| 1 | BAP1, KLF5, WWP1
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| BAP1 antagonizes WWP1-mediated transcription factor KLF5 ubiquitination and inhibits autophagy to promote melanoma progression
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| Jia X, Chen H, Ren Y, Dejizhuoga, Gesangyuzhen, Gao N, Feng H, Huang W, Liao Y, Yu H.
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| Exp Cell Res. May 1;402(1):112506. doi: 10.1016/j.yexcr.2021.112506. Epub 2021 Jan 29. 2021
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| 2 | WWP1
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| WWP1 as a potential tumor oncogene regulates PTEN-Akt signaling pathway in human gastric carcinoma.
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| Zhang L, Wu Z, Ma Z, Liu H, Wu Y, Zhang Q.
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| Tumour Biol 36(2):787-98. doi: 10.1007/s13277-014-2696-0. Epub 2014 Oct 9.
2015
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| 3 | PPM1G, TP73, WWP1, WWP2
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| WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ΔNp73 levels.
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| Chaudhary N, Maddika S.
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| Mol Cell Biol 34(19):3754-64. doi: 10.1128/MCB.00101-14. Epub 2014 Jul 28.
2014
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| 4 | TRAF6, WWP1
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| WW domain containing E3 ubiquitin protein ligase 1 (WWP1) negatively regulates TLR4-mediated TNF-α and IL-6 production by proteasomal degradation of TNF receptor associated factor 6 (TRAF6).
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| Lin XW, Xu WC, Luo JG, Guo XJ, Sun T, Zhao XL, Fu ZJ.
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| PLoS One 8(6):e67633. doi: 10.1371/journal.pone.0067633. Print 2013.
2013
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| 5 | LATS1, WWP1
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| WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.
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| Yeung B, Ho KC, Yang X.
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| PLoS One 8(4):e61027. doi: 10.1371/journal.pone.0061027. Epub 2013 Apr 3.
2013
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| 6 | WWP1
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| WWP1 gene is a potential molecular target of human oral cancer.
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| Lin JH, Hsieh SC, Chen JN, Tsai MH, Chang CC.
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| Oral Surg Oral Med Oral Pathol Oral Radiol 116(2):221-31. doi: 10.1016/j.oooo.2013.05.006.
2013
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| 7 | PRKAA2, WWP1
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| E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal muscle C2C12 cells.
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| Lee JO, Lee SK, Kim N, Kim JH, You GY, Moon JW, Jie S, Kim SJ, Lee YW, Kang HJ, Lim Y, Park SH, Kim HS.
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| J Biol Chem 288(7):4673-80. doi: 10.1074/jbc.M112.406009. Epub 2013 Jan 4.
2013
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| 8 | EZR, WWP1
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| Ezrin ubiquitylation by the E3 ubiquitin ligase, WWP1, and consequent regulation of hepatocyte growth factor receptor activity.
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| Zaarour RF, Chirivino D, Del Maestro L, Daviet L, Atfi A, Louvard D, Arpin M.
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| PLoS One 7(5):e37490. doi: 10.1371/journal.pone.0037490. Epub 2012 May 22.
2012
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| 9 | WWP1
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| WWP1: a versatile ubiquitin E3 ligase in signaling and diseases.
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| Zhi X, Chen C.
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| Cell Mol Life Sci 69(9):1425-34. doi: 10.1007/s00018-011-0871-7. Epub 2011 Nov 4. Review.
2012
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| 10 | CDKN1B, WWP1
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| WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) delays cellular senescence by promoting p27(Kip1) degradation in human diploid fibroblasts.
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| Cao X, Xue L, Han L, Ma L, Chen T, Tong T.
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| J Biol Chem 286(38):33447-56. Epub 2011 Jul 27.
2011
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| 11 | WWP1
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| The E3 ubiquitin ligase WWP1 regulates ΔNp63-dependent transcription through Lys63 linkages.
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| Peschiaroli A, Scialpi F, Bernassola F, El Sherbini el S, Melino G.
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| Biochem Biophys Res Commun 402(2):425-30. doi: 10.1016/j.bbrc.2010.10.050. Epub 2010 Oct 15.
2010
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| 12 | ERBB4, WWP1
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| WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer.
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| Li Y, Zhou Z, Alimandi M, Chen C.
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| Oncogene 28(33):2948-58. Epub 2009 Jun 29.
2009
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| 13 | ITCH, SPART, WWP1
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| Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5.
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| Edwards TL, Clowes VE, Tsang HT, Connell JW, Sanderson CM, Luzio JP, Reid E.
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| Biochem J 423(1):31-9. Erratum in: Biochem J. 2009 Nov 1;423(3):442. PMID: 19580544 2009
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| 14 | ITCH, SPART, WWP1
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| Identification of novel spartin-interactors shows spartin is a multifunctional protein.
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| Milewska M, McRedmond J, Byrne PC.
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| J Neurochem 111(4):1022-30. Epub 2009 Sep 16.PMID: 19765186 2009
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| 15 | SPART, WWP1
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| A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.
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| Eastman SW, Yassaee M, Bieniasz PD.
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| J Cell Biol 184(6):881-94.PMID: 19307600 2009
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| 16 | ERBB2, RNF11, WWP1
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| The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11.
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| Chen C, Zhou Z, Liu R, Li Y, Azmi PB, Seth AK.
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| Oncogene 27(54):6845-55. Epub 2008 Aug 25. 2008
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| 17 | RTN4, WWP1
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| Identification and structural mechanism for a novel interaction between a ubiquitin ligase WWP1 and Nogo-A, a key inhibitor for central nervous system regeneration.
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| Qin H, Pu HX, Li M, Ahmed S, Song J.
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| Biochemistry 47(51):13647-58.PMID: 19035836 2008
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| 18 | WWP1
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| WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis.
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| Li Y, Zhou Z, Chen C.
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| Cell Death Differ 15(12):1941-51. Epub 2008 Sep 19.PMID: 18806757 2008
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| 19 | WWP1, KLF5
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| Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells.
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| Chen C, Sun X, Guo P, Dong XY, Sethi P, Cheng X, Zhou J, Ling J, Simons JW, Lingrel JB, Dong JT.
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| J Biol Chem 280(50):41553-61. Epub 2005 Oct 13. 2005
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| 20 | WWP1
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| Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase.
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| Verdecia MA, Joazeiro CA, Wells NJ, Ferrer JL, Bowman ME, Hunter T, Noel JP.
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| Mol Cell 11(1):249-59. 2003
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| 21 | WWP1
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| Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein.
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| Flasza M, Gorman P, Roylance R, Canfield AE, Baron M.
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| Biochem Biophys Res Commun 290(1):431-7. 2002
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| 22 | ATN1, AUTS2, WWP2, MAGI1, WWP1
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| Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.
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| Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA.
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| Mol Cell Neurosci 11(3):149-60. 1998
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| 23 | MAGI1, WWP1
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| Identification of novel human WW domain-containing proteins by cloning of ligand targets.
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| Pirozzi G, McConnell SJ, Uveges AJ, Carter JM, Sparks AB, Kay BK, Fowlkes DM.
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| J Biol Chem 272(23):14611-6. 1997
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