| 1 | DDB2, XRCC5, XRCC6
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| Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2.
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| Fantini D, Huang S, Asara JM, Bagchi S, Raychaudhuri P.
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| Mol Biol Cell 28(1):192-200. doi: 10.1091/mbc.E16-08-0573. Epub 2016 Nov 9.
2017
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| 2 | XRCC5
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| The novel allele (3R) of the VNTR polymorphism in the XRCC5 promoter region dramatically decreases the gene expression.
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| Rajaei M, Saadat I, Saadat M.
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| Biochem Biophys Res Commun 430(2):640-1. doi: 10.1016/j.bbrc.2012.11.099. Epub 2012 Dec 5.
2013
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| 3 | NEK1, XRCC5
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| Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression.
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| Patil M, Pabla N, Ding HF, Dong Z.
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| Cell Cycle 12(16):2608-16. doi: 10.4161/cc.25624. Epub 2013 Jul 10.
2013
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| 4 | RECQL, XRCC5, XRCC6
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| Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks.
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| Parvathaneni S, Stortchevoi A, Sommers JA, Brosh RM Jr, Sharma S.
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| PLoS One 8(5):e62481. doi: 10.1371/journal.pone.0062481. Print 2013.
2013
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| 5 | DEAF1, PRKDC, XRCC5, XRCC6
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| Deformed epidermal autoregulatory factor-1 (DEAF1) interacts with the Ku70 subunit of the DNA-dependent protein kinase complex.
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| Jensik PJ, Huggenvik JI, Collard MW.
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| PLoS One 7(3):e33404. doi: 10.1371/journal.pone.0033404. Epub 2012 Mar 19.
2012
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| 6 | XRCC5
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| Introducing a novel allele for the polymorphism of variable number of tandem repeats in the promoter region of XRCC5.
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| Rajaei M, Saadat I, Saadat M.
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| Biochem Biophys Res Commun 427(3):503-5. doi: 10.1016/j.bbrc.2012.09.085. Epub 2012 Sep 26.
2012
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| 7 | XRCC5, XRCC6
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| KARP-1 works as a heterodimer with Ku70, but the function of KARP-1 cannot perfectly replace that of Ku80 in DSB repair.
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| Koike M, Yutoku Y, Koike A.
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| Exp Cell Res 317(16):2267-75. doi: 10.1016/j.yexcr.2011.06.015. Epub 2011 Jul 2.
2011
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| 8 | COIL, XRCC5, XRCC6
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| Coilin interacts with Ku proteins and inhibits in vitro non-homologous DNA end joining.
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| Velma V, Carrero ZI, Cosman AM, Hebert MD.
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| FEBS Lett 584(23):4735-9. Epub 2010 Nov 9.
2010
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| 9 | XRCC5, XRCC6
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| Ku80 facilitates chromatin binding of the telomere binding protein, TRF2.
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| Fink LS, Lerner CA, Torres PF, Sell C.
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| Cell Cycle 9(18):3798-806. Epub 2010 Sep 25.
2010
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| 10 | XRCC5
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| Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene.
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| Hersh CP, Pillai SG, Zhu G, Lomas DA, Bakke P, Gulsvik A, DeMeo DL, Klanderman BJ, Lazarus R, Litonjua AA, Sparrow D, Reilly JJ, Agusti A, Calverley PM, Donner CF, Levy RD, Make BJ, Paré PD, Rennard SI, Vestbo J, Wouters EF, Scholand MB, Coon H, Hoidal J, Silverman EK.
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| Am J Respir Crit Care Med 182(5):605-13. Epub 2010 May 12.
2010
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| 11 | XRCC5, XRCC6
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| Exogenously expressed human Ku70 stabilizes Ku80 in Xenopus oocytes and induces heterologous DNA-PK catalytic activity.
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| Kanungo J.
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| Mol Cell Biochem 338(1-2):291-8. Epub 2010 Jan 3.
2010
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| 12 | XRCC5, XRCC6
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| Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression.
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| Ohno M, Kunimoto M, Nishizuka M, Osada S, Imagawa M.
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| Biochem Biophys Res Commun 390(3):738-42. Epub 2009 Oct 13.
2009
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| 13 | XRCC5
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| Molecular analysis of Ku redox regulation.
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| Bennett SM, Neher TM, Shatilla A, Turchi JJ.
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| BMC Mol Biol 10:86.
2009
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| 14 | JUN, XRCC5, XRCC6
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| Purification and identification of positive regulators binding to a novel element in the c-Jun promoter.
|
| Jiang D, Zhou Y, Moxley RA, Jarrett HW.
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| Biochemistry 47(35):9318-34. Epub 2008 Aug 9.
2008
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| 15 | XRCC5
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| Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response.
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| Holcomb VB, Rodier F, Choi Y, Busuttil RA, Vogel H, Vijg J, Campisi J, Hasty P.
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| Cancer Res 68(22):9497-502.
2008
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| 16 | XRCC3, XRCC4, XRCC5
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| Variation in DNA repair genes XRCC3, XRCC4, XRCC5 and susceptibility to myeloma.
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| Hayden PJ, Tewari P, Morris DW, Staines A, Crowley D, Nieters A, Becker N, de SanjosŽ S, Foretova L, MaynadiŽ M, Cocco PL, Boffetta P, Brennan P, Chanock SJ, Browne PV, Lawler M.
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| Hum Mol Genet 16(24):3117-27. Epub 2007 Sep 26. 2007
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| 17 | XRCC6, LIG4, PRKDC, XRCC4, XRCC5
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| Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.
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| Calsou P, Delteil C, Frit P, Drouet J, Salles B.
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| J Mol Biol 326(1):93-103. 2003
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| 18 | XRCC5
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| Molecular cloning and characterization of rKAB1, which interacts with KARP-1, localizes in the nucleus and protects cells against oxidative death.
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| Do E, Taira E, Irie Y, Gan Y, Tanaka H, Kuo CH, Miki N.
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| Mol Cell Biochem 248(1-2):77-83. 2003
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| 19 | XRCC5
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| Ku86 is essential in human somatic cells.
|
| Li G, Nelsen C, Hendrickson EA.
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| Proc Natl Acad Sci U S A 99(2):832-7. 2002
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| 20 | XRCC6, LIG4, POLM, PRKDC, XRCC4, XRCC5
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| Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair.
|
| Mahajan KN, Nick McElhinny SA, Mitchell BS, Ramsden DA.
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| Mol Cell Biol 22(14):5194-202. 2002
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| 21 | WRN, XRCC5
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| A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA.
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| Orren DK, Machwe A, Karmakar P, Piotrowski J, Cooper MP, Bohr VA.
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| Nucleic Acids Res 29(9):1926-1934. 2001
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| 22 | XRCC6, LIG4, XRCC4, XRCC5
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| Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice.
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| Gu Y, Sekiguchi J, Gao Y, Dikkes P, Frank K, Ferguson D, Hasty P, Chun J, Alt FW.
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| Proc Natl Acad Sci U S A 97(6):2668-73. 2000
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| 23 | XRCC5
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| DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation.
|
| Difilippantonio MJ, Zhu J, Chen HT, Meffre E, Nussenzweig MC, Max EE, Ried T, Nussenzweig A.
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| Nature 404(6777):510-4. 2000
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| 24 | XRCC5
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| An alternate form of Ku80 is required for DNA end-binding activity in mammalian mitochondria.
|
| Coffey G, Campbell C.
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| Nucleic Acids Res 28(19):3793-800. 2000
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| 25 | XRCC6, XRCC5, LIG4, PRKDC, XRCC4
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| Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair.
|
| Hanakahi LA, Bartlet-Jones M, Chappell C, Pappin D, West SC.
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| Cell 102(6):721-9. 2000
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| 26 | XRCC5, XRCC6
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| Molecular cloning and sequencing of cDNAs encoding homologues of human Ku70 and Ku80 autoantigen from Xenopus and their expression in various Xenopus tissues.
|
| Yagura T, et al.
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| Biochim Biophys Acta 1445(1):160-4. 1999
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| 27 | CLU, XRCC5, PRKDC, XRCC6BP1
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| Isolation of Ku70-binding proteins (KUBs).
|
| Yang CR, Yeh S, Leskov K, Odegaard E, Hsu HL, Chang C, Kinsella TJ, ChenDJ, Boothman DA.
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| Nucleic Acids Res 27(10):2165-74. 1999
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| 28 | XRCC5
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| Ku80 is required for immunoglobulin isotype switching.
|
| Casellas R, et al.
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| EMBO J 17 : 2404-2411. 1998
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| 29 | CLU, XRCC5, LIG4, XRCC4
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| A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis.
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| Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ, Sekiguchi JM, Rathbun GA, Swat W, Wang J, Bronson RT, Malynn BA, Bryans M, Zhu C, Chaudhuri J, Davidson L, Ferrini R, Stamato T, Orkin SH, Greenberg ME, Alt FW.
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| Cell 95(7):891-902. 1998
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| 30 | XRCC1, XRCC3, XRCC5
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| Rare microsatellite polymorphisms in the DNA repair genes XRCC1, XRCC3 and XRCC5 associated with cancer in patients of varying radiosensitivity.
|
| Price EA, et al.
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| Somat Cell Mol Genet 23 : 237-247. 1997
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| 31 | XRCC5
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| Requirement for Ku80 in growth and immunoglobulin V(D)J recombination.
|
| Nussenzweig A, et al.
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| Nature 382 : 551-555. 1996
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| 32 | ATM, XRCC6, XRCC5, PRKDC
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| DNA-dependent protein kinase catalytic subunit : a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product.
|
| Hartley KO, et al.
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| Cell 82 : 849-856. 1995
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| 33 | XRCC5
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| A YAC contig encompassing the XRCC5 (Ku80) DNA repair gene and complementation of defective cells by YAC protoplast fusion.
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| Blunt T, Taccioli GE, Priestley A, Hafezparast M, McMillan T, Liu J, Cole CC, White J, Alt FW, Jackson SP, et al.
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| Genomics 30 : 320-328. 1995
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| 34 | XRCC6, XRCC5
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| Chromosomal location and expression of the genes coding for Ku p70 and p80 in human cell lines and normal tissues.
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| Cai QQ, Plet A, Imbert J, Lafage-Pochitaloff M, Cerdan C, Blanchard JM.
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| Cytogenet Cell Genet 65 : 221-227. 1994
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| 35 | XRCC5
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| Regional assignment of a human DNA repair gene (XRCC5) to 2q35 by X-ray hybrid mapping.
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| Chen DJ, et al.
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| Genomics 21 : 423-427. 1994
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| 36 | XRCC5
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| Ku80 : product of the XRCC5 gene and its role in DNA repair and V(D)J recombination.
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| Taccioli GE, Gottlieb TM, Blunt T, Priestley A, Demengeot J, Mizuta R, Lehmann AR, Alt FW, Jackson SP, Jeggo PA.
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| Science 265 : 1442-1445. 1994
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| 37 | XRCC6, XRCC5
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| Human DNA helicase II : a novel DNA unwinding enzyme identified as the Ku autoantigen.
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| Tuteja N, Tuteja R, Ochem A, Taneja P, Huang NW, Simoncsits A, Susic S, Rahman K, Marusic L, Chen J, et al.
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| EMBO J 13 : 4991-5001. 1994
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| 38 | XRCC5
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| Subchromosomal localization of a gene (XRCC5) involved in double strand break repair to the region 2q34-36.
|
| Hafezparast M, et al.
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| Somat Cell Mol Genet 19 : 413-421. 1993
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| 39 | XRCC5
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| Assignment of a human DNA double-strand break repair gene (XRCC5) to chromosome 2.
|
| Chen DJ, et al.
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| Genomics 13 : 1088-1094. 1992
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| 40 | XRCC5
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| Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2.
|
| Jeggo PA, et al.
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| Proc Natl Acad Sci U S A 89 : 6423-6427. 1992
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| 41 | XRCC6, XRCC5
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| Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.
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| Dvir A, Peterson SR, Knuth MW, Lu H, Dynan WS.
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| Proc Natl Acad Sci U S A 89 : 11920-11924. 1992
|