| 1 | USP50, XRCC6
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| Induction of deubiquitinating enzyme USP50 during erythropoiesis and its potential role in the regulation of Ku70 stability.
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| Cai J, Wei J, Schrott V, Zhao J, Bullock G, Zhao Y.
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| J Investig Med 66(1):1-6. doi: 10.1136/jim-2017-000622. Epub 2017 Nov 3.
2018
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| 2 | DDB2, XRCC5, XRCC6
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| Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2.
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| Fantini D, Huang S, Asara JM, Bagchi S, Raychaudhuri P.
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| Mol Biol Cell 28(1):192-200. doi: 10.1091/mbc.E16-08-0573. Epub 2016 Nov 9.
2017
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| 3 | KDM5B, KDM5B, XRCC6
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| Histone demethylase KDM5B is a key regulator of genome stability.
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| Li X, Liu L, Yang S, Song N, Zhou X, Gao J, Yu N, Shan L, Wang Q, Liang J, Xuan C, Wang Y, Shang Y, Shi L.
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| Proc Natl Acad Sci U S A 111(19):7096-101. doi: 10.1073/pnas.1324036111. Epub 2014 Apr 28.
2014
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| 4 | PTTG1, TERT, XRCC6
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| Changes in PTTG1 by human TERT gene expression modulate the self-renewal of placenta-derived mesenchymal stem cells.
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| Lee HJ, Choi JH, Jung J, Kim JK, Lee SS, Kim GJ.
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| Cell Tissue Res 357(1):145-57. doi: 10.1007/s00441-014-1874-0. Epub 2014 May 11.
2014
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| 5 | RECQL, XRCC5, XRCC6
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| Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks.
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| Parvathaneni S, Stortchevoi A, Sommers JA, Brosh RM Jr, Sharma S.
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| PLoS One 8(5):e62481. doi: 10.1371/journal.pone.0062481. Print 2013.
2013
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| 6 | CFLAR, XRCC6
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| Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis.
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| Kerr E, Holohan C, McLaughlin KM, Majkut J, Dolan S, Redmond K, Riley J, McLaughlin K, Stasik I, Crudden M, Van Schaeybroeck S, Fenning C, O'Connor R, Kiely P, Sgobba M, Haigh D, Johnston PG, Longley DB.
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| Cell Death Differ 19(8):1317-27. doi: 10.1038/cdd.2012.8. Epub 2012 Feb 10.
2012
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| 7 | DEAF1, PRKDC, XRCC5, XRCC6
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| Deformed epidermal autoregulatory factor-1 (DEAF1) interacts with the Ku70 subunit of the DNA-dependent protein kinase complex.
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| Jensik PJ, Huggenvik JI, Collard MW.
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| PLoS One 7(3):e33404. doi: 10.1371/journal.pone.0033404. Epub 2012 Mar 19.
2012
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| 8 | PARP1, TOP2B, XRCC6
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| Topoisomerase IIβ associates with Ku70 and PARP-1 during double strand break repair of DNA in neurons.
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| Mandraju R, Chekuri A, Bhaskar C, Duning K, Kremerskothen J, Kondapi AK.
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| Arch Biochem Biophys 516(2):128-37. doi: 10.1016/j.abb.2011.09.017. Epub 2011 Oct 10.
2011
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| 9 | XRCC5, XRCC6
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| KARP-1 works as a heterodimer with Ku70, but the function of KARP-1 cannot perfectly replace that of Ku80 in DSB repair.
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| Koike M, Yutoku Y, Koike A.
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| Exp Cell Res 317(16):2267-75. doi: 10.1016/j.yexcr.2011.06.015. Epub 2011 Jul 2.
2011
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| 10 | XRCC6
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| Accumulation of Ku70 at DNA double-strand breaks in living epithelial cells.
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| Koike M, Yutoku Y, Koike A.
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| Exp Cell Res 317(17):2429-37. doi: 10.1016/j.yexcr.2011.07.018. Epub 2011 Jul 29.
2011
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| 11 | IFNL1, XRCC6
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| Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN.
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| Zhang X, Brann TW, Zhou M, Yang J, Oguariri RM, Lidie KB, Imamichi H, Huang DW, Lempicki RA, Baseler MW, Veenstra TD, Young HA, Lane HC, Imamichi T.
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| J Immunol 186(8):4541-5. doi: 10.4049/jimmunol.1003389. Epub 2011 Mar 11.
2011
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| 12 | COIL, XRCC5, XRCC6
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| Coilin interacts with Ku proteins and inhibits in vitro non-homologous DNA end joining.
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| Velma V, Carrero ZI, Cosman AM, Hebert MD.
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| FEBS Lett 584(23):4735-9. Epub 2010 Nov 9.
2010
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| 13 | XRCC5, XRCC6
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| Ku80 facilitates chromatin binding of the telomere binding protein, TRF2.
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| Fink LS, Lerner CA, Torres PF, Sell C.
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| Cell Cycle 9(18):3798-806. Epub 2010 Sep 25.
2010
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| 14 | XRCC5, XRCC6
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| Exogenously expressed human Ku70 stabilizes Ku80 in Xenopus oocytes and induces heterologous DNA-PK catalytic activity.
|
| Kanungo J.
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| Mol Cell Biochem 338(1-2):291-8. Epub 2010 Jan 3.
2010
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| 15 | BAZ1A, SMARCA5, XRCC6
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| The ACF1 complex is required for DNA double-strand break repair in human cells.
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| Lan L, Ui A, Nakajima S, Hatakeyama K, Hoshi M, Watanabe R, Janicki SM, Ogiwara H, Kohno T, Kanno S, Yasui A.
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| Mol Cell 40(6):976-87.
2010
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| 16 | MDM2, XRCC6
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| Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization.
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| Gama V, Gomez JA, Mayo LD, Jackson MW, Danielpour D, Song K, Haas AL, Laughlin MJ, Matsuyama S.
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| Cell Death Differ 16(5):758-69. Epub 2009 Feb 27. 2009
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| 17 | LAMA2, MDC1A, XRCC6
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| Ku70 regulates Bax-mediated pathogenesis in laminin-alpha2-deficient human muscle cells and mouse models of congenital muscular dystrophy.
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| Vishnudas VK, Miller JB.
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| Hum Mol Genet 18(23):4467-77. Epub 2009 Aug 19.PMID: 19692349 2009
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| 18 | XRCC5, XRCC6
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| Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression.
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| Ohno M, Kunimoto M, Nishizuka M, Osada S, Imagawa M.
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| Biochem Biophys Res Commun 390(3):738-42. Epub 2009 Oct 13.
2009
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| 19 | JUN, XRCC5, XRCC6
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| Purification and identification of positive regulators binding to a novel element in the c-Jun promoter.
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| Jiang D, Zhou Y, Moxley RA, Jarrett HW.
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| Biochemistry 47(35):9318-34. Epub 2008 Aug 9.
2008
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| 20 | SIRT3, XRCC6
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| SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70.
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| Sundaresan NR, Samant SA, Pillai VB, Rajamohan SB, Gupta MP.
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| Mol Cell Biol 28(20):6384-401. Epub 2008 Aug 18.PMID: 18710944 2008
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| 21 | CCNE1, XRCC6
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| Interaction of a cyclin E fragment with Ku70 regulates Bax-mediated apoptosis.
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| Mazumder S, Plesca D, Kinter M, Almasan A.
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| Mol Cell Biol 27(9):3511-20. Epub 2007 Feb 26.PMID: 17325036 2007
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| 22 | DCLRE1C, XRCC6
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| Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends.
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| Drouet J, Frit P, Delteil C, de Villartay JP, Salles B, Calsou P.
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| J Biol Chem 281(38):27784-93. Epub 2006 Jul 19. 2006
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| 23 | XRCC6, LIG4, PRKDC, XRCC4, XRCC5
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| Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.
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| Calsou P, Delteil C, Frit P, Drouet J, Salles B.
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| J Mol Biol 326(1):93-103. 2003
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| 24 | XRCC6, LIG4, POLM, PRKDC, XRCC4, XRCC5
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| Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair.
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| Mahajan KN, Nick McElhinny SA, Mitchell BS, Ramsden DA.
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| Mol Cell Biol 22(14):5194-202. 2002
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| 25 | XRCC6, LIG4, XRCC4, XRCC5
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| Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice.
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| Gu Y, Sekiguchi J, Gao Y, Dikkes P, Frank K, Ferguson D, Hasty P, Chun J, Alt FW.
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| Proc Natl Acad Sci U S A 97(6):2668-73. 2000
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| 26 | XRCC6, XRCC5, LIG4, PRKDC, XRCC4
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| Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair.
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| Hanakahi LA, Bartlet-Jones M, Chappell C, Pappin D, West SC.
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| Cell 102(6):721-9. 2000
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| 27 | XRCC5, XRCC6
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| Molecular cloning and sequencing of cDNAs encoding homologues of human Ku70 and Ku80 autoantigen from Xenopus and their expression in various Xenopus tissues.
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| Yagura T, et al.
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| Biochim Biophys Acta 1445(1):160-4. 1999
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| 28 | XRCC6, MRE11A
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| Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis.
|
| Goedecke W, Eijpe M, Offenberg HH, van Aalderen M, Heyting C.
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| Nat Genet 23(2):194-8. 1999
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| 29 | XRCC6, RAD54B
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| Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells.
|
| Takata M, Sasaki MS, Sonoda E, Morrison C, Hashimoto M, Utsumi H, Yamaguchi-Iwai Y, Shinohara A, Takeda S.
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| EMBO J 17(18):5497-508. 1998
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| 30 | ATM, XRCC6, XRCC5, PRKDC
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| DNA-dependent protein kinase catalytic subunit : a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product.
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| Hartley KO, et al.
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| Cell 82 : 849-856. 1995
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| 31 | XRCC6, XRCC5
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| Chromosomal location and expression of the genes coding for Ku p70 and p80 in human cell lines and normal tissues.
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| Cai QQ, Plet A, Imbert J, Lafage-Pochitaloff M, Cerdan C, Blanchard JM.
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| Cytogenet Cell Genet 65 : 221-227. 1994
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| 32 | XRCC6, XRCC5
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| Human DNA helicase II : a novel DNA unwinding enzyme identified as the Ku autoantigen.
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| Tuteja N, Tuteja R, Ochem A, Taneja P, Huang NW, Simoncsits A, Susic S, Rahman K, Marusic L, Chen J, et al.
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| EMBO J 13 : 4991-5001. 1994
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| 33 | XRCC6, XRCC5
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| Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.
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| Dvir A, Peterson SR, Knuth MW, Lu H, Dynan WS.
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| Proc Natl Acad Sci U S A 89 : 11920-11924. 1992
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| 34 | XRCC6, CYP2D6
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| Localization of TSHR gene and cytochrome p450 IID subfamily on chromosome 22 by linkage analysis.
|
| Mitchell AL, et al.
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| (HGM10) Cytogenet Cell Genet 51 : 1045. 1989
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| 35 | XRCC6
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| Cloning and characterization of a cDNA that encodes a 70-kDa novel human thyroid autoantigen.
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| Chan JYC, et al.
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| J Biol Chem 264 : 3651-3654. 1989
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| 36 | XRCC6
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| Molecular cloning of cDNA encoding the p70 (Ku) lupus autoantigen.
|
| Reeves WH, et al.
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| J Biol Chem 264 : 5047-5052. 1989
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| 37 | TSHRL1, TSHRL2, TSHRL3, XRCC6
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| The TSH receptor gene is located on human chromosome 22 and homologous sequences are present on chromosomes 1q,8,10, and Xq.
|
| McBride OW, et al.
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| Am J Hum Genet 41 : A177. 1987
|