Citations for
1LIG4, RAD51, XRCC4
Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans.
Li Z, Zhang W, Chen Y, Guo W, Zhang J, Tang H, Xu Z, Zhang H, Tao Y, Wang F, Jiang Y, Sun FL, Mao Z.
Cell Death Differ 23(11):1765-1777. doi: 10.1038/cdd.2016.65. 2016
2XRCC2, XRCC4, ZNF281
ZNF281 contributes to the DNA damage response by controlling the expression of XRCC2 and XRCC4.
Pieraccioli M, Nicolai S, Antonov A, Somers J, Malewicz M, Melino G, Raschellà G.
Oncogene 35(20):2592-601. doi: 10.1038/onc.2015.320. Epub 2015 Aug 24. 2016
3MOPD5, XRCC4
Mutations in the NHEJ Component XRCC4 Cause Primordial Dwarfism.
Murray JE, van der Burg M, IJspeert H, Carroll P, Wu Q, Ochi T, Leitch A, Miller ES, Kysela B, Jawad A, Bottani A, Brancati F, Cappa M, Cormier-Daire V, Deshpande C, Faqeih EA, Graham GE, Ranza E, Blundell TL, Jackson AP, Stewart GS, Bicknell LS.
Am J Hum Genet 96(3):412-24. doi: 10.1016/j.ajhg.2015.01.013. Epub 2015 Feb 26. 2015
4MOPD5, XRCC4
An XRCC4 splice mutation is associated with severe short stature, gonadal failure, and early-onset metabolic syndrome.
de Bruin C, Mericq V, Andrew SF, van Duyvenvoorde HA, Verkaik NS, Losekoot M, Porollo A, Garcia H, Kuang Y, Hanson D, Clayton P, van Gent DC, Wit JM, Hwa V, Dauber A.
J Clin Endocrinol Metab Clin Endocrinol Metab. 2015 Mar 5:jc20151098. [Epub ahead of print] 2015
5C9orf142, NHEJ1, XRCC4
DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair.
Ochi T, Blackford AN, Coates J, Jhujh S, Mehmood S, Tamura N, Travers J, Wu Q, Draviam VM, Robinson CV, Blundell TL, Jackson SP.
Science 347(6218):185-8. doi: 10.1126/science.1261971. 2015
6MOPD5, XRCC4
An XRCC4 splice mutation associated with severe short stature, gonadal failure, and early-onset metabolic syndrome.
de Bruin C, Mericq V, Andrew SF, van Duyvenvoorde HA, Verkaik NS, Losekoot M, Porollo A, Garcia H, Kuang Y, Hanson D, Clayton P, van Gent DC, Wit JM, Hwa V, Dauber A.
J Clin Endocrinol Metab 100(5):E789-98. doi: 10.1210/jc.2015-1098. Epub 2015 Mar 5. 2015
7MOPD5, XRCC4
Mutations in XRCC4 cause primary microcephaly, short stature and increased genomic instability.
Rosin N, Elcioglu NH, Beleggia F, Isgüven P, Altmüller J, Thiele H, Steindl K, Joset P, Rauch A, Nürnberg P, Wollnik B, Yigit G.
Hum Mol Genet 24(13):3708-17. doi: 10.1093/hmg/ddv115. Epub 2015 Apr 3. 2015
8XRCC4
DNA double strand break repair in mitosis is suppressed by phosphorylation of XRCC4.
Lees-Miller SP.
PLoS Genet 10(8):e1004598. doi: 10.1371/journal.pgen.1004598. eCollection 2014 Aug. No abstract available. 2014
9XRCC4
Canonical non-homologous end joining in mitosis induces genome instability and is suppressed by M-phase-specific phosphorylation of XRCC4.
Terasawa M, Shinohara A, Shinohara M.
PLoS Genet 10(8):e1004563. doi: 10.1371/journal.pgen.1004563. eCollection 2014 Aug. 2014
10LIG4, NHEJ1, XRCC4
C-Terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin.
Liu S, Liu X, Kamdar RP, Wanotayan R, Sharma MK, Adachi N, Matsumoto Y.
Biochem Biophys Res Commun 439(2):173-8. doi: 10.1016/j.bbrc.2013.08.068. Epub 2013 Aug 28. 2013
11NHEJ1, XRCC4
XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.
Mahaney BL, Hammel M, Meek K, Tainer JA, Lees-Miller SP.
Biochem Cell Biol 91(1):31-41. doi: 10.1139/bcb-2012-0058. Epub 2013 Feb 5. Review. 2013
12NHEJ1, XRCC4
A human XRCC4-XLF complex bridges DNA.
Andres SN, Vergnes A, Ristic D, Wyman C, Modesti M, Junop M.
Nucleic Acids Res 40(4):1868-78. doi: 10.1093/nar/gks022. Epub 2012 Jan 27. 2012
13NHEJ1, XRCC4
XRCC4 protein interactions with XRCC4-like factor (XLF) create an extended grooved scaffold for DNA ligation and double strand break repair.
Hammel M, Rey M, Yu Y, Mani RS, Classen S, Liu M, Pique ME, Fang S, Mahaney BL, Weinfeld M, Schriemer DC, Lees-Miller SP, Tainer JA.
J Biol Chem 286(37):32638-50. Epub 2011 Jul 20. 2011
14LIG4, XRCC4
XRCC4 controls nuclear import and distribution of Ligase IV and exchanges faster at damaged DNA in complex with Ligase IV.
Berg E, Christensen MO, Dalla Rosa I, Wannagat E, Jänicke RU, Rösner LM, Dirks WG, Boege F, Mielke C.
DNA Repair (Amst) 10(12):1232-42. doi: 10.1016/j.dnarep.2011.09.012. Epub 2011 Oct 5. 2011
15XRCC4
XRCC4 controls nuclear import and distribution of Ligase IV and exchanges faster at damaged DNA in complex with Ligase IV.
Berg E, Christensen MO, Dalla Rosa I, Wannagat E, Jänicke RU, Rösner LM, Dirks WG, Boege F, Mielke C.
DNA Repair (Amst) 10(12):1232-42. doi: 10.1016/j.dnarep.2011.09.012. Epub 2011 Oct 5. 2011
16NHEJ1, XRCC4
XLF regulates filament architecture of the XRCC4·ligase IV complex.
Hammel M, Yu Y, Fang S, Lees-Miller SP, Tainer JA.
Structure 18(11):1431-42. 2010
17NHEJ1, XRCC4
Delineation of the Xrcc4-interacting region in the globular head domain of cernunnos/XLF.
Malivert L, Ropars V, Nunez M, Drevet P, Miron S, Faure G, Guerois R, Mornon JP, Revy P, Charbonnier JB, Callebaut I, de Villartay JP.
J Biol Chem 285(34):26475-83. Epub 2010 Jun 17. 2010
18PNKP, XRCC4
Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining.
Mani RS, Yu Y, Fang S, Lu M, Fanta M, Zolner AE, Tahbaz N, Ramsden DA, Litchfield DW, Lees-Miller SP, Weinfeld M.
J Biol Chem 285(48):37619-29. Epub 2010 Sep 17. 2010
19LIG4, XRCC4
Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4.
Wu PY, Frit P, Meesala S, Dauvillier S, Modesti M, Andres SN, Huang Y, Sekiguchi J, Calsou P, Salles B, Junop MS.
Mol Cell Biol 29(11):3163-72. Epub 2009 Mar 30. 2009
20XRCC4
Lung cancer susceptibility and prognosis associated with polymorphisms in the nonhomologous end-joining pathway genes: a multiple genotype-phenotype study.
Tseng RC, Hsieh FJ, Shih CM, Hsu HS, Chen CY, Wang YC.
Cancer 115(13):2939-48. 2009
21XRCC4
Significant association of an XRCC4 single nucleotide polymorphism with bladder cancer susceptibility in Taiwan.
Chang CH, Chang CL, Tsai CW, Wu HC, Chiu CF, Wang RF, Liu CS, Lin CC, Bau DT.
Anticancer Res 29(5):1777-82. 2009
22XRCC4
Lung cancer susceptibility and genetic polymorphism of DNA repair gene XRCC4 in Taiwan.
Hsu NY, Wang HC, Wang CH, Chang CL, Chiu CF, Lee HZ, Tsai CW, Bau DT.
Cancer Biomark 5(4):159-65. 2009
23LIG4, XRCC4
Polymorphisms of LIG4 and XRCC4 involved in the NHEJ pathway interact to modify risk of glioma.
Liu Y, Zhou K, Zhang H, Shugart YY, Chen L, Xu Z, Zhong Y, Liu H, Jin L, Wei Q, Huang F, Lu D, Zhou L.
Hum Mutat 29(3):381-9. 2008
24XRCC4
XRCC4 codon 247*A and XRCC4 promoter -1394*T related genotypes but not XRCC4 intron 3 gene polymorphism are associated with higher susceptibility for endometriosis.
Hsieh YY, Bau DT, Chang CC, Tsai CH, Chen CP, Tsai FJ.
Mol Reprod Dev 75(5):946-51.PMID: 18246529 2008
25XRCC4
Processing of DNA for nonhomologous end-joining is controlled by kinase activity and XRCC4/ligase IV.
Budman J, Kim SA, Chu G.
J Biol Chem 282(16):11950-9. Epub 2007 Jan 31. 2007
26XRCC4, NHEJ1
Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence.
Gu J, Lu H, Tsai AG, Schwarz K, Lieber MR.
Nucleic Acids Res 35(17):5755-62. Epub 2007 Aug 23. 2007
27XRCC3, XRCC4, XRCC5
Variation in DNA repair genes XRCC3, XRCC4, XRCC5 and susceptibility to myeloma.
Hayden PJ, Tewari P, Morris DW, Staines A, Crowley D, Nieters A, Becker N, de SanjosŽ S, Foretova L, MaynadiŽ M, Cocco PL, Boffetta P, Brennan P, Chanock SJ, Browne PV, Lawler M.
Hum Mol Genet 16(24):3117-27. Epub 2007 Sep 26. 2007
28LIG4, XRCC4
Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase.
Karlsson KH, Stenerlöw B.
BMC Mol Biol 8:97. 2007
29XRCC4
Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends.
Guirouilh-Barbat J, Rass E, Plo I, Bertrand P, Lopez BS.
Proc Natl Acad Sci U S A 104(52):20902-7. Epub 2007 Dec 18. 2007
30XRCC4
A role for XRCC4 in age at diagnosis and breast cancer risk.
Allen-Brady K, Cannon-Albright LA, Neuhausen SL, Camp NJ.
Cancer Epidemiol Biomarkers Prev 15(7):1306-10. 2006
31XRCC4, NHEJ1
Cernunnos interacts with the XRCC4 x DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1.
Callebaut I, Malivert L, Fischer A, Mornon JP, Revy P, de Villartay JP.
J Biol Chem 281(20):13857-60. Epub 2006 Mar 29. 2006
32XRCC4
SUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair.
Yurchenko V, Xue Z, Sadofsky MJ.
Mol Cell Biol 26(5):1786-94. 2006
33XRCC4
Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4.
Mari PO, Florea BI, Persengiev SP, Verkaik NS, Brüggenwirth HT, Modesti M, Giglia-Mari G, Bezstarosti K, Demmers JA, Luider TM, Houtsmuller AB, van Gent DC.
Proc Natl Acad Sci U S A 103(49):18597-602. Epub 2006 Nov 21. 2006
34XRCC6, LIG4, PRKDC, XRCC4, XRCC5
Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.
Calsou P, Delteil C, Frit P, Drouet J, Salles B.
J Mol Biol 326(1):93-103. 2003
35XRCC6, LIG4, POLM, PRKDC, XRCC4, XRCC5
Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair.
Mahajan KN, Nick McElhinny SA, Mitchell BS, Ramsden DA.
Mol Cell Biol 22(14):5194-202. 2002
36XRCC6, LIG4, XRCC4, XRCC5
Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice.
Gu Y, Sekiguchi J, Gao Y, Dikkes P, Frank K, Ferguson D, Hasty P, Chun J, Alt FW.
Proc Natl Acad Sci U S A 97(6):2668-73. 2000
37XRCC6, XRCC5, LIG4, PRKDC, XRCC4
Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair.
Hanakahi LA, Bartlet-Jones M, Chappell C, Pappin D, West SC.
Cell 102(6):721-9. 2000
38XRCC4
DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity.
Modesti M, et al.
EMBO J 18(7):2008-18 1999
39XRCC4
V(D)J recombination intermediates and non-standard products in XRCC4-deficient cells.
Han JO, Erskine LA, Purugganan MM, Stamato TD, Roth DB.
Nucleic Acids Res 26 : 3769-3775. 1998
40CLU, XRCC5, LIG4, XRCC4
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis.
Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ, Sekiguchi JM, Rathbun GA, Swat W, Wang J, Bronson RT, Malynn BA, Bryans M, Zhu C, Chaudhuri J, Davidson L, Ferrini R, Stamato T, Orkin SH, Greenberg ME, Alt FW.
Cell 95(7):891-902. 1998
41CACNB1, COMT, PPP2R5B, SATB1, SRP14, XRCC4
Identification and chromosomal localization of human genes containing CAG/CTG repeats expressed in testis and brain.
Bulle F, Chiannilkulchai N, Pawlak A, Weissenbach J, Gyapay G, Guellaen G.
Genome Res 7(7):705-15. 1997
42XRCC4
The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination.
Li Z, et al.
Cell 83 : 1079-1089. 1995
43XRCC4
Regional localization of the XRCC4 human radiation repair gene.
Otevrel T, et al.
Genomics 27 : 211-214. 1995
44XRCC4
Human chromosome 5 complements the DNA double-strand break-repair deficiency and gamma-ray sensitivity of the XR-1 hamster variant.
Giaccia AJ, et al.
Am J Hum Genet 47 : 459-469. 1990
45XRCC4
Drouet J, Delteil C, Lefrancois J, Concannon P, Salles B, Calsou P.
DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks NA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks. 0