| 1 | NR4A2, WWOX
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| Rare Inherited and De Novo CNVs Reveal Complex Contributions to ASD Risk in Multiplex Families.
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| Leppa VM, Kravitz SN, Martin CL, Andrieux J, Le Caignec C, Martin-Coignard D, DyBuncio C, Sanders SJ, Lowe JK, Cantor RM, Geschwind DH.
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| Am J Hum Genet 99(3):540-54. doi: 10.1016/j.ajhg.2016.06.036. Epub 2016 Aug 25.
2016
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| 2 | EIEE28, WWOX
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| WWOX-related encephalopathies: delineation of the phenotypical spectrum and emerging genotype-phenotype correlation.
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| Mignot C, Lambert L, Pasquier L, Bienvenu T, Delahaye-Duriez A, Keren B, Lefranc J, Saunier A, Allou L, Roth V, Valduga M, Moustaïne A, Auvin S, Barrey C, Chantot-Bastaraud S, Lebrun N, Moutard ML, Nougues MC, Vermersch AI, Héron B, Pipiras E, Héron D, Olivier-Faivre L, Guéant JL, Jonveaux P, Philippe C.
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| J Med Genet 52(1):61-70. doi: 10.1136/jmedgenet-2014-102748. Epub 2014 Nov 19.
2015
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| 3 | EIEE28, WWOX
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| WWOX and severe autosomal recessive epileptic encephalopathy: first case in the prenatal period.
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| Valduga M, Philippe C, Lambert L, Bach-Segura P, Schmitt E, Masutti JP, François B, Pinaud P, Vibert M, Jonveaux P.
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| J Hum Genet Hum Genet. 2015 M 2015
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| 4 | WWOX, XYDSD
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| A multi-exon deletion within WWOX is associated with a 46,XY disorder of sex development.
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| White S, Hewitt J, Turbitt E, van der Zwan Y, Hersmus R, Drop S, Koopman P, Harley V, Cools M, Looijenga L, Sinclair A.
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| Eur J Hum Genet 20(3):348-51. doi: 10.1038/ejhg.2011.204. Epub 2011 Nov 9. 2012
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| 5 | WWOX
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| Wwox inactivation enhances mammary tumorigenesis.
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| Abdeen SK, Salah Z, Maly B, Smith Y, Tufail R, Abu-Odeh M, Zanesi N, Croce CM, Nawaz Z, Aqeilan RI.
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| Oncogene 30(36):3900-6. doi: 10.1038/onc.2011.115. Epub 2011 Apr 18.
2011
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| 6 | WWOX
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| WWOX gene and gene product: tumor suppression through specific protein interactions.
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| Salah Z, Aqeilan R, Huebner K.
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| Future Oncol 6(2):249-59.PMID: 20146584 2010
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| 7 | WWOX
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| WWOX gene may contribute to progression of non-small-cell lung cancer (NSCLC).
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| Baykara O, Demirkaya A, Kaynak K, Tanju S, Toker A, Buyru N.
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| Tumour Biol umour Biol. 2010 May 18. [Epub ahead of print]PMID: 20480411 2010
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| 8 | WWOX
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| Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein.
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| Bouteille N, Driouch K, Hage PE, Sin S, Formstecher E, Camonis J, Lidereau R, Lallemand F.
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| Oncogene 28(28):2569-80. Epub 2009 May 25.PMID: 19465938 2009
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| 9 | WWOX
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| WWOX: its genomics, partners, and functions.
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| Del Mare S, Salah Z, Aqeilan RI.
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| J Cell Biochem 108(4):737-45. Review.PMID: 19708029 2009
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| 10 | EIEE28, WWOX
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| A spontaneous mutation of the Wwox gene and audiogenic seizures in rats with lethal dwarfism and epilepsy.
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| Suzuki H, Katayama K, Takenaka M, Amakasu K, Saito K, Suzuki K.
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| Genes Brain Behav 8(7):650-60. doi: 10.1111/j.1601-183X.2009.00502.x. Epub 2009 May 20.
2009
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| 11 | WWOX
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| WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels.
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| Lee JC, Weissglas-Volkov D, Kyttälä M, Dastani Z, Cantor RM, Sobel EM, Plaisier CL, Engert JC, van Greevenbroek MM, Kane JP, Malloy MJ, Pullinger CR, Huertas-Vazquez A, Aguilar-Salinas CA, Tusie-Luna T, de Bruin TW, Aouizerat BE, van der Kallen CC, Croce CM, Aqeilan RI, Marcil M, Viikari JS, Lehtimäki T, Raitakari OT, Kuusisto J, Laakso M, Taskinen MR, Genest J, Pajukanta P.
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| Am J Hum Genet 83(2):180-92.
2008
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| 12 | WWOX
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| The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism.
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| Aqeilan RI, Hassan MQ, de Bruin A, Hagan JP, Volinia S, Palumbo T, Hussain S, Lee SH, Gaur T, Stein GS, Lian JB, Croce CM.
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| J Biol Chem 283(31):21629-39. Epub 2008 May 16.
2008
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| 13 | WWOX
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| Homozygous deletions may be markers of nearby heterozygous mutations: The complex deletion at FRA16D in the HCT116 colon cancer cell line removes exons of WWOX.
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| Alsop AE, Taylor K, Zhang J, Gabra H, Paige AJ, Edwards PA.
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| Genes Chromosomes Cancer 47(5):437-47.PMID: 18273838 2008
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| 14 | WWOX
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| Targeted deletion of Wwox reveals a tumor suppressor function.
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| Aqeilan RI, Trapasso F, Hussain S, Costinean S, Marshall D, Pekarsky Y, Hagan JP, Zanesi N, Kaou M, Stein GS, Lian JB, Croce CM.
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| Proc Natl Acad Sci U S A 104(10):3949-54. Epub 2007 Feb 27. 2007
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| 15 | WWOX
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| WW domain-containing oxidoreductase: a candidate tumor suppressor.
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| Chang NS, Hsu LJ, Lin YS, Lai FJ, Sheu HM.
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| Trends Mol Med 13(1):12-22. Epub 2006 Dec 4. 2007
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| 16 | WWOX
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| WWOX expression in different histologic types and subtypes of non-small cell lung cancer.
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| Donati V, Fontanini G, Dell'Omodarme M, Prati MC, Nuti S, Lucchi M, Mussi A, Fabbri M, Basolo F, Croce CM, Aqeilan RI.
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| Clin Cancer Res 13(3):884-91. 2007
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| 17 | ERBB2, WWOX
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| Wwox suppresses prostate cancer cell growth through modulation of ErbB2-mediated androgen receptor signaling.
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| Qin HR, Iliopoulos D, Nakamura T, Costinean S, Volinia S, Druck T, Sun J, Okumura H, Huebner K.
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| Mol Cancer Res 5(9):957-65. Epub 2007 Aug 17.PMID: 17704139 2007
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| 18 | CYLD, WWOX
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| Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma.
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| Jenner MW, Leone PE, Walker BA, Ross FM, Johnson DC, Gonzalez D, Chiecchio L, Dachs Cabanas E, Dagrada GP, Nightingale M, Protheroe RK, Stockley D, Else M, Dickens NJ, Cross NC, Davies FE, Morgan GJ.
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| Blood 110(9):3291-300. Epub 2007 Jul 3.PMID: 17609426 2007
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| 19 | WWOX
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| Association between decreased WWOX protein expression and thyroid cancer development.
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| Dias EP, Pimenta FJ, Sarquis MS, Dias Filho MA, Aldaz CM, Fujii JB, Gomez RS, De Marco L.
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| Thyroid 17(11):1055-9.PMID: 18047428 2007
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| 20 | WWOX
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| Characterization of the tumor suppressor gene WWOX in primary human oral squamous cell carcinomas.
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| Pimenta FJ, Gomes DA, Perdig‹o PF, Barbosa AA, Romano-Silva MA, Gomez MV, Aldaz CM, De Marco L, Gomez RS.
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| Int J Cancer 118(5):1154-8. 2006
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| 21 | WWOX
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| Common chromosomal fragile site FRA16D mutation in cancer cells.
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| Finnis M, Dayan S, Hobson L, Chenevix-Trench G, Friend K, Ried K, Venter D, Woollatt E, Baker E, Richards RI.
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| Hum Mol Genet 14(10):1341-9. Epub 2005 Apr 6. 2005
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| 22 | WWOX
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| WWOX gene restoration prevents lung cancer growth in vitro and in vivo.
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| Fabbri M, Iliopoulos D, Trapasso F, Aqeilan RI, Cimmino A, Zanesi N, Yendamuri S, Han SY, Amadori D, Huebner K, Croce CM.
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| Proc Natl Acad Sci U S A 102(43):15611-6. Epub 2005 Oct 13. 2005
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| 23 | WWOX
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| FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila.
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| O'Keefe LV, Liu Y, Perkins A, Dayan S, Saint R, Richards RI.
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| Oncogene 24(43):6590-6. Erratum in: Oncogene. 2006 Dec 7;25(58):7662. 2005
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| 24 | WWOX
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| Functional association between Wwox tumor suppressor protein and p73, a p53 homolog.
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| Aqeilan RI, Pekarsky Y, Herrero JJ, Palamarchuk A, Letofsky J, Druck T, Trapasso F, Han SY, Melino G, Huebner K, Croce CM.
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| Proc Natl Acad Sci U S A 101(13):4401-6. 2004
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| 25 | WWOX
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| WWOX, the common chromosomal fragile site, FRA16D, cancer gene.
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| Ludes-Meyers JH, Bednarek AK, Popescu NC, Bedford M, Aldaz CM.
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| Cytogenet Genome Res 100(1-4):101-10. 2003
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| 26 | WWOX, FHIT
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| Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies.
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| Ishii H, Vecchione A, Furukawa Y, Sutheesophon K, Han SY, Druck T, Kuroki T, Trapasso F, Nishimura M, Saito Y, Ozawa K, Croce CM, Huebner K, Furukawa Y.
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| Mol Cancer Res 1(13):940-7. 2003
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| 27 | WWOX
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| The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1.
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| Krummel KA, Denison SR, Calhoun E, Phillips LA, Smith DI.
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| Genes Chromosomes Cancer 34(2):154-67. 2002
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| 28 | WWOX
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| Alternative transcripts of the candidate tumor suppressor gene, WWOX, are expressed at high levels in human breast tumors.
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| Driouch K, Prydz H, Monese R, Johansen H, Lidereau R, Frengen E.
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| Oncogene 21(12):1832-40. 2002
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| 29 | WWOX
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| WWOX: a candidate tumor suppressor gene involved in multiple tumor types.
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| Paige AJ, Taylor KJ, Taylor C, Hillier SG, Farrington S, Scott D, Porteous DJ, Smyth JF, Gabra H, Watson JE.
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| Proc Natl Acad Sci U S A 98(20):11417-22. 2001
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| 30 | WWOX
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| WWOX, the FRA16D gene, behaves as a suppressor of tumor growth
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| Bednarek AK, Keck-Waggoner CL, Daniel RL, Laflin KJ, Bergsagel PL, Kiguchi K, Brenner AJ, Aldaz CM.
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| Cancer Res 61(22):8068-73. 2001
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| 31 | WWOX
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| Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells.
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| Ried K, Finnis M, Hobson L, Mangelsdorf M, Dayan S, Nancarrow JK, Woollatt E, Kremmidiotis G, Gardner A, Venter D, Baker E, Richards RI.
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| Hum Mol Genet 9(11):1651-63. 2000
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| 32 | WWOX
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| WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer.
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| Bednarek AK, Laflin KJ, Daniel RL, Liao Q, Hawkins KA, Aldaz CM.
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| Cancer Res 60(8):2140-5. 2000
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| 33 | MGUS,WWOX
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| The characterization of the common fragile site FRA16D and its involvement in multiple myeloma translocations.
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| Krummel KA, Roberts LR, Kawakami M, Glover TW, Smith DI.
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| Genomics 69(1):37-46. 2000
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| 34 | FHIT, FRA14C, FRA1C, FRA1E, FRA1F, FRA1G, FRA1I, FRA1K, FRA20B, FRA2C, FRA2F, FRA2H, FRA4A, FRA4C, FRA6B, FRA7C, FRA7F, WWOX
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| Common fragile sites : their prevalence in subjects with constitutional and acquired chromosomal instability.
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| Tedeschi B, et al.
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| Am J Med Genet 27 : 471-482. 1987
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| 35 | FHIT, FRA10D, FRA10E, FRA10F, FRA11C, FRA11D, FRA11F, FRA11G, FRA12B, FRA13A, FRA13C, FRA14B, FRA14C, FRA16C, FRA17B, FRA18A, FRA18B, FRA18C, FRA1C, FRA1E, FRA1F, FRA1G, FRA1I, FRA20B, FRA22B, FRA2C, FRA2D, FRA2E, FRA2F, FRA2H, FRA2J, FRA3A, FRA3C, FRA4A, FRA4C, FRA5C, FRA6B, FRA6C, FRA7B, FRA7C, FRA7E, FRA7G, FRA7H, FRA8B, FRA8C, FRA8D, FRA9D, FRAXB, FRAXC, WWOX
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| Constitutive fragile sites and cancer.
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| Yunis JJ, et al.
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| Science 226 : 1199-1204. 1984
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| 36 | WWOX
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| The fragile X chromosome.
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| Sutherland GR.
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| Int Rev Cytol 81 : 107-143. 1983
|