| J Immunol 192(11):5273-84. doi: 10.4049/jimmunol.1302209. Epub 2014 Apr 23.
2014
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| 10 | ZAP70
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| Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL.
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| Jenkins MR, Stinchcombe JC, Au-Yeung BB, Asano Y, Ritter AT, Weiss A, Griffiths GM.
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| Elife 3:e01310. doi: 10.7554/eLife.01310.
2014
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| 11 | IMD48, ZAP70
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| A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell receptor signalling.
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| Cauwe B, Tian L, Franckaert D, Pierson W, Staats KA, Schlenner SM, Liston A.
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| Immunology 141(3):377-87. doi: 10.1111/imm.12199. 2014
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| 12 | ZAP70
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| A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell receptor signalling.
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| Cauwe B, Tian L, Franckaert D, Pierson W, Staats KA, Schlenner SM, Liston A.
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| Immunology 141(3):377-87. doi: 10.1111/imm.12199.
2014
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| 13 | NFKB1, ZAP70
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| Expression of ZAP70 in chronic lymphocytic leukaemia activates NF-κB signalling.
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| Pede V, Rombout A, Vermeire J, Naessens E, Vanderstraeten H, Philippé J, Verhasselt B.
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| Br J Haematol 163(5):621-30. doi: 10.1111/bjh.12588. Epub 2013 Oct 8.
2013
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| 14 | TMEM102, ZAP70
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| CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration.
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| Chiang YJ, Ho KC, Sun CT, Chiu JJ, Lee FJ, Liao F, Yang-Yen HF, Yen JJ.
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| PLoS One 8(4):e61761. doi: 10.1371/journal.pone.0061761. Print 2013.
2013
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| 15 | ZAP70
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| Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker.
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| Yan Q, Barros T, Visperas PR, Deindl S, Kadlecek TA, Weiss A, Kuriyan J.
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| Mol Cell Biol 33(11):2188-201. doi: 10.1128/MCB.01637-12. Epub 2013 Mar 25.
2013
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| 16 | SYK, ZAP70
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| Zap70 inhibits Syk-mediated osteoclast function.
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| Zou W, Croke M, Fukunaga T, Broekelmann TJ, Mecham RP, Teitelbaum SL.
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| J Cell Biochem 114(8):1871-8. doi: 10.1002/jcb.24531.
2013
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| 17 | NCK1, ZAP70
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| Nck recruitment to the TCR required for ZAP70 activation during thymic development.
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| Borroto A, Arellano I, Dopfer EP, Prouza M, Suchànek M, Fuentes M, Orfao A, Schamel WW, Alarcón B.
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| J Immunol 190(3):1103-12. doi: 10.4049/jimmunol.1202055. Epub 2012 Dec 24.
2013
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| 18 | CD52, SIGLEC10, ZAP70
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| T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10
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| Bandala-Sanchez E, Zhang Y, Reinwald S, Dromey JA, Lee BH, Qian J, Böhmer RM, Harrison LC.
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| Nat Immunol. Jul;14(7):741-8. doi: 10.1038/ni.2610. Epub 2013 May 19. 2013
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| 19 | ZAP70
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| Pitfalls and limitations of ZAP-70 detection in chronic lymphocytic leukemia.
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| Vroblova V, Smolej L, Krejsek J.
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| Hematology 17(5):268-74. doi: 10.1179/1607845412Y.0000000015. Review.
2012
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| 20 | UBASH3A, UBASH3B, ZAP70
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| Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathways.
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| San Luis B, Sondgeroth B, Nassar N, Carpino N.
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| J Biol Chem 286(18):15943-54. doi: 10.1074/jbc.M110.177634. Epub 2011 Mar 10. 2011
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| 21 | ITGB2, LCK, ZAP70
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| The integrin LFA-1 signals through ZAP-70 to regulate expression of high-affinity LFA-1 on T lymphocytes.
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| Evans R, Lellouch AC, Svensson L, McDowall A, Hogg N.
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| Blood 117(12):3331-42. doi: 10.1182/blood-2010-06-289140. Epub 2011 Jan 3.
2011
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| 22 | CXCL12, GNAI2, RASGRP1, ZAP70
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| G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1-induced T cell functions.
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| Kremer KN, Kumar A, Hedin KE.
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| J Immunol 187(6):3177-85. doi: 10.4049/jimmunol.1100206. Epub 2011 Aug 19.
2011
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| 23 | LCP2, ZAP70
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| SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering.
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| Liu H, Purbhoo MA, Davis DM, Rudd CE.
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| Proc Natl Acad Sci U S A 107(22):10166-71. Epub 2010 May 13.PMID: 20534575 2010
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| 24 | ZAP70
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| A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity.
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| Au-Yeung BB, Levin SE, Zhang C, Hsu LY, Cheng DA, Killeen N, Shokat KM, Weiss A.
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| Nat Immunol 11(12):1085-92. doi: 10.1038/ni.1955. Epub 2010 Oct 31.
2010
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| 25 | IMD48, ZAP70
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| Hypomorphic mutation of ZAP70 in human results in a late onset immunodeficiency and no autoimmunity.
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| Picard C, Dogniaux S, Chemin K, Maciorowski Z, Lim A, Mazerolles F, Rieux-Laucat F, Stolzenberg MC, Debre M, Magny JP, Le Deist F, Fischer A, Hivroz C.
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| Eur J Immunol 39(7):1966-76. 2009
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| 26 | ZAP70
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| ZAP-70 mRNA expression provides clinically valuable information in early-stage chronic lymphocytic leukemia.
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| Reinoso-Martín C, Jantus-Lewintre E, Ballesteros CG, Campos CB, Ferrer JR, García-Conde J.
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| Haematologica 93(9):1422-4. No abstract available.
2008
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| 27 | ZAP70
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| ZAP70 in chronic lymphocytic leukaemia.
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| Amin S, Parker A, Mann J.
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| Int J Biochem Cell Biol 40(9):1654-8. Epub 2007 May 31. Review.
2008
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| 28 | CD38, ZAP70
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| Significance of zeta-associated protein (ZAP-70) and CD38 expression in chronic lymphocytic leukemia.
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| el-Sharnouby JA, el-Shakankiri AA, Hendy OM, Ahmed LM, Taha AM.
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| Egypt J Immunol 13(2):69-84.
2006
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| 29 | DBNL, ZAP70
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| HIP-55 is important for T-cell proliferation, cytokine production, and immune responses.
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| Han J, Shui JW, Zhang X, Zheng B, Han S, Tan TH.
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| Mol Cell Biol 25(16):6869-78.
2005
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| 30 | ZAP70
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| Identification of a novel isoform of ZAP-70, truncated ZAP kinase.
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| Kuroyama H, Ikeda T, Kasai M, Yamasaki S, Tatsumi M, Utsuyama M, Saito T, Hirokawa K.
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| Biochem Biophys Res Commun 315(4):935-41. 2004
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| 31 | DUSP3, ZAP70
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| Tyrosine phosphorylation of VHR phosphatase by ZAP-70.
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| Alonso A, Rahmouni S, Williams S, van Stipdonk M, Jaroszewski L, Godzik A, Abraham RT, Schoenberger SP, Mustelin T.
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| Nat Immunol 4(1):44-8. Epub 2002 Nov 25. 2003
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| 32 | IMD48, ZAP70
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| Specific immunoglobulin E responses in ZAP-70-deficient patients are mediated by Syk-dependent T-cell receptor signalling.
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| Toyabe S, Watanabe A, Harada W, Karasawa T, Uchiyama M.
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| Immunology 103(2):164-71.
2001
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| 33 | ZAP70
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| LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
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| Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE.
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| Cell 92(1):83-92. 1998
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| 34 | IMD48, ZAP70
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| Severe combined immunodeficiency due to a defect in the tyrosine kinase ZAP-70.
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| Elder ME.
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| Pediatr Res 39 : 743-748. 1996
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| 35 | IMD48, ZAP70
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| ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency.
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| Chan AC, et al.
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| Science 264 : 1599-1601. 1994
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| 36 | IMD48, ZAP70
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| Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase.
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| Elder ME, et al.
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| Science 264 : 1596-1599. 1994
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| 37 | SYK, ZAP70
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| Chromosomal location of the Syk and ZAP-70 tyrosine kinase genes in mice and humans.
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| Ku G, et al.
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| Immunogenetics 40 : 300-302. 1994
|