| 1 | ACTN2, ACTN3, ATF4, ATF6, XBP1
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| Differential regulation of Actn2 and Actn3 expression during unfolded protein response in C2C12 myotubes
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| Harada N, Gotoda Y, Hatakeyama A, Nakagawa T, Miyatake Y, Kuroda M, Masumoto S, Tsutsumi R, Nakaya Y, Sakaue H.
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| J Muscle Res Cell Motil. Sep;41(2-3):199-209. doi: 10.1007/s10974-020-09582-7. Epub 2020 May 25 2020
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| 2 | TLR7, XBP1, iFNA1
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| TLR7-mediated activation of XBP1 correlates with the IFNα production in humans.
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| Beisel C, Ziegler S, Martrus Zapater G, Chapel A, Griesbeck M, Hildebrandt H, Lohse AW, Altfeld M.
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| Cytokine 94:55-58. doi: 10.1016/j.cyto.2017.04.006. Epub 2017 Apr 10.
2017
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| 3 | ERN1, METTL14, XBP1
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| The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells.
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| Hassler JR, Scheuner DL, Wang S, Han J, Kodali VK, Li P, Nguyen J, George JS, Davis C, Wu SP, Bai Y, Sartor M, Cavalcoli J, Malhi H, Baudouin G, Zhang Y, Yates JR III, Itkin-Ansari P, Volkmann N, Kaufman RJ.
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| PLoS Biol 13(10):e1002277. doi: 10.1371/journal.pbio.1002277. eCollection 2015 Oct.
2015
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| 4 | ELL2, XBP1
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| Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response.
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| Park KS, Bayles I, Szlachta-McGinn A, Paul J, Boiko J, Santos P, Liu J, Wang Z, Borghesi L, Milcarek C.
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| J Immunol 193(9):4663-74. doi: 10.4049/jimmunol.1401608. Epub 2014 Sep 19.
2014
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| 5 | BRD7, XBP1
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| BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K
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| Park SW, Herrema H, Salazar M, Cakir I, Cabi S, Basibuyuk Sahin F, Chiu YH, Cantley LC, Ozcan U
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| Cell Metab. Jul 1;20(1):73-84. doi: 10.1016/j.cmet.2014.04.006. Epub 2014 May 15. Erratum in: Cell Metab. 2014 Dec 2;20(6):1088. 2014
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| 6 | BECN1, XBP1
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| XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation.
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| Margariti A, Li H, Chen T, Martin D, Vizcay-Barrena G, Alam S, Karamariti E, Xiao Q, Zampetaki A, Zhang Z, Wang W, Jiang Z, Gao C, Ma B, Chen YG, Cockerill G, Hu Y, Xu Q, Zeng L.
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| J Biol Chem 288(2):859-72. doi: 10.1074/jbc.M112.412783. Epub 2012 Nov 26.
2013
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| 7 | ATF6, RUNX2, XBP1
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| XBP1S associates with RUNX2 and regulates chondrocyte hypertrophy.
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| Liu Y, Zhou J, Zhao W, Li X, Jiang R, Liu C, Guo FJ.
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| J Biol Chem 287(41):34500-13. doi: 10.1074/jbc.M112.385922. Epub 2012 Aug 3. Retraction in: J Biol Chem. 2015 Apr 24;290(17):10643.
2012
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| 8 | ERN1, SLC33A1, XBP1
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| SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathway.
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| Pehar M, Jonas MC, Hare TM, Puglielli L.
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| J Biol Chem 287(35):29921-30. doi: 10.1074/jbc.M112.363911. Epub 2012 Jul 11.
2012
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| 9 | FOXO1, HTT, XBP1
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| Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy.
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| Vidal RL, Figueroa A, Court FA, Thielen P, Molina C, Wirth C, Caballero B, Kiffin R, Segura-Aguilar J, Cuervo AM, Glimcher LH, Hetz C.
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| Hum Mol Genet 21(10):2245-62. doi: 10.1093/hmg/dds040. Epub 2012 Feb 14.
2012
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| 10 | MYD88, TBC1D23, TICAM2, XBP1
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| Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP.
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| De Arras L, Yang IV, Lackford B, Riches DW, Prekeris R, Freedman JH, Schwartz DA, Alper S.
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| J Immunol 188(6):2905-13. doi: 10.4049/jimmunol.1102595. Epub 2012 Feb 6.
2012
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| 11 | ERN1, XBP1
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| The IRE1α-XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix.
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| Tohmonda T, Miyauchi Y, Ghosh R, Yoda M, Uchikawa S, Takito J, Morioka H, Nakamura M, Iwawaki T, Chiba K, Toyama Y, Urano F, Horiuchi K.
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| EMBO Rep 12(5):451-7. Epub 2011 Mar 18.
2011
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| 12 | XBP1
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| Reconstitution and characterization of the unconventional splicing of XBP1u mRNA in vitro.
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| Shinya S, Kadokura H, Imagawa Y, Inoue M, Yanagitani K, Kohno K.
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| Nucleic Acids Res 39(12):5245-54. Epub 2011 Mar 11.
2011
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| 13 | XBP1
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| ER stress and its regulator X-box-binding protein-1 enhance polyIC-induced innate immune response in dendritic cells.
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| Hu F, Yu X, Wang H, Zuo D, Guo C, Yi H, Tirosh B, Subjeck JR, Qiu X, Wang XY.
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| Eur J Immunol 41(4):1086-97. doi: 10.1002/eji.201040831. Epub 2011 Mar 14.
2011
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| 14 | XBP1
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| The ER stress factor XBP1s prevents amyloid-beta neurotoxicity.
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| Casas-Tinto S, Zhang Y, Sanchez-Garcia J, Gomez-Velazquez M, Rincon-Limas DE, Fernandez-Funez P.
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| Hum Mol Genet 20(11):2144-60. Epub 2011 Mar 9.
2011
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| 15 | XBP1
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| Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction.
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| Zhou Y, Lee J, Reno CM, Sun C, Park SW, Chung J, Lee J, Fisher SJ, White MF, Biddinger SB, Ozcan U.
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| Nat Med 17(3):356-65. Epub 2011 Feb 13.
2011
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| 16 | ERN1, XBP1
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| Translational pausing ensures membrane targeting and cytoplasmic splicing of XBP1u mRNA.
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| Yanagitani K, Kimata Y, Kadokura H, Kohno K.
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| Science 331(6017):586-9. Epub 2011 Jan 13. 2011
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| 17 | IL3, XBP1
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| Anti-apoptotic function of Xbp1 as an IL-3 signaling molecule in hematopoietic cells.
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| Kurata M, Yamazaki Y, Kanno Y, Ishibashi S, Takahara T, Kitagawa M, Nakamura T.
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| Cell Death Dis 2:e118.
2011
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| 18 | TMTC3, XBP1
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| The involvement of SMILE/TMTC3 in endoplasmic reticulum stress response.
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| Racapé M, Duong Van Huyen JP, Danger R, Giral M, Bleicher F, Foucher Y, Pallier A, Pilet P, Tafelmeyer P, Ashton-Chess J, Dugast E, Pettré S, Charreau B, Soulillou JP, Brouard S.
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| PLoS One 6(5):e19321. doi: 10.1371/journal.pone.0019321.
2011
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| 19 | NOS2, XBP1
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| XBP1U inhibits the XBP1S-mediated upregulation of the iNOS gene expression in mammalian ER stress response.
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| Guo F, Lin EA, Liu P, Lin J, Liu C.
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| Cell Signal 22(12):1818-28. Epub 2010 Jul 15.
2010
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| 20 | XBP1
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| Emerging roles for XBP1, a sUPeR transcription factor.
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| He Y, Sun S, Sha H, Liu Z, Yang L, Xue Z, Chen H, Qi L.
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| Gene Expr 15(1):13-25. Review.
2010
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| 21 | XBP1
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| Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation.
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| Wang FM, Chen YJ, Ouyang HJ.
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| Biochem J 433(1):245-52.
2010
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| 22 | XBP1
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| XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum.
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| Huh WJ, Esen E, Geahlen JH, Bredemeyer AJ, Lee AH, Shi G, Konieczny SF, Glimcher LH, Mills JC.
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| Gastroenterology 139(6):2038-49. Epub 2010 Oct 14.
2010
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| 23 | XBP1
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| SUMO modification regulates the transcriptional activity of XBP1.
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| Chen H, Qi L.
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| Biochem J 429(1):95-102.
2010
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| 24 | XBP1
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| XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells.
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| Hu CC, Dougan SK, McGehee AM, Love JC, Ploegh HL.
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| EMBO J 28(11):1624-36. Epub 2009 Apr 30.
2009
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| 25 | XBP1
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| Preventing oxidative stress: a new role for XBP1.
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| Liu Y, Adachi M, Zhao S, Hareyama M, Koong AC, Luo D, Rando TA, Imai K, Shinomura Y.
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| Cell Death Differ 16(6):847-57. Epub 2009 Feb 27.
2009
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| 26 | XBP1
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| XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy.
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| Hetz C, Thielen P, Matus S, Nassif M, Court F, Kiffin R, Martinez G, Cuervo AM, Brown RH, Glimcher LH.
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| Genes Dev 23(19):2294-306. Epub 2009 Sep 17.PMID: 19762508 2009
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| 27 | XBP1
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| Regulation of hepatic lipogenesis by the transcription factor XBP1.
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| Lee AH, Scapa EF, Cohen DE, Glimcher LH.
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| Science 320(5882):1492-6. 2008
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| 28 | XBP1
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| XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease.
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| Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EE, Higgins DE, Schreiber S, Glimcher LH, Blumberg RS.
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| Cell 134(5):743-56.
2008
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| 29 | XBP1
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| Overexpression of human X-box binding protein 1 (XBP-1) in colorectal adenomas and adenocarcinomas.
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| Fujimoto T, Yoshimatsu K, Watanabe K, Yokomizo H, Otani T, Matsumoto A, Osawa G, Onda M, Ogawa K.
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| Anticancer Res 27(1A):127-31.
2007
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| 30 | BHLHA15, XBP1
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| XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks.
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| Acosta-Alvear D, Zhou Y, Blais A, Tsikitis M, Lents NH, Arias C, Lennon CJ, Kluger Y, Dynlacht BD.
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| Mol Cell 27(1):53-66. 2007
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| 31 | XBP1, WFS1
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| XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells.
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| Kakiuchi C, Ishiwata M, Hayashi A, Kato T.
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| J Neurochem 97(2):545-55. Epub 2006 Mar 15. 2006
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| 32 | XBP1
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| Analysis of the XBP1 splicing mechanism using endoplasmic reticulum stress-indicators.
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| Iwawaki T, Akai R.
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| Biochem Biophys Res Commun 350(3):709-15. Epub 2006 Sep 28.
2006
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| 33 | DNAJB9, XBP1
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| XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress.
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| Kanemoto S, Kondo S, Ogata M, Murakami T, Urano F, Imaizumi K.
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| Biochem Biophys Res Commun 331(4):1146-53. 2005
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| 34 | MAPK8, XBP1, IRS1
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| Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.
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| Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS.
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| Science 306(5695):457-61. 2004
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| 35 | CEBPB, XBP1
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| Human CCAAT/enhancer-binding protein beta gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence.
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| Chen C, Dudenhausen EE, Pan YX, Zhong C, Kilberg MS.
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| J Biol Chem 279(27):27948-56. Epub 2004 Apr 20. 2004
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| 36 | XBP1
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| XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.
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| Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, Le QT, Koong AC.
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| Cancer Res 64(17):5943-7. 2004
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| 37 | XBP1
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| Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder.
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| Kakiuchi C, Iwamoto K, Ishiwata M, Bundo M, Kasahara T, Kusumi I, Tsujita T, Okazaki Y, Nanko S, Kunugi H, Sasaki T, Kato T.
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| Nat Genet 35(2):171-5. Epub 2003 Aug 31. 2003
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| 38 | ATF6, ERN1, MBTPS2, XBP1
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| IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response.
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| Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T, Yoshida H, Mori K, Kaufman RJ.
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| Genes Dev 16(4):452-66. 2002
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| 39 | XBP1
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| XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.
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| Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K.
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| Cell 107(7):881-91. 2001
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| 40 | XBP1
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| An essential role in liver development for transcription factor XBP-1.
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| Reimold AM, Etkin A, Clauss I, Perkins A, Friend DS, Zhang J, Horton HF, Scott A, Orkin SH, Byrne MC, Grusby MJ, Glimcher LH.
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| Genes Dev 14(2):152-7. 2000
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| 41 | XBP1, XBPP1
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| An HLA-DRalpha promoter DNA-binding protein is expressed ubiquitously and maps to human chromosomes 22 and 5.
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| Liou HC, et al.
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| Immunogenetics 34 : 286-292. 1991
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| 42 | XBP1
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| BanI polymorphism at the XBP1 locus.
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| Fontaine B, et al.
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| Nucleic Acids Res 18 : 5578. 1990
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| 43 | XBP1
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| A new member of the leucine zipper class of proteins that binds to the HLA DR-alpha promoter.
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| Liou HC, et al.
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| Science 247 : 1581-1584. 1990
|