Citations for
Identification of subcellular targeting sequences of Cten reveals its role in cell proliferation.
Hong SY, Shih YP, Lo A, Lo SH.
Biochim Biophys Acta Mol Cell Res 1866(3):450-458. doi: 10.1016/j.bbamcr.2018.10.008. Epub 2018 Oct 13. 2019
Down-regulation of AR splice variants through XPO1 suppression contributes to the inhibition of prostate cancer progression.
Aboukameel A, Muqbil I, Baloglu E, Senapedis W, Landesman Y, Argueta C, Kauffman M, Chang H, Kashyap T, Shacham S, Neggers JE, Daelemans D, Heath EI, Azmi AS.
Oncotarget 9(82):35327-35342. doi: 10.18632/oncotarget.26239. eCollection 2018 Oct 19. 2018
Importin-β and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function.
Gilistro E, de Turris V, Damizia M, Verrico A, Moroni S, De Santis R, Rosa A, Lavia P.
J Cell Sci 130(15):2564-2578. doi: 10.1242/jcs.197905. Epub 2017 Jun 9. 2017
The nuclear export factor CRM1 controls juxta-nuclear microtubule-dependent virus transport.
Wang IH, Burckhardt CJ, Yakimovich A, Morf MK, Greber UF.
J Cell Sci 130(13):2185-2195. doi: 10.1242/jcs.203794. Epub 2017 May 17. 2017
Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
Fung HY, Fu SC, Chook YM.
Elife 6. pii: e23961. doi: 10.7554/eLife.23961. 2017
A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K.
García-Santisteban I, Arregi I, Alonso-Marińo M, Urbaneja MA, Garcia-Vallejo JJ, Bańuelos S, Rodríguez JA.
Cell Mol Life Sci 73(24):4685-4699. Epub 2016 Jun 16. 2016
XPO1 Inhibition Preferentially Disrupts the 3D Nuclear Organization of Telomeres in Tumor Cells.
Taylor-Kashton C, Lichtensztejn D, Baloglu E, Senapedis W, Shacham S, Kauffman MG, Kotb R, Mai S.
J Cell Physiol 231(12):2711-9. doi: 10.1002/jcp.25378. Epub 2016 Apr 8. 2016
8NUP98, XPO1
Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes.
Oka M, Mura S, Yamada K, Sangel P, Hirata S, Maehara K, Kawakami K, Tachibana T, Ohkawa Y, Kimura H, Yoneda Y.
Elife 5:e09540. doi: 10.7554/eLife.09540. 2016
NXT1, a Novel Influenza A NP Binding Protein, Promotes the Nuclear Export of NP via a CRM1-Dependent Pathway.
Chutiwitoonchai N, Aida Y.
Viruses Jul 28;8(8):209. doi: 10.3390/v8080209 2016
The Cellular Distribution of RanGAP1 Is Regulated by CRM1-Mediated Nuclear Export in Mammalian Cells.
Cha K, Sen P, Raghunayakula S, Zhang XD.
PLoS One 10(10):e0141309. doi: 10.1371/journal.pone.0141309. eCollection 2015. 2015
Structural determinants of nuclear export signal orientation in binding to exportin CRM1.
Fung HY, Fu SC, Brautigam CA, Chook YM.
Elife 4. doi: 10.7554/eLife.10034. 2015
Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein.
Ishizawa J, Kojima K, Hail N Jr, Tabe Y, Andreeff M.
Pharmacol Ther 153:25-35. doi: 10.1016/j.pharmthera.2015.06.001. Epub 2015 Jun 3. Review. 2015
Elevated expression of the nuclear export protein, Crm1 (exportin 1), associates with human oesophageal squamous cell carcinoma.
van der Watt PJ, Zemanay W, Govender D, Hendricks DT, Parker MI, Leaner VD.
Oncol Rep 32(2):730-8. doi: 10.3892/or.2014.3231. Epub 2014 Jun 4. 2014
The interaction of CRM1 and the nuclear pore protein Tpr.
Zhao CL, Mahboobi SH, Moussavi-Baygi R, Mofrad MR.
PLoS One 9(4):e93709. doi: 10.1371/journal.pone.0093709. eCollection 2014. 2014
15AKT3, XPO1
AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1.
Corum DG, Tsichlis PN, Muise-Helmericks RC.
FASEB J 28(1):395-407. doi: 10.1096/fj.13-235382. Epub 2013 Sep 30. 2014
Structural basis for cooperativity of CRM1 export complex formation.
Monecke T, Haselbach D, Voß B, Russek A, Neumann P, Thomson E, Hurt E, Zachariae U, Stark H, Grubmüller H, Dickmanns A, Ficner R.
Proc Natl Acad Sci U S A 110(3):960-5. doi: 10.1073/pnas.1215214110. Epub 2012 Dec 31. 2013
Human inducible nitric oxide synthase (iNOS) expression depends on chromosome region maintenance 1 (CRM1)- and eukaryotic translation initiation factor 4E (elF4E)-mediated nucleocytoplasmic mRNA transport.
Bollmann F, Fechir K, Nowag S, Koch K, Art J, Kleinert H, Pautz A.
Nitric Oxide 30:49-59. doi: 10.1016/j.niox.2013.02.083. Epub 2013 Mar 5. 2013
Transcription-independent role of Bach1 in mitosis through a nuclear exporter Crm1-dependent mechanism.
Li J, Shiraki T, Igarashi K.
FEBS Lett 586(4):448-54. Epub 2012 Jan 28. 2012
Characterization of BRCA1 protein targeting, dynamics, and function at the centrosome: a role for the nuclear export signal, CRM1, and Aurora A kinase.
Brodie KM, Henderson BR.
J Biol Chem 287(10):7701-16. Epub 2012 Jan 18. 2012
A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family.
García-Santisteban I, Bańuelos S, Rodríguez JA.
Biochem J 441(1):209-17. 2012
cAMP-dependent proteolysis of GATA-6 is linked to JNK-signaling pathway.
Ushijima H, Maeda M.
Biochem Biophys Res Commun 423(4):679-83. doi: 10.1016/j.bbrc.2012.06.013. Epub 2012 Jun 10. 2012
Importin-β negatively regulates multiple aspects of mitosis including RANGAP1 recruitment to kinetochores.
Roscioli E, Di Francesco L, Bolognesi A, Giubettini M, Orlando S, Harel A, Schininŕ ME, Lavia P.
J Cell Biol 196(4):435-50. doi: 10.1083/jcb.201109104. Epub 2012 Feb 13. 2012
23IPO7, XPO1
Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis.
Golomb L, Bublik DR, Wilder S, Nevo R, Kiss V, Grabusic K, Volarevic S, Oren M.
Mol Cell 45(2):222-32. doi: 10.1016/j.molcel.2011.11.022. Erratum in: Mol Cell. 2012 Jul 13;47(1):150. 2012
24DEL2P15, OTX1, XPO1
2p15-p16.1 microdeletion syndrome: molecular characterization and association of the OTX1 and XPO1 genes with autism spectrum disorders.
Liu X, Malenfant P, Reesor C, Lee A, Hudson ML, Harvard C, Qiao Y, Persico AM, Cohen IL, Chudley AE, Forster-Gibson C, Rajcan-Separovic E, Lewis MS, Holden JJ.
Eur J Hum Genet ur J Hum Genet. 2011 Jul 13. doi: 10.1038/ejhg.2011.112. [Epub ahead of print] 2011
Electrostatic interactions involving the extreme C terminus of nuclear export factor CRM1 modulate its affinity for cargo.
Fox AM, Ciziene D, McLaughlin SH, Stewart M.
J Biol Chem 286(33):29325-35. Epub 2011 Jun 27. 2011
The nuclear exporter, Crm1, is regulated by NFY and Sp1 in cancer cells and repressed by p53 in response to DNA damage.
van der Watt PJ, Leaner VD.
Biochim Biophys Acta 1809(7):316-26. Epub 2011 Jun 13. 2011
CRM1 controls the composition of nucleoplasmic pre-snoRNA complexes to licence them for nucleolar transport.
Pradet-Balade B, Girard C, Boulon S, Paul C, Azzag K, Bordonné R, Bertrand E, Verheggen C.
EMBO J 30(11):2205-18. Epub 2011 Apr 26. 2011
Insights into the function of the CRM1 cofactor RanBP3 from the structure of its Ran-binding domain.
Langer K, Dian C, Rybin V, Müller CW, Petosa C.
PLoS One 6(2):e17011. 2011
A Competitive binding mechanism between Skp1 and exportin 1 (CRM1) controls the localization of a subset of F-box proteins.
Nelson DE, Laman H.
J Biol Chem 286(22):19804-15. doi: 10.1074/jbc.M111.220079. Epub 2011 Mar 4. 2011
Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export.
Esmaili AM, Johnson EL, Thaivalappil SS, Kuhn HM, Kornbluth S, Irusta PM.
Cell Cycle 9(19):3913-20. Epub 2010 Oct 25. 2010
An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1.
Koyama M, Matsuura Y.
EMBO J 29(12):2002-13. Epub 2010 May 18. 2010
32NUP98, XPO1
The mobile FG nucleoporin Nup98 is a cofactor for Crm1-dependent protein export.
Oka M, Asally M, Yasuda Y, Ogawa Y, Tachibana T, Yoneda Y.
Mol Biol Cell 21(11):1885-96. Epub 2010 Apr 7. 2010
The karyopherin CRM1 is required for dendritic cell maturation.
Chemnitz J, Turza N, Hauber I, Steinkasserer A, Hauber J.
Immunobiology 215(5):370-9. Epub 2009 Jul 9. 2010
Nuclear export complexes in the frame.
Cook AG, Conti E.
Curr Opin Struct Biol 20(2):247-52. doi: 10.1016/ Epub 2010 Feb 18. Review. 2010
A fraction of Crm1 locates at centrosomes by its CRIME domain and regulates the centrosomal localization of pericentrin.
Liu Q, Jiang Q, Zhang C.
Biochem Biophys Res Commun 384(3):383-8. Epub 2009 May 5. 2009
Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP.
Monecke T, Güttler T, Neumann P, Dickmanns A, Görlich D, Ficner R.
Science 324(5930):1087-91. Epub 2009 Apr 23. 2009
The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.
van der Watt PJ, Maske CP, Hendricks DT, Parker MI, Denny L, Govender D, Birrer MJ, Leaner VD.
Int J Cancer 124(8):1829-40. 2009
Structural basis for assembly and disassembly of the CRM1 nuclear export complex.
Dong X, Biswas A, Chook YM.
Nat Struct Mol Biol 16(5):558-60. Epub 2009 Apr 1. 2009
39CRM1, NUP62, XPO1
Oxidative stress inhibits nuclear protein export by multiple mechanisms that target FG nucleoporins and Crm1.
Crampton N, Kodiha M, Shrivastava S, Umar R, Stochaj U.
Mol Biol Cell 20(24):5106-16. Epub . 2009
Modulation of integrin-linked kinase nucleo-cytoplasmic shuttling by ILKAP and CRM1.
Nakrieko KA, Vespa A, Mason D, Irvine TS, D'Souza SJ, Dagnino L.
Cell Cycle 7(14):2157-66. Epub 2008 May 7.PMID: 18635968 2008
STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7.
Dorfman J, Macara IG.
Mol Biol Cell 19(4):1614-26. Epub 2008 Feb 6. 2008
CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein.
Cheong JK, Gunaratnam L, Hsu SI.
J Biol Chem 283(17):11661-76. doi: 10.1074/jbc.M708365200. Epub 2008 Mar 3. 2008
CRM1 mediates nuclear export of HDAC7 independently of HDAC7 phosphorylation and association with 14-3-3s.
Gao C, Li X, Lam M, Liu Y, Chakraborty S, Kao HY.
FEBS Lett 580(21):5096-104. Epub 2006 Sep 1. 2006
44NPM1, XPO1
Characterization of centrosomal association of nucleophosmin/B23 linked to Crm1 activity.
Shinmura K, Tarapore P, Tokuyama Y, George KR, Fukasawa K.
FEBS Lett 579(29):6621-34. Epub 2005 Nov 9. 2005
45XPO1, XPO7
Exportin 7 defines a novel general nuclear export pathway.
Mingot JM, Bohnsack MT, Jäkle U, Görlich D.
EMBO J 23(16):3227-36. Epub 2004 Jul 29. 2004
CRM1-mediated nuclear export determines the cytoplasmic localization of the antiapoptotic protein Survivin.
Rodriguez JA, Span SW, Ferreira CG, Kruyt FA, Giaccone G.
Exp Cell Res 275(1):44-53. 2002
RanBP3 influences interactions between CRM1 and its nuclear protein export substrates.
Englmeier L, Fornerod M, Bischoff FR, Petosa C, Mattaj IW, Kutay U.
EMBO Rep 2(10):926-32. Epub 2001 Sep 24. 2001
Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor.
McBride KM, McDonald C, Reich NC.
EMBO J 19(22):6196-206. 2000
Evidence for specific nucleocytoplasmic transport pathways used by leucine-rich nuclear export signals.
Elfgang C, et al.
Proc Natl Acad Sci U S A 96(11):6229-34. 1999
50XPO1, NUP88, C1QBP
Chromosomal localization of genes encoding CAN/Nup214-interacting proteins-human CRM1 localizes to 2p16, whereas Nup88 localizes to 17p13 and is physically linked to SF2p32.
Fornerod M, van Baal S, Valentine V, Shapiro DN, Grosveld G.
Genomics 42(3):538-40. 1997
51XPO1, NUP88
The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88.
Fornerod M, et al.
EMBO J 16 : 807-816. 1997
CRM1 is an export receptor for leucine-rich nuclear export signals.
Fornerod M, Ohno M, Yoshida M, Mattaj IW.
Cell 90(6):1051-60. 1997
CRM1 is responsible for intracellular transport mediated by the nuclear export signal.
Fukuda M, Asano S, Nakamura T, Adachi M, Yoshida M, Yanagida M, Nishida E.
Nature 390(6657):308-11. 1997
Exportin 1 (Crm1p) is an essential nuclear export factor.
Stade K, Ford CS, Guthrie C, Weis K.
Cell 90(6):1041-50. 1997
Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins.
Kudo N, Khochbin S, Nishi K, Kitano K, Yanagida M, Yoshida M, Horinouchi S.
J Biol Chem 272(47):29742-51. 1997