| 1 | CLDN7, SCNN1A, WNK4
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| Claudin-7 Modulates Cl- and Na+ Homeostasis and WNK4 Expression in Renal Collecting Duct Cells
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| Fan J, Tatum R, Hoggard J, Chen YH.
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| Int J Mol Sci. Aug 3;20(15):3798. doi: 10.3390/ijms20153798. 2019
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| 2 | SLC12A7, STK39, WNK4
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| Phosphoregulation of K+ -Cl- cotransporters during cell swelling: Novel insights.
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| Frenette-Cotton R, Marcoux AA, Garneau AP, Noel M, Isenring P.
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| J Cell Physiol. Jan;233(1):396-408. doi: 10.1002/jcp.25899. Epub 2017 Jun 5 2018
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| 3 | OXSR1, SLC12A3, STK39, WNK1, WNK4
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| Revisiting the NaCl cotransporter regulation by with-no-lysine kinases.
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| Bazúa-Valenti S, Gamba G.
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| Am J Physiol Cell Physiol 308(10):C779-91. doi: 10.1152/ajpcell.00065.2015. Epub 2015 Mar 18. Review. 2015
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| 4 | CUL3, KLHL3, PHA2B, PHA2C, PHA2D, PHA2E, WNK2, WNK4
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| Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3.
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| Yoshizaki Y, Mori Y, Tsuzaki Y, Mori T, Nomura N, Wakabayashi M, Takahashi D, Zeniya M, Kikuchi E, Araki Y, Ando F, Isobe K, Nishida H, Ohta A, Susa K, Inoue Y, Chiga M, Rai T, Sasaki S, Uchida S, Sohara E.
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| Biochem Biophys Res Commun 467(2):229-34. doi: 10.1016/j.bbrc.2015.09.184. Epub 2015 Oct 3. 2015
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| 5 | OXSR1, STK39, WNK1, WNK4
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| Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.
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| Vorontsova I, Lam L, Delpire E, Lim J, Donaldson P.
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| Invest Ophthalmol Vis Sci 56(1):310-21. doi: 10.1167/iovs.14-15911. 2014
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| 6 | CUL3, KLHL3, WNK4
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| Insights in cullin 3/WNK4 and its relationship to blood pressure regulation and electrolyte homeostasis.
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| Andérica-Romero AC, Escobar L, Padilla-Flores T, Pedraza-Chaverri J.
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| Cell Signal 26(6):1166-72. doi: 10.1016/j.cellsig.2014.01.032. Epub 2014 Feb 8. Review.
2014
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| 7 | CUL3, KLHL3, PHA2D, PHA2E, WNK4
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| Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms.
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| Mori Y, Wakabayashi M, Mori T, Araki Y, Sohara E, Rai T, Sasaki S, Uchida S.
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| Biochem Biophys Res Commun 439(1):30-4. doi: 10.1016/j.bbrc.2013.08.035. Epub 2013 Aug 17. 2013
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| 8 | KLHL3, WNK4
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| Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.
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| Wu G, Peng JB.
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| FEBS Lett 587(12):1717-22. doi: 10.1016/j.febslet.2013.04.032. Epub 2013 May 9.
2013
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| 9 | CUL3, KLHL3, WNK4
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| Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.
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| Shibata S, Zhang J, Puthumana J, Stone KL, Lifton RP.
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| Proc Natl Acad Sci U S A 110(19):7838-43. doi: 10.1073/pnas.1304592110. Epub 2013 Apr 1.
2013
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| 10 | KLHL3, WNK4
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| Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.
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| Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, Nomura N, Mori Y, Matsuo H, Murata T, Nomura S, Asano T, Kawaguchi H, Nonoyama S, Rai T, Sasaki S, Uchida S.
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| Cell Rep 3(3):858-68. doi: 10.1016/j.celrep.2013.02.024. Epub 2013 Feb 28.
2013
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| 11 | SLC12A3, STX12, WNK4
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| WNK4 inhibits plasma membrane targeting of NCC through regulation of syntaxin13 SNARE formation.
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| Chung WY, Park HW, Han JW, Lee MG, Kim JY.
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| Cell Signal 25(12):2469-2477. doi: 10.1016/j.cellsig.2013.08.006. [Epub ahead of print] 2013
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| 12 | WNK4
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| Regulation of large conductance Ca2+- activated K+ channels by WNK4 kinase.
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| Wang Z, Subramanya AR, Satlin LM, Pastor-Soler NM, Carattino MD, Kleyman TR.
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| Am J Physiol Cell Physiol m J Physiol Cell Physiol. 2013 Jul 24. [Epub ahead of print]
2013
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| 13 | WNK4
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| WNK4 is an essential effector of anterior formation in FGF signaling.
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| Shimizu M, Goto T, Sato A, Shibuya H.
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| Genes Cells 18(6):442-9. doi: 10.1111/gtc.12048. Epub 2013 Mar 21.
2013
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| 14 | KLHL2, WNK1, WNK4
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| KLHL2 interacts with and ubiquitinates WNK kinases.
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| Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S.
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| Biochem Biophys Res Commun 437(3):457-62. doi: 10.1016/j.bbrc.2013.06.104. Epub 2013 Jul 6.
2013
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| 15 | CUL3, KLHL3, KLHL3, PHA2D, PHA2E, WNK4
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| Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities.
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| Boyden LM, Choi M, Choate KA, Nelson-Williams CJ, Farhi A, Toka HR, Tikhonova IR, Bjornson R, Mane SM, Colussi G, Lebel M, Gordon RD, Semmekrot BA, Poujol A, Välimäki MJ, De Ferrari ME, Sanjad SA, Gutkin M, Karet FE, Tucci JR, Stockigt JR, Keppler-Noreuil KM, Porter CC, Anand SK, Whiteford ML, Davis ID, Dewar SB, Bettinelli A, Fadrowski JJ, Belsha CW, Hunley TE, Nelson RD, Trachtman H, Cole TR, Pinsk M, Bockenhauer D, Shenoy M, Vaidyanathan P, Foreman JW, Rasoulpour M, Thameem F, Al-Shahrouri HZ, Radhakrishnan J, Gharavi AG, Goilav B, Lifton RP.
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| Nature 482(7383):98-102. doi: 10.1038/nature10814.
2012
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| 16 | WNK4
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| Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process.
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| Castañeda-Bueno M, Cervantes-Pérez LG, Vázquez N, Uribe N, Kantesaria S, Morla L, Bobadilla NA, Doucet A, Alessi DR, Gamba G.
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| Proc Natl Acad Sci U S A 109(20):7929-34. doi: 10.1073/pnas.1200947109. Epub 2012 May 1.
2012
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| 17 | PHA2B, WNK4
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| Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions.
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| Na T, Wu G, Peng JB.
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| Biochem Biophys Res Commun 419(2):293-8. doi: 10.1016/j.bbrc.2012.02.013. Epub 2012 Feb 11.
2012
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| 18 | SLC9A3R2, TRPV5, WNK4
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| Concerted actions of NHERF2 and WNK4 in regulating TRPV5.
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| Jing H, Na T, Zhang W, Wu G, Liu C, Peng JB.
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| Biochem Biophys Res Commun 404(4):979-84. Epub 2010 Dec 25.
2011
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| 19 | WNK4
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| A WNK4 gene variant relates to osteoporosis and not to hypertension in the Portuguese population.
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| Mendes AI, Mascarenhas MR, Matos S, Sousa I, Ferreira J, Barbosa AP, Bicho M, Jordan P.
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| Mol Genet Metab 102(4):465-9. Epub 2010 Dec 22.
2011
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| 20 | WNK4
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| Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature.
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| Park HW, Kim JY, Choi SK, Lee YH, Zeng W, Kim KH, Muallem S, Lee MG.
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| Proc Natl Acad Sci U S A 108(26):10750-5. doi: 10.1073/pnas.1104271108. Epub 2011 Jun 13.
2011
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| 21 | WNK4
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| mmunolocalization of WNK4 in mouse kidney.
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| Ohno M, Uchida K, Ohashi T, Nitta K, Ohta A, Chiga M, Sasaki S, Uchida S.
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| Histochem Cell Biol 136(1):25-35. doi: 10.1007/s00418-011-0827-x. Epub 2011 Jun 10.
2011
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| 22 | KCNMA1, WNK4
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| WNK4 kinase inhibits Maxi K channel activity by a kinase-dependent mechanism.
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| Zhuang J, Zhang X, Wang D, Li J, Zhou B, Shi Z, Gu D, Denson DD, Eaton DC, Cai H.
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| Am J Physiol Renal Physiol 301(2):F410-9. doi: 10.1152/ajprenal.00518.2010. Epub 2011 May 25.
2011
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| 23 | TRPV5, WNK1, WNK2, WNK3, WNK4
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| WNK4 kinase stimulates caveola-mediated endocytosis of TRPV5 amplifying the dynamic range of regulation of the channel by protein kinase C.
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| Cha SK, Huang CL.
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| J Biol Chem 285(9):6604-11. Epub 2010 Jan 8.PMID: 20061383 2010
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| 24 | SLC12A3, WNK4
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| WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway.
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| Zhou B, Zhuang J, Gu D, Wang H, Cebotaru L, Guggino WB, Cai H.
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| J Am Soc Nephrol 21(1):82-92. doi: 10.1681/ASN.2008121275. Epub 2009 Oct 29.
2010
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| 25 | PHA2B, SLC12A3, WNK4
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| Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway.
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| San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G.
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| Proc Natl Acad Sci U S A 106(11):4384-9. Epub 2009 Feb 24.
2009
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| 26 | SLC12A3, WNK4
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| WNK4 Diverts the Thiazide-sensitive NaCl Cotransporter to the Lysosome and Stimulates AP-3 Interaction.
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| Subramanya AR, Liu J, Ellison DH, Wade JB, Welling PA.
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| J Biol Chem 284(27):18471-80. Epub 2009 Apr 28.
2009
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| 27 | SLC12A3, WNK4
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| WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction.
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| Subramanya AR, Liu J, Ellison DH, Wade JB, Welling PA.
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| J Biol Chem 284(27):18471-80. doi: 10.1074/jbc.M109.008185. Epub 2009 Apr 28.
2009
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| 28 | TRPV5, TRPV6, WNK4
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| WNK4 regulates the secretory pathway via which TRPV5 is targeted to the plasma membrane.
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| Jiang Y, Cong P, Williams SR, Zhang W, Na T, Ma HP, Peng JB.
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| Biochem Biophys Res Commun 375(2):225-9. Epub 2008 Aug 12.
2008
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| 29 | KCNJ1, PHA2B, WNK4
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| The acidic motif of WNK4 is crucial for its interaction with the K channel ROMK.
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| Murthy M, Cope G, O'Shaughnessy KM.
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| Biochem Biophys Res Commun 375(4):651-4. Epub 2008 Aug 26.
2008
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| 30 | OXSR1, STK39, WNK1, WNK2, WNK3, WNK4
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| The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway.
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| Richardson C, Alessi DR.
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| J Cell Sci 121(Pt 20):3293-304. Review.
2008
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| 31 | WNK3, WNK4
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| WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter.
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| San-Cristobal P, Ponce-Coria J, Vázquez N, Bobadilla NA, Gamba G.
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| Am J Physiol Renal Physiol 295(4):F1199-206. Epub 2008 Aug 13.
2008
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| 32 | SLC12A3, WNK1, WNK3, WNK4
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| The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex.
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| Yang CL, Zhu X, Ellison DH.
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| J Clin Invest 117(11):3403-11. 2007
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| 33 | KCNJ1, WNK4
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| Intersectin links WNK kinases to endocytosis of ROMK1.
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| He G, Wang HR, Huang SK, Huang CL.
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| J Clin Invest 117(4):1078-87. Epub 2007 Mar 22.
2007
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| 34 | WNK4
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| Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule.
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| Lalioti MD, Zhang J, Volkman HM, Kahle KT, Hoffmann KE, Toka HR, Nelson-Williams C, Ellison DH, Flavell R, Booth CJ, Lu Y, Geller DS, Lifton RP.
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| Nat Genet 38(10):1124-32. Epub 2006 Sep 10. 2006
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| 35 | CYPHB1, CYPHB2, NR3C2, HSD11B2, SCNN1B, SCNN1G, PSALD, PHA2C, WNK1, PHA2B, WNK4, DIDAN, PPARG, MTHHH, MT-TI
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| The genetic dissection of essential hypertension.
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| Cowley AW Jr.
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| Nat Rev Genet 7(11):829-40. Epub 2006 Oct 10. Review. 2006
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| 36 | PHA2B, WNK4
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| A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene.
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| Golbang AP, Murthy M, Hamad A, Liu CH, Cope G, Van't Hoff W, Cuthbert A, O'Shaughnessy KM.
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| Hypertension 46(2):295-300. Epub 2005 Jul 5. 2005
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| 37 | WNK4, SLC12A3, KCNJ1
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| WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia.
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| ahle KT, Gimenez I, Hassan H, Wilson FH, Wong RD, Forbush B, Aronson PS, Lifton RP.
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| Proc Natl Acad Sci U S A 101(7):2064-9. Epub 2004 Feb 09. 2004
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| 38 | WNK4, PHA2B
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| Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension.
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| Kahle KT, Macgregor GG, Wilson FH, Van Hoek AN, Brown D, Ardito T, Kashgarian M, Giebisch G, Hebert SC, Boulpaep EL, Lifton RP.
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| Proc Natl Acad Sci U S A 101(41):14877-82. Epub 2004 Oct 1. 2004
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| 39 | WNK4
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| Human chromosome 17 in essential hypertension
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| Knight J, Munroe PB, Pembroke JC, Caulfield MJ.
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| Ann Hum Genet 67(Pt 2):193-206. 2003
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| 40 | WNK4
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| WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion.
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| Kahle KT, Wilson FH, Leng Q, Lalioti MD, O'Connell AD, Dong K, Rapson AK, MacGregor GG, Giebisch G, Hebert SC, Lifton RP.
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| Nat Genet 35(4):372-6. Epub 2003 Nov 09. 2003
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| 41 | PHA2B, PHA2C, WNK1, WNK4
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| Human hypertension caused by mutations in WNK kinases.
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| Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP.
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| Science 293(5532):1107-12. 2001
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| 42 | WNK1, WNK2, WNK3, WNK4
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| WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.
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| Verissimo F, Jordan P.
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| Oncogene 20(39):5562-9. 2001
|