1 | DLC1, MET, TNS4, XPO1
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| Identification of subcellular targeting sequences of Cten reveals its role in cell proliferation.
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| Hong SY, Shih YP, Lo A, Lo SH.
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| Biochim Biophys Acta Mol Cell Res 1866(3):450-458. doi: 10.1016/j.bbamcr.2018.10.008. Epub 2018 Oct 13.
2019
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2 | SETBP1, XPO1
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| Interaction with XPO1 is essential for SETBP1 to induce myeloid transformation. 2019 PMID:
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| Nguyen N, Oakley K, Han Y, Kwok M, Crouch G, Du Y.
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| Leukemia Nov;33(11):2758-2762. doi: 10.1038/s41375-019-0521-x. Epub 2019 Jul 23. 2019
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3 | AR, XPO1
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| Down-regulation of AR splice variants through XPO1 suppression contributes to the inhibition of prostate cancer progression.
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| Aboukameel A, Muqbil I, Baloglu E, Senapedis W, Landesman Y, Argueta C, Kauffman M, Chang H, Kashyap T, Shacham S, Neggers JE, Daelemans D, Heath EI, Azmi AS.
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| Oncotarget 9(82):35327-35342. doi: 10.18632/oncotarget.26239. eCollection 2018 Oct 19.
2018
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4 | KPNB1, RANBP2, RANGAP1, XPO1
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| Importin-β and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function.
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| Gilistro E, de Turris V, Damizia M, Verrico A, Moroni S, De Santis R, Rosa A, Lavia P.
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| J Cell Sci 130(15):2564-2578. doi: 10.1242/jcs.197905. Epub 2017 Jun 9.
2017
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5 | XPO1
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| The nuclear export factor CRM1 controls juxta-nuclear microtubule-dependent virus transport.
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| Wang IH, Burckhardt CJ, Yakimovich A, Morf MK, Greber UF.
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| J Cell Sci 130(13):2185-2195. doi: 10.1242/jcs.203794. Epub 2017 May 17.
2017
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6 | XPO1
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| Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
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| Fung HY, Fu SC, Chook YM.
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| Elife 6. pii: e23961. doi: 10.7554/eLife.23961.
2017
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7 | XPO1
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| A cellular reporter to evaluate CRM1 nuclear export activity: functional analysis of the cancer-related mutant E571K.
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| García-Santisteban I, Arregi I, Alonso-Marińo M, Urbaneja MA, Garcia-Vallejo JJ, Bańuelos S, Rodríguez JA.
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| Cell Mol Life Sci 73(24):4685-4699. Epub 2016 Jun 16.
2016
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8 | XPO1
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| XPO1 Inhibition Preferentially Disrupts the 3D Nuclear Organization of Telomeres in Tumor Cells.
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| Taylor-Kashton C, Lichtensztejn D, Baloglu E, Senapedis W, Shacham S, Kauffman MG, Kotb R, Mai S.
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| J Cell Physiol 231(12):2711-9. doi: 10.1002/jcp.25378. Epub 2016 Apr 8.
2016
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9 | NUP98, XPO1
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| Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes.
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| Oka M, Mura S, Yamada K, Sangel P, Hirata S, Maehara K, Kawakami K, Tachibana T, Ohkawa Y, Kimura H, Yoneda Y.
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| Elife 5:e09540. doi: 10.7554/eLife.09540.
2016
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10 | NXT1, XPO1
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| NXT1, a Novel Influenza A NP Binding Protein, Promotes the Nuclear Export of NP via a CRM1-Dependent Pathway.
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| Chutiwitoonchai N, Aida Y.
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| Viruses Jul 28;8(8):209. doi: 10.3390/v8080209 2016
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11 | RANGAP1, XPO1
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| The Cellular Distribution of RanGAP1 Is Regulated by CRM1-Mediated Nuclear Export in Mammalian Cells.
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| Cha K, Sen P, Raghunayakula S, Zhang XD.
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| PLoS One 10(10):e0141309. doi: 10.1371/journal.pone.0141309. eCollection 2015.
2015
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12 | XPO1
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| Structural determinants of nuclear export signal orientation in binding to exportin CRM1.
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| Fung HY, Fu SC, Brautigam CA, Chook YM.
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| Elife 4. doi: 10.7554/eLife.10034.
2015
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13 | XPO1
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| Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein.
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| Ishizawa J, Kojima K, Hail N Jr, Tabe Y, Andreeff M.
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| Pharmacol Ther 153:25-35. doi: 10.1016/j.pharmthera.2015.06.001. Epub 2015 Jun 3. Review.
2015
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14 | XPO1
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| Elevated expression of the nuclear export protein, Crm1 (exportin 1), associates with human oesophageal squamous cell carcinoma.
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| van der Watt PJ, Zemanay W, Govender D, Hendricks DT, Parker MI, Leaner VD.
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| Oncol Rep 32(2):730-8. doi: 10.3892/or.2014.3231. Epub 2014 Jun 4.
2014
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15 | SNUPN, TPR, XPO1
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| The interaction of CRM1 and the nuclear pore protein Tpr.
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| Zhao CL, Mahboobi SH, Moussavi-Baygi R, Mofrad MR.
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| PLoS One 9(4):e93709. doi: 10.1371/journal.pone.0093709. eCollection 2014.
2014
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16 | AKT3, XPO1
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| AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1.
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| Corum DG, Tsichlis PN, Muise-Helmericks RC.
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| FASEB J 28(1):395-407. doi: 10.1096/fj.13-235382. Epub 2013 Sep 30.
2014
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17 | XPO1
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| Structural basis for cooperativity of CRM1 export complex formation.
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| Monecke T, Haselbach D, Voß B, Russek A, Neumann P, Thomson E, Hurt E, Zachariae U, Stark H, Grubmüller H, Dickmanns A, Ficner R.
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| Proc Natl Acad Sci U S A 110(3):960-5. doi: 10.1073/pnas.1215214110. Epub 2012 Dec 31.
2013
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18 | EIF4E, NOS2, XPO1
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| Human inducible nitric oxide synthase (iNOS) expression depends on chromosome region maintenance 1 (CRM1)- and eukaryotic translation initiation factor 4E (elF4E)-mediated nucleocytoplasmic mRNA transport.
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| Bollmann F, Fechir K, Nowag S, Koch K, Art J, Kleinert H, Pautz A.
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| Nitric Oxide 30:49-59. doi: 10.1016/j.niox.2013.02.083. Epub 2013 Mar 5.
2013
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19 | BACH1, XPO1
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| Transcription-independent role of Bach1 in mitosis through a nuclear exporter Crm1-dependent mechanism.
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| Li J, Shiraki T, Igarashi K.
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| FEBS Lett 586(4):448-54. Epub 2012 Jan 28.
2012
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20 | XPO1
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| Characterization of BRCA1 protein targeting, dynamics, and function at the centrosome: a role for the nuclear export signal, CRM1, and Aurora A kinase.
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| Brodie KM, Henderson BR.
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| J Biol Chem 287(10):7701-16. Epub 2012 Jan 18.
2012
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21 | XPO1
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| A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family.
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| García-Santisteban I, Bańuelos S, Rodríguez JA.
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| Biochem J 441(1):209-17.
2012
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22 | GATA6, XPO1
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| cAMP-dependent proteolysis of GATA-6 is linked to JNK-signaling pathway.
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| Ushijima H, Maeda M.
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| Biochem Biophys Res Commun 423(4):679-83. doi: 10.1016/j.bbrc.2012.06.013. Epub 2012 Jun 10.
2012
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23 | KPNB1, RANBP2, RANGAP1, XPO1
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| Importin-β negatively regulates multiple aspects of mitosis including RANGAP1 recruitment to kinetochores.
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| Roscioli E, Di Francesco L, Bolognesi A, Giubettini M, Orlando S, Harel A, Schininŕ ME, Lavia P.
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| J Cell Biol 196(4):435-50. doi: 10.1083/jcb.201109104. Epub 2012 Feb 13.
2012
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24 | IPO7, XPO1
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| Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis.
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| Golomb L, Bublik DR, Wilder S, Nevo R, Kiss V, Grabusic K, Volarevic S, Oren M.
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| Mol Cell 45(2):222-32. doi: 10.1016/j.molcel.2011.11.022. Erratum in: Mol Cell. 2012 Jul 13;47(1):150.
2012
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25 | DEL2P15, OTX1, XPO1
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| 2p15-p16.1 microdeletion syndrome: molecular characterization and association of the OTX1 and XPO1 genes with autism spectrum disorders.
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| Liu X, Malenfant P, Reesor C, Lee A, Hudson ML, Harvard C, Qiao Y, Persico AM, Cohen IL, Chudley AE, Forster-Gibson C, Rajcan-Separovic E, Lewis MS, Holden JJ.
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| Eur J Hum Genet ur J Hum Genet. 2011 Jul 13. doi: 10.1038/ejhg.2011.112. [Epub ahead of print]
2011
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26 | XPO1
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| Electrostatic interactions involving the extreme C terminus of nuclear export factor CRM1 modulate its affinity for cargo.
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| Fox AM, Ciziene D, McLaughlin SH, Stewart M.
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| J Biol Chem 286(33):29325-35. Epub 2011 Jun 27.
2011
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27 | XPO1
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| The nuclear exporter, Crm1, is regulated by NFY and Sp1 in cancer cells and repressed by p53 in response to DNA damage.
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| van der Watt PJ, Leaner VD.
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| Biochim Biophys Acta 1809(7):316-26. Epub 2011 Jun 13.
2011
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28 | XPO1
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| CRM1 controls the composition of nucleoplasmic pre-snoRNA complexes to licence them for nucleolar transport.
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| Pradet-Balade B, Girard C, Boulon S, Paul C, Azzag K, Bordonné R, Bertrand E, Verheggen C.
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| EMBO J 30(11):2205-18. Epub 2011 Apr 26.
2011
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29 | RANBP3, XPO1
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| Insights into the function of the CRM1 cofactor RanBP3 from the structure of its Ran-binding domain.
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| Langer K, Dian C, Rybin V, Müller CW, Petosa C.
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| PLoS One 6(2):e17011.
2011
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30 | FBXO7, SKP1, XPO1
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| A Competitive binding mechanism between Skp1 and exportin 1 (CRM1) controls the localization of a subset of F-box proteins.
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| Nelson DE, Laman H.
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| J Biol Chem 286(22):19804-15. doi: 10.1074/jbc.M111.220079. Epub 2011 Mar 4.
2011
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31 | AVEN, XPO1
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| Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export.
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| Esmaili AM, Johnson EL, Thaivalappil SS, Kuhn HM, Kornbluth S, Irusta PM.
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| Cell Cycle 9(19):3913-20. Epub 2010 Oct 25.
2010
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32 | XPO1
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| An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1.
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| Koyama M, Matsuura Y.
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| EMBO J 29(12):2002-13. Epub 2010 May 18.
2010
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33 | NUP98, XPO1
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| The mobile FG nucleoporin Nup98 is a cofactor for Crm1-dependent protein export.
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| Oka M, Asally M, Yasuda Y, Ogawa Y, Tachibana T, Yoneda Y.
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| Mol Biol Cell 21(11):1885-96. Epub 2010 Apr 7.
2010
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34 | XPO1
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| The karyopherin CRM1 is required for dendritic cell maturation.
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| Chemnitz J, Turza N, Hauber I, Steinkasserer A, Hauber J.
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| Immunobiology 215(5):370-9. Epub 2009 Jul 9.
2010
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35 | CSE1L, KPNB1, XPO1, XPOT
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| Nuclear export complexes in the frame.
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| Cook AG, Conti E.
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| Curr Opin Struct Biol 20(2):247-52. doi: 10.1016/j.sbi.2010.01.012. Epub 2010 Feb 18. Review.
2010
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36 | XPO1
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| A fraction of Crm1 locates at centrosomes by its CRIME domain and regulates the centrosomal localization of pericentrin.
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| Liu Q, Jiang Q, Zhang C.
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| Biochem Biophys Res Commun 384(3):383-8. Epub 2009 May 5.
2009
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37 | SNUPN, XPO1
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| Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP.
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| Monecke T, Güttler T, Neumann P, Dickmanns A, Görlich D, Ficner R.
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| Science 324(5930):1087-91. Epub 2009 Apr 23. 2009
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38 | KPNB1, XPO1
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| The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.
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| van der Watt PJ, Maske CP, Hendricks DT, Parker MI, Denny L, Govender D, Birrer MJ, Leaner VD.
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| Int J Cancer 124(8):1829-40.
2009
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39 | SNUPN, XPO1
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| Structural basis for assembly and disassembly of the CRM1 nuclear export complex.
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| Dong X, Biswas A, Chook YM.
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| Nat Struct Mol Biol 16(5):558-60. Epub 2009 Apr 1.
2009
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40 | CRM1, NUP62, XPO1
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| Oxidative stress inhibits nuclear protein export by multiple mechanisms that target FG nucleoporins and Crm1.
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| Crampton N, Kodiha M, Shrivastava S, Umar R, Stochaj U.
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| Mol Biol Cell 20(24):5106-16. Epub . 2009
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41 | ILK, ILKAP, XPO1
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| Modulation of integrin-linked kinase nucleo-cytoplasmic shuttling by ILKAP and CRM1.
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| Nakrieko KA, Vespa A, Mason D, Irvine TS, D'Souza SJ, Dagnino L.
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| Cell Cycle 7(14):2157-66. Epub 2008 May 7.PMID: 18635968 2008
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42 | STK11, STRADA, XPO1, XPO7
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| STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7.
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| Dorfman J, Macara IG.
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| Mol Biol Cell 19(4):1614-26. Epub 2008 Feb 6.
2008
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43 | SERTAD2, XPO1
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| CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein.
|
| Cheong JK, Gunaratnam L, Hsu SI.
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| J Biol Chem 283(17):11661-76. doi: 10.1074/jbc.M708365200. Epub 2008 Mar 3.
2008
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44 | HDAC7, XPO1
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| CRM1 mediates nuclear export of HDAC7 independently of HDAC7 phosphorylation and association with 14-3-3s.
|
| Gao C, Li X, Lam M, Liu Y, Chakraborty S, Kao HY.
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| FEBS Lett 580(21):5096-104. Epub 2006 Sep 1. 2006
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45 | NPM1, XPO1
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| Characterization of centrosomal association of nucleophosmin/B23 linked to Crm1 activity.
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| Shinmura K, Tarapore P, Tokuyama Y, George KR, Fukasawa K.
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| FEBS Lett 579(29):6621-34. Epub 2005 Nov 9. 2005
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46 | XPO1, XPO7
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| Exportin 7 defines a novel general nuclear export pathway.
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| Mingot JM, Bohnsack MT, Jäkle U, Görlich D.
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| EMBO J 23(16):3227-36. Epub 2004 Jul 29.
2004
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47 | BIRC5, XPO1
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| CRM1-mediated nuclear export determines the cytoplasmic localization of the antiapoptotic protein Survivin.
|
| Rodriguez JA, Span SW, Ferreira CG, Kruyt FA, Giaccone G.
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| Exp Cell Res 275(1):44-53. 2002
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48 | RANBP3, XPO1
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| RanBP3 influences interactions between CRM1 and its nuclear protein export substrates.
|
| Englmeier L, Fornerod M, Bischoff FR, Petosa C, Mattaj IW, Kutay U.
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| EMBO Rep 2(10):926-32. Epub 2001 Sep 24.
2001
|
49 | STAT1, XPO1
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| Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor.
|
| McBride KM, McDonald C, Reich NC.
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| EMBO J 19(22):6196-206. 2000
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50 | EIF5A, XPO1
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| Evidence for specific nucleocytoplasmic transport pathways used by leucine-rich nuclear export signals.
|
| Elfgang C, et al.
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| Proc Natl Acad Sci U S A 96(11):6229-34. 1999
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51 | XPO1, NUP88, C1QBP
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| Chromosomal localization of genes encoding CAN/Nup214-interacting proteins-human CRM1 localizes to 2p16, whereas Nup88 localizes to 17p13 and is physically linked to SF2p32.
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| Fornerod M, van Baal S, Valentine V, Shapiro DN, Grosveld G.
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| Genomics 42(3):538-40. 1997
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52 | XPO1, NUP88
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| The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88.
|
| Fornerod M, et al.
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| EMBO J 16 : 807-816. 1997
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53 | XPO1
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| CRM1 is an export receptor for leucine-rich nuclear export signals.
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| Fornerod M, Ohno M, Yoshida M, Mattaj IW.
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| Cell 90(6):1051-60. 1997
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54 | XPO1
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| CRM1 is responsible for intracellular transport mediated by the nuclear export signal.
|
| Fukuda M, Asano S, Nakamura T, Adachi M, Yoshida M, Yanagida M, Nishida E.
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| Nature 390(6657):308-11. 1997
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55 | XPO1
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| Exportin 1 (Crm1p) is an essential nuclear export factor.
|
| Stade K, Ford CS, Guthrie C, Weis K.
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| Cell 90(6):1041-50. 1997
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56 | XPO1
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| Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins.
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| Kudo N, Khochbin S, Nishi K, Kitano K, Yanagida M, Yoshida M, Horinouchi S.
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| J Biol Chem 272(47):29742-51. 1997
|