Citations for
1SEPTIN4, XIAP
The ARTS of Cell Death.
Koren E, Fuchs Y.
J Cell Death 12:1179066019836967. doi: 10.1177/1179066019836967. eCollection 2019. 2019
2SEPTIN4, XIAP
ARTS mediates apoptosis and regeneration of the intestinal stem cell niche.
Koren E, Yosefzon Y, Ankawa R, Soteriou D, Jacob A, Nevelsky A, Ben-Yosef R, Bar-Sela G, Fuchs Y.
Nat Commun 9(1):4582. doi: 10.1038/s41467-018-06941-4. 2018
3USP11, XIAP
Regulation of XIAP Turnover Reveals a Role for USP11 in Promotion of Tumorigenesis.
Zhou Z, Luo A, Shrivastava I, He M, Huang Y, Bahar I, Liu Z, Wan Y.
EBioMedicine 15:48-61. doi: 10.1016/j.ebiom.2016.12.014. Epub 2016 Dec 23. 2017
4XIAP
Phosphorylation of XIAP by CDK1-cyclin-B1 controls mitotic cell death.
Hou Y, Allan LA, Clarke PR.
J Cell Sci 130(2):502-511. doi: 10.1242/jcs.192310. Epub 2016 Dec 7. 2017
5SERTAD1, XIAP
The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms.
Hu W, Yu X, Liu Z, Sun Y, Chen X, Yang X, Li X, Lam WK, Duan Y, Cao X, Steller H, Liu K, Huang P.
Elife 6. pii: e28021. doi: 10.7554/eLife.28021. 2017
6BCL2, SEPTIN4, XIAP
Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis.
Edison N, Curtz Y, Paland N, Mamriev D, Chorubczyk N, Haviv-Reingewertz T, Kfir N, Morgenstern D, Kupervaser M, Kagan J, Kim HT, Larisch S.
Cell Rep 21(2):442-454. doi: 10.1016/j.celrep.2017.09.052. 2017
7XIAP
Loss of XIAP facilitates switch to TNFα-induced necroptosis in mouse neutrophils.
Wicki S, Gurzeler U, Wei-Lynn Wong W, Jost PJ, Bachmann D, Kaufmann T.
Cell Death Dis 7(10):e2422. doi: 10.1038/cddis.2016.311. 2016
8SERTAD1, XIAP
Inhibitory role of TRIP-Br1 oncoprotein in hypoxia-induced apoptosis in breast cancer cell lines.
Li C, Jung S, Yang Y, Kim KI, Lim JS, Cheon CI, Lee MS.
Int J Oncol 48(6):2639-46. doi: 10.3892/ijo.2016.3454. Epub 2016 Mar 24. 2016
9BIRC5, FOXM1, XIAP
FOXM1 targets XIAP and Survivin to modulate breast cancer survival and chemoresistance.
Nestal de Moraes G, Delbue D, Silva KL, Robaina MC, Khongkow P, Gomes AR, Zona S, Crocamo S, Mencalha AL, Magalhães LM, Lam EW, Maia RC.
Cell Signal 27(12):2496-505. doi: 10.1016/j.cellsig.2015.09.013. Epub 2015 Sep 25. 2015
10XIAP
Role of X-Linked Inhibitor of Apoptosis as a Prognostic Marker and Therapeutic Target in Papillary Thyroid Carcinoma.
Hussain AR, Bu R, Ahmed M, Jehan Z, Beg S, Al-Sobhi S, Al-Dayel F, Siraj AK, Uddin S, Al-Kuraya KS.
J Clin Endocrinol Metab 100(7):E974-85. doi: 10.1210/jc.2014-4356. Epub 2015 May 14. 2015
11XIAP, XLP2
Symptomatic males and female carriers in a large Caucasian kindred with XIAP deficiency.
Dziadzio M, Ammann S, Canning C, Boyle F, Hassan A, Cale C, Elawad M, Fiil BK, Gyrd-Hansen M, Salzer U, Speckmann C, Grimbacher B.
J Clin Immunol 35(5):439-44. doi: 10.1007/s10875-015-0166-0. Epub 2015 May 6. 2015
12BECN1, BIRC2, XIAP
XIAP and cIAP1 amplifications induce Beclin 1-dependent autophagy through NFκB activation.
Lin F, Ghislat G, Luo S, Renna M, Siddiqi F, Rubinsztein DC.
Hum Mol Genet 24(10):2899-913. doi: 10.1093/hmg/ddv052. Epub 2015 Feb 10. 2015
13XIAP
Co-ordinated brain and craniofacial development depend upon Patched1/XIAP regulation of cell survival.
Aoto K, Trainor PA.
Hum Mol Genet 24(3):698-713. doi: 10.1093/hmg/ddu489. Epub 2014 Oct 6. 2015
14MAP2K5, MAP3K3, XIAP
Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1.
Takeda AN, Oberoi-Khanuja TK, Glatz G, Schulenburg K, Scholz RP, Carpy A, Macek B, Remenyi A, Rajalingam K.
EMBO J 33(16):1784-801. doi: 10.15252/embj.201487808. Epub 2014 Jun 28. 2014
15STAG2, THOC2, XIAP
Definition of minimal duplicated region encompassing the XIAP and STAG2 genes in the Xq25 microduplication syndrome.
Di Benedetto D, Musumeci SA, Avola E, Alberti A, Buono S, Scuderi C, Grillo L, Galesi O, Spalletta A, Giudice ML, Luciano D, Vinci M, Bianca S, Romano C, Fichera M.
Am J Med Genet A 164A(8):1923-30. doi: 10.1002/ajmg.a.36570. Epub 2014 Apr 14. 2014
16RIPK3, XIAP
XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation.
Yabal M, Müller N, Adler H, Knies N, Groß CJ, Damgaard RB, Kanegane H, Ringelhan M, Kaufmann T, Heikenwälder M, Strasser A, Groß O, Ruland J, Peschel C, Gyrd-Hansen M, Jost PJ.
Cell Rep 7(6):1796-808. doi: 10.1016/j.celrep.2014.05.008. Epub 2014 May 29. 2014
17BIRC2, RHOA, XIAP
A novel role for inhibitor of apoptosis (IAP) proteins as regulators of endothelial barrier function by mediating RhoA activation.
Hornburger MC, Mayer BA, Leonhardt S, Willer EA, Zahler S, Beyerle A, Rajalingam K, Vollmar AM, Fürst R.
FASEB J 28(4):1938-46. doi: 10.1096/fj.13-235754. Epub 2013 Dec 26. 2014
18HTRA2, XIAP
Omi/HtrA2 and XIAP are components of platelet apoptosis signalling.
Winkler J, Rand ML, Schmugge M, Speer O.
Thromb Haemost 109(3). [Epub ahead of print] 2013
19PTK2, PTK2B, XIAP
XIAP reverses various functional activities of FRNK in endothelial cells.
Ahn S, Kim HJ, Chi SG, Park H.
Biochem Biophys Res Commun 419(2):419-24. doi: 10.1016/j.bbrc.2012.02.037. Epub 2012 Feb 14. 2012
20ARHGDIA, XIAP
RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility.
Yu J, Zhang D, Liu J, Li J, Yu Y, Wu XR, Huang C.
J Biol Chem 287(17):13752-60. doi: 10.1074/jbc.M111.337469. Epub 2012 Mar 5. 2012
21LYP, SH2D1A, XIAP, XLP2
Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency).
Pachlopnik Schmid J, Canioni D, Moshous D, Touzot F, Mahlaoui N, Hauck F, Kanegane H, Lopez-Granados E, Mejstrikova E, Pellier I, Galicier L, Galambrun C, Barlogis V, Bordigoni P, Fourmaintraux A, Hamidou M, Dabadie A, Le Deist F, Haerynck F, Ouachée-Chardin M, Rohrlich P, Stephan JL, Lenoir C, Rigaud S, Lambert N, Milili M, Schiff C, Chapel H, Picard C, de Saint Basile G, Blanche S, Fischer A, Latour S.
Blood 117(5):1522-9. Epub 2010 Nov 30. 2011
22BIRC2, BIRC3, XIAP
Inhibitor of apoptosis proteins as novel targets in inflammatory processes.
Mayer BA, Rehberg M, Erhardt A, Wolf A, Reichel CA, Kracht M, Krombach F, Tiegs G, Zahler S, Vollmar AM, Fürst R.
Arterioscler Thromb Vasc Biol 31(10):2240-50. Epub 2011 Aug 4. 2011
23TRIM32, XIAP
TRIM32 protein sensitizes cells to tumor necrosis factor (TNFα)-induced apoptosis via its RING domain-dependent E3 ligase activity against X-linked inhibitor of apoptosis (XIAP).
Ryu YS, Lee Y, Lee KW, Hwang CY, Maeng JS, Kim JH, Seo YS, You KH, Song B, Kwon KS.
J Biol Chem 286(29):25729-38. Epub 2011 May 31. 2011
24CD40LG, XIAP
Human X-linked variable immunodeficiency caused by a hypomorphic mutation in XIAP in association with a rare polymorphism in CD40LG.
Rigaud S, Lopez-Granados E, Sibéril S, Gloire G, Lambert N, Lenoir C, Synaeve C, Stacey M, Fugger L, Stephan JL, Fischer A, Picard C, Durandy A, Chapel H, Latour S.
Blood 118(2):252-61. Epub 2011 May 4. 2011
25BIRC2, BIRC3, VGLL4, XIAP
A novel inhibitor of apoptosis protein (IAP)-interacting protein, Vestigial-like (Vgl)-4, counteracts apoptosis-inhibitory function of IAPs by nuclear sequestration.
Jin HS, Park HS, Shin JH, Kim DH, Jun SH, Lee CJ, Lee TH.
Biochem Biophys Res Commun 412(3):454-9. Epub 2011 Aug 4. 2011
26ARHGDIA, XIAP
X-linked inhibitor of apoptosis protein (XIAP) mediates cancer cell motility via Rho GDP dissociation inhibitor (RhoGDI)-dependent regulation of the cytoskeleton.
Liu J, Zhang D, Luo W, Yu Y, Yu J, Li J, Zhang X, Zhang B, Chen J, Wu XR, Rosas-Acosta G, Huang C.
J Biol Chem 286(18):15630-40. doi: 10.1074/jbc.M110.176982. Epub 2011 Mar 14. 2011
27XIAP
XIAP as a ubiquitin ligase in cellular signaling.
Galbán S, Duckett CS.
Cell Death Differ 17(1):54-60. Epub . 2010
28HAX1, XIAP
Molecular interaction between HAX-1 and XIAP inhibits apoptosis.
Kang YJ, Jang M, Park YK, Kang S, Bae KH, Cho S, Lee CK, Park BC, Chi SW, Park SG.
Biochem Biophys Res Commun 393(4):794-9. Epub 2010 Feb 18.PMID: 20171186 2010
29CCS, XIAP
Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination.
Brady GF, Galbán S, Liu X, Basrur V, Gitlin JD, Elenitoba-Johnson KS, Wilson TE, Duckett CS.
Mol Cell Biol 30(8):1923-36. Epub 2010 Feb 12.PMID: 20154138 2010
30GZMM, XIAP
Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells.
Hu D, Liu S, Shi L, Li C, Wu L, Fan Z.
J Biol Chem 285(24):18326-35. Epub 2010 Apr 20.PMID: 20406824 2010
31PTK2, XIAP
XIAP is essential for shear stress-enhanced Tyr-576 phosphorylation of FAK.
Ahn S, Park H.
Biochem Biophys Res Commun 399(2):256-61. Epub 2010 Jul 22.PMID: 20655298 2010
32DIABLO, XIAP
Smac/DIABLO release from mitochondria and XIAP inhibition are essential to limit clonogenicity of Type I tumor cells after TRAIL receptor stimulation.
Maas C, Verbrugge I, de Vries E, Savich G, van de Kooij LW, Tait SW, Borst J.
Cell Death Differ 17(10):1613-23. Epub 2010 Apr 16. 2010
33CFLAR, XIAP
Combined inhibition of FLIP and XIAP induces Bax-independent apoptosis in type II colorectal cancer cells.
Wilson TR, McEwan M, McLaughlin K, Le Clorennec C, Allen WL, Fennell DA, Johnston PG, Longley DB.
Oncogene 28(1):63-72. Epub 2008 Sep 29. 2009
34BIIRC2, BIRC3, XIAP
cIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation.
Jin HS, Lee DH, Kim DH, Chung JH, Lee SJ, Lee TH.
Cancer Res 69(5):1782-91. Epub 2009 Feb 17. 2009
35XIAP
S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease.
Tsang AH, Lee YI, Ko HS, Savitt JM, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Chung KK.
Proc Natl Acad Sci U S A 106(12):4900-5. Epub 2009 Mar 9. Erratum in: Proc Natl Acad Sci U S A. 2009 May 26;106(21):8791. 2009
36COMMD1, XIAP
COMMD1 expression is controlled by critical residues that determine XIAP binding.
Maine GN, Mao X, Muller PA, Komarck CM, Klomp LW, Burstein E.
Biochem J 417(2):601-9. 2009
37XIAP
X-linked Inhibitor of Apoptosis Protein (XIAP) Regulates PTEN Ubiquitination, Content, and Compartmentalization.
Van Themsche C, Leblanc V, Parent S, Asselin E.
J Biol Chem 284(31):20462-6. Epub 2009 May 27. 2009
38XIAP
XIAP discriminates between type I and type II FAS-induced apoptosis.
Jost PJ, Grabow S, Gray D, McKenzie MD, Nachbur U, Huang DC, Bouillet P, Thomas HE, Borner C, Silke J, Strasser A, Kaufmann T.
Nature 460(7258):1035-9. Epub 2009 Jul 22. 2009
39NOD1, NOD2, RIPK2, XIAP
XIAP mediates NOD signaling via interaction with RIP2.
Krieg A, Correa RG, Garrison JB, Le Negrate G, Welsh K, Huang Z, Knoefel WT, Reed JC.
Proc Natl Acad Sci U S A 106(34):14524-9. Epub 2009 Aug 10.PMID: 19667203 2009
40XIAP
XIAP effects on retinal detachment-induced photoreceptor apoptosis
Zadro-Lamoureux LA, Zacks DN, Baker AN, Zheng QD, Hauswirth WW, Tsilfidis C.
Invest Ophthalmol Vis Sci. 50(4):1530 2009
41XIAP
p34SEI-1 inhibits apoptosis through the stabilization of the X-linked inhibitor of apoptosis protein: p34SEI-1 as a novel target for anti-breast cancer strategies.
Hong SW, Kim CJ, Park WS, Shin JS, Lee SD, Ko SG, Jung SI, Park IC, An SK, Lee WK, Lee WJ, Jin DH, Lee MS.
Cancer Res. 69(3):741-6. 2009
42BIRC5, LAMTOR5, XIAP
Increased expression of inhibitor of apoptosis proteins, survivin and XIAP, in non-small cell lung carcinoma.
Krepela E, Dankova P, Moravcikova E, Krepelova A, Prochazka J, Cermak J, Schützner J, Zatloukal P, Benkova K.
Int J Oncol 35(6):1449-62.PMID: 19885569 2009
43BIRC2, BIRC3, XIAP
cIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation.
Jin HS, Lee DH, Kim DH, Chung JH, Lee SJ, Lee TH.
Cancer Res 69(5):1782-91. Epub 2009 Feb 17. 2009
44AATF, XIAP
Che-1 activates XIAP expression in response to DNA damage.
Bruno T, Iezzi S, De Nicola F, Di Padova M, Desantis A, Scarsella M, Di Certo MG, Leonetti C, Floridi A, Passananti C, Fanciulli M.
Cell Death Differ 15(3):515-20. Epub 2007 Nov 30. 2008
45XIAP
XIAP regulates intracellular ROS by enhancing antioxidant gene expression.
Resch U, Schichl YM, Sattler S, de Martin R.
Biochem Biophys Res Commun 375(1):156-61. Epub 2008 Aug 8. 2008
46RAF1, STUB1, XIAP
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility.
Dogan T, Harms GS, Hekman M, Karreman C, Oberoi TK, Alnemri ES, Rapp UR, Rajalingam K.
Nat Cell Biol 10(12):1447-55. Epub 2008 Nov 16. Erratum in: Nat Cell Biol. 2009 Jan;11(1):110. 2008
47XIAP
XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2.
Winsauer G, Resch U, Hofer-Warbinek R, Schichl YM, de Martin R.
Cell Signal. 20(11):2107-12. 2008
48AIFM1, XIAP
Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP.
Wilkinson JC, Wilkinson AS, Galbán S, Csomos RA, Duckett CS.
Mol Cell Biol 28(1):237-47. Epub 2007 Oct 29.PMID: 17967870 2008
49XIAP
X-linked inhibitor of apoptosis protein increases mitochondrial antioxidants through NF-kappaB activation.
Kairisalo M, Korhonen L, Blomgren K, Lindholm D.
Biochem Biophys Res Commun 364(1):138-44. Epub 2007 Oct 4. 2007
50KCNJ6, TAB1, XIAP
XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization.
Lu M, Lin SC, Huang Y, Kang YJ, Rich R, Lo YC, Myszka D, Han J, Wu H.
Mol Cell 26(5):689-702. 2007
51CASP3, CASP9, XIAP
Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9.
Denault JB, Eckelman BP, Shin H, Pop C, Salvesen GS.
Biochem J 405(1):11-9. 2007
52XIAP
Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex.
Arora V, Cheung HH, Plenchette S, Micali OC, Liston P, Korneluk RG.
J Biol Chem. 282(36):26202-9. 2007
53XIAP
Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection.
Dohi T, Xia F, Altieri DC.
Mol Cell. 27(1):17-28. 2007
54XIAP
X-linked inhibitor of apoptosis regulates T cell effector function.
Zehntner SP, Bourbonnière L, Moore CS, Morris SJ, Methot D, St Jean M, Lacasse E, Hebb AL, Robertson GS, Durkin J, Gillard JW, Owens T.
J Immunol 179(11):7553-60.PMID: 18025200 2007
55AFP, XIAP
Alpha-fetoprotein antagonizes X-linked inhibitor of apoptosis protein anticaspase activity and disrupts XIAP-caspase interaction.
Dudich E, Semenkova L, Dudich I, Denesyuk A, Tatulov E, Korpela T.
FEBS J 273(16):3837-49. Epub 2006 Jul 26. 2006
56LYP, XIAP, XLP2
XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome.
Rigaud S, Fondaneche MC, Lambert N, Pasquier B, Mateo V, Soulas P, Galicier L, Le Deist F, Rieux-Laucat F, Revy P, Fischer A, de Saint Basile G, Latour S.
Nature 444(7115):110-4. 2006
57XIAP
XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders.
Mufti AR, Burstein E, Csomos RA, Graf PC, Wilkinson JC, Dick RD, Challa M, Son JK, Bratton SB, Su GL, Brewer GJ, Jakob U, Duckett CS.
Mol Cell. 21(6):775-85. 2006
58XIAP
XIAP-mediated neuroprotection in retinal ischemia.
Renwick J, Narang MA, Coupland SG, Xuan JY, Baker AN, Brousseau J, Petrin D, Munger R, Leonard BC, Hauswirth WW, Korneluk RG, Tsilfidis C.
Gene Ther. 13(4):339-47. 2006
59CASP9, DIABLO, XIAP
X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO.
Morizane Y, Honda R, Fukami K, Yasuda H.
J Biochem (Tokyo) 137(2):125-32. 2005
60MAP3K7, MAPK8, XIAP
X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1).
Kaur S, Wang F, Venkatraman M, Arsura M.
J Biol Chem 280(46):38599-608. Epub 2005 Sep 12. 2005
61XIAP
X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia.
Wang X, Zhu C, Wang X, Hagberg H, Korhonen L, Sandberg M, Lindholm D, Blomgren K.
Neurobiol Dis 16(1):179-89. 2004
62COMMD1, COMMD8, XIAP
A novel role for XIAP in copper homeostasis through regulation of MURR1.
Burstein E, Ganesh L, Dick RD, van De Sluis B, Wilkinson JC, Klomp LW, Wijmenga C, Brewer GJ, Nabel GJ, Duckett CS.
EMBO J 23(1):244-54. Epub 2003 Dec 18. 2004
63BIRC2, BIRC3, XAF1, XIAP
Motoneuron resistance to apoptotic cell death in vivo correlates with the ratio between X-linked inhibitor of apoptosis proteins (XIAPs) and its inhibitor, XIAP-associated factor 1.
Perrelet D, Perrin FE, Liston P, Korneluk RG, MacKenzie A, Ferrer-Alcon M, Kato AC.
J Neurosci 24(15):3777-85. 2004
64XIAP
Interaction of checkpoint kinase 1 and the X-linked inhibitor of apoptosis during mitosis.
Galvan V, Kurakin AV, Bredesen DE.
FEBS Lett. 558(1-3):57-62. 2004
65XIAP
X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells.
Cummins JM, Kohli M, Rago C, Kinzler KW, Vogelstein B, Bunz F.
Cancer Res. 64(9):3006-8. 2004
66XIAP
Overexpression of X-linked inhibitor of apoptosis in human hepatocellular carcinoma.
Shiraki K, Sugimoto K, Yamanaka Y, Yamaguchi Y, Saitou Y, Ito K, Yamamoto N, Yamanaka T, Fujikawa K, Murata K, Nakano T.
Int J Mol Med 12(5):705-8. 2003
67DIABLO, XIAP
Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac.
Huang Y, Rich RL, Myszka DG, Wu H.
J Biol Chem 278(49):49517-22. Epub 2003 Sep 25. 2003
68GSTP1, XIAP
The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein.
Hegde R, Srinivasula SM, Datta P, Madesh M, Wassell R, Zhang Z, Cheong N, Nejmeh J, Fernandes-Alnemri T, Hoshino S, Alnemri ES.
J Biol Chem 278(40):38699-706. Epub 2003 Jul 15. 2003
69XIAP
XIAP protects photoreceptors from n-methyl-n-nitrosourea-induced retinal degeneration.
Petrin D, Baker A, Brousseau J, Coupland S, Liston P, Hauswirth WW, Komeluk RG, Tsilfidis C.
Adv Exp Med Biol. 533:385-93. 2003
70ALS2CR2, XIAP
ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis.
Sanna MG, da Silva Correia J, Luo Y, Chuang B, Paulson LM, Nguyen B, Deveraux QL, Ulevitch RJ.
J Biol Chem 277(34):30454-62. 2002
71HTRA2, XIAP
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.
Verhagen AM, Silke J, Ekert PG, Pakusch M, Kaufmann H, Connolly LM, Day CL, Tikoo A, Burke R, Wrobel C, Moritz RL, Simpson RJ, Vaux DL.
J Biol Chem 277(1):445-54. Epub 2001 Oct 16. 2002
72XIAP
Potential synergistic protection of retinal ganglion cells from axotomy-induced apoptosis by adenoviral administration of glial cell line-derived neurotrophic factor and X-chromosome-linked inhibitor of apoptosis.
Straten G, Schmeer C, Kretz A, Gerhardt E, Kügler S, Schulz JB, Gravel C, Bähr M, Isenmann S.
Neurobiol Dis. 11(1):123-33. 2002
73CASP7, XIAP
Structural basis of caspase-7 inhibition by XIAP.
Chai J, Shiozaki E, Srinivasula SM, Wu Q, Dataa P, Alnemri ES, Shi Y.
Cell 104(5):769-80. 2001
74CASP7, XIAP
Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain.
Huang Y, Park YC, Rich RL, Segal D, Myszka DG, Wu H.
Cell 104(5):781-90. 2001
75CASP3, XIAP
Structural basis for the inhibition of caspase-3 by XIAP.
Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS.
Cell 104(5):791-800. 2001
76DIABLO, XIAP
Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP.
Silke J, Ekert PG, Day CL, Hawkins CJ, Baca M, Chew J, Pakusch M, Verhagen AM, Vaux DL.
EMBO J 20(12):3114-23. 2001
77BIRC8, XIAP
Genomic organization of the x-linked inhibitor of apoptosis and identification of a novel testis-specific transcript.
Lagace M, Xuan JY, Young SS, McRoberts C, Maier J, Rajcan-Separovic E, Korneluk RG.
Genomics 77(3):181-8. 2001
78CASP9, DIABLO, XIAP
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis.
Srinivasula SM, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, Lee RA, Robbins PD, Fernandes-Alnemri T, Shi Y, Alnemri ES.
Nature 410(6824):112-6. 2001
79XIAP
Neurotrophin receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell death.
Jordan BW, Dinev D, LeMellay V, Troppmair J, Gotz R, Wixler L, Sendtner M, Ludwig S, Rapp UR.
J Biol Chem. 276(43):39985-9. 2001
80XIAP
X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling.
Birkey Reffey S, Wurthner JU, Parks WT, Roberts AB, Duckett CS.
J Biol Chem. 276(28):26542-9 2001
81XIAP
Characterization of XIAP-deficient mice.
Harlin H, Reffey SB, Duckett CS, Lindsten T, Thompson CB.
Mol Cell Biol. 21(10):3604-8. 2001
82MAP3K7, NFKB1, NFKB2, XIAP
Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1.
Hofer-Warbinek R, Schmid JA, Stehlik C, Binder BR, Lipp J, de Martin R.
J Biol Chem 275(29):22064-8. 2000
83DIABLO, XIAP
Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
Liu Z, Sun C, Olejniczak ET, Meadows RP, Betz SF, Oost T, Herrmann J, Wu JC, Fesik SW.
Nature 408(6815):1004-8. 2000
84DIABLO, XIAP
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.
Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL.
Cell 102(1):43-53. 2000
85XIAP
XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway.
Yamaguchi K, et al.
EMBO J 18 : 179-187. 1999
86XIAP
Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases.
Deveraux QL, et al.
EMBO J 18(19):5242-5251 1999
87DFFA, DFFB, XIAP
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD.
Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S.
Nature 391(6662):43-50. Erratum in: Nature 1998 May 28;393(6683):396. 1998
88XIAP
Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis.
Sakahira H, Enari M, Nagata S.
Nature 391(6662):96-9. 1998
89XIAP
Genomic organization and primary characterization of miap-3: the murine homologue of human X-linked IAP.
Farahani R, Fong WG, Korneluk RG, MacKenzie AE.
Genomics 42(3):514-8. 1997
90XIAP
X-linked IAP is a direct inhibitor of cell-death proteases.
Deveraux QL, Takahashi R, Salvesen GS, Reed JC.
Nature 388(6639):300-4. 1997
91BIRC2, BIRC3, CD47, NAIP, XIAP
Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.
Liston P, et al.
Nature 379 : 349-353. 1996
92BIRC2, BIRC3, XIAP
Assignment of human inhibitor of apoptosis protein (IAP) genes xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by fluorescence in situ hybridization.
Rajcan-Separovic E, et al.
Genomics 37 : 404-406. 1996
93BIRC2, BIRC3, XIAP
ITA, a vertebrate homologue of IAP that is expressed in T lymphocytes.
Digby MR, et al.
DNA Cell Biol 15 : 981-988. 1996