| 1 | OXSR1, SLC12A2, STK39, WNK1
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| WNK1 kinase balances T cell adhesion versus migration in vivo.
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| Köchl R, Thelen F, Vanes L, Brazão TF, Fountain K, Xie J, Huang CL, Lyck R, Stein JV, Tybulewicz VL.
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| Nat Immunol 17(9):1075-83. doi: 10.1038/ni.3495. Epub 2016 Jul 11. Erratum in: Nat Immunol. 2017 Jan 19;18(2):246.
2016
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| 2 | NEDD4L, SLC12A3, WNK1
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| Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action.
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| Roy A, Al-Qusairi L, Donnelly BF, Ronzaud C, Marciszyn AL, Gong F, Chang YP, Butterworth MB, Pastor-Soler NM, Hallows KR, Staub O, Subramanya AR.
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| J Clin Invest 125(9):3433-48. doi: 10.1172/JCI75245. Epub 2015 Aug 4.
2015
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| 3 | SLC12A5, WNK1
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| WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.
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| Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J, Khanna AR, Bishop PN, Shokat KM, Medina I.
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| Sci Signal 8(383):ra65. doi: 10.1126/scisignal.aaa0354.
2015
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| 4 | OXSR1, SLC12A3, STK39, WNK1, WNK4
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| Revisiting the NaCl cotransporter regulation by with-no-lysine kinases.
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| Bazúa-Valenti S, Gamba G.
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| Am J Physiol Cell Physiol 308(10):C779-91. doi: 10.1152/ajpcell.00065.2015. Epub 2015 Mar 18. Review. 2015
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| 5 | WNK1
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| WNK1 activates large-conductance Ca2+-activated K+ channels through modulation of ERK1/2 signaling.
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| Liu Y, Song X, Shi Y, Shi Z, Niu W, Feng X, Gu D, Bao HF, Ma HP, Eaton DC, Zhuang J, Cai H.
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| J Am Soc Nephrol 26(4):844-54. doi: 10.1681/ASN.2014020186. Epub 2014 Aug 21.
2015
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| 6 | OXSR1, STK39, WNK1, WNK4
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| Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.
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| Vorontsova I, Lam L, Delpire E, Lim J, Donaldson P.
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| Invest Ophthalmol Vis Sci 56(1):310-21. doi: 10.1167/iovs.14-15911. 2014
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| 7 | OXSR1, STK39, WNK1
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| Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.
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| Dbouk HA, Weil LM, Perera GK, Dellinger MT, Pearson G, Brekken RA, Cobb MH.
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| Proc Natl Acad Sci U S A 111(45):15999-6004. doi: 10.1073/pnas.1419057111. Epub 2014 Oct 31. 2014
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| 8 | PHA2C, WNK1
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| Chloride sensing by WNK1 involves inhibition of autophosphorylation.
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| Piala AT, Moon TM, Akella R, He H, Cobb MH, Goldsmith EJ.
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| Sci Signal 7(324):ra41. doi: 10.1126/scisignal.2005050.
2014
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| 9 | PHA2C, WNK1
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| WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron.
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| Vidal-Petiot E, Elvira-Matelot E, Mutig K, Soukaseum C, Baudrie V, Wu S, Cheval L, Huc E, Cambillau M, Bachmann S, Doucet A, Jeunemaitre X, Hadchouel J.
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| Proc Natl Acad Sci U S A 110(35):14366-71. doi: 10.1073/pnas.1304230110. Epub 2013 Aug 12.
2013
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| 10 | KLHL2, WNK1, WNK4
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| KLHL2 interacts with and ubiquitinates WNK kinases.
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| Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S.
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| Biochem Biophys Res Commun 437(3):457-62. doi: 10.1016/j.bbrc.2013.06.104. Epub 2013 Jul 6.
2013
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| 11 | OXSR1, WNK1
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| WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade.
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| Xie J, Yoon J, Yang SS, Lin SH, Huang CL.
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| J Biol Chem 288(12):8566-74. doi: 10.1074/jbc.M113.451575. Epub 2013 Feb 5. 2013
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| 12 | WNK1
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| Kidney-specific WNK1 regulates sodium reabsorption and potassium secretion in mouse cortical collecting duct.
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| Cheng CJ, Baum M, Huang CL.
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| Am J Physiol Renal Physiol 304(4):F397-402. doi: 10.1152/ajprenal.00589.2012. Epub 2012 Nov 28.
2013
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| 13 | PHA2C, WNK1
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| Novel missense mutations of WNK1 in patients with hypokalemic salt-losing tubulopathies.
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| Zhang C, Zhu Y, Huang F, Jiang G, Chang J, Li R.
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| Clin Genet 83(6):545-52. doi: 10.1111/cge.12008. Epub 2012 Sep 27.
2013
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| 14 | OXSR1, WNK1
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| Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity.
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| Sengupta S, Tu SW, Wedin K, Earnest S, Stippec S, Luby-Phelps K, Cobb MH.
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| J Biol Chem 287(45):37868-79. doi: 10.1074/jbc.M112.398750. Epub 2012 Sep 18.
2012
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| 15 | OXSR1, WNK1
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| WNK1 is required for mitosis and abscission.
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| Tu SW, Bugde A, Luby-Phelps K, Cobb MH.
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| Proc Natl Acad Sci U S A 108(4):1385-90. Epub 2011 Jan 10.
2011
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| 16 | TRPV5, WNK1, WNK2, WNK3, WNK4
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| WNK4 kinase stimulates caveola-mediated endocytosis of TRPV5 amplifying the dynamic range of regulation of the channel by protein kinase C.
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| Cha SK, Huang CL.
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| J Biol Chem 285(9):6604-11. Epub 2010 Jan 8.PMID: 20061383 2010
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| 17 | TBC1D4, WNK1
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| Protein kinase WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2/USP6-BUB2-Cdc16 domain family member 4 (TBC1D4)-Rab8A complex.
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| Mendes AI, Matos P, Moniz S, Jordan P.
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| J Biol Chem 285(50):39117-26. Epub 2010 Oct 11.
2010
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| 18 | LINGO1, WNK1
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| LINGO-1 interacts with WNK1 to regulate nogo-induced inhibition of neurite extension.
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| Zhang Z, Xu X, Zhang Y, Zhou J, Yu Z, He C.
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| J Biol Chem 284(23):15717-28. Epub 2009 Apr 10. 2009
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| 19 | WNK1
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| Variations in the WNK1 gene modulates the effect of dietary intake of sodium and potassium on blood pressure determination.
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| Osada Y, Miyauchi R, Goda T, Kasezawa N, Horiike H, Iida M, Sasaki S, Yamakawa-Kobayashi K.
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| J Hum Genet 54(8):474-8. Epub 2009 Jul 17.PMID: 19609280 2009
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| 20 | CCT5, ELP1, HSAN1, HSAN2A, HSAN3, HSAN4, HSAN5, NGF, NTRK1, SNSP, SPTLC1, WNK1
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| Genes for hereditary sensory and autonomic neuropathies: a genotype-phenotype correlation.
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| Rotthier A, Baets J, De Vriendt E, Jacobs A, Auer-Grumbach M, Lévy N, Bonello-Palot N, Kilic SS, Weis J, Nascimento A, Swinkels M, Kruyt MC, Jordanova A, De Jonghe P, Timmerman V.
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| Brain 132(Pt 10):2699-711. Epub 2009 Aug 3.PMID: 19651702 2009
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| 21 | HSAN2A, WNK1
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| Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II.
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| Shekarabi M, Girard N, Rivière JB, Dion P, Houle M, Toulouse A, Lafrenière RG, Vercauteren F, Hince P, Laganiere J, Rochefort D, Faivre L, Samuels M, Rouleau GA.
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| J Clin Invest 118(7):2496-505.PMID: 18521183 2008
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| 22 | OXSR1, SLC12A3, STK39, WNK1
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| Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.
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| Richardson C, Rafiqi FH, Karlsson HK, Moleleki N, Vandewalle A, Campbell DG, Morrice NA, Alessi DR.
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| J Cell Sci 121(Pt 5):675-84. Epub 2008 Feb 12.PMID: 18270262 2008
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| 23 | OXSR1, STK39, WNK1, WNK2, WNK3, WNK4
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| The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway.
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| Richardson C, Alessi DR.
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| J Cell Sci 121(Pt 20):3293-304. Review.
2008
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| 24 | SLC12A3, WNK1, WNK3, WNK4
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| The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex.
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| Yang CL, Zhu X, Ellison DH.
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| J Clin Invest 117(11):3403-11. 2007
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| 25 | CYPHB1, CYPHB2, NR3C2, HSD11B2, SCNN1B, SCNN1G, PSALD, PHA2C, WNK1, PHA2B, WNK4, DIDAN, PPARG, MTHHH, MT-TI
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| The genetic dissection of essential hypertension.
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| Cowley AW Jr.
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| Nat Rev Genet 7(11):829-40. Epub 2006 Oct 10. Review. 2006
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| 26 | HSAN2A, WNK1
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| Novel mutations in the HSN2 gene causing hereditary sensory and autonomic neuropathy type II.
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| Coen K, Pareyson D, Auer-Grumbach M, Buyse G, Goemans N, Claeys KG, Verpoorten N, Laurˆ M, Scaioli V, Salmhofer W, Pieber TR, Nelis E, De Jonghe P, Timmerman V.
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| Neurology 66(5):748-51. 2006
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| 27 | WNK1, PHA2C
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| Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study.
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| Newhouse SJ, Wallace C, Dobson R, Mein C, Pembroke J, Farrall M, Clayton D, Brown M, Samani N, Dominiczak A, Connell JM, Webster J, Lathrop GM, Caulfield M, Munroe PB.
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| Hum Mol Genet 14(13):1805-14. Epub 2005 May 11. 2005
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| 28 | HSAN2A, WNK1
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| Two mutations in the HSN2 gene explain the high prevalence of HSAN2 in French Canadians.
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| Roddier K, Thomas T, Marleau G, Gagnon AM, Dicaire MJ, St-Denis A, Gosselin I, Sarrazin AM, Larbrisseau A, Lambert M, Vanasse M, Gaudet D, Rouleau GA, Brais B.
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| Neurology 64(10):1762-7. 2005
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| 29 | WNK1
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| Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population.
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| Tobin MD, Raleigh SM, Newhouse S, Braund P, Bodycote C, Ogleby J, Cross D, Gracey J, Hayes S, Smith T, Ridge C, Caulfield M, Sheehan NA, Munroe PB, Burton PR, Samani NJ.
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| Circulation 112(22):3423-9. Epub 2005 Nov 21. 2005
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| 30 | WNK1
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| Properties of WNK1 and implications for other family members.
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| Lenertz LY, Lee BH, Min X, Xu BE, Wedin K, Earnest S, Goldsmith EJ, Cobb MH.
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| J Biol Chem 280(29):26653-8. Epub 2005 May 9. 2005
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| 31 | WNK1
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| WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension.
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| Xu BE, Lee BH, Min X, Lenertz L, Heise CJ, Stippec S, Goldsmith EJ, Cobb MH.
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| Cell Res 15(1):6-10. Review. 2005
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| 32 | WNK1, STK39, OXSR1
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| WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.
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| Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H.
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| J Biol Chem 280(52):42685-93. Epub 2005 Oct 31. 2005
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| 33 | HSAN2A, WNK1
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| Identification of a Novel Gene (HSN2) Causing Hereditary Sensory and Autonomic Neuropathy Type II through the Study of Canadian Genetic Isolates.
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| Lafreniere RG, MacDonald ML, Dube MP, MacFarlane J, O'Driscoll M, Brais B, Meilleur S, Brinkman RR, Dadivas O, Pape T, Platon C, Radomski C, Risler J, Thompson J, Guerra-Escobio AM, Davar G, Breakefield XO, Pimstone SN, Green R, Pryse-Phillips W, Goldberg YP, Younghusband HB, Hayden MR, Sherrington R, Rouleau GA, Samuels ME.
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| Am J Hum Genet 74(5):1064-73. Epub 2004 Apr 01. 2004
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| 34 | WNK1, SYT2, SYT3
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| WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding.
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| Lee BH, Min X, Heise CJ, Xu BE, Chen S, Shu H, Luby-Phelps K, Goldsmith EJ, Cobb MH.
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| Mol Cell 15(5):741-51. 2004
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| 35 | HSAN2A, WNK1
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| A mutation in the HSN2 gene causes sensory neuropathy type II in a Lebanese family.
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| Riviere JB, Verlaan DJ, Shekarabi M, Lafreniere RG, Benard M, Der Kaloustian VM, Shbaklo Z, Rouleau GA.
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| Ann Neurol 56(4):572-5. 2004
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| 36 | WNK1, PHA2C
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| WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain.
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| O'Reilly M, Marshall E, Speirs HJ, Brown RW.
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| J Am Soc Nephrol 14(10):2447-56. 2003
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| 37 | WNK1
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| Regulation of WNK1 by an autoinhibitory domain and autophosphorylation.
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| Xu BE, Min X, Stippec S, Lee BH, Goldsmith EJ, Cobb MH.
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| J Biol Chem 277(50):48456-62. 2002
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| 38 | PHA2B, PHA2C, WNK1, WNK4
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| Human hypertension caused by mutations in WNK kinases.
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| Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP.
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| Science 293(5532):1107-12. 2001
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| 39 | WNK1, WNK2, WNK3, WNK4
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| WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.
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| Verissimo F, Jordan P.
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| Oncogene 20(39):5562-9. 2001
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| 40 | WNK1, TAOK2
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| PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization.
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| Moore TM, Garg R, Johnson C, Coptcoat MJ, Ridley AJ, Morris JD.
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| J Biol Chem 275(6):4311-22. 2000
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| 41 | WNK1, WNK2
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| WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II.
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| Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH.
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| J Biol Chem 275(22):16795-801. 2000
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| 42 | ADAMTS3, AKAP6, ALMS1, ANKRD28, AREL1, ARHGEF10, ARHGEF11, ARHGEF17, ARNT2, BAZ2A, CABIN1, CAST, CHD9, CIC, CLEC16A, CLOCK, CTNND1, DCLK1, DDX46, DIDO1, DNAH9, DNM3, DOCK3, DYNC1H1, ECM29, ENTPD4, EPB41L1, EZH1, FRMPD4, GCC2, HECW1, HERC2, HISPPD1, HUWE1, IGSF1, KAT6B, KHNYN, KIAA0319, KIAA0355, KIAA0379, KIF3B, KMT2B, LBA1, MADD, MAST4, MCF2L, MDN1, MTMR3, MYO6, N4BP3, NACAD, NRCAM, PCDH9, PCDHGA8, PCDHGC3, PDZD2, PER2, PFAS, PLEKHM1, PLXNB2, PRORP, PRUNE2, PTPRN2, RAPGEF2, RIMBP2, RIMS1, RIPOR2, RUSC2, SALL2, SEC16A, SEMA3C, SEMA3E, SETD1A, SFRS14, SNPH, SPECC1L, SPTBN2, SR140, SRCAP, SRRM2, SYNJ2, TECPR2, TLN2, TRIM66, TTC37, UBR2, WNK1, XPO6, ZBTB39, ZBTB5, ZFYVE16, ZFYVE26, ZMYM3, ZNF518A, ZNF609, ZNF629, ZNF646
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| Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
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| Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A,Kotani H, Nomura N, Ohara O.
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| DNA Res 4(2):141-50. 1997
|