Citations for
1NR4A2, WWOX
Rare Inherited and De Novo CNVs Reveal Complex Contributions to ASD Risk in Multiplex Families.
Leppa VM, Kravitz SN, Martin CL, Andrieux J, Le Caignec C, Martin-Coignard D, DyBuncio C, Sanders SJ, Lowe JK, Cantor RM, Geschwind DH.
Am J Hum Genet 99(3):540-54. doi: 10.1016/j.ajhg.2016.06.036. Epub 2016 Aug 25. 2016
2EIEE28, WWOX
WWOX-related encephalopathies: delineation of the phenotypical spectrum and emerging genotype-phenotype correlation.
Mignot C, Lambert L, Pasquier L, Bienvenu T, Delahaye-Duriez A, Keren B, Lefranc J, Saunier A, Allou L, Roth V, Valduga M, Moustaïne A, Auvin S, Barrey C, Chantot-Bastaraud S, Lebrun N, Moutard ML, Nougues MC, Vermersch AI, Héron B, Pipiras E, Héron D, Olivier-Faivre L, Guéant JL, Jonveaux P, Philippe C.
J Med Genet 52(1):61-70. doi: 10.1136/jmedgenet-2014-102748. Epub 2014 Nov 19. 2015
3EIEE28, WWOX
WWOX and severe autosomal recessive epileptic encephalopathy: first case in the prenatal period.
Valduga M, Philippe C, Lambert L, Bach-Segura P, Schmitt E, Masutti JP, François B, Pinaud P, Vibert M, Jonveaux P.
J Hum Genet Hum Genet. 2015 M 2015
4WWOX, XYDSD
A multi-exon deletion within WWOX is associated with a 46,XY disorder of sex development.
White S, Hewitt J, Turbitt E, van der Zwan Y, Hersmus R, Drop S, Koopman P, Harley V, Cools M, Looijenga L, Sinclair A.
Eur J Hum Genet 20(3):348-51. doi: 10.1038/ejhg.2011.204. Epub 2011 Nov 9. 2012
5WWOX
Wwox inactivation enhances mammary tumorigenesis.
Abdeen SK, Salah Z, Maly B, Smith Y, Tufail R, Abu-Odeh M, Zanesi N, Croce CM, Nawaz Z, Aqeilan RI.
Oncogene 30(36):3900-6. doi: 10.1038/onc.2011.115. Epub 2011 Apr 18. 2011
6WWOX
WWOX gene and gene product: tumor suppression through specific protein interactions.
Salah Z, Aqeilan R, Huebner K.
Future Oncol 6(2):249-59.PMID: 20146584 2010
7WWOX
WWOX gene may contribute to progression of non-small-cell lung cancer (NSCLC).
Baykara O, Demirkaya A, Kaynak K, Tanju S, Toker A, Buyru N.
Tumour Biol umour Biol. 2010 May 18. [Epub ahead of print]PMID: 20480411 2010
8WWOX
Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein.
Bouteille N, Driouch K, Hage PE, Sin S, Formstecher E, Camonis J, Lidereau R, Lallemand F.
Oncogene 28(28):2569-80. Epub 2009 May 25.PMID: 19465938 2009
9WWOX
WWOX: its genomics, partners, and functions.
Del Mare S, Salah Z, Aqeilan RI.
J Cell Biochem 108(4):737-45. Review.PMID: 19708029 2009
10EIEE28, WWOX
A spontaneous mutation of the Wwox gene and audiogenic seizures in rats with lethal dwarfism and epilepsy.
Suzuki H, Katayama K, Takenaka M, Amakasu K, Saito K, Suzuki K.
Genes Brain Behav 8(7):650-60. doi: 10.1111/j.1601-183X.2009.00502.x. Epub 2009 May 20. 2009
11WWOX
WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels.
Lee JC, Weissglas-Volkov D, Kyttälä M, Dastani Z, Cantor RM, Sobel EM, Plaisier CL, Engert JC, van Greevenbroek MM, Kane JP, Malloy MJ, Pullinger CR, Huertas-Vazquez A, Aguilar-Salinas CA, Tusie-Luna T, de Bruin TW, Aouizerat BE, van der Kallen CC, Croce CM, Aqeilan RI, Marcil M, Viikari JS, Lehtimäki T, Raitakari OT, Kuusisto J, Laakso M, Taskinen MR, Genest J, Pajukanta P.
Am J Hum Genet 83(2):180-92. 2008
12WWOX
The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism.
Aqeilan RI, Hassan MQ, de Bruin A, Hagan JP, Volinia S, Palumbo T, Hussain S, Lee SH, Gaur T, Stein GS, Lian JB, Croce CM.
J Biol Chem 283(31):21629-39. Epub 2008 May 16. 2008
13WWOX
Homozygous deletions may be markers of nearby heterozygous mutations: The complex deletion at FRA16D in the HCT116 colon cancer cell line removes exons of WWOX.
Alsop AE, Taylor K, Zhang J, Gabra H, Paige AJ, Edwards PA.
Genes Chromosomes Cancer 47(5):437-47.PMID: 18273838 2008
14WWOX
Targeted deletion of Wwox reveals a tumor suppressor function.
Aqeilan RI, Trapasso F, Hussain S, Costinean S, Marshall D, Pekarsky Y, Hagan JP, Zanesi N, Kaou M, Stein GS, Lian JB, Croce CM.
Proc Natl Acad Sci U S A 104(10):3949-54. Epub 2007 Feb 27. 2007
15WWOX
WW domain-containing oxidoreductase: a candidate tumor suppressor.
Chang NS, Hsu LJ, Lin YS, Lai FJ, Sheu HM.
Trends Mol Med 13(1):12-22. Epub 2006 Dec 4. 2007
16WWOX
WWOX expression in different histologic types and subtypes of non-small cell lung cancer.
Donati V, Fontanini G, Dell'Omodarme M, Prati MC, Nuti S, Lucchi M, Mussi A, Fabbri M, Basolo F, Croce CM, Aqeilan RI.
Clin Cancer Res 13(3):884-91. 2007
17ERBB2, WWOX
Wwox suppresses prostate cancer cell growth through modulation of ErbB2-mediated androgen receptor signaling.
Qin HR, Iliopoulos D, Nakamura T, Costinean S, Volinia S, Druck T, Sun J, Okumura H, Huebner K.
Mol Cancer Res 5(9):957-65. Epub 2007 Aug 17.PMID: 17704139 2007
18CYLD, WWOX
Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma.
Jenner MW, Leone PE, Walker BA, Ross FM, Johnson DC, Gonzalez D, Chiecchio L, Dachs Cabanas E, Dagrada GP, Nightingale M, Protheroe RK, Stockley D, Else M, Dickens NJ, Cross NC, Davies FE, Morgan GJ.
Blood 110(9):3291-300. Epub 2007 Jul 3.PMID: 17609426 2007
19WWOX
Association between decreased WWOX protein expression and thyroid cancer development.
Dias EP, Pimenta FJ, Sarquis MS, Dias Filho MA, Aldaz CM, Fujii JB, Gomez RS, De Marco L.
Thyroid 17(11):1055-9.PMID: 18047428 2007
20WWOX
Characterization of the tumor suppressor gene WWOX in primary human oral squamous cell carcinomas.
Pimenta FJ, Gomes DA, Perdig‹o PF, Barbosa AA, Romano-Silva MA, Gomez MV, Aldaz CM, De Marco L, Gomez RS.
Int J Cancer 118(5):1154-8. 2006
21WWOX
Common chromosomal fragile site FRA16D mutation in cancer cells.
Finnis M, Dayan S, Hobson L, Chenevix-Trench G, Friend K, Ried K, Venter D, Woollatt E, Baker E, Richards RI.
Hum Mol Genet 14(10):1341-9. Epub 2005 Apr 6. 2005
22WWOX
WWOX gene restoration prevents lung cancer growth in vitro and in vivo.
Fabbri M, Iliopoulos D, Trapasso F, Aqeilan RI, Cimmino A, Zanesi N, Yendamuri S, Han SY, Amadori D, Huebner K, Croce CM.
Proc Natl Acad Sci U S A 102(43):15611-6. Epub 2005 Oct 13. 2005
23WWOX
FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila.
O'Keefe LV, Liu Y, Perkins A, Dayan S, Saint R, Richards RI.
Oncogene 24(43):6590-6. Erratum in: Oncogene. 2006 Dec 7;25(58):7662. 2005
24WWOX
Functional association between Wwox tumor suppressor protein and p73, a p53 homolog.
Aqeilan RI, Pekarsky Y, Herrero JJ, Palamarchuk A, Letofsky J, Druck T, Trapasso F, Han SY, Melino G, Huebner K, Croce CM.
Proc Natl Acad Sci U S A 101(13):4401-6. 2004
25WWOX
WWOX, the common chromosomal fragile site, FRA16D, cancer gene.
Ludes-Meyers JH, Bednarek AK, Popescu NC, Bedford M, Aldaz CM.
Cytogenet Genome Res 100(1-4):101-10. 2003
26WWOX, FHIT
Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies.
Ishii H, Vecchione A, Furukawa Y, Sutheesophon K, Han SY, Druck T, Kuroki T, Trapasso F, Nishimura M, Saito Y, Ozawa K, Croce CM, Huebner K, Furukawa Y.
Mol Cancer Res 1(13):940-7. 2003
27WWOX
The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1.
Krummel KA, Denison SR, Calhoun E, Phillips LA, Smith DI.
Genes Chromosomes Cancer 34(2):154-67. 2002
28WWOX
Alternative transcripts of the candidate tumor suppressor gene, WWOX, are expressed at high levels in human breast tumors.
Driouch K, Prydz H, Monese R, Johansen H, Lidereau R, Frengen E.
Oncogene 21(12):1832-40. 2002
29WWOX
WWOX: a candidate tumor suppressor gene involved in multiple tumor types.
Paige AJ, Taylor KJ, Taylor C, Hillier SG, Farrington S, Scott D, Porteous DJ, Smyth JF, Gabra H, Watson JE.
Proc Natl Acad Sci U S A 98(20):11417-22. 2001
30WWOX
WWOX, the FRA16D gene, behaves as a suppressor of tumor growth
Bednarek AK, Keck-Waggoner CL, Daniel RL, Laflin KJ, Bergsagel PL, Kiguchi K, Brenner AJ, Aldaz CM.
Cancer Res 61(22):8068-73. 2001
31WWOX
Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells.
Ried K, Finnis M, Hobson L, Mangelsdorf M, Dayan S, Nancarrow JK, Woollatt E, Kremmidiotis G, Gardner A, Venter D, Baker E, Richards RI.
Hum Mol Genet 9(11):1651-63. 2000
32WWOX
WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer.
Bednarek AK, Laflin KJ, Daniel RL, Liao Q, Hawkins KA, Aldaz CM.
Cancer Res 60(8):2140-5. 2000
33MGUS,WWOX
The characterization of the common fragile site FRA16D and its involvement in multiple myeloma translocations.
Krummel KA, Roberts LR, Kawakami M, Glover TW, Smith DI.
Genomics 69(1):37-46. 2000
34FHIT, FRA14C, FRA1C, FRA1E, FRA1F, FRA1G, FRA1I, FRA1K, FRA20B, FRA2C, FRA2F, FRA2H, FRA4A, FRA4C, FRA6B, FRA7C, FRA7F, WWOX
Common fragile sites : their prevalence in subjects with constitutional and acquired chromosomal instability.
Tedeschi B, et al.
Am J Med Genet 27 : 471-482. 1987
35FHIT, FRA10D, FRA10E, FRA10F, FRA11C, FRA11D, FRA11F, FRA11G, FRA12B, FRA13A, FRA13C, FRA14B, FRA14C, FRA16C, FRA17B, FRA18A, FRA18B, FRA18C, FRA1C, FRA1E, FRA1F, FRA1G, FRA1I, FRA20B, FRA22B, FRA2C, FRA2D, FRA2E, FRA2F, FRA2H, FRA2J, FRA3A, FRA3C, FRA4A, FRA4C, FRA5C, FRA6B, FRA6C, FRA7B, FRA7C, FRA7E, FRA7G, FRA7H, FRA8B, FRA8C, FRA8D, FRA9D, FRAXB, FRAXC, WWOX
Constitutive fragile sites and cancer.
Yunis JJ, et al.
Science 226 : 1199-1204. 1984
36WWOX
The fragile X chromosome.
Sutherland GR.
Int Rev Cytol 81 : 107-143. 1983