Citations for
1ERN1, METTL14, XBP1
The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells.
Hassler JR, Scheuner DL, Wang S, Han J, Kodali VK, Li P, Nguyen J, George JS, Davis C, Wu SP, Bai Y, Sartor M, Cavalcoli J, Malhi H, Baudouin G, Zhang Y, Yates JR III, Itkin-Ansari P, Volkmann N, Kaufman RJ.
PLoS Biol 13(10):e1002277. doi: 10.1371/journal.pbio.1002277. eCollection 2015 Oct. 2015
2ELL2, XBP1
Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response.
Park KS, Bayles I, Szlachta-McGinn A, Paul J, Boiko J, Santos P, Liu J, Wang Z, Borghesi L, Milcarek C.
J Immunol 193(9):4663-74. doi: 10.4049/jimmunol.1401608. Epub 2014 Sep 19. 2014
3BECN1, XBP1
XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation.
Margariti A, Li H, Chen T, Martin D, Vizcay-Barrena G, Alam S, Karamariti E, Xiao Q, Zampetaki A, Zhang Z, Wang W, Jiang Z, Gao C, Ma B, Chen YG, Cockerill G, Hu Y, Xu Q, Zeng L.
J Biol Chem 288(2):859-72. doi: 10.1074/jbc.M112.412783. Epub 2012 Nov 26. 2013
4ATF6, RUNX2, XBP1
XBP1S associates with RUNX2 and regulates chondrocyte hypertrophy.
Liu Y, Zhou J, Zhao W, Li X, Jiang R, Liu C, Guo FJ.
J Biol Chem 287(41):34500-13. doi: 10.1074/jbc.M112.385922. Epub 2012 Aug 3. Retraction in: J Biol Chem. 2015 Apr 24;290(17):10643. 2012
5ERN1, SLC33A1, XBP1
SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathway.
Pehar M, Jonas MC, Hare TM, Puglielli L.
J Biol Chem 287(35):29921-30. doi: 10.1074/jbc.M112.363911. Epub 2012 Jul 11. 2012
6FOXO1, HTT, XBP1
Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy.
Vidal RL, Figueroa A, Court FA, Thielen P, Molina C, Wirth C, Caballero B, Kiffin R, Segura-Aguilar J, Cuervo AM, Glimcher LH, Hetz C.
Hum Mol Genet 21(10):2245-62. doi: 10.1093/hmg/dds040. Epub 2012 Feb 14. 2012
7MYD88, TBC1D23, TICAM2, XBP1
Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP.
De Arras L, Yang IV, Lackford B, Riches DW, Prekeris R, Freedman JH, Schwartz DA, Alper S.
J Immunol 188(6):2905-13. doi: 10.4049/jimmunol.1102595. Epub 2012 Feb 6. 2012
8ERN1, XBP1
The IRE1α-XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix.
Tohmonda T, Miyauchi Y, Ghosh R, Yoda M, Uchikawa S, Takito J, Morioka H, Nakamura M, Iwawaki T, Chiba K, Toyama Y, Urano F, Horiuchi K.
EMBO Rep 12(5):451-7. Epub 2011 Mar 18. 2011
9XBP1
Reconstitution and characterization of the unconventional splicing of XBP1u mRNA in vitro.
Shinya S, Kadokura H, Imagawa Y, Inoue M, Yanagitani K, Kohno K.
Nucleic Acids Res 39(12):5245-54. Epub 2011 Mar 11. 2011
10XBP1
ER stress and its regulator X-box-binding protein-1 enhance polyIC-induced innate immune response in dendritic cells.
Hu F, Yu X, Wang H, Zuo D, Guo C, Yi H, Tirosh B, Subjeck JR, Qiu X, Wang XY.
Eur J Immunol 41(4):1086-97. doi: 10.1002/eji.201040831. Epub 2011 Mar 14. 2011
11XBP1
The ER stress factor XBP1s prevents amyloid-beta neurotoxicity.
Casas-Tinto S, Zhang Y, Sanchez-Garcia J, Gomez-Velazquez M, Rincon-Limas DE, Fernandez-Funez P.
Hum Mol Genet 20(11):2144-60. Epub 2011 Mar 9. 2011
12XBP1
Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction.
Zhou Y, Lee J, Reno CM, Sun C, Park SW, Chung J, Lee J, Fisher SJ, White MF, Biddinger SB, Ozcan U.
Nat Med 17(3):356-65. Epub 2011 Feb 13. 2011
13ERN1, XBP1
Translational pausing ensures membrane targeting and cytoplasmic splicing of XBP1u mRNA.
Yanagitani K, Kimata Y, Kadokura H, Kohno K.
Science 331(6017):586-9. Epub 2011 Jan 13. 2011
14IL3, XBP1
Anti-apoptotic function of Xbp1 as an IL-3 signaling molecule in hematopoietic cells.
Kurata M, Yamazaki Y, Kanno Y, Ishibashi S, Takahara T, Kitagawa M, Nakamura T.
Cell Death Dis 2:e118. 2011
15TMTC3, XBP1
The involvement of SMILE/TMTC3 in endoplasmic reticulum stress response.
Racapé M, Duong Van Huyen JP, Danger R, Giral M, Bleicher F, Foucher Y, Pallier A, Pilet P, Tafelmeyer P, Ashton-Chess J, Dugast E, Pettré S, Charreau B, Soulillou JP, Brouard S.
PLoS One 6(5):e19321. doi: 10.1371/journal.pone.0019321. 2011
16NOS2, XBP1
XBP1U inhibits the XBP1S-mediated upregulation of the iNOS gene expression in mammalian ER stress response.
Guo F, Lin EA, Liu P, Lin J, Liu C.
Cell Signal 22(12):1818-28. Epub 2010 Jul 15. 2010
17XBP1
Emerging roles for XBP1, a sUPeR transcription factor.
He Y, Sun S, Sha H, Liu Z, Yang L, Xue Z, Chen H, Qi L.
Gene Expr 15(1):13-25. Review. 2010
18XBP1
Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation.
Wang FM, Chen YJ, Ouyang HJ.
Biochem J 433(1):245-52. 2010
19XBP1
XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum.
Huh WJ, Esen E, Geahlen JH, Bredemeyer AJ, Lee AH, Shi G, Konieczny SF, Glimcher LH, Mills JC.
Gastroenterology 139(6):2038-49. Epub 2010 Oct 14. 2010
20XBP1
SUMO modification regulates the transcriptional activity of XBP1.
Chen H, Qi L.
Biochem J 429(1):95-102. 2010
21XBP1
XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells.
Hu CC, Dougan SK, McGehee AM, Love JC, Ploegh HL.
EMBO J 28(11):1624-36. Epub 2009 Apr 30. 2009
22XBP1
Preventing oxidative stress: a new role for XBP1.
Liu Y, Adachi M, Zhao S, Hareyama M, Koong AC, Luo D, Rando TA, Imai K, Shinomura Y.
Cell Death Differ 16(6):847-57. Epub 2009 Feb 27. 2009
23XBP1
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy.
Hetz C, Thielen P, Matus S, Nassif M, Court F, Kiffin R, Martinez G, Cuervo AM, Brown RH, Glimcher LH.
Genes Dev 23(19):2294-306. Epub 2009 Sep 17.PMID: 19762508 2009
24XBP1
Regulation of hepatic lipogenesis by the transcription factor XBP1.
Lee AH, Scapa EF, Cohen DE, Glimcher LH.
Science 320(5882):1492-6. 2008
25XBP1
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease.
Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EE, Higgins DE, Schreiber S, Glimcher LH, Blumberg RS.
Cell 134(5):743-56. 2008
26XBP1
Overexpression of human X-box binding protein 1 (XBP-1) in colorectal adenomas and adenocarcinomas.
Fujimoto T, Yoshimatsu K, Watanabe K, Yokomizo H, Otani T, Matsumoto A, Osawa G, Onda M, Ogawa K.
Anticancer Res 27(1A):127-31. 2007
27BHLHA15, XBP1
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks.
Acosta-Alvear D, Zhou Y, Blais A, Tsikitis M, Lents NH, Arias C, Lennon CJ, Kluger Y, Dynlacht BD.
Mol Cell 27(1):53-66. 2007
28XBP1, WFS1
XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells.
Kakiuchi C, Ishiwata M, Hayashi A, Kato T.
J Neurochem 97(2):545-55. Epub 2006 Mar 15. 2006
29XBP1
Analysis of the XBP1 splicing mechanism using endoplasmic reticulum stress-indicators.
Iwawaki T, Akai R.
Biochem Biophys Res Commun 350(3):709-15. Epub 2006 Sep 28. 2006
30DNAJB9, XBP1
XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress.
Kanemoto S, Kondo S, Ogata M, Murakami T, Urano F, Imaizumi K.
Biochem Biophys Res Commun 331(4):1146-53. 2005
31MAPK8, XBP1, IRS1
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS.
Science 306(5695):457-61. 2004
32CEBPB, XBP1
Human CCAAT/enhancer-binding protein beta gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence.
Chen C, Dudenhausen EE, Pan YX, Zhong C, Kilberg MS.
J Biol Chem 279(27):27948-56. Epub 2004 Apr 20. 2004
33XBP1
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.
Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, Le QT, Koong AC.
Cancer Res 64(17):5943-7. 2004
34XBP1
Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder.
Kakiuchi C, Iwamoto K, Ishiwata M, Bundo M, Kasahara T, Kusumi I, Tsujita T, Okazaki Y, Nanko S, Kunugi H, Sasaki T, Kato T.
Nat Genet 35(2):171-5. Epub 2003 Aug 31. 2003
35ATF6, ERN1, MBTPS2, XBP1
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response.
Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T, Yoshida H, Mori K, Kaufman RJ.
Genes Dev 16(4):452-66. 2002
36XBP1
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.
Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K.
Cell 107(7):881-91. 2001
37XBP1
An essential role in liver development for transcription factor XBP-1.
Reimold AM, Etkin A, Clauss I, Perkins A, Friend DS, Zhang J, Horton HF, Scott A, Orkin SH, Byrne MC, Grusby MJ, Glimcher LH.
Genes Dev 14(2):152-7. 2000
38XBP1, XBPP1
An HLA-DRalpha promoter DNA-binding protein is expressed ubiquitously and maps to human chromosomes 22 and 5.
Liou HC, et al.
Immunogenetics 34 : 286-292. 1991
39XBP1
BanI polymorphism at the XBP1 locus.
Fontaine B, et al.
Nucleic Acids Res 18 : 5578. 1990
40XBP1
A new member of the leucine zipper class of proteins that binds to the HLA DR-alpha promoter.
Liou HC, et al.
Science 247 : 1581-1584. 1990