| 1 | WRN
|
| Acidic domain of WRNp is critical for autophagy and up-regulates age associated proteins.
|
| Maity J, Das B, Bohr VA, Karmakar P.
|
| DNA Repair (Amst) 68:1-11. doi: 10.1016/j.dnarep.2018.05.003. Epub 2018 May 18.
2018
|
| 2 | RECQL5, WRN
|
| RECQL5 plays co-operative and complementary roles with WRN syndrome helicase.
|
| Popuri V, Huang J, Ramamoorthy M, Tadokoro T, Croteau DL, Bohr VA.
|
| Nucleic Acids Res 45(3):1566. doi: 10.1093/nar/gkw1216.
2017
|
| 3 | WRN
|
| Single-molecule studies reveal reciprocating of WRN helicase core along ssDNA during DNA unwinding.
|
| Wu WQ, Hou XM, Zhang B, Fossé P, René B, Mauffret O, Li M, Dou SX, Xi XG.
|
| Sci Rep 7:43954. doi: 10.1038/srep43954.
2017
|
| 4 | WRN
|
| Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase Are Involved in Unwinding G-quadruplex DNA.
|
| Ketkar A, Voehler M, Mukiza T, Eoff RL.
|
| J Biol Chem 292(8):3154-3163. doi: 10.1074/jbc.M116.767699. Epub 2017 Jan 9.
2017
|
| 5 | BLM, WRN
|
| Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases.
|
| de Renty C, Ellis NA.
|
| Ageing Res Rev 33:36-51. doi: 10.1016/j.arr.2016.05.010. Epub 2016 May 26. Review.
2017
|
| 6 | WRN
|
| WRN regulates pathway choice between classical and alternative non-homologous end joining.
|
| Shamanna RA, Lu H, de Freitas JK, Tian J, Croteau DL, Bohr VA.
|
| Nat Commun 7:13785. doi: 10.1038/ncomms13785.
2016
|
| 7 | CDK1, DNA2, EXO1, WRN
|
| CDK1 phosphorylates WRN at collapsed replication forks.
|
| Palermo V, Rinalducci S, Sanchez M, Grillini F, Sommers JA, Brosh RM Jr, Zolla L, Franchitto A, Pichierri P.
|
| Nat Commun 7:12880. doi: 10.1038/ncomms12880.
2016
|
| 8 | BLM, DNA2, WRN
|
| Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases.
|
| Pinto C, Kasaciunaite K, Seidel R, Cejka P.
|
| Elife 5. pii: e18574. doi: 10.7554/eLife.18574.
2016
|
| 9 | WRN
|
| Absence of premature senescence in Werner's syndrome keratinocytes.
|
| Ibrahim B, Sheerin AN, Jennert-Burston K, Bird JL, Massala MV, Illsley M, James SE, Faragher RG.
|
| Exp Gerontol 83:139-47. doi: 10.1016/j.exger.2016.07.017. Epub 2016 Aug 2.
2016
|
| 10 | WRN
|
| The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription.
|
| Tang W, Robles AI, Beyer RP, Gray LT, Nguyen GH, Oshima J, Maizels N, Harris CC, Monnat RJ Jr.
|
| Hum Mol Genet 25(10):2060-2069. Epub 2016 Mar 16.
2016
|
| 11 | ATR, WRN
|
| Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway.
|
| Su F, Bhattacharya S, Abdisalaam S, Mukherjee S, Yajima H, Yang Y, Mishra R, Srinivasan K, Ghose S, Chen DJ, Yannone SM, Asaithamby A.
|
| Oncotarget 7(1):46-65. doi: 10.18632/oncotarget.6659.
2016
|
| 12 | BLM, PARP1, RECQL, RECQL4, RECQL5, WRN
|
| RecQ helicases and PARP1 team up in maintaining genome integrity.
|
| Veith S, Mangerich A.
|
| Ageing Res Rev 23(Pt A):12-28. doi: 10.1016/j.arr.2014.12.006. Epub 2014 Dec 30. Review.
2015
|
| 13 | PARP1, RECQL5, WRN
|
| Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities.
|
| Khadka P, Hsu JK, Veith S, Tadokoro T, Shamanna RA, Mangerich A, Croteau DL, Bohr VA.
|
| Mol Cell Biol 35(23):3974-89. doi: 10.1128/MCB.00427-15. Epub 2015 Sep 21.
2015
|
| 14 | WRN
|
| The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events.
|
| Edwards DN, Machwe A, Chen L, Bohr VA, Orren DK.
|
| Nat Commun 6:8331. doi: 10.1038/ncomms9331.
2015
|
| 15 | WRN
|
| WRN translocation from nucleolus to nucleoplasm is regulated by SIRT1 and required for DNA repair and the development of chemoresistance.
|
| Lee SY, Lee H, Kim ES, Park S, Lee J, Ahn B.
|
| Mutat Res 774:40-8. doi: 10.1016/j.mrfmmm.2015.03.001. Epub 2015 Mar 11.
2015
|
| 16 | BLM, DNA2, RMI1, RMI2, WRN
|
| DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells.
|
| Sturzenegger A, Burdova K, Kanagaraj R, Levikova M, Pinto C, Cejka P, Janscak P.
|
| J Biol Chem 289(39):27314-26. doi: 10.1074/jbc.M114.578823. Epub 2014 Aug 13.
2014
|
| 17 | WRN
|
| Transient overexpression of Werner protein rescues starvation induced autophagy in Werner syndrome cells.
|
| Maity J, Bohr VA, Laskar A, Karmakar P.
|
| Biochim Biophys Acta 1842(12 Pt A):2387-94. doi: 10.1016/j.bbadis.2014.09.007. Epub 2014 Sep 23.
2014
|
| 18 | RECQL, WRN
|
| Human RECQL1 participates in telomere maintenance.
|
| Popuri V, Hsu J, Khadka P, Horvath K, Liu Y, Croteau DL, Bohr VA.
|
| Nucleic Acids Res 42(9):5671-88. doi: 10.1093/nar/gku200. Epub 2014 Mar 12.
2014
|
| 19 | BLM, DNA2, WRN
|
| DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells.
|
| Sturzenegger A, Burdova K, Kanagaraj R, Levikova M, Pinto C, Cejka P, Janscak P.
|
| J Biol Chem 289(39):27314-26. doi: 10.1074/jbc.M114.578823. Epub 2014 Aug 13.
2014
|
| 20 | WRN
|
| WRN loss induces switching of telomerase-independent mechanisms of telomere elongation.
|
| Gocha AR, Acharya S, Groden J.
|
| PLoS One 9(4):e93991. doi: 10.1371/journal.pone.0093991. eCollection 2014.
2014
|
| 21 | MUS81, WRN
|
| The WRN and MUS81 proteins limit cell death and genome instability following oncogene activation.
|
| Murfuni I, Nicolai S, Baldari S, Crescenzi M, Bignami M, Franchitto A, Pichierri P.
|
| Oncogene 32(5):610-20. doi: 10.1038/onc.2012.80. Epub 2012 Mar 12.
2013
|
| 22 | RECQL5, WRN
|
| RECQL5 plays co-operative and complementary roles with WRN syndrome helicase.
|
| Popuri V, Huang J, Ramamoorthy M, Tadokoro T, Croteau DL, Bohr VA.
|
| Nucleic Acids Res 41(2):881-99. doi: 10.1093/nar/gks1134. Epub 2012 Nov 23. Erratum in: Nucleic Acids Res. 2016 Dec 6;:. Nucleic Acids Res. 2017 F 2013
|
| 23 | RECQL4, RTS, TERF1, TERF2, WRN
|
| RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance.
|
| Ghosh AK, Rossi ML, Singh DK, Dunn C, Ramamoorthy M, Croteau DL, Liu Y, Bohr VA.
|
| J Biol Chem 287(1):196-209. doi: 10.1074/jbc.M111.295063. Epub 2011 Oct 28.
2012
|
| 24 | POLD1, WRN
|
| The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δ.
|
| Kamath-Loeb AS, Shen JC, Schmitt MW, Loeb LA.
|
| J Biol Chem 287(15):12480-90. doi: 10.1074/jbc.M111.332577. Epub 2012 Feb 17.
2012
|
| 25 | WRN
|
| The Werner syndrome protein promotes CAG/CTG repeat stability by resolving large (CAG)(n)/(CTG)(n) hairpins.
|
| Chan NL, Hou C, Zhang T, Yuan F, Machwe A, Huang J, Orren DK, Gu L, Li GM.
|
| J Biol Chem 287(36):30151-6. doi: 10.1074/jbc.M112.389791. Epub 2012 Jul 11.
2012
|
| 26 | POLN, WRN
|
| Enhancement of human DNA polymerase η activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome protein.
|
| Maddukuri L, Ketkar A, Eddy S, Zafar MK, Griffin WC, Eoff RL.
|
| J Biol Chem 287(50):42312-23. doi: 10.1074/jbc.M112.410332. Epub 2012 Oct 8.
2012
|
| 27 | POT1, WRN
|
| Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation.
|
| Takahashi K, Imano R, Kibe T, Seimiya H, Muramatsu Y, Kawabata N, Tanaka G, Matsumoto Y, Hiromoto T, Koizumi Y, Nakazawa N, Yanagida M, Yukawa M, Tsuchiya E, Ueno M.
|
| Mol Cell Biol 31(3):495-506. Epub 2010 Nov 22.
2011
|
| 28 | RPA1, WRN
|
| Molecular cooperation between the Werner syndrome protein and replication protein A in relation to replication fork blockage.
|
| Machwe A, Lozada E, Wold MS, Li GM, Orren DK.
|
| J Biol Chem 286(5):3497-508. Epub 2010 Nov 24.
2011
|
| 29 | ERCC5, WRN
|
| The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome.
|
| Trego KS, Chernikova SB, Davalos AR, Perry JJ, Finger LD, Ng C, Tsai MS, Yannone SM, Tainer JA, Campisi J, Cooper PK.
|
| Cell Cycle 10(12):1998-2007. Epub 2011 Jun 15.
2011
|
| 30 | RECQL, WRN
|
| RECQL1 and WRN proteins are potential therapeutic targets in head and neck squamous cell carcinoma.
|
| Arai A, Chano T, Futami K, Furuichi Y, Ikebuchi K, Inui T, Tameno H, Ochi Y, Shimada T, Hisa Y, Okabe H.
|
| Cancer Res 71(13):4598-607. Epub 2011 May 13.
2011
|
| 31 | BLM, WRN
|
| The Werner and Bloom syndrome proteins help resolve replication blockage by converting (regressed) holliday junctions to functional replication forks.
|
| Machwe A, Karale R, Xu X, Liu Y, Orren DK.
|
| Biochemistry 50(32):6774-88. Epub 2011 Jul 21.
2011
|
| 32 | ERCC5, WRN, XPG
|
| XPG and WRN: an unexpected partnership.
|
| Kamath-Loeb AS, Loeb LA.
|
| Cell Cycle 10(18):3051. Epub 2011 Sep 15. No abstract available.
2011
|
| 33 | WRN
|
| WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations.
|
| Friedrich K, Lee L, Leistritz DF, Nürnberg G, Saha B, Hisama FM, Eyman DK, Lessel D, Nürnberg P, Li C, Garcia-F-Villalta MJ, Kets CM, Schmidtke J, Cruz VT, Van den Akker PC, Boak J, Peter D, Compoginis G, Cefle K, Ozturk S, López N, Wessel T, Poot M, Ippel PF, Groff-Kellermann B, Hoehn H, Martin GM, Kubisch C, Oshima J.
|
| Hum Genet 128(1):103-11. Epub 2010 May 5.PMID: 20443122 2010
|
| 34 | TERF2, WRN
|
| Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase.
|
| Nora GJ, Buncher NA, Opresko PL.
|
| Nucleic Acids Res 38(12):3984-98. Epub 2010 Mar 9. 2010
|
| 35 | DHX9, WRN
|
| WRN helicase unwinds Okazaki fragment-like hybrids in a reaction stimulated by the human DHX9 helicase.
|
| Chakraborty P, Grosse F.
|
| Nucleic Acids Res 38(14):4722-30. Epub 2010 Apr 12.
2010
|
| 36 | WRN
|
| Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity.
|
| Perry JJ, Asaithamby A, Barnebey A, Kiamanesch F, Chen DJ, Han S, Tainer JA, Yannone SM.
|
| J Biol Chem 285(33):25699-707. Epub 2010 Jun 1.
2010
|
| 37 | ATM, ATR, RAD51, WRN
|
| ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery.
|
| Ammazzalorso F, Pirzio LM, Bignami M, Franchitto A, Pichierri P.
|
| EMBO J 29(18):3156-69. Epub 2010 Aug 27. 2010
|
| 38 | POT1, WRN
|
| Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN.
|
| Arnoult N, Saintome C, Ourliac-Garnier I, Riou JF, Londoño-Vallejo A.
|
| Genes Dev 23(24):2915-24.
2009
|
| 39 | WRN
|
| The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer.
|
| Compton SA, Tolun G, Kamath-Loeb AS, Loeb LA, Griffith JD.
|
| J Biol Chem 283(36):24478-83. Epub 2008 Jul 2.
2008
|
| 40 | MUS81, WRN
|
| The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis.
|
| Muftuoglu M, Oshima J, von Kobbe C, Cheng WH, Leistritz DF, Bohr VA.
|
| Hum Genet 124(4):369-77. Epub 2008 Sep 23. Review. 2008
|
| 41 | MUS81, WRN
|
| Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway.
|
| Franchitto A, Pirzio LM, Prosperi E, Sapora O, Bignami M, Pichierri P.
|
| J Cell Biol 183(2):241-52. Epub 2008 Oct 13.
2008
|
| 42 | WRN
|
| Werner syndrome helicase activity is essential in maintaining fragile site stability.
|
| Pirzio LM, Pichierri P, Bignami M, Franchitto A.
|
| J Cell Biol 180(2):305-14. Epub 2008 Jan 21.PMID: 18209099 2008
|
| 43 | WRN
|
| Werner protein cooperates with the XRCC4-DNA ligase IV complex in end-processing.
|
| Kusumoto R, Dawut L, Marchetti C, Wan Lee J, Vindigni A, Ramsden D, Bohr VA.
|
| Biochemistry 47(28):7548-56. Epub 2008 Jun 18.PMID: 18558713 2008
|
| 44 | WRN
|
| Telomere dysfunction as a cause of genomic instability in Werner syndrome.
|
| Crabbe L, Jauch A, Naeger CM, Holtgreve-Grez H, Karlseder J.
|
| Proc Natl Acad Sci U S A 104(7):2205-10. Epub 2007 Feb 6. 2007
|
| 45 | WRN, LMNA, PRO1
|
| Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases.
|
| Kudlow BA, Kennedy BK, Monnat RJ Jr.
|
| Nat Rev Mol Cell Biol 8(5):394-404. 2007
|
| 46 | WRN, NEIL1
|
| The Human Werner Syndrome Protein Stimulates Repair of Oxidative DNA Base Damage by the DNA Glycosylase NEIL1.
|
| Das A, Boldogh I, Lee JW, Harrigan JA, Hegde ML, Piotrowski J, de Souza Pinto N, Ramos W, Greenberg MM, Hazra TK, Mitra S, Bohr VA.
|
| J Biol Chem 282(36):26591-602. Epub 2007 Jul 3. 2007
|
| 47 | MSH2, WRN
|
| Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors.
|
| Saydam N, Kanagaraj R, Dietschy T, Garcia PL, Pena-Diaz J, Shevelev I, Stagljar I, Janscak P.
|
| Nucleic Acids Res 35(17):5706-16. Epub 2007 Aug 22. 2007
|
| 48 | WRN
|
| Metal-catalyzed Oxidation of the Werner Syndrome Protein Causes Loss of Catalytic Activities and Impaired Protein-Protein Interactions.
|
| Harrigan JA, Piotrowski J, Di Noto L, Levine RL, Bohr VA.
|
| J Biol Chem 282(50):36403-11. Epub 2007 Oct 2. 2007
|
| 49 | WRN
|
| The role of WRN in DNA repair is affected by post-translational modifications.
|
| Kusumoto R, Muftuoglu M, Bohr VA.
|
| Mech Ageing Dev 128(1):50-7. Epub 2006 Nov 20. Review.
2007
|
| 50 | BGS, BLM, RAPADILINO, RECQL4, WRN
|
| The molecular role of the Rothmund-Thomson-, RAPADILINO- and Baller-Gerold-gene product, RECQL4: recent progress.
|
| Dietschy T, Shevelev I, Stagljar I.
|
| Cell Mol Life Sci 64(7-8):796-802. Review.
2007
|
| 51 | BLM, BLMS, WRN
|
| The Werner and Bloom syndrome proteins catalyze regression of a model replication fork.
|
| Machwe A, Xiao L, Groden J, Orren DK.
|
| Biochemistry 45(47):13939-46. 2006
|
| 52 | WRN
|
| The spectrum of WRN mutations in Werner syndrome patients.
|
| Huang S, Lee L, Hanson NB, Lenaerts C, Hoehn H, Poot M, Rubin CD, Chen DF, Yang CC, Juch H, Dorn T, Spiegel R, Oral EA, Abid M, Battisti C, Lucci-Cordisco E, Neri G, Steed EH, Kidd A, Isley W, Showalter D, Vittone JL, Konstantinow A, Ring J, Meyer P, Wenger SL, von Herbay A, Wollina U, Schuelke M, Huizenga CR, Leistritz DF, Martin GM, Mian IS, Oshima J.
|
| Hum Mutat 27(6):558-67. 2006
|
| 53 | WRN
|
| A role for WRN in telomere-based DNA damage responses.
|
| Eller MS, Liao X, Liu S, Hanna K, Backvall H, Opresko PL, Bohr VA, Gilchrest BA.
|
| Proc Natl Acad Sci U S A 103(41):15073-8. Epub 2006 Oct 2. 2006
|
| 54 | WRN
|
| The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta.
|
| Harrigan JA, Wilson DM 3rd, Prasad R, Opresko PL, Beck G, May A, Wilson SH, Bohr VA.
|
| Nucleic Acids Res 34(2):745-54. Print 2006. 2006
|
| 55 | WRN, RPA1, BLM
|
| Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases.
|
| Doherty KM, Sommers JA, Gray MD, Lee JW, von Kobbe C, Thoma NH, Kureekattil RP, Kenny MK, Brosh RM Jr.
|
| J Biol Chem 280(33):29494-505. Epub 2005 Jun 17. 2005
|
| 56 | WRN, DHX9
|
| Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity.
|
| Friedemann J, Grosse F, Zhang S.
|
| J Biol Chem 280(35):31303-13. Epub 2005 Jul 1. 2005
|
| 57 | BLM,POT1,WRN
|
| POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.
|
| Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech TR, Bohr VA.
|
| J Biol Chem 280(37):32069-80. Epub 2005 Jul 18. 2005
|
| 58 | WRN
|
| Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain.
|
| Lee JW, Kusumoto R, Doherty KM, Lin GX, Zeng W, Cheng WH, von Kobbe C, Brosh RM Jr, Hu JS, Bohr VA.
|
| J Biol Chem 280(47):39627-36. Epub 2005 Sep 7. 2005
|
| 59 | WRN
|
| Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells.
|
| Baird DM, Davis T, Rowson J, Jones CJ, Kipling D.
|
| Hum Mol Genet 13(14):1515-24. Epub 2004 May 18. 2004
|
| 60 | WRN
|
| Essential role of limiting telomeres in the pathogenesis of Werner syndrome.
|
| Chang S, Multani AS, Cabrera NG, Naylor ML, Laud P, Lombard D, Pathak S, Guarente L, DePinho RA.
|
| Nat Genet 36(8):877-82. Epub 2004 Jul 04. 2004
|
| 61 | WRN, FEN1
|
| In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication.
|
| arma S, Sommers JA, Brosh RM Jr.
|
| Hum Mol Genet 13(19):2247-61. Epub 2004 Jul 28. 2004
|
| 62 | WRN
|
| Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.
|
| Crabbe L, Verdun RE, Haggblom CI, Karlseder J.
|
| Science 306(5703):1951-3. 2004
|
| 63 | TERF2, WRN
|
| TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA.
|
| Machwe A, Xiao L, Orren DK.
|
| Oncogene 23(1):149-56. 2004
|
| 64 | WRN
|
| The Werner syndrome protein has separable recombination and survival functions.
|
| Swanson C, Saintigny Y, Emond MJ, Monnat RJ Jr.
|
| DNA Repair (Amst) 3(5):475-82. 2004
|
| 65 | WRN
|
| The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function.
|
| Blank A, Bobola MS, Gold B, Varadarajan S, D Kolstoe D, Meade EH, Rabinovitch PS, Loeb LA, Silber JR.
|
| DNA Repair (Amst) 3(6):629-38. 2004
|
| 66 | WRN
|
| The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2.
|
| Opresko PL, Otterlei M, Graakjaer J, Bruheim P, Dawut L, Kolvraa S, May A, Seidman MM, Bohr VA.
|
| Mol Cell 14(6):763-74. 2004
|
| 67 | WRN
|
| The enzymatic activities of the Werner syndrome protein are disabled by the amino acid polymorphism R834C.
|
| Kamath-Loeb AS, Welcsh P, Waite M, Adman ET, Loeb LA.
|
| J Biol Chem 279(53):55499-505. Epub 2004 Oct 15. 2004
|
| 68 | WRN
|
| Gene expression profiling in Werner syndrome closely resembles that of normal aging.
|
| Kyng KJ, May A, Kolvraa S, Bohr VA.
|
| Proc Natl Acad Sci U S A 100(21):12259-64. Epub 2003 Oct 03. 2003
|
| 69 | WRN
|
| Neurological complications of Werner's syndrome.
|
| Anderson NE, Haas LF.
|
| J Neurol 250(10):1174-8. 2003
|
| 70 | BLM, MRE11A, NBS1, RAD50, WRN, NBN
|
| Protecting genomic integrity during DNA replication: correlation between Werner's and Bloom's syndrome gene products and the MRE11 complex.
|
| Franchitto A, Pichierri P.
|
| Hum Mol Genet 11(20):2447-53. 2002
|
| 71 | WRN
|
| Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase.
|
| Brosh RM Jr, Waheed J, Sommers JA.
|
| J Biol Chem 277(26):23236-45. Epub 2002 Apr 15. 2002
|
| 72 | WRN, BLM
|
| Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins.
|
| von Kobbe C, Karmakar P, Dawut L, Opresko P, Zeng X, Brosh RM Jr, Hickson ID, Bohr VA.
|
| J Biol Chem 277(24):22035-44. Epub 2002 Mar 27. 2002
|
| 73 | WRN, FEN1
|
| Biochemical characterization of the WRN-FEN-1 functional interaction.
|
| Brosh RM Jr, Driscoll HC, Dianov GL, Sommers JA.
|
| Biochemistry 41(40):12204-16. 2002
|
| 74 | TERF2, BLM, WRN
|
| Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases.
|
| Opresko PL, von Kobbe C, Laine JP, Harrigan J, Hickson ID, Bohr VA.
|
| J Biol Chem 277(43):41110-9. Epub 2002 Aug 13. 2002
|
| 75 | WRN
|
| The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro.
|
| Orren DK, Theodore S, Machwe A.
|
| Biochemistry 41(46):13483-8. 2002
|
| 76 | WRN, PRKAR1B
|
| Regulation of the Werner helicase through a direct interaction with a subunit of protein kinase A.
|
| Nguyen DT, Rovira II, Finkel T.
|
| FEBS Lett 521(1-3):170-4. 2002
|
| 77 | WRN, XRCC5
|
| A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA.
|
| Orren DK, Machwe A, Karmakar P, Piotrowski J, Cooper MP, Bohr VA.
|
| Nucleic Acids Res 29(9):1926-1934. 2001
|
| 78 | WRN
|
| The Werner syndrome gene and global sequence variation.
|
| Passarino G, Shen P, Van Kirk JB, Lin AA, De Benedictis G, Cavalli Sforza LL, Oefner PJ, Underhill PA.
|
| Genomics 71(1):118-22. 2001
|
| 79 | BLM, WRN
|
| The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases.
|
| Mohaghegh P, Karow JK, Brosh Jr RM Jr, Bohr VA, Hickson ID.
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| Nucleic Acids Res 29(13):2843-9. 2001
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| 80 | FEN1, WRN
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| Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity.
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| Brosh RM Jr, von Kobbe C, Sommers JA, Karmakar P, Opresko PL, Piotrowski J, Dianova I, Dianov GL, Bohr VA.
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| EMBO J 20(20):5791-801. 2001
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| 81 | PRKDC, WRN
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| Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase.
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| Yannone SM, Roy S, Chan DW, Murphy MB, Huang S, Campisi J, Chen DJ.
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| J Biol Chem 276(41):38242-8. 2001
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| 82 | ATM, ATR, TREX1, WRN
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| ATR and ATRIP: partners in checkpoint signaling.
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| Cortez D, Guntuku S, Qin J, Elledge SJ.
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| Science 294(5547):1713-6. 2001
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| 83 | WRN
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| Telomerase prevents the accelerated cell ageing of werner syndrome fibroblasts.
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| 84 | POLD1, WRN
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| Functional interaction between the Werner Syndrome protein and DNA polymerase delta.
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| Proc Natl Acad Sci U S A 97(9):4603-8. 2000
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| 85 | SLC2A1, WRN
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| Association of impaired phosphatidylinositol 3-kinase activity in GLUT1-containing vesicles with malinsertion of glucose transporters into the plasma membrane of fibroblasts from a patient with severe insulin resistance and clinical features of Werner syndrome.
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| Kausch C, Hamann A, Uphues I, Niendorf A, Muller-Wieland D, Joost HG, Algenstaedt P, Dreyer M, Rudiger HW, Haring HU, Eckel J, Matthaei S.
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| J Clin Endocrinol Metab 85(2):905-18. 2000
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| 86 | TSG8B, WRN
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| Chromosome translocations in breast cancer with breakpoints at 8p12.
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| Courtay-Cahen C, Morris JS, Edwards PA.
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| Genomics 66(1):15-25. 2000
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| 87 | POLD2, WRN
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| Werner protein recruits DNA polymerase delta to the nucleolus.
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| Szekely AM, Chen YH, Zhang C, Oshima J, Weissman SM.
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| Proc Natl Acad Sci U S A 97(21):11365-70. 2000
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| 88 | WRN
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| Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis.
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| Castro E, Edland SD, Lee L, Ogburn CE, Deeb SS, Brown G, Panduro A, Riestra R, Tilvis R, Louhija J, Penttinen R, Erkkola R, Wang L, Martin GM, Oshima J.
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| Am J Med Genet 95(4):374-80. 2000
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| 89 | WRN
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| The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseases.
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| Shen JC, Loeb LA.
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| Trends Genet 16(5):213-20. Review. 2000
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| 90 | WRN
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| Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest.
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| Constantinou A, Tarsounas M, Karow JK, Brosh RM, Bohr VA, Hickson ID, West SC.
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| EMBO Rep 1(1):80-4. 2000
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| 91 | WRN
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| Polymorphisms at the Werner locus : I. Newly identified polymorphisms, ethnic variability of 1367Cy/arg, and its stability in a population of Finnish centenarians.
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| Castro E, et al.
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| Am J Med Genet 82 : 399-403. 1999
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| 92 | WRN
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| WRN mutations in Werner syndrome.
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| Moser MJ, et al.
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| Hum Mutat 13 : 271-279. 1999
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| 93 | WRN
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| Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding.
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| Suzuki N, et al.
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| Nucleic Acids Res 27(11):2361-2368. 1999
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| 94 | WRN
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| Cell fusion corrects the 4-nitroquinoline 1-oxide sensitivity of Werner syndrome fibroblast cell lines.
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| Prince PR, et al.
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| Hum Genet 105(1-2):132-8. 1999
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| 95 | WRN
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| The Werner syndrome protein is involved in RNA polymerase II transcription.
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| Balajee AS, Machwe A, May A, Gray MD, Oshima J, Martin GM, Nehlin JO, Brosh R, Orren DK, Bohr VA.
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| Mol Biol Cell 10(8):2655-68 1999
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| 96 | WRN
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| Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization.
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| Shiratori M, Sakamoto S, Suzuki N, Tokutake Y, Kawabe Y, Enomoto T, Sugimoto M, Goto M, Matsumoto T, Furuichi Y.
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| J Cell Biol 144(1):1-9 1999
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| 97 | TP53, WRN
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| Physical and functional interaction between p53 and the Werner's syndrome protein.
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| Blander G, Kipnis J, Leal JF, Yu CE, Schellenberg GD, Oren M.
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| J Biol Chem 274(41):29463-9. 1999
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| 98 | WRN
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| Physical map of the human chromosome 8p12-p21 encompassing tumor suppressor and Werner's syndrome gene loci.
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| Ichikawa K, et al.
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| DNA Res 5 : 103-113. 1998
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| 99 | WRN
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| Characterization of Werner syndrome protien DNA helicase activity : directionality, substrate dependence and stimulation by replication protein A.
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| Shen JC, et al.
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| Nucleic Acids Res 26 : 2879-2885. 1998
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| 100 | WRN
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| Nucleolar localization of the Werner syndrome protein in human cells.
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| Marciniak RA, et al.
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| Proc Natl Acad Sci U S A 95 : 6887-6892. 1998
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| 101 | WRN
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| Structure and function of the human Werner syndrome gene promoter : evidence for transcriptional modulation.
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| Wang L, et al.
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| Nucleic Acids Res 26 : 3480-3485. 1998
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| 102 | WRN
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| Replication focus-forming activity 1 and the Werner syndrome gene product.
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| Yan H, et al.
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| Nat Genet 19 : 375-379. 1998
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| 103 | WRN
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| The premature ageing syndrome protein, WRN, is a 3'-5' exonuclease.
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| Huang S, et al.
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| Nat Genet 20 : 114-116. 1998
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| 104 | BLM, RECQL4, RECQL5, WRN
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| Cloning of two new human helicase genes of the RecQ family : biological significance of multiple species in higher eukaryotes.
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| Kitao S, Ohsugi I, Ichikawa K, Goto M, Furuichi Y, Shimamoto A.
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| Genomics 54 : 443-452. 1998
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| 105 | WRN
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| Werner syndrome protein. II. Characterization of the integral 3'-->5' DNA exonuclease.
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| Kamath-Loeb AS, et al.
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| J Biol Chem 273 : 34145-34150. 1998
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| 106 | WRN
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| Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.
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| Shen JC, et al.
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| J Biol Chem 273 : 34139-34144. 1998
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| 107 | WRN
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| Analysis of helicase gene mutations in Japanese Werner's syndrome patients.
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| Goto M, et al.
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| Hum Genet 99 : 191-193. 1997
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| 108 | WRN
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| Mutations in the consensus helicase domains of the Werner syndrome gene.
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| Yu CE, et al.
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| Am J Hum Genet 60 : 330-341. 1997
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| 109 | WRN
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| Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population.
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| Ye L, et al.
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| Am J Med Genet 68 : 494-498. 1997
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| 110 | WRN
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| Mutation and haplotype analyses of the Werner's syndrome gene based on its genomic structure: genetic epidemiology in the Japanese population.
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| Matsumoto T, Imamura O, Yamabe Y, Kuromitsu J, Tokutake Y, Shimamoto A, Suzuki N, Satoh M, Kitao S, Ichikawa K, Kataoka H, Sugawara K, Thomas W, Mason B, Tsuchihashi Z, Drayna D, Sugawara M, Sugimoto M, Furuichi Y, Goto M.
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| Hum Genet 100(1):123-30. 1997
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| 111 | D8S339, WRN
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| A 2.8 megabase YAC contig spanning D8S339, which is tightly linked to the Werner syndrome locus.
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| Genome 40 : 77-83. 1997
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| 112 | WRN
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| Impaired nuclear localization of defective DNA helicases in Werner's syndrome.
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| Matsumoto T, Shimamoto A, Goto M, Furuichi Y.
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| Nat Genet 16(4):335-6. 1997
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| 113 | WRN
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| The Werner syndrome protein is a DNA helicase.
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| Gray MD, Shen JC, Kamath-Loeb AS, Blank A, Sopher BL, Martin GM, Oshima J, Loeb LA.
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| Nat Genet 17(1):100-3. 1997
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| 114 | WRN
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| Werner syndrome : characterization of mutations in the WRN gene in an affected family.
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| Eur J Hum Genet 5(6):364-70. 1997
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| 115 | GTF2E2, NRG1, NEFL, FGFR1, POLB, PPP2CB, WRN
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| Integrated map of the chromosome 8p12-p21 region, a region involved in human cancers and Werner syndrome.
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| Imbert A, et al.
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| Genomics 32 : 29-38. 1996
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| 116 | WRN
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| Positional cloning of the Werner's syndrome gene.
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| Yu CE, et al.
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| Science 272 : 258-262. 1996
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| 117 | WRN, POLB
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| A 3.1-Mb YAC contig within the Werner syndrome region, on the short arm of human chromosome 8.
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| Chaffanet M, et al.
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| Cytogenet Cell Genet 72 : 63-68. 1996
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| 118 | WRN
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| Toward localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping : lessons learned from analysis of 35 chromosome 8p11.1-21.1 markers.
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| Am J Hum Genet 58 : 1286-1302. 1996
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| 119 | D8S2138, D8S2144, D8S2150, D8S2156, D8S2162, D8S2168, D8S2174, D8S2180, D8S2186, D8S2192, D8S2196, D8S2206, WRN
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| Narrowing the position of the Werner syndrome locus by homozygosity analysis-extension of homozygosity analysis.
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| Nakura J, et al.
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| Genomics 36 : 130-141. 1996
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| 120 | WRN
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| Cloning the gene for Werner syndrome : a disease with many symptoms of premature aging.
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| Trends in Genet 12 : 283-286. 1996
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| 121 | WRN, D8S2134
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| A YAC, P1, and cosmid contig and 17 new polymorphic markers for the Werner syndrome region at 8p12-p21.
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| Yu CE, et al.
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| Genomics 35 : 431-440. 1996
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| 122 | WRN
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| Homozygous and compound heterozygous mutations at the Werner syndrome locus.
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| Hum Mol Genet 5 : 1909-1913. 1996
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| 123 | WRN
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| Estimation of the physical distance between major genomic markers in the Werner syndrome locus (8p11.2-12) by dual-color FISH analysis.
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| Jpn J Hum Genet 41 : 291-297. 1996
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| 124 | BLM, WRN
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| Human homologues of yeast helicase.
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| Nature 383 : 678-679. 1996
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| 125 | WRN, D8S1055
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| Genetic association between chromosome 8 microsatellite (MS8-134) and Werner syndrome (WRN) : chromosome microdissection and homozygosity mapping.
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| Genomics 28 : 566-569. 1995
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| 126 | WRN
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| FFA-1, a protein that promotes the formation of replication centers within nuclei.
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| Yan H, et al.
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| Science 269 : 1883-1885. 1995
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| 127 | WRN, TSG8B, TSG8A
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| Deletion mapping of chromosome 8p in colorectal carcinoma and dysplasia arising in ulcerative colitis, prostatic carcinoma, and malignant fibrous histiocytomas.
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| Am J Pathol 144 : 1-6. 1994
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| 128 | WRN
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| Evidence against DNA polymerase beta as a candidate gene for Werner syndrome.
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| Hum Genet 93 : 507-512. 1994
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| 129 | WRN, POLB
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| Identification of mutations in DNA polymerase beta mRNAs from patients with Werner syndrome.
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| Biochem Biophys Res Commun 200(1):219-25. 1994
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| 130 | WRN
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| Integrated mapping analysis of the Werner syndrome region of chromosome 8.
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| Oshima J, et al.
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| Genomics 23 : 100-113. 1994
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| 131 | WRN
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| Homozygosity mapping of the Werner syndrome locus (WRN).
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| Genomics 23 : 600-608. 1994
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| 132 | WRN
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| Isolation and mapping of microsatellites from a library microdissected from the Werner syndrome region, 8p11.2-p22.
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| Jpn J Hum Genet 38 : 391-397. 1993
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| 133 | WRN
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| A genetic analysis of the Werner syndrome region on human chromosome 8p.
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| Genomics 16 : 685-690. 1993
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| 134 | WRN
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| Close linkage of the gene for Werner's syndrome to ANK1 and D8S87 on the short arm of chromosome 8.
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| Nakura J, et al.
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| Gerontology 39 : 11-15. 1993
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| 135 | WRN
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| Genetic linkage of Werner's syndrome to five markers on chromosome 8.
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| 136 | WRN
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| Homozygosity mapping and Werner's syndrome.
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| 137 | WRN
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| 138 | WRN
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| Clonal structural chromosomal rearrangements in primary fibroblast cultures and in lymphocytes of patients with Werner's Syndrome.
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| 139 | WRN
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| Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism.
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