| 1 | C2CD5, CDK5, NDEL1, YWHAE
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| Regulation of in vivo dynein force production by CDK5 and 14-3-3ε and KIAA0528.
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| Chapman DE, Reddy BJN, Huy B, Bovyn MJ, Cruz SJS, Al-Shammari ZM, Han H, Wang W, Smith DS, Gross SP.
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| Nat Commun 10(1):228. doi: 10.1038/s41467-018-08110-z.
2019
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| 2 | ASH2L, DNMT1, MT1A, UHRF1, YWHAE, ZNF479
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| ZNF479 downregulates metallothionein-1 expression by regulating ASH2L and DNMT1 in hepatocellular carcinoma
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| Wu YJ, Ko BS, Liang SM, Lu YJ, Jan YJ, Jiang SS, Shyue SK, Chen L, Liou JY.
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| Cell Death Dis. May 28;10(6):408. doi: 10.1038/s41419-019-1651-9. 2019
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| 3 | YWHAE
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| Analysis of 14-3-3 isoforms expressed in photoreceptors.
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| Inamdar SM, Lankford CK, Laird JG, Novbatova G, Tatro N, Whitmore SS, Scheetz TE, Baker SA.
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| Exp Eye Res 170:108-116. doi: 10.1016/j.exer.2018.02.022. Epub 2018 Feb 24.
2018
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| 4 | BHMT, BHMT2, HMGB1, YWHAE
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| Identification of hepatic protein-protein interaction targets for betaine homocysteine S-methyltransferase.
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| Garrido F, Pacheco M, Vargas-Martínez R, Velasco-García R, Jorge I, Serrano H, Portillo F, Vázquez J, Pajares MÁ.
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| PLoS One 13(6):e0199472. doi: 10.1371/journal.pone.0199472. eCollection 2018.
2018
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| 5 | YWHAE
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| Complete ablation of the 14-3-3epsilon protein results in multiple defects in neuropsychiatric behaviors.
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| Wachi T, Cornell B, Toyo-Oka K.
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| Behav Brain Res 319:31-36. doi: 10.1016/j.bbr.2016.11.016. Epub 2016 Nov 11.
2017
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| 6 | MAP3K5, YWHAE
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| Structural Insight into the 14-3-3 Protein-dependent Inhibition of Protein Kinase ASK1 (Apoptosis Signal-regulating kinase 1).
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| Petrvalska O, Kosek D, Kukacka Z, Tosner Z, Man P, Vecer J, Herman P, Obsilova V, Obsil T.
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| J Biol Chem 291(39):20753-65. doi: 10.1074/jbc.M116.724310. Epub 2016 Aug 11.
2016
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| 7 | DUP17P13, YWHAE
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| Regulation of neuronal morphogenesis by 14-3-3epsilon (Ywhae) via the microtubule binding protein, doublecortin.
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| Cornell B, Wachi T, Zhukarev V, Toyo-Oka K.
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| Hum Mol Genet 25(20):4405-4418. doi: 10.1093/hmg/ddw270. Erratum in: Hum Mol Genet. 2016 Oct 15;25(20):4610.
2016
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| 8 | ANPEP, YWHAE
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| The pro-inflammatory cytokine 14-3-3ε is a ligand of CD13 in cartilage.
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| Nefla M, Sudre L, Denat G, Priam S, Andre-Leroux G, Berenbaum F, Jacques C.
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| J Cell Sci 128(17):3250-62. doi: 10.1242/jcs.169573. Epub 2015 Jul 24.
2015
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| 9 | YWHAE
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| The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and brain morphology in schizophrenia: a voxel-based morphometric study.
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| Kido M, Nakamura Y, Nemoto K, Takahashi T, Aleksic B, Furuichi A, Nakamura Y, Ikeda M, Noguchi K, Kaibuchi K, Iwata N, Ozaki N, Suzuki M.
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| PLoS One 9(8):e103571. doi: 10.1371/journal.pone.0103571. eCollection 2014.
2014
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| 10 | YWHAE
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| Cleft lip/palate associated with 17p13.3 duplication involving a single candidate gene (YWHAE).
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| Tucker ME, Escobar LF.
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| Clin Genet 85(6):600-1. doi: 10.1111/cge.12237. Epub 2013 Jul 31. No abstract available.
2014
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| 11 | NAV2, YWHAE
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| 14-3-3ε and NAV2 interact to regulate neurite outgrowth and axon elongation.
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| Marzinke MA, Mavencamp T, Duratinsky J, Clagett-Dame M.
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| Arch Biochem Biophys 540(1-2):94-100. doi: 10.1016/j.abb.2013.10.012. Epub 2013 Oct 23.
2013
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| 12 | YWHAE
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| 14-3-3ε overexpression contributes to epithelial-mesenchymal transition of hepatocellular carcinoma.
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| Liu TA, Jan YJ, Ko BS, Liang SM, Chen SC, Wang J, Hsu C, Wu YM, Liou JY.
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| PLoS One 8(3):e57968. doi: 10.1371/journal.pone.0057968. Epub 2013 Mar 6.
2013
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| 13 | BHLHA9, YWHAE
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| Identification of a rare 17p13.3 duplication including the BHLHA9 and YWHAE genes in a family with developmental delay and behavioural problems.
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| Capra V, Mirabelli-Badenier M, Stagnaro M, Rossi A, Tassano E, Gimelli S, Gimelli G.
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| BMC Med Genet 13:93. doi: 10.1186/1471-2350-13-93. 2012
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| 14 | CCNE1, CDKN1B, YWHAE
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| 14-3-3ε plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle.
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| Kosaka Y, Cieslik KA, Li L, Lezin G, Maguire CT, Saijoh Y, Toyo-oka K, Gambello MJ, Vatta M, Wynshaw-Boris A, Baldini A, Yost HJ, Brunelli L.
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| Mol Cell Biol 32(24):5089-102. doi: 10.1128/MCB.00829-12. Epub 2012 Oct 15.
2012
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| 15 | DDX58, YWHAE
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| The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.
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| Liu HM, Loo YM, Horner SM, Zornetzer GA, Katze MG, Gale M Jr.
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| Cell Host Microbe 11(5):528-37. doi: 10.1016/j.chom.2012.04.006.
2012
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| 16 | DUP17P13, PAFAH1B1, YWHAE
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| A new 17p13.3 microduplication including the PAFAH1B1 and YWHAE genes resulting from an unbalanced X;17 translocation.
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| Hyon C, Marlin S, Chantot-Bastaraud S, Mabboux P, Beaujard MP, Al Ageeli E, Vazquez MP, Picard A, Siffroi JP, Portnoď MF.
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| Eur J Med Genet 54(3):287-91. Epub 2010 Dec 31.
2011
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| 17 | DISC1, YWHAE
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| Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner.
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| Ramsey AJ, Milenkovic M, Oliveira AF, Escobedo-Lozoya Y, Seshadri S, Salahpour A, Sawa A, Yasuda R, Caron MG.
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| Proc Natl Acad Sci U S A 108(14):5795-800. Epub 2011 Mar 21.
2011
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| 18 | DEL17P13, DEL17P13D, DUP17P13, MDS, PAFAH1B1, YWHAE
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| Further molecular and clinical delineation of co-locating 17p13.3 microdeletions and microduplications that show distinctive phenotypes.
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| Bruno DL, Anderlid BM, Lindstrand A, van Ravenswaaij-Arts C, Ganesamoorthy D, Lundin J, Martin CL, Douglas J, Nowak C, Adam MP, Kooy RF, Van der Aa N, Reyniers E, Vandeweyer G, Stolte-Dijkstra I, Dijkhuizen T, Yeung A, Delatycki M, Borgström B, Thelin L, Cardoso C, van Bon B, Pfundt R, de Vries BB, Wallin A, Amor DJ, James PA, Slater HR, Schoumans J.
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| J Med Genet 47(5):299-311.PMID: 20452996 2010
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| 19 | MDS, YWHAE
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| Deletion of YWHAE in a patient with periventricular heterotopias and pronounced corpus callosum hypoplasia.
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| Mignon-Ravix C, Cacciagli P, El-Waly B, Moncla A, Milh M, Girard N, Chabrol B, Philip N, Villard L.
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| J Med Genet 47(2):132-6. Epub 2009 Jul 26.PMID: 19635726 2010
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| 20 | DEL17P13D, MDS, PAFAH1B1, YWHAE
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| Further delineation of the 17p13.3 microdeletion involving YWHAE but distal to PAFAH1B1: four additional patients.
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| Schiff M, Delahaye A, Andrieux J, Sanlaville D, Vincent-Delorme C, Aboura A, Benzacken B, Bouquillon S, Elmaleh-Berges M, Labalme A, Passemard S, Perrin L, Manouvrier-Hanu S, Edery P, Verloes A, Drunat S.
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| Eur J Med Genet 53(5):303-8. Epub 2010 Jul 3.PMID: 20599530 2010
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| 21 | HDAC7, YWHAE, YWHAH, YWHAZ
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| Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin.
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| Margariti A, Zampetaki A, Xiao Q, Zhou B, Karamariti E, Martin D, Yin X, Mayr M, Li H, Zhang Z, De Falco E, Hu Y, Cockerill G, Xu Q, Zeng L.
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| Circ Res 106(7):1202-11. Epub 2010 Mar 11.
2010
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| 22 | DEL17P13D, MDS, YWHAE
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| Microdeletions including YWHAE in the Miller-Dieker syndrome region on chromosome 17p13.3 result in facial dysmorphisms, growth restriction, and cognitive impairment.
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| Nagamani SC, Zhang F, Shchelochkov OA, Bi W, Ou Z, Scaglia F, Probst FJ, Shinawi M, Eng C, Hunter JV, Sparagana S, Lagoe E, Fong CT, Pearson M, Doco-Fenzy M, Landais E, Mozelle M, Chinault AC, Patel A, Bacino CA, Sahoo T, Kang SH, Cheung SW, Lupski JR, Stankiewicz P.
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| J Med Genet 46(12):825-33. Epub 2009 Jul 6. 2009
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| 23 | DISC1, YWHAE
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| Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia.
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| Ikeda M, Hikita T, Taya S, Uraguchi-Asaki J, Toyo-oka K, Wynshaw-Boris A, Ujike H, Inada T, Takao K, Miyakawa T, Ozaki N, Kaibuchi K, Iwata N.
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| Hum Mol Genet 17(20):3212-22. Epub 2008 Jul 24.
2008
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| 24 | MDS, NDEL1, PAFAH1B1, YWHAE
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| Lissencephaly and LIS1: insights into the molecular mechanisms of neuronal migration and development.
|
| Wynshaw-Boris A.
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| Clin Genet 72(4):296-304. 2007
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| 25 | DISC1, YWHAE
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| DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1.
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| Taya S, Shinoda T, Tsuboi D, Asaki J, Nagai K, Hikita T, Kuroda S, Kuroda K, Shimizu M, Hirotsune S, Iwamatsu A, Kaibuchi K.
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| J Neurosci 27(1):15-26. 2007
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| 26 | CRK, LIS1, YWHAE, MDS, PAFAH1B1
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| Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3.
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| Cardoso C, Leventer RJ, Ward HL, Toyo-Oka K, Chung J, Gross A, Martin CL, Allanson J, Pilz DT, Olney AH, Mutchinick OM, Hirotsune S, Wynshaw-Boris A, Dobyns WB, Ledbetter DH.
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| Am J Hum Genet 72(4):918-30. Epub 2003 Mar 05. 2003
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| 27 | ATXN1, YWHAB, YWHAE, YWHAH, YWHAZ
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| Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.
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| Chen HK, Fernandez-Funez P, Acevedo SF, Lam YC, Kaytor MD, Fernandez MH, Aitken A, Skoulakis EM, Orr HT, Botas J, Zoghbi HY.
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| Cell 113(4):457-68. 2003
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| 28 | CDK5, LIS1, NDEL1, YWHAE
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| 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome.
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| Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai LH, Dobyns W, Ledbetter D, Hirotsune S, Wynshaw-Boris A.
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| Nat Genet 34(3):274-85. 2003
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| 29 | MDS, ARX, DCX, PAFAH1B1, RELN, YWHAE
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| Lissencephaly and the molecular basis of neuronal migration.
|
| Kato M, Dobyns WB.
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| Hum Mol Genet 12 Spec No 1:R89-96. Review. 2003
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| 30 | YWHAE
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| Identification of frequent G(2) checkpoint impairment and a homozygous deletion of 14-3-3epsilon at 17p13.3 in small cell lung cancers.
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| Konishi H, Nakagawa T, Harano T, Mizuno K, Saito H, Masuda A, Matsuda H, Osada H, Takahashi T.
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| Cancer Res 62(1):271-6. 2002
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| 31 | KCNH2, YWHAE
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| 14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity.
|
| Kagan A, Melman YF, Krumerman A, McDonald TV.
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| EMBO J 21(8):1889-98. 2002
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| 32 | YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAR, YWHAZ
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| 14-3-3 proteins block apoptosis and differentially regulate MAPK cascades.
|
| Xing H, Zhang S, Weinheimer C, Kovacs A, Muslin AJ.
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| EMBO J 19(3):349-358 2000
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| 33 | CLCA1, YWHAE
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| Modulation of the Ca(2+)-activated Cl(-) channel by 14-3-3epsilon.
|
| han HC, Wu WL, So SC, Chung YW, Tsang LL, Wang XF, Yan YC, Luk SC, Siu SS, Tsui SK, Fung KP, Lee CY, Waye MM.
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| Biochem Biophys Res Commun 270(2):581-7. 2000
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| 34 | LIS1, MDS, PLA2G7, YWHAE
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| A revision of the lissencephaly and Miller-Dieker syndrome critical regions in chromosome 17p13.3.
|
| Chong SS, et al.
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| Hum Mol Genet 6 : 147-155. 1997
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| 35 | YWHAE
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| Assignment of the human 14-3-3 epsilon isoform (YWHAE) to human chromosome 17p13 by in situ hybridization.
|
| Luk SC, Garcia-Barcelo M, Tsui SK, Fung KP, Lee CY, Waye MM.
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| Cytogenet Cell Genet 78(2):105-6. 1997
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| 36 | YWHAB, YWHAE, YWHAH, YWHAZ
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| The structural basis for 14-3-3 : phosphopeptide binding specificity.
|
| Yaffe MB, Rittinger K, Volinia S, Caron PR, Aitken A, Leffers H, Gamblin SJ, Smerdon SJ, Cantley LC.
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| Cell 91(7):961-71. 1997
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| 37 | LIS1, MDS, YWHAE
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| 14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region.
|
| Chong SS, et al.
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| Genome Res 6 : 735-741. 1996
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| 38 | LIS1, YWHAE
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| Function of 14-3-3 proteins.
|
| Jin DY, et al.
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| Nature 382 : 308. 1996
|
| 39 | LIS1, YWHAE
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| Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats.
|
| Reiner O, et al.
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| Nature 364 : 717-721. 1993
|