Citations for
1PPM1G, TP73, WWP1, WWP2
WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ΔNp73 levels.
Chaudhary N, Maddika S.
Mol Cell Biol 34(19):3754-64. doi: 10.1128/MCB.00101-14. Epub 2014 Jul 28. 2014
Paip1, an effective stimulator of translation initiation, is targeted by WWP2 for ubiquitination and degradation.
Lv Y, Zhang K, Gao H.
Mol Cell Biol 34(24):4513-22. doi: 10.1128/MCB.00524-14. Epub 2014 Sep 29. Erratum in: Mol Cell Biol. 2015 Feb;35(3):631. 2014
E3 ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation.
Yang Y, Liao B, Wang S, Yan B, Jin Y, Shu HB, Wang YY.
Proc Natl Acad Sci U S A 110(13):5115-20. doi: 10.1073/pnas.1220271110. Epub 2013 Mar 11. 2013
WWP2 is an E3 ubiquitin ligase for PTEN.
Maddika S, Kavela S, Rani N, Palicharla VR, Pokorny JL, Sarkaria JN, Chen J.
Nat Cell Biol 13(6):728-33. Epub 2011 May 1. 2011
5MED25, SOX9, WWP2
Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25.
Nakamura Y, Yamamoto K, He X, Otsuki B, Kim Y, Murao H, Soeda T, Tsumaki N, Deng JM, Zhang Z, Behringer RR, Crombrugghe B, Postlethwait JH, Warman ML, Nakamura T, Akiyama H.
Nat Commun 2:251. 2011
Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT.
Soond SM, Chantry A.
Oncogene 30(21):2451-62. Epub 2011 Jan 24. 2011
The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid.
Zou W, Chen X, Shim JH, Huang Z, Brady N, Hu D, Drapp R, Sigrist K, Glimcher LH, Jones D.
Nat Cell Biol 13(1):59-65. Epub 2010 Dec 19. 2011
WWP2 ubiquitin ligase and its isoforms: new biological insight and promising disease targets.
Chantry A.
Cell Cycle 10(15):2437-9. Epub 2011 Aug 1. 2011
Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects.
Marcucci R, Brindle J, Paro S, Casadio A, Hempel S, Morrice N, Bisso A, Keegan LP, Del Sal G, O'Connell MA.
EMBO J 30(20):4211-22. doi: 10.1038/emboj.2011.303. 2011
Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner.
Liao B, Jin Y.
Cell Res 20(3):332-44. Epub 2009 Dec 8. 2010
WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells.
Xu H, Wang W, Li C, Yu H, Yang A, Wang B, Jin Y.
Cell Res 19(5):561-73. Erratum in: Cell Res. 2009 Jun;19(6):796. 2009
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2.
Foot NJ, Dalton HE, Shearwin-Whyatt LM, Dorstyn L, Tan SS, Yang B, Kumar S.
Blood 112(10):4268-75. Epub 2008 Sep 5.PMID: 18776082 2008
Wwp2-mediated ubiquitination of the RNA polymerase II large subunit in mouse embryonic pluripotent stem cells.
Li H, Zhang Z, Wang B, Zhang J, Zhao Y, Jin Y.
Mol Cell Biol 27(15):5296-305. Epub 2007 May 25. 2007
Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.
Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA.
Mol Cell Neurosci 11(3):149-60. 1998