| 1 | ROR1, WNT5A
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| The signaling pathways activated by ROR1 in cancer.
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| Quezada MJ, Lopez-Bergami P.
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| Cell Signal. Apr;104:110588. doi: 10.1016/j.cellsig.2023.110588. Epub 2023 Jan 5. 2023
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| 2 | WNT5A, WNT7A
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| Porcupine-dependent Wnt signaling controls stromal proliferation and endometrial gland maintenance through the action of distinct WNTs.
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| Farah O, Biechele S, Rossant J, Dufort D.
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| Dev Biol 422(1):58-69. doi: 10.1016/j.ydbio.2016.11.023. Epub 2016 Dec 10.
2017
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| 3 | MOV10, WNT5A
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| Regulation of lipid synthesis by the RNA helicase Mov10 controls Wnt5a production.
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| Wang W, Snyder N, Worth AJ, Blair IA, Witze ES.
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| Oncogenesis 4:e154. doi: 10.1038/oncsis.2015.15.
2015
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| 4 | POSTN, WNT5A
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| Wnt5a Induces Collagen Production by Human Periodontal Ligament Cells Through TGFβ1-Mediated Upregulation of Periostin Expression.
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| Hasegawa D, Wada N, Maeda H, Yoshida S, Mitarai H, Tomokiyo A, Monnouchi S, Hamano S, Yuda A, Akamine A.
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| J Cell Physiol 230(11):2647-60. doi: 10.1002/jcp.24950.
2015
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| 5 | WNT11, WNT5A
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| Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation.
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| Andre P, Song H, Kim W, Kispert A, Yang Y.
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| Development 142(8):1516-27. doi: 10.1242/dev.119065. Epub 2015 Mar 26.
2015
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| 6 | FZD5, WNT5A
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| Monocyte-secreted Wnt5a interacts with FZD5 in microvascular endothelial cells and induces angiogenesis through tissue factor signaling.
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| Arderiu G, Espinosa S, Peña E, Aledo R, Badimon L.
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| J Mol Cell Biol 6(5):380-93. doi: 10.1093/jmcb/mju036. Epub 2014 Sep 19.
2014
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| 7 | MCAM, WNT5A
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| Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension.
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| Ye Z, Zhang C, Tu T, Sun M, Liu D, Lu D, Feng J, Yang D, Liu F, Yan X.
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| Nat Commun 4:2803. doi: 10.1038/ncomms3803.
2013
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| 8 | PRICKLE1, VANGL2, WNT5A
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| Prickle1 stunts limb growth through alteration of cell polarity and gene expression.
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| Yang T, Bassuk AG, Fritzsch B.
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| Dev Dyn 242(11):1293-306. doi: 10.1002/dvdy.24025. Epub 2013 Sep 6.
2013
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| 9 | WNT3A, WNT5A
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| WNT-3A and WNT-5A counteract lipopolysaccharide-induced pro-inflammatory changes in mouse primary microglia.
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| Halleskog C, Schulte G.
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| J Neurochem 125(6):803-8. doi: 10.1111/jnc.12250. Epub 2013 Apr 22.
2013
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| 10 | FHL2, WNT10B, WNT3A, WNT5A
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| The LIM-only protein FHL2 controls mesenchymal cell osteogenic differentiation and bone formation through Wnt5a and Wnt10b.
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| Brun J, Fromigué O, Dieudonné FX, Marty C, Chen J, Dahan J, Wei Y, Marie PJ.
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| Bone 53(1):6-12. doi: 10.1016/j.bone.2012.11.020. Epub 2012 Nov 29.
2013
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| 11 | FZD5, WNT5A
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| The Wingless homolog Wnt5a stimulates phagocytosis but not bacterial killing.
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| Maiti G, Naskar D, Sen M.
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| Proc Natl Acad Sci U S A 109(41):16600-5. doi: 10.1073/pnas.1207789109. Epub 2012 Sep 24.
2012
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| 12 | ROR2, WNT5A
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| Wnt5a signaling is a substantial constituent in bone morphogenetic protein-2-mediated osteoblastogenesis.
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| Nemoto E, Ebe Y, Kanaya S, Tsuchiya M, Nakamura T, Tamura M, Shimauchi H.
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| Biochem Biophys Res Commun 422(4):627-32. doi: 10.1016/j.bbrc.2012.05.039. Epub 2012 May 15.
2012
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| 13 | MMP13, ROR2, WNT5A
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| Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression.
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| Yamagata K, Li X, Ikegaki S, Oneyama C, Okada M, Nishita M, Minami Y.
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| J Biol Chem 287(2):1588-99. doi: 10.1074/jbc.M111.315127. Epub 2011 Nov 28.
2012
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| 14 | FZD2, WNT5A
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| Suppression of Frizzled-2-mediated Wnt/Ca²⁺ signaling significantly attenuates intracellular calcium accumulation in vitro and in a rat model of traumatic brain injury.
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| Niu LJ, Xu RX, Zhang P, Du MX, Jiang XD.
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| Neuroscience 213:19-28. doi: 10.1016/j.neuroscience.2012.03.057. Epub 2012 Apr 19.
2012
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| 15 | WNT11, WNT5A
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| Wnt5a and Wnt11 are essential for second heart field progenitor development.
|
| Cohen ED, Miller MF, Wang Z, Moon RT, Morrisey EE.
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| Development 139(11):1931-40. doi: 10.1242/dev.069377.
2012
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| 16 | CAMK2A, NCOR2, NOTCH1, RBPJ, WNT5A
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| Wnt5a controls Notch1 signaling through CaMKII-mediated degradation of the SMRT corepressor protein.
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| Ann EJ, Kim HY, Seo MS, Mo JS, Kim MY, Yoon JH, Ahn JS, Park HS.
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| J Biol Chem 287(44):36814-29. doi: 10.1074/jbc.M112.356048. Epub 2012 Aug 10.
2012
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| 17 | ROR2, WNT5A
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| Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of carcinoma cells following Snail-mediated epithelial-mesenchymal transition.
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| Ren D, Minami Y, Nishita M.
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| Genes Cells 16(3):304-15. doi: 10.1111/j.1365-2443.2011.01487.x.
2011
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| 18 | ROR2, WNT5A
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| Wnt5a regulates growth, patterning, and odontoblast differentiation of developing mouse tooth.
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| Lin M, Li L, Liu C, Liu H, He F, Yan F, Zhang Y, Chen Y.
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| Dev Dyn 240(2):432-40. doi: 10.1002/dvdy.22550.
2011
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| 19 | BDB1, RBNS2, ROR2, VANGL2, WNT5A
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| Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B.
|
| Wang B, Sinha T, Jiao K, Serra R, Wang J.
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| Hum Mol Genet 20(2):271-85. Epub 2010 Oct 20.
2011
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| 20 | WNT5A
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| Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence.
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| Bitler BG, Nicodemus JP, Li H, Cai Q, Wu H, Hua X, Li T, Birrer MJ, Godwin AK, Cairns P, Zhang R.
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| Cancer Res 71(19):6184-94. doi: 10.1158/0008-5472.CAN-11-1341. Epub 2011 Aug 4.
2011
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| 21 | KITLG, ROR2, WNT5A
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| Ror2 enhances polarity and directional migration of primordial germ cells.
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| Laird DJ, Altshuler-Keylin S, Kissner MD, Zhou X, Anderson KV.
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| PLoS Genet 7(12):e1002428. doi: 10.1371/journal.pgen.1002428. Epub 2011 Dec 22.
2011
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| 22 | WNT5A
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| WNT5A mutations in patients with autosomal dominant Robinow syndrome.
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| Person AD, Beiraghi S, Sieben CM, Hermanson S, Neumann AN, Robu ME, Schleiffarth JR, Billington CJ Jr, van Bokhoven H, Hoogeboom JM, Mazzeu JF, Petryk A, Schimmenti LA, Brunner HG, Ekker SC, Lohr JL.
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| Dev Dyn 239(1):327-337 2010
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| 23 | FZD2, WNT5A
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| Wnt5a regulates distinct signalling pathways by binding to Frizzled2.
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| Sato A, Yamamoto H, Sakane H, Koyama H, Kikuchi A.
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| EMBO J 29(1):41-54. Epub 2009 Nov 12.PMID: 19910923 2010
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| 24 | APC, CTNNB1, DISC1, DLG4, FZD1, GSK3B, NEUROD1, PRICKLE1, SFRP1, SYN1, WNT1, WNT3, WNT3A, WNT5A, WNT7A
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| Emerging roles of Wnts in the adult nervous system.
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| Inestrosa NC, Arenas E.
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| Nat Rev Neurosci. 11(2):77-86. 2010
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| 25 | WNT5A
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| Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.
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| Gavin BJ, McMahon JA, McMahon AP.
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| Genes Dev. 4(12B):2319-32. 2010
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| 26 | APC, DVL1, WNT5A
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| Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells.
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| Matsumoto S, Fumoto K, Okamoto T, Kaibuchi K, Kikuchi A.
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| EMBO J 29(7):1192-204. Epub 2010 Mar 11. 2010
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| 27 | WNT5A
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| WNT5A inhibits human dental papilla cell proliferation and migration.
|
| Peng L, Ye L, Dong G, Ren LB, Wang CL, Xu P, Zhou XD.
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| Biochem Biophys Res Commun 390(3):1072-8. Epub 2009 Oct 28.PMID: 19878652 2009
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| 28 | WNT5A
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| WNT5A gene is aberrantly methylated from the early stages of colorectal cancers.
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| Hibi K, Mizukami H, Goto T, Kitamura Y, Sakata M, Saito M, Ishibashi K, Kigawa G, Nemoto H, Sanada Y.
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| Hepatogastroenterology 56(93):1007-9.PMID: 19760930 2009
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| 29 | WNT5A
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| Activation of Wnt5A signaling is required for CXC chemokine ligand 12-mediated T-cell migration.
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| Ghosh MC, Collins GD, Vandanmagsar B, Patel K, Brill M, Carter A, Lustig A, Becker KG, Wood WW 3rd, Emeche CD, French AD, O'Connell MP, Xu M, Weeraratna AT, Taub DD.
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| Blood 114(7):1366-73. Epub 2009 Jun 11.PMID: 19520808 2009
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| 30 | WNT5A
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| Wnt5a increases cardiac gene expressions of cultured human circulating progenitor cells via a PKC delta activation.
|
| Koyanagi M, Iwasaki M, Haendeler J, Leitges M, Zeiher AM, Dimmeler S.
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| PLoS One 4(6):e5765.PMID: 19492056 2009
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| 31 | WNT5A
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| Wnt5A activates the calpain-mediated cleavage of filamin A.
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| O'Connell MP, Fiori JL, Baugher KM, Indig FE, French AD, Camilli TC, Frank BP, Earley R, Hoek KS, Hasskamp JH, Elias EG, Taub DD, Bernier M, Weeraratna AT.
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| J Invest Dermatol. 129(7):1782-9. 2009
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| 32 | WNT5A
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| WNT5A is a regulator of fibroblast proliferation and resistance to apoptosis.
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| Vuga LJ, Ben-Yehudah A, Kovkarova-Naumovski E, Oriss T, Gibson KF, Feghali-Bostwick C, Kaminski N.
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| Am J Respir Cell Mol Biol. 41(5):583-9. 2009
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| 33 | WNT5A
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| Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon.
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| Romanowska M, Evans A, Kellock D, Bray SE, McLean K, Donandt S, Foerster J.
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| PLoS One. 4(4):e5354. 2009
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| 34 | WNT5A
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| Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors.
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| Witze ES, Litman ES, Argast GM, Moon RT, Ahn NG.
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| Science 320(5874):365-9. 2008
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| 35 | WNT4, WNT5A
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| Wnt4 and Wnt5a promote adipocyte differentiation.
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| Nishizuka M, Koyanagi A, Osada S, Imagawa M.
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| FEBS Lett 582(21-22):3201-5. Epub 2008 Aug 15.
2008
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| 36 | PAX2, WNT5A
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| WNT5A is regulated by PAX2 and may be involved in blastemal predominant Wilms tumorigenesis.
|
| Tamimi Y, Ekuere U, Laughton N, Grundy P.
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| Neoplasia 10(12):1470-80.PMID: 19048125 2008
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| 37 | WNT5A
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| Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10.
|
| Pereira C, Schaer DJ, Bachli EB, Kurrer MO, Schoedon G.
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| Arterioscler Thromb Vasc Biol. 28(3):504-10. 2008
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| 38 | WNT5A
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| Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration.
|
| Cheng CW, Yeh JC, Fan TP, Smith SK, Charnock-Jones DS.
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| Biochem Biophys Res Commun. 365(2):285-90 2008
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| 39 | WNT5A
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| CaSR stimulates secretion of Wnt5a from colonic myofibroblasts to stimulate CDX2 and sucrase-isomaltase using Ror2 on intestinal epithelia.
|
| Pacheco II, Macleod RJ.
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| Am J Physiol Gastrointest Liver Physiol. 295(4):G748-59. 2008
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| 40 | WNT5A
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| Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo.
|
| Andersson ER, Prakash N, Cajanek L, Minina E, Bryja V, Bryjova L, Yamaguchi TP, Hall AC, Wurst W, Arenas E.
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| PLoS One. 3(10):e3517. 2008
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| 41 | WNT5A
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| Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation.
|
| Nemeth MJ, Topol L, Anderson SM, Yang Y, Bodine DM.
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| Proc Natl Acad Sci U S A 104(39):15436-41. Epub 2007 Sep 19. 2007
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| 42 | CACNA2D3, WNT5A, ZLS
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| Extensive molecular genetic analysis of the 3p14.3 region in patients with Zimmermann-Laband syndrome.
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| Abo-Dalo B, Kim HG, Roes M, Stefanova M, Higgins A, Shen Y, Mundlos S, Quade BJ, Gusella JF, Kutsche K.
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| Am J Med Genet A 143(22):2668-74. 2007
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| 43 | TMOD1, WNT5A
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| Induced expression of the transcription of tropomodulin 1 by Wnt5a and characterization of the tropomodulin 1 promoter.
|
| Yun S, Rim Y, Jho EH.
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| Biochem Biophys Res Commun 363(3):727-32. Epub 2007 Sep 20.
2007
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| 44 | WNT5A
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| WNT5A, a putative tumour suppressor of lymphoid malignancies, is inactivated by aberrant methylation in acute lymphoblastic leukaemia.
|
| Roman-Gomez J, Jimenez-Velasco A, Cordeu L, Vilas-Zornoza A, San Jose-Eneriz E, Garate L, Castillejo JA, Martin V, Prosper F, Heiniger A, Torres A, Agirre X.
|
| Eur J Cancer 43(18):2736-46.PMID: 18032022 2007
|
| 45 | CRIP1, S100P, WNT5A
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| Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer.
|
| Wang Q, Williamson M, Bott S, Brookman-Amissah N, Freeman A, Nariculam J, Hubank MJ, Ahmed A, Masters JR.
|
| Oncogene 26(45):6560-5. Epub 2007 May 7.PMID: 17486081 2007
|
| 46 | WNT5A
|
| Dishevelled promotes axon differentiation by regulating atypical protein kinase C.
|
| Zhang X, Zhu J, Yang GY, Wang QJ, Qian L, Chen YM, Chen F, Tao Y, Hu HS, Wang T, Luo ZG.
|
| Nat Cell Biol. 9(7):743-54. 2007
|
| 47 | FZD5, WNT5A
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| The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation.
|
| Blumenthal A, Ehlers S, Lauber J, Buer J, Lange C, Goldmann T, Heine H, Brandt E, Reiling N.
|
| Blood 108(3):965-73. Epub 2006 Apr 6. 2006
|
| 48 | WNT5A
|
| Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2.
|
| Masckauchán TN, Agalliu D, Vorontchikhina M, Ahn A, Parmalee NL, Li CM, Khoo A, Tycko B, Brown AM, Kitajewski J.
|
| Mol Biol Cell. 17(12):5163-72 2006
|
| 49 | WNT5A
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| The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.
|
| Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, Koshida I, Suzuki K, Yamada G, Schwabe GC, Mundlos S, Shibuya H, Takada S, Minami Y.
|
| Genes Cells. 8(7):645-54. 2003
|
| 50 | WNT5A
|
| Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation.
|
| Topol L, Jiang X, Choi H, Garrett-Beal L, Carolan PJ, Yang Y.
|
| J Cell Biol. 162(5):899-908. 2003
|
| 51 | FZD1, WNT3, WNT3A, WNT5A
|
| Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.
|
| Gazit A, Yaniv A, Bafico A, Pramila T, Igarashi M, Kitajewski J, Aaronson SA.
|
| Oncogene. 18(44):5959-66. 1999
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| 52 | WNT5A
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| Characterization of the complete genomic structure of the human WNT-5A gene, functional analysis of its promoter, chromosomal mapping, and expression in early human embryogenesis.
|
| Danielson KG, et al.
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| J Biol Chem 270 : 31225-31234. 1995
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| 53 | WNT5A
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| Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21.
|
| Clark CC, et al.
|
| Genomics 18 : 249-260. 1993
|