Citations for
1NR4A1, WT1
The stress-response molecule NR4A1 resists ROS-induced pancreatic β-cells apoptosis via WT1.
Zong C, Qin D, Yu C, Gao P, Chen J, Lu S, Zhang Y, Liu Y, Yang Y, Pu Z, Li X, Fu Y, Guan Q, Wang X.
Cell Signal 35:129-139. doi: 10.1016/j.cellsig.2017.03.012. [Epub ahead of print] 2017
2MAGI2, WT1
Alternatively spliced isoforms of WT1 control podocyte-specific gene expression.
Lefebvre J, Clarkson M, Massa F, Bradford ST, Charlet A, Buske F, Lacas-Gervais S, Schulz H, Gimpel C, Hata Y, Schaefer F, Schedl A.
Kidney Int 88(2):321-31. doi: 10.1038/ki.2015.140. Epub 2015 May 20. 2015
3ABCB1, EPS8, WT1
Overexpression of EPS8 is associated with poor prognosis in patients with acute lymphoblastic leukemia.
He YZ, Liang Z, Wu MR, Wen Q, Deng L, Song CY, Wu BY, Tu SF, Huang R, Li YH.
Leuk Res. Jun;39(6):575-81. doi: 10.1016/j.leukres.2015.03.007. Epub 2015 Mar 20. 2015
4MAD2L1, WT1
WT1 interacts with MAD2 and regulates mitotic checkpoint function.
Shandilya J, Toska E, Richard DJ, Medler KF, Roberts SG.
Nat Commun 5:4903. doi: 10.1038/ncomms5903. 2014
5WT1, ZNF224
Role of WT1-ZNF224 interaction in the expression of apoptosis- regulating genes.
Montano G, Cesaro E, Fattore L, Vidovic K, Palladino C, Crescitelli R, Izzo P, Turco MC, Costanzo P.
Hum Mol Genet um Mol Genet. 2013 Jan 28. [Epub ahead of print] 2013
6WT1
The Wilms Tumor Gene, Wt1, Maintains Testicular Cord Integrity by Regulating the Expression of Col4a1 and Col4a2.
Chen SR, Chen M, Wang XN, Zhang J, Wen Q, Ji SY, Zheng QS, Gao F, Liu YX.
Biol Reprod iol Reprod. 2013 Jan 16. [Epub ahead of print] 2013
7WT1
The Wilms' tumor gene (WT1) regulates E-cadherin expression and migration of prostate cancer cells.
Brett A, Pandey S, Fraizer G.
Mol Cancer 12(1):3. [Epub ahead of print] 2013
8USP18, WT1
Ubiquitin specific protease 18 (Usp18) is a WT1 transcriptional target.
Shahidul Makki M, Cristy Ruteshouser E, Huff V.
Exp Cell Res xp Cell Res. 2013 Jan 2. doi:pii: S0014-4827(12)00498-3. 10.1016/j.yexcr.2012.12.021. [Epub ahead of print] 2013
9DEL9Q22, PTCH1, WT1
Wilms' tumor in patients with 9q22.3 microdeletion syndrome suggests a role for PTCH1 in nephroblastomas.
Isidor B, Bourdeaut F, Lafon D, Plessis G, Lacaze E, Kannengiesser C, Rossignol S, Pichon O, Briand A, Martin-Coignard D, Piccione M, David A, Delattre O, Jeanpierre C, Sévenet N, Le Caignec C.
Eur J Hum Genet ur J Hum Genet. 2012 Nov 21. doi: 10.1038/ejhg.2012.252. [Epub ahead of print] 2012
10SOX11, WNT4, WT1
WT1 and Sox11 regulate synergistically the promoter of the Wnt4 gene that encodes a critical signal for nephrogenesis.
Murugan S, Shan J, Kühl SJ, Tata A, Pietilä I, Kühl M, Vainio SJ.
Exp Cell Res 318(10):1134-45. doi: 10.1016/j.yexcr.2012.03.008. Epub 2012 Mar 17. 2012
11IDMS, WT1
Focal segmental glomerulosclerosis in patients with complete deletion of one WT1 allele.
Iijima K, Someya T, Ito S, Nozu K, Nakanishi K, Matsuoka K, Ohashi H, Nagata M, Kamei K, Sasaki S.
Pediatrics 129(6):e1621-5. doi: 10.1542/peds.2011-1323. Epub 2012 May 14. 2012
12WT1
Nuclear transport of Wilms' tumour protein Wt1 involves importins α and β.
Depping R, Schindler SG, Jacobi C, Kirschner KM, Scholz H.
Cell Physiol Biochem 29(1-2):223-32. doi: 10.1159/000337603. Epub 2012 Mar 1. 2012
13WT1
Abnormal WT1 expression in human fetuses with bilateral renal agenesis and cardiac malformations.
Loo CK, Pereira TN, Ramm GA.
Birth Defects Res A Clin Mol Teratol 94(2):116-22. doi: 10.1002/bdra.22881. Epub 2012 Jan 13. 2012
14BASP1, INPP5J, WT1
Repression of transcription by WT1-BASP1 requires the myristoylation of BASP1 and the PIP2-dependent recruitment of histone deacetylase.
Toska E, Campbell HA, Shandilya J, Goodfellow SJ, Shore P, Medler KF, Roberts SG.
Cell Rep 2(3):462-9. doi: 10.1016/j.celrep.2012.08.005. Epub 2012 Aug 30. 2012
15WT1
Common variants at 11p13 are associated with susceptibility to tuberculosis.
Thye T, Owusu-Dabo E, Vannberg FO, van Crevel R, Curtis J, Sahiratmadja E, Balabanova Y, Ehmen C, Muntau B, Ruge G, Sievertsen J, Gyapong J, Nikolayevskyy V, Hill PC, Sirugo G, Drobniewski F, van de Vosse E, Newport M, Alisjahbana B, Nejentsev S, Ottenhoff TH, Hill AV, Horstmann RD, Meyer CG.
Nat Genet 44(3):257-9. doi: 10.1038/ng.1080. 2012
16EYA1, NR2F2, WT1
COUP-TFII is essential for metanephric mesenchyme formation and kidney precursor cell survival.
Yu CT, Tang K, Suh JM, Jiang R, Tsai SY, Tsai MJ.
Development 139(13):2330-9. doi: 10.1242/dev.076299. 2012
17MEN1, PAX2, WT1
Tumor suppressor menin represses paired box gene 2 expression via Wilms tumor suppressor protein-polycomb group complex.
Xu B, Zeng DQ, Wu Y, Zheng R, Gu L, Lin X, Hua X, Jin GH.
J Biol Chem 286(16):13937-44. Epub 2011 Mar 4. 2011
18WT1
WT1 regulates epicardial epithelial to mesenchymal transition through β-catenin and retinoic acid signaling pathways.
von Gise A, Zhou B, Honor LB, Ma Q, Petryk A, Pu WT.
Dev Biol 356(2):421-31. Epub 2011 May 30. 2011
19SRPK1, WT1
WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing.
Amin EM, Oltean S, Hua J, Gammons MV, Hamdollah-Zadeh M, Welsh GI, Cheung MK, Ni L, Kase S, Rennel ES, Symonds KE, Nowak DG, Royer-Pokora B, Saleem MA, Hagiwara M, Schumacher VA, Harper SJ, Hinton DR, Bates DO, Ladomery MR.
Cancer Cell 20(6):768-80. doi: 10.1016/j.ccr.2011.10.016. 2011
20WT1
WT1 protein directly regulates expression of vascular endothelial growth factor and is a mediator of tumor response to hypoxia.
McCarty G, Awad O, Loeb DM.
J Biol Chem 286(51):43634-43. doi: 10.1074/jbc.M111.310128. Epub 2011 Oct 26. 2011
21WT1
Expression of WT1 during normal human kidney development.
Fanni D, Fanos V, Monga G, Gerosa C, Locci A, Nemolato S, Van Eyken P, Faa G.
J Matern Fetal Neonatal Med 24 Suppl 2:44-7. doi: 10.3109/14767058.2011.606619. Epub 2011 Sep 2. 2011
22LIMS1, WT1
PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expression.
Wang D, Li Y, Wu C, Liu Y.
PLoS One 6(2):e17048. doi: 10.1371/journal.pone.0017048. 2011
23ALDH1A2, WT1
Wt1 controls retinoic acid signalling in embryonic epicardium through transcriptional activation of Raldh2.
Guadix JA, Ruiz-Villalba A, Lettice L, Velecela V, Muñoz-Chápuli R, Hastie ND, Pérez-Pomares JM, Martínez-Estrada OM.
Development 138(6):1093-7. doi: 10.1242/dev.044594. 2011
24BASP1, WT1
WT1 and its transcriptional cofactor BASP1 redirect the differentiation pathway of an established blood cell line.
Goodfellow SJ, Rebello MR, Toska E, Zeef LA, Rudd SG, Medler KF, Roberts SG.
Biochem J 435(1):113-25. doi: 10.1042/BJ20101734. 2011
25TBX18, WT1
Developmental patterns and characteristics of epicardial cell markers Tbx18 and Wt1 in murine embryonic heart.
Zeng B, Ren XF, Cao F, Zhou XY, Zhang J.
J Biomed Sci 18:67. doi: 10.1186/1423-0127-18-67. 2011
26IDMS, WT1
A murine model of Denys-Drash syndrome reveals novel transcriptional targets of WT1 in podocytes.
Ratelade J, Arrondel C, Hamard G, Garbay S, Harvey S, Biebuyck N, Schulz H, Hastie N, Pontoglio M, Gubler MC, Antignac C, Heidet L.
Hum Mol Genet 19(1):1-15. Epub .PMID: 19797313 2010
27WT1
Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin.
Martínez-Estrada OM, Lettice LA, Essafi A, Guadix JA, Slight J, Velecela V, Hall E, Reichmann J, Devenney PS, Hohenstein P, Hosen N, Hill RE, Muñoz-Chapuli R, Hastie ND.
Nat Genet 42(1):89-93. Epub 2009 Dec 20.PMID: 20023660 2010
28CXXC5, WT1
A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway.
Kim MS, Yoon SK, Bollig F, Kitagaki J, Hur W, Whye NJ, Wu YP, Rivera MN, Park JY, Kim HS, Malik K, Bell DW, Englert C, Perantoni AO, Lee SB.
J Biol Chem 285(19):14585-93. Epub 2010 Mar 10. 2010
29WT1, ZNF224
Biochemical and functional interaction between ZNF224 and ZNF255, two members of the Kruppel-like zinc-finger protein family and WT1 protein isoforms.
Florio F, Cesaro E, Montano G, Izzo P, Miles C, Costanzo P.
Hum Mol Genet 19(18):3544-56. Epub 2010 Jun 30.PMID: 20591825 2010
30WT1
Wilms' tumor protein Wt1 regulates the Interleukin-10 (IL-10) gene.
Sciesielski LK, Kirschner KM, Scholz H, Persson AB.
FEBS Lett 584(22):4665-71. doi: 10.1016/j.febslet.2010.10.045. Epub 2010 Oct 26. 2010
31HTRA2, WT1
The Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi.
Hartkamp J, Carpenter B, Roberts SG.
Mol Cell 37(2):159-71. doi: 10.1016/j.molcel.2009.12.023. 2010
32CITED2, NR5A1, SRY, WT1
The transcription co-factor CITED2 functions during sex determination and early gonad development.
Buaas FW, Val P, Swain A.
Hum Mol Genet 18(16):2989-3001. Epub 2009 May 20.PMID: 19457926 2009
33BASP1, WT1
Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation.
Green LM, Wagner KJ, Campbell HA, Addison K, Roberts SG.
Nucleic Acids Res 37(2):431-40. doi: 10.1093/nar/gkn955. Epub 2008 Dec 2. 2009
34WT1
WT1 expression at diagnosis does not predict survival in pediatric AML: a report from the Children's Oncology Group.
Noronha SA, Farrar JE, Alonzo TA, Gerbing RB, Lacayo NJ, Dahl GV, Ravindranath Y, Arceci RJ, Loeb DM.
Pediatr Blood Cancer 53(6):1136-9.PMID: 19618455 2009
35IDMS, WT1
Membranoproliferative glomerulonephritis associated with a mutation in Wilms' tumour suppressor gene 1.
Bockenhauer D, van't Hoff W, Chernin G, Heeringa SF, Sebire NJ.
Pediatr Nephrol 24(7):1399-401. Epub 2009 Feb 11.PMID: 19205749 2009
36DDS, WT1, CDH
Denys-Drash syndrome and congenital diaphragmatic hernia: another case with the 1097G > A(Arg366His) mutation.
Antonius T, van Bon B, Eggink A, van der Burgt I, Noordam K, van Heijst A.
Am J Med Genet A 146(4):496-9. 2008
37AMER1, CTNNB1, WT1
Wilms tumor genetics: mutations in WT1, WTX, and CTNNB1 account for only about one-third of tumors.
Ruteshouser EC, Robinson SM, Huff V.
Genes Chromosomes Cancer 47(6):461-70. 2008
38WT1
Wilms tumour gene 1 overexpression in bone marrow as a marker for minimal residual disease in acute myeloid leukaemia.
Hämäläinen MM, Kairisto V, Juvonen V, Johansson J, Aurén J, Kohonen K, Remes K, Salmi TT, Helenius H, Pelliniemi TT.
Eur J Haematol 80(3):201-7. Epub 2007 Dec 10.PMID: 18081724 2008
39FS, WT1
Characteristics of testicular dysgenesis syndrome and decreased expression of SRY and SOX9 in Frasier syndrome.
Schumacher V, Gueler B, Looijenga LH, Becker JU, Amann K, Engers R, Dotsch J, Stoop H, Schulz W, Royer-Pokora B.
Mol Reprod Dev 75(9):1484-94. 2008
40WT1, WT1, WAGR
A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis.
Hancock AL, Brown KW, Moorwood K, Moon H, Holmgren C, Mardikar SH, Dallosso AR, Klenova E, Loukinov D, Ohlsson R, Lobanenkov VV, Malik K.
Hum Mol Genet 16(3):343-54. Epub 2007 Jan 8. 2007
41IGF2, BWS, WT1
Paternally inherited submicroscopic duplication at 11p15.5 implicates insulin-like growth factor II in overgrowth and Wilms' tumorigenesis.
Algar EM, St Heaps L, Darmanian A, Dagar V, Prawitt D, Peters GB, Collins F.
Cancer Res 67(5):2360-5. Epub 2007 Feb 26. 2007
42WAGR, WT1
Complete sex reversal in a WAGR syndrome patient.
Le Caignec C, Delnatte C, Vermeesch JR, Boceno M, Joubert M, Lavenant F, David A, Rival JM.
Am J Med Genet A 143(22):2692-5. 2007
43WAGR, WT1, AN
Raised risk of Wilms tumour in patients with aniridia and submicroscopic WT1 deletion.
van Heyningen V, Hoovers JM, de Kraker J, Crolla JA.
J Med Genet 44(12):787-90. Epub 2007 Jul 14. 2007
44WT1
Human lymphocytes express the transcriptional regulator, Wilms tumor 1: the role of WT1 in mediating nitric oxide-dependent repression of lymphocyte proliferation.
Marcet-Palacios M, Davoine F, Adamko DJ, Moqbel R, Befus AD.
Biochem Biophys Res Commun 363(2):283-7. Epub 2007 Sep 4. 2007
45WAGR, PAX6, WT1
WAGR(O?) syndrome and congenital ptosis caused by an unbalanced t(11;15)(p13;p11.2)dn demonstrating a 7 megabase deletion by FISH.
Lennon PA, Scott DA, Lonsdorf D, Wargowski DS, Kirkpatrick S, Patel A, Cheung SW.
Am J Med Genet A 140(11):1214-8. 2006
46WT1, SOX9
The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis.
Gao F, Maiti S, Alam N, Zhang Z, Deng JM, Behringer RR, Lecureuil C, Guillou F, Huff V.
Proc Natl Acad Sci U S A 103(32):11987-92. Epub 2006 Jul 28. 2006
47WT1, WTAP
Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA.
Horiuchi K, Umetani M, Minami T, Okayama H, Takada S, Yamamoto M, Aburatani H, Reid PC, Housman DE, Hamakubo T, Kodama T.
Proc Natl Acad Sci U S A 103(46):17278-83. Epub 2006 Nov 6. 2006
48ACTN4, CD2AP, NPHS1, NPHS2, SRN1, SRN4, WT1
Mutations in the Wilms' tumor 1 gene cause isolated steroid resistant nephrotic syndrome and occur in exons 8 and 9.
Mucha B, Ozaltin F, Hinkes BG, Hasselbacher K, Ruf RG, Schultheiss M, Hangan D, Hoskins BE, Everding AS, Bogdanovic R, Seeman T, Hoppe B, Hildebrandt F; Members of the APN Study Group.
Pediatr Res 59(2):325-31. 2006
49CTCF, H19, IGF2, BWS, WT1
Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor.
Prawitt D, Enklaar T, Gartner-Rupprecht B, Spangenberg C, Oswald M, Lausch E, Schmidtke P, Reutzel D, Fees S, Lucito R, Korzon M, Brozek I, Limon J, Housman DE, Pelletier J, Zabel B.
Proc Natl Acad Sci U S A 102(11):4085-90. Epub 2005 Mar 2. 2005
50WT1, EP300
Histone acetyltransferase p300 promotes the activation of human WT1 promoter and intronic enhancer.
Shao Y, Lu J, Zhang G, Liu C, Huang B.
Arch Biochem Biophys 436(1):62-8. 2005
51WT1
Genomic imprinting at the WT1 gene involves a novel coding transcript (AWT1) that shows deregulation in Wilms' tumours.
Dallosso AR, Hancock AL, Brown KW, Williams AC, Jackson S, Malik K.
Hum Mol Genet 13(4):405-15. Epub 2003 Dec 17. 2004
52WT1, SRD5A2, AR, PPSH
Mutation analysis of five candidate genes in Chinese patients with hypospadias.
Wang Y, Li Q, Xu J, Liu Q, Wang W, Lin Y, Ma F, Chen T, Li S, Shen Y.
Eur J Hum Genet 12(9):706-12. 2004
53BASP1, WT1
BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1.
Carpenter B, Hill KJ, Charalambous M, Wagner KJ, Lahiri D, James DI, Andersen JS, Schumacher V, Royer-Pokora B, Mann M, Ward A, Roberts SG.
Mol Cell Biol 24(2):537-49. 2004
54WT1, ETV4
Activation of the WT1 tumor suppressor gene promoter by Pea3.
Discenza MT, Vaz D, Hassell JA, Pelletier J.
FEBS Lett 560(1-3):183-91. 2004
55WT1
Overexpression of the Wilms' tumor gene WT1 in human bone and soft-tissue sarcomas.
Ueda T, Oji Y, Naka N, Nakano Y, Takahashi E, Koga S, Asada M, Ikeba A, Nakatsuka S, Abeno S, Hosen N, Tomita Y, Aozasa K, Tamai N, Myoui A, Yoshikawa H, Sugiyama H.
Cancer Sci 94(3):271-6. 2003
56DDS, WT1
Murine Denys-Drash syndrome: evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis.
Patek CE, Fleming S, Miles CG, Bellamy CO, Ladomery M, Spraggon L, Mullins J, Hastie ND, Hooper ML.
Hum Mol Genet 12(18):2379-94. Epub 2003 Jul 22. 2003
57WT1
The complex life of WT1.
Wagner KD, Wagner N, Schedl A.
J Cell Sci 116(Pt 9):1653-8. Review.PMID: 12665546 2003
58WT1
WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis.
Guo JK, Menke AL, Gubler MC, Clarke AR, Harrison D, Hammes A, Hastie ND, Schedl A.
Hum Mol Genet 11(6):651-9. 2002
59COL1A1, DDIT3, EWSR1, SUZ12, JAZF1, NR4A3, WT1
Cytogenetics and molecular genetics of bone and soft-tissue tumors.
Sandberg AA.
Am J Med Genet 115(3):189-93. 2002
60GBGT1, WT1
An unusual phenotype of Frasier syndrome due to IVS9 +4C>T mutation in the WT1 gene: predominantly male ambiguous genitalia and absence of gonadal dysgenesis.
Melo KF, Martin RM, Costa EM, Carvalho FM, Jorge AA, Arnhold IJ, Mendonca BB.
J Clin Endocrinol Metab 87(6):2500-5. Review. 2002
61WT1
A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development.
Natoli TA, Liu J, Eremina V, Hodgens K, Li C, Hamano Y, Mundel P, Kalluri R, Miner JH, Quaggin SE, Kreidberg JA.
J Am Soc Nephrol 13(8):2058-67. 2002
62WT1
Downregulation of Wilms' tumor 1 protein inhibits breast cancer proliferation.
Zapata-Benavides P, Tuna M, Lopez-Berestein G, Tari AM.
Biochem Biophys Res Commun 295(4):784-90. 2002
63GBGT1, WT1
Molecular analysis of Frasier syndrome: mutation in the WT1 gene in a girl with gonadal dysgenesis and nephronophthisis.
Perez de Nanclares G, Castano L, Bilbao JR, Vallo A, Rica I, Vela A, Martul P.
J Pediatr Endocrinol Metab 15(7):1047-50. 2002
64WT1
The Wilms tumor suppressor WT1 directs stage-specific quiescence and differentiation of human hematopoietic progenitor cells.
Ellisen LW, Carlesso N, Cheng T, Scadden DT, Haber DA.
EMBO J 20(8):1897-909. 2001
65DDS, GBGT1, WT1
Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation.
Hammes A, Guo JK, Lutsch G, Leheste JR, Landrock D, Ziegler U, Gubler MC, Schedl A.
Cell 106(3):319-29. 2001
66WT1
Mutations/deletions of the WT1 gene, loss of heterozygosity on chromosome arms 11p and 11q, chromosome ploidy and histology in Wilms' tumors in Japan.
Nakadate H, Yokomori K, Watanabe N, Tsuchiya T, Namiki T, Kobayshi H, Suita S, Tsunematsu Y, Horikoshi Y, Hatae Y, Endo M, Komada Y, Eguchi H, Toyoda Y, Kikuta A, Kobayashi R, Kaneko Y.
Int J Cancer 94(3):396-400. 2001
67IDMS, WT1
Constitutional WT1 correlate with clinical features in children with progressive nephropathy.
Takata A, Kikuchi H, Fukuzawa R, Ito S, Honda M, Hata J.
J Med Genet 37(9):698-701. No abstract available. 2000
68GBGT1, WT1
The same mutation affecting the splicing of WT1 gene is present on Frasier syndrome patients with or without Wilms' tumor.
Barbosa AS, et al.
Hum Mutat 13 : 146-153. 1999
69PAX2, WT1
WT1 and PAX-2 podocyte expression in Denys-Drash syndrome and isolated diffuse mesangial sclerosis.
Yang Y, et al.
Am J Pathol 154(1):181-92. 1999
70NR0B2, WT1
The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation.
Kim J, et al.
Mol Cell Biol 19(3):2289-99. 1999
71WT1
The Wilms' tumor gene WT1 is a good marker for diagnosis of disease progression of myelodysplastic syndromes.
Tamaki H, et al.
Leukemia 13(3):393-9. 1999
72WT1, TSG11G
Induction of rat WT1 gene expression correlates with human chromosome 11p11.2-p12-mediated suppression of tumorigenicity in rat liver epithelial tumor cell lines.
Coleman WB, et al.
Int J Oncol 14(5):957-63. 1999
73WT1
WT1 and GATA1 expression in myelodysplastic syndrome and acute leukemia.
Patmasiriwat P, et al.
Leukemia 13(6):891-900. 1999
74WT1
Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud.
Donovan MJ, et al.
Dev Genet 24(3-4):252-62 1999
75WT1
Tumor-associated WT1 missense mutants indicate that transcriptional activation by WT1 is critical for growth control.
English MA, et al.
J Biol Chem 274(19):13258-63 1999
76GBGT1, WT1
Exon 9 mutations in the WT1 gene, without influencing KTS splice isoforms, are also responsible for Frasier syndrome.
Kohsaka T, Tagawa M, Takekoshi Y, Yanagisawa H, Tadokoro K, Yamada M.
Hum Mutat 14(6):466-70 1999
77GBGT1, WT1
A Japanese case with Frasier syndrome caused by the splice junction mutation of WT1 gene.
Okuhara K, Tajima S, Nakae J, Sasaki S, Tochimaru H, Abe S, Fujieda K.
Endocr J 46(5):639-42. 1999
78WT1
Restriction landmark genome scanning for aberrant methylation in primary refractory and relapsed acute myeloid leukemia; involvement of the WIT-1 gene.
Plass C, Yu F, Yu L, Strout MP, El-Rifai W, Elonen E, Knuutila S,Marcucci G, Young DC, Held WA, Bloomfield CD, Caligiuri MA.
Oncogene 18(20):3159-65. 1999
79GBGT1, WT1
Do intronic mutations affecting splicing of WT1 exon 9 cause Frasier syndrome?
Kikuchi H, Takata A, Akasaka Y, Fukuzawa R, Yoneyama H, Kurosawa Y, Honda M, Kamiyama Y, Hata J.
J Med Genet 35(1):45-8. 1998
80WT1
Loss of WT1 function leads to ectopic myogenesis in Wilms'tumour.
Miyagawa K, Kent J, Moore A, Charlieu JP, Little MH, Williamson KA, Kelsey A, Brown KW, Hassam S, Briner J, Hayashi Y, Hirai H, Yazaki Y, van Heyningen V, Hastie ND.
Nat Genet 18(1):15-7. No abstract available. 1998
81GBGT1, WT1
Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/-KTS splice isoforms.
Klamt B, et al.
Hum Mol Genet 7 : 709-714. 1998
82IDMS, WT1
Identification of constitutional WT1 mutations, in patients with isolated diffuse mesangial sclerosis, and analysis of genotype/phenotype correlations by use of a computerized mutation database.
Jeanpierre C, et al.
Am J Hum Genet 62 : 824-833. 1998
83IDMS, WT1
Spectrum of early onset nephrotic syndrome associated with WT1 missense mutations.
Schumacher V, et al.
Kidney Int 53 : 1594-1600. 1998
84NR0B2, DDS, NR5A1, WT1
Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression.
Nachtigal MW, et al.
Cell 93 : 445-454. 1998
85APC, BRCA1, DPP4, MLH1, MSH2, MSH6, NF1, PMS2, RB1, TP53, VHL, WT1, FAP
Tumour suppressor gene mutations in humans and mice : parallels and contrasts.
Hooper ML.
EMBO J 17(23):6783-9. 1998
86GUD, WT1
Constitutional WT1 mutations in Wilms' tumor patients.
Diller L, Ghahremani M, Morgan J, Grundy P, Reeves C, Breslow N, Green D, Neuberg D, Pelletier J, Li FP.
J Clin Oncol 16 : 3634-3640. 1998
87WT1
Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70.
Maheswaran S, et al.
Genes Dev 12(8):1108-20 1998
88PAX6, WT1
A sequence-ready 3-Mb PAC contig covering 16 breakpoints of the Wilms tumor/anirida region of human chromosome 11p13.
Niederfuhr A, Hummerich H, Gawin B, Boyle S, Little PF, Gessler M.
Genomics 53(2):155-63 1998
89NPHS4, WT1
Identification of constitutional WT1 mutations, in patients with isolated diffuse mesangial sclerosis, and analysis of genotype/phenotype correlations by use of a computerized mutation database.
Jeanpierre C, Denamur E, Henry I, Cabanis MO, Luce S, Cécille A, Elion J, Peuchmaur M, Loirat C, Niaudet P, Gubler MC, Junien C.
Am J Hum Genet 62(4):824-33. 1998
90WT1
A clinical overview of WT1 gene mutations.
Little M, et al.
Hum Mutat 9 : 209-225. 1997
91WT1
Paternal expression of WT1 in human fibroblasts and lymphocytes.
Mitsuya K, Sui H, Meguro M, Kugoh H, Jinno Y, Niikawa N, Oshimura M.
Hum Mol Genet 6(13):2243-6. 1997
92GBGT1, WT1, FS
Donor splice-site mutations in WT1 are responsible for Frasier syndrome.
Barbaux S, Niaudet P, Gubler MC, Grunfeld JP, Jaubert F, Kuttenn F, Fekete CN, Souleyreau-Therville N, Thibaud E, Fellous M, McElreavey K.
Nat Genet 17(4):467-70. 1997
93DDS, GBGT1, WT1
Sugar and spice and all things splice?
Van Heyningen V.
Nat Genet 17(4):367-8. No abstract available. 1997
94WT1
Differential regulation of two sets of mesonephric tubules by WT-1.
Sainio K, et al.
Development 124(7):1293-9 1997
95WT1
An RNA recognition motif in Wilms' tumour protein (WT1) revealed by structural modelling.
Kennedy D, et al.
Nat Genet 12 : 329-332. 1996
96TSG11A, WT1
Mutations in the Wilms' tumor gene WT1 in leukemias.
King-Underwood L, et al.
Blood 87 : 2171-2179. 1996
97SLC26A4, WT1
A novel mutation H373Y in the Wilms' tumor suppressor gene, WT1, associated with Denys-Drash syndrome.
Ghahremani M, et al.
Hum Hered 46 : 336-338. 1996
98WT1
Familial Wilms' tumor associated with a WT1 zinc finger mutation.
Kaplinsky C, et al.
Genomics 38 : 451-453. 1996
99WT1
Identification of an antisense WT1 promoter in intron 1 : implications for WT1 gene regulation.
Malik KTA, et al.
Oncogene 11 : 1589-1595. 1995
100DSRCT, EWSR1, WT1
Characterization of the genomic breakpoint and chimeric transcripts in the EWS-WT1 gene fusion of desmoplastic small round cell Tumor.
Gerald WL, et al.
Proc Natl Acad Sci U S A 92 : 1028-1032. 1995
101SLC26A4, WT1
DNA binding capacity of the WT1 protein is abolished by Denys-Drash syndrome WT1 point mutations.
Little M, et al.
Hum Mol Genet 4 : 351-358. 1995
102WT1
Homozygous intragenic deletion in the WT1 gene in a sporadic Wilms' tumour associated with high levels of expression of a truncated transcript.
Algar EM, et al.
Hum Mutat 5 : 221-227. 1995
103WT1
WTI exon I deletion/insertion mutations in Wilms tumor patients, associated with di- and trinucleotide repeats and deletion hotspot consensus sequences.
Huff V, et al.
Am J Hum Genet 56 : 84-90. 1995
104GBGT1, WT1
Truncated WT1 mutants alter the subnuclear localization of the wild-type protein.
Englert C, et al.
Proc Natl Acad Sci U S A 92 : 11960-11964. 1995
105WT1
Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing.
Larsson SH, et al.
Cell 81(3):391-401 1995
106WT1, SLC26A4
WT1 mutations in patients with Denys-Drash syndrome : a novel mutation in exon 8 and paternal allele origin.
Nordenskjšld A, et al.
Hum Genet 93 : 115-120. 1994
107WT1
Antisense transcripts and protein binding motifs within the Wilms tumour (WT1) locus.
Campbell CE, et al.
Oncogene 9 : 583-595. 1994
108WT1
Infrequent mutation of the WT1 gene in 77 Wilms' tumors.
Gessler M, et al.
Hum Mutat 3 : 212-222. 1994
109WT1, TSG11A
Fine structure analysis of the WT1 gene in sporadic Wilms tumors.
Varanasi R, et al.
Proc Natl Acad Sci U S A 91 : 3554-3558. 1994
110SLC26A4, WT1
WT1 mutations associated with incomplete Denys-Drash syndrome define a domain predicted to behave in a dominant-negative fashion.
Bardeesy N, et al.
Genomics 21 : 663-665. 1994
111EWSR1, WT1
Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor.
Ladanyi M, et al.
Cancer Res 54 : 2837-2840. 1994
112WT1, WT2
Molecular genetic analysis of chromosome 11p in familial Wilms tumor.
Baird PN, et al.
Br J Cancer 69 : 1072-1077. 1994
113AN, WT1, WAGR
Molecular analysis of aniridia patients for deletions involving the Wilms' tumor gene.
Drechsler M, et al.
Hum Genet 94 : 331-338. 1994
114WT1, WAGR
The Wilms tumour (WT1) gene is mutated in a secondary leukaemia in a WAGR patient.
Pritchard-Jones K, et al.
Hum Mol Genet 3 : 1633-1637. 1994
115WT1
Novel replication inhibitory function of the developmental regulator/transcription repressor protein WT1 encoded by the Wilms'tumor gene.
Anant S, et al.
Oncogene 9 : 3113-3126. 1994
116WT1, WT2
The genetics of Wilms' tumor-A case of disrupted development.
Hastie ND.
Annu Rev Genet 28 : 523-558. 1994
117WT1
Genetics of Wilms' tumor : a blend of aberrant development and genomic imprinting.
Junien C, et al.
Kidney Int 46 : 1264-1279. 1994
118WT1
Mosaic and polymorphic imprinting of the WT1 gene in humans.
Jinno Y, et al.
Nat Genet 6 : 305-309. 1994
119WT1
Cloning of novel Wilms tumor gene (WT1) cDNAs; evidence for antisense transcription of WT1.
Eccles MR, Grubb G, Ogawa O, Szeto J, Reeve AE.
Oncogene 9(7):2059-63. 1994
120WT1, SLC26A4
Evidence that WT1 mutations in Denys-Drash syndrome patients may act in a dominant-negative fashion.
Little M, et al.
Hum Mol Genet 2 : 259-264. 1993
121WT1, SLC26A4
A point mutation found in the WT1 gene in a sporadic Wilms' tumor without genitourinary abnormalities is identical with the most frequent point mutation in Denys-Drash syndrome.
Akasaka Y, et al.
FEBS Lett 317 : 39-43. 1993
122WT1, SLC26A4
Further evidence that imbalance of WT1 isoforms may be involved in Denys-Drash syndrome.
Kšnig A, et al.
Hum Mol Genet 2 : 1967-1968. 1993
123WT1, SLC26A4
A novel mutation of the WT1 gene (a tumor suppressor gene for Wilms'tumor) in a patient with Denys-Drash syndrome.
Sakai A, et al.
Hum Mol Genet 2 : 1969-1970. 1993
124WT1
PCR detection of 9 polymorphisms in the WT1 gene.
Tadokoro K, et al.
Hum Mol Genet 2 : 2205-2206. 1993
125TSG11A, WT1
Inactivation of WT1 in nephrogenic rests, genetic precursors to Wilms'tumour.
Park S, et al.
Nat Genet 5 : 363-367. 1993
126WT1, WAGR
Homozygous inactivation of WTI in a Wilms' tumor associated with the WAGR syndrome.
Gessler M, et al.
Genes Chromosomes Cancer 7 : 131-136. 1993
127SLC26A4, FS, WT1
Distinct molecular origins for Denys-Drash and Frasier syndromes.
Poulat F, et al.
Hum Genet 91 : 285-286. 1993
128WT1
Homozygous somatic WT1 point mutations in sporadic unilateral Wilms tumor.
Coppes MJ, et al.
Proc Natl Acad Sci U S A 90 : 1416-1419. 1993
129WT1, SLC26A4
Exon skipping due to a mutation in a donor splice site in the WT-1 gene is associated with Wilms' tumor and severe genital malformations.
Schneider S, et al.
Hum Genet 91 : 599-604. 1993
130TSG11A, WT1
The Wilms tumour gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human mesothelioma.
Park S, et al.
Nat Genet 4 : 415-420. 1993
131WT1
Insertional inactivation of the WT1 gene in tumour cells from a patient with WAGR syndrome.
Santos A, et al.
Hum Genet 92 : 83-86. 1993
132WT1, WT2, TSG11A, ST5
Deletion of WT1 and WIT1 genes and loss of heterozygosity on chromosome 11p in Wilms tumors in Japan.
Kaneko Y, et al.
Jpn J Cancer Res 84 : 616-624. 1993
133WT1, SLC26A4
Mutational screening of the Wilms's tumour gene, WT1, in males with genital abnormalities.
Clarkson PA, et al.
J Med Genet 30 : 767-772. 1993
134WT1
Low frequency of mutations in the WT1 coding region in Wilms' tumor.
Brown KW, et al.
Genes Chromosomes Cancer 8 : 74-79. 1993
135SLC26A4, WT1
A novel insertional mutation at the third zinc finger coding region of the WT1 gene in Denys-Drash syndrome.
Ogawa O, et al.
Hum Mol Genet 2 : 203-204. 1993
136WT1
Genetic mosaicism in normal tissues of Wilms' tumour patients.
Chao LY, et al.
Nat Genet 3 : 127-131. 1993
137WT1
WT-1 is required for early kidney development.
Kreidberg JA, et al.
Cell 74(4):679-91 1993
138WT1
Sequence of the WT1 upstream region including the Wit-1 gene.
Gessler M, Bruns GA.
Genomics 17(2):499-501. 1993
139WT1
The genomic organization and expression of the WT1 gene.
Gessler M, et al.
Genomics 12 : 807-813. 1992
140WT1
Intragenic homozygous deletion of the WT1 gene in Wilms' tumor.
Tadokoro K, et al.
Oncogene 7 : 1215-1221. 1992
141WT1
RNA polymerase chain reaction detects different levels of four alternatively spliced WT1 transcripts in Wilms' tumors.
Brenner B, et al.
Oncogene 7 : 1431-1433. 1992
142WT1, SLC26A4
Germline intronic and exonic mutations in the Wilm's tumour gene (WT1) affecting urogenital development.
Bruening W, et al.
Nat Genet 1 : 144-148. 1992
143WT1
Identification of mutations in the WT1 gene in tumours from patients with the WAGR syndrome.
Baird PN, et al.
Oncogene 7 : 2141-2149. 1992
144WT1, SLC26A4
Inherited WT1 mutation in Denys-Drash syndrome.
Coppes MJ, et al.
Cancer Res 52 : 6125-6128. 1992
145WT1, WAGR
Inactivation of the remaining allele of the WT1 gene in a Wilms' tumour from a WAGR patient.
Brown KW, et al.
Oncogene 7 : 763-768. 1992
146WT1
A single base pair polymorphism in the WT1 gene detected by single-strand conformation polymorphism analysis.
Groves N, et al.
Hum Genet 90 : 440-442. 1992
147WT1
Equivalent expression of paternally and maternally inherited WT1 alleles in normal fetal tissue and Wilms' tumours.
Little MH, et al.
Oncogene 7 : 635-641. 1992
148WT1
Zinc finger point mutations within the WTI gene in Wilms tumor patients.
Little MH, et al.
Proc Natl Acad Sci U S A 89 : 4791-4795. 1992
149WT1
Identification of the cellular protein encoded by the human Wilms' tumor (WT1) gene.
Telerman A, et al.
Oncogene 7 : 2545-2548. 1992
150WT1, WT2, TSG11A, ST5
Loss of heterozygosity mapping in Wilms tumor indicates the involvement of three distinct regions and a limited role for nondisjunction or mitotic recombination.
Coppes MJ, et al.
Genes Chromosomes Cancer 5 : 326-334. 1992
151WT1
TaqI RFLPs at the Wilms' tumor gene (WT1).
Tadokoro K, et al.
Nucleic Acids Res 19 : 2514. 1991
152WT1
Evidence for WTI as a Wilms tumor (WT) gene: intragenic germinal deletion in bilateral WT.
Huff V, et al.
Am J Hum Genet 48 : 997-1003. 1991
153WT1
A tumor chromosome rearrangement further defines the 11p13 Wilms tumor locus.
Davis LM, et al.
Genomics 10 : 588-592. 1991
154WT1
Direct pulsed field gel electrophoresis of Wilms' tumors shows that DNA deletions in 11p13 are rare.
Royer-Pokora B, et al.
Genes Chromosomes Cancer 3 : 89-100. 1991
155WT1
Familial predisposition to Wilms tumor does not segregate with the WT1 gene.
Schwartz CE, et al.
Genomics 10 : 927-930. 1991
156WT1
Structural rearrangements of the WT1 gene in Wilms' tumour cells.
Cowell JK, et al.
Oncogene 6 : 595-599. 1991
157WAGR, WT1
The distal region of 11p13 and associated genetic diseases.
Mannens M, et al.
Genomics 11 : 284-293. 1991
158WT1
WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour.
Pelletier J, et al.
Nature 353 : 431-434. 1991
159WT1
Characterization of regions on human chromosome 11p involved in the development of Wilms' tumour associated congenital diseases. A model to study genomic imprinting in man.
Mannens M, et al.
(HGM11) Cytogenet Cell Genet 58 : 1967. 1991
160WT1
Alternative splicing and genomic structure of the Wilms tumor gene WT1.
Haber DA, et al.
Proc Natl Acad Sci U S A 88 : 9618-9622. 1991
161WT1
Hinfl polymorphism within the 3' untranslated region of the candidate Wilms tumour gene.
Hoban PR, et al.
Nucleic Acids Res 19 : 1164. 1991
162WT1
Smallest region of overlap in Wilms tumor deletions uniquely implicates an 11p13 zinc finger gene as the disease locus.
Ton CCT, et al.
Genomics 10 : 293-297. 1991
163WT1
Parental origin of de novo constitutional deletions of chromosomal band 11p13.
Huff V, et al.
Am J Hum Genet 47 : 155-160. 1990
164WAGR, WT1
Constitutional and somatic deletions of two different regions of maternal chromosome 11 in Wilms tumor.
Jeanpierre C, et al.
Genomics 7 : 434-438. 1990
165TSG16B, WT1
Homozygous deletion in Wilms tumours of a Zinc-finger gene identified by chromosome jumping.
Gessler M, et al.
Nature 343 : 774-778. 1990
166WT1, WT2
Loss of heterozygosity in Wilms' tumour involves two distinct regions of chromosome 11.
Wadey RB, et al.
Oncogene 5 : 901-907. 1990
167WT1
An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor.
Haber DA, et al.
Cell 61 : 1257-1269. 1990
168WT1
Wilms tumor locus on 11p13 defined by multiple CpG island-associated transcripts.
Bonetta L, et al.
Science 250 : 994-997. 1990
169WT1
Complete physical map of the WAGR region of 11p13 localizes a candidate Wilms' tumor gene.
Rose EA, et al.
Cell 60 : 495-508. 1990
170WT1
Isolation and charaterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus.
Call KM, et al.
Cell 60 : 509-520. 1990
171WT1
Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor.
Huang A, Campbell CE, Bonetta L, McAndrews-Hill MS, Chilton-MacNeill S,Coppes MJ, Law DJ, Feinberg AP, Yeger H, Williams BR.
Science 250(4983):991-4. 1990
172WT1, D11S378
Mapping of regions of loss of heterozygosity in Wilms' tumors.
Wadey RB, et al.
(HGM10) Cytogenet Cell Genet 51 : 1100. 1989
173WT1
Characterization of a homozygous deletion mapping to the Wilms tumor region on 11p13.
Bonetta L, et al.
(HGM10) Cytogenet Cell Genet 51 : 965. 1989
174WT1
Loss of constitutional heterozygosity in Wilms' tumor is limited to chromosome 11 and does not involve other chromosomal regions associated with known tumor suppressor genes.
Mannens M, et al.
(HGM10) Cytogenet Cell Genet 51 : 1039. 1989
175WT1
Loss of alleles for 11p regions in hereditary and sporadic childhood tumors.
Henry I, et al.
(HGM10) Cytogenet Cell Genet 51 : 1012-1013. 1989
176 WT1, LMO2, TRD@
The chromosome 11 region flanking the t(11;14) breakpoint in human T-ALL is deleted in Wilms' tumor hybrids.
Finver SN, et al.
Oncogene Res 5 : 143-148. 1989
177WT1, WT2
Molecular nature of genetic changes resulting in loss of heterozygosity of chromosome 11 in Wilm's tumours.
Mannens M, et al.
Hum Genet 81 : 41-48. 1988
178D11S87, TRA@, WT1
Homozygous deletion of a DNA marker from chromosome 11p13 in sporadic Wilms tumor.
Lewis WH, et al.
Genomics 3 : 25-31. 1988