Citations for
1OXSR1, SLC12A2, STK39, WNK1
WNK1 kinase balances T cell adhesion versus migration in vivo.
Köchl R, Thelen F, Vanes L, Brazão TF, Fountain K, Xie J, Huang CL, Lyck R, Stein JV, Tybulewicz VL.
Nat Immunol 17(9):1075-83. doi: 10.1038/ni.3495. Epub 2016 Jul 11. Erratum in: Nat Immunol. 2017 Jan 19;18(2):246. 2016
2NEDD4L, SLC12A3, WNK1
Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action.
Roy A, Al-Qusairi L, Donnelly BF, Ronzaud C, Marciszyn AL, Gong F, Chang YP, Butterworth MB, Pastor-Soler NM, Hallows KR, Staub O, Subramanya AR.
J Clin Invest 125(9):3433-48. doi: 10.1172/JCI75245. Epub 2015 Aug 4. 2015
3SLC12A5, WNK1
WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.
Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J, Khanna AR, Bishop PN, Shokat KM, Medina I.
Sci Signal 8(383):ra65. doi: 10.1126/scisignal.aaa0354. 2015
4OXSR1, SLC12A3, STK39, WNK1, WNK4
Revisiting the NaCl cotransporter regulation by with-no-lysine kinases.
Bazúa-Valenti S, Gamba G.
Am J Physiol Cell Physiol 308(10):C779-91. doi: 10.1152/ajpcell.00065.2015. Epub 2015 Mar 18. Review. 2015
5WNK1
WNK1 activates large-conductance Ca2+-activated K+ channels through modulation of ERK1/2 signaling.
Liu Y, Song X, Shi Y, Shi Z, Niu W, Feng X, Gu D, Bao HF, Ma HP, Eaton DC, Zhuang J, Cai H.
J Am Soc Nephrol 26(4):844-54. doi: 10.1681/ASN.2014020186. Epub 2014 Aug 21. 2015
6OXSR1, STK39, WNK1, WNK4
Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.
Vorontsova I, Lam L, Delpire E, Lim J, Donaldson P.
Invest Ophthalmol Vis Sci 56(1):310-21. doi: 10.1167/iovs.14-15911. 2014
7OXSR1, STK39, WNK1
Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.
Dbouk HA, Weil LM, Perera GK, Dellinger MT, Pearson G, Brekken RA, Cobb MH.
Proc Natl Acad Sci U S A 111(45):15999-6004. doi: 10.1073/pnas.1419057111. Epub 2014 Oct 31. 2014
8PHA2C, WNK1
Chloride sensing by WNK1 involves inhibition of autophosphorylation.
Piala AT, Moon TM, Akella R, He H, Cobb MH, Goldsmith EJ.
Sci Signal 7(324):ra41. doi: 10.1126/scisignal.2005050. 2014
9PHA2C, WNK1
WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron.
Vidal-Petiot E, Elvira-Matelot E, Mutig K, Soukaseum C, Baudrie V, Wu S, Cheval L, Huc E, Cambillau M, Bachmann S, Doucet A, Jeunemaitre X, Hadchouel J.
Proc Natl Acad Sci U S A 110(35):14366-71. doi: 10.1073/pnas.1304230110. Epub 2013 Aug 12. 2013
10KLHL2, WNK1, WNK4
KLHL2 interacts with and ubiquitinates WNK kinases.
Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S.
Biochem Biophys Res Commun 437(3):457-62. doi: 10.1016/j.bbrc.2013.06.104. Epub 2013 Jul 6. 2013
11OXSR1, WNK1
WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade.
Xie J, Yoon J, Yang SS, Lin SH, Huang CL.
J Biol Chem 288(12):8566-74. doi: 10.1074/jbc.M113.451575. Epub 2013 Feb 5. 2013
12WNK1
Kidney-specific WNK1 regulates sodium reabsorption and potassium secretion in mouse cortical collecting duct.
Cheng CJ, Baum M, Huang CL.
Am J Physiol Renal Physiol 304(4):F397-402. doi: 10.1152/ajprenal.00589.2012. Epub 2012 Nov 28. 2013
13PHA2C, WNK1
Novel missense mutations of WNK1 in patients with hypokalemic salt-losing tubulopathies.
Zhang C, Zhu Y, Huang F, Jiang G, Chang J, Li R.
Clin Genet 83(6):545-52. doi: 10.1111/cge.12008. Epub 2012 Sep 27. 2013
14OXSR1, WNK1
Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity.
Sengupta S, Tu SW, Wedin K, Earnest S, Stippec S, Luby-Phelps K, Cobb MH.
J Biol Chem 287(45):37868-79. doi: 10.1074/jbc.M112.398750. Epub 2012 Sep 18. 2012
15OXSR1, WNK1
WNK1 is required for mitosis and abscission.
Tu SW, Bugde A, Luby-Phelps K, Cobb MH.
Proc Natl Acad Sci U S A 108(4):1385-90. Epub 2011 Jan 10. 2011
16TRPV5, WNK1, WNK2, WNK3, WNK4
WNK4 kinase stimulates caveola-mediated endocytosis of TRPV5 amplifying the dynamic range of regulation of the channel by protein kinase C.
Cha SK, Huang CL.
J Biol Chem 285(9):6604-11. Epub 2010 Jan 8.PMID: 20061383 2010
17TBC1D4, WNK1
Protein kinase WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2/USP6-BUB2-Cdc16 domain family member 4 (TBC1D4)-Rab8A complex.
Mendes AI, Matos P, Moniz S, Jordan P.
J Biol Chem 285(50):39117-26. Epub 2010 Oct 11. 2010
18LINGO1, WNK1
LINGO-1 interacts with WNK1 to regulate nogo-induced inhibition of neurite extension.
Zhang Z, Xu X, Zhang Y, Zhou J, Yu Z, He C.
J Biol Chem 284(23):15717-28. Epub 2009 Apr 10. 2009
19WNK1
Variations in the WNK1 gene modulates the effect of dietary intake of sodium and potassium on blood pressure determination.
Osada Y, Miyauchi R, Goda T, Kasezawa N, Horiike H, Iida M, Sasaki S, Yamakawa-Kobayashi K.
J Hum Genet 54(8):474-8. Epub 2009 Jul 17.PMID: 19609280 2009
20CCT5, ELP1, HSAN1, HSAN2A, HSAN3, HSAN4, HSAN5, NGF, NTRK1, SNSP, SPTLC1, WNK1
Genes for hereditary sensory and autonomic neuropathies: a genotype-phenotype correlation.
Rotthier A, Baets J, De Vriendt E, Jacobs A, Auer-Grumbach M, Lévy N, Bonello-Palot N, Kilic SS, Weis J, Nascimento A, Swinkels M, Kruyt MC, Jordanova A, De Jonghe P, Timmerman V.
Brain 132(Pt 10):2699-711. Epub 2009 Aug 3.PMID: 19651702 2009
21HSAN2A, WNK1
Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II.
Shekarabi M, Girard N, Rivière JB, Dion P, Houle M, Toulouse A, Lafrenière RG, Vercauteren F, Hince P, Laganiere J, Rochefort D, Faivre L, Samuels M, Rouleau GA.
J Clin Invest 118(7):2496-505.PMID: 18521183 2008
22OXSR1, SLC12A3, STK39, WNK1
Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.
Richardson C, Rafiqi FH, Karlsson HK, Moleleki N, Vandewalle A, Campbell DG, Morrice NA, Alessi DR.
J Cell Sci 121(Pt 5):675-84. Epub 2008 Feb 12.PMID: 18270262 2008
23OXSR1, STK39, WNK1, WNK2, WNK3, WNK4
The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway.
Richardson C, Alessi DR.
J Cell Sci 121(Pt 20):3293-304. Review. 2008
24SLC12A3, WNK1, WNK3, WNK4
The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex.
Yang CL, Zhu X, Ellison DH.
J Clin Invest 117(11):3403-11. 2007
25CYPHB1, CYPHB2, NR3C2, HSD11B2, SCNN1B, SCNN1G, PSALD, PHA2C, WNK1, PHA2B, WNK4, DIDAN, PPARG, MTHHH, MT-TI
The genetic dissection of essential hypertension.
Cowley AW Jr.
Nat Rev Genet 7(11):829-40. Epub 2006 Oct 10. Review. 2006
26HSAN2A, WNK1
Novel mutations in the HSN2 gene causing hereditary sensory and autonomic neuropathy type II.
Coen K, Pareyson D, Auer-Grumbach M, Buyse G, Goemans N, Claeys KG, Verpoorten N, Laurˆ M, Scaioli V, Salmhofer W, Pieber TR, Nelis E, De Jonghe P, Timmerman V.
Neurology 66(5):748-51. 2006
27WNK1, PHA2C
Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study.
Newhouse SJ, Wallace C, Dobson R, Mein C, Pembroke J, Farrall M, Clayton D, Brown M, Samani N, Dominiczak A, Connell JM, Webster J, Lathrop GM, Caulfield M, Munroe PB.
Hum Mol Genet 14(13):1805-14. Epub 2005 May 11. 2005
28HSAN2A, WNK1
Two mutations in the HSN2 gene explain the high prevalence of HSAN2 in French Canadians.
Roddier K, Thomas T, Marleau G, Gagnon AM, Dicaire MJ, St-Denis A, Gosselin I, Sarrazin AM, Larbrisseau A, Lambert M, Vanasse M, Gaudet D, Rouleau GA, Brais B.
Neurology 64(10):1762-7. 2005
29WNK1
Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population.
Tobin MD, Raleigh SM, Newhouse S, Braund P, Bodycote C, Ogleby J, Cross D, Gracey J, Hayes S, Smith T, Ridge C, Caulfield M, Sheehan NA, Munroe PB, Burton PR, Samani NJ.
Circulation 112(22):3423-9. Epub 2005 Nov 21. 2005
30WNK1
Properties of WNK1 and implications for other family members.
Lenertz LY, Lee BH, Min X, Xu BE, Wedin K, Earnest S, Goldsmith EJ, Cobb MH.
J Biol Chem 280(29):26653-8. Epub 2005 May 9. 2005
31WNK1
WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension.
Xu BE, Lee BH, Min X, Lenertz L, Heise CJ, Stippec S, Goldsmith EJ, Cobb MH.
Cell Res 15(1):6-10. Review. 2005
32WNK1, STK39, OXSR1
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.
Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H.
J Biol Chem 280(52):42685-93. Epub 2005 Oct 31. 2005
33HSAN2A, WNK1
Identification of a Novel Gene (HSN2) Causing Hereditary Sensory and Autonomic Neuropathy Type II through the Study of Canadian Genetic Isolates.
Lafreniere RG, MacDonald ML, Dube MP, MacFarlane J, O'Driscoll M, Brais B, Meilleur S, Brinkman RR, Dadivas O, Pape T, Platon C, Radomski C, Risler J, Thompson J, Guerra-Escobio AM, Davar G, Breakefield XO, Pimstone SN, Green R, Pryse-Phillips W, Goldberg YP, Younghusband HB, Hayden MR, Sherrington R, Rouleau GA, Samuels ME.
Am J Hum Genet 74(5):1064-73. Epub 2004 Apr 01. 2004
34WNK1, SYT2, SYT3
WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding.
Lee BH, Min X, Heise CJ, Xu BE, Chen S, Shu H, Luby-Phelps K, Goldsmith EJ, Cobb MH.
Mol Cell 15(5):741-51. 2004
35HSAN2A, WNK1
A mutation in the HSN2 gene causes sensory neuropathy type II in a Lebanese family.
Riviere JB, Verlaan DJ, Shekarabi M, Lafreniere RG, Benard M, Der Kaloustian VM, Shbaklo Z, Rouleau GA.
Ann Neurol 56(4):572-5. 2004
36WNK1, PHA2C
WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain.
O'Reilly M, Marshall E, Speirs HJ, Brown RW.
J Am Soc Nephrol 14(10):2447-56. 2003
37WNK1
Regulation of WNK1 by an autoinhibitory domain and autophosphorylation.
Xu BE, Min X, Stippec S, Lee BH, Goldsmith EJ, Cobb MH.
J Biol Chem 277(50):48456-62. 2002
38PHA2B, PHA2C, WNK1, WNK4
Human hypertension caused by mutations in WNK kinases.
Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP.
Science 293(5532):1107-12. 2001
39WNK1, WNK2, WNK3, WNK4
WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.
Verissimo F, Jordan P.
Oncogene 20(39):5562-9. 2001
40WNK1, TAOK2
PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization.
Moore TM, Garg R, Johnson C, Coptcoat MJ, Ridley AJ, Morris JD.
J Biol Chem 275(6):4311-22. 2000
41WNK1, WNK2
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II.
Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH.
J Biol Chem 275(22):16795-801. 2000
42ADAMTS3, AKAP6, ALMS1, ANKRD28, AREL1, ARHGEF10, ARHGEF11, ARHGEF17, ARNT2, BAZ2A, CABIN1, CAST, CHD9, CIC, CLEC16A, CLOCK, CTNND1, DCLK1, DDX46, DIDO1, DNAH9, DNM3, DOCK3, DYNC1H1, ECM29, ENTPD4, EPB41L1, EZH1, FAM65B, FRMPD4, GCC2, HECW1, HERC2, HISPPD1, HUWE1, IGSF1, KAT6B, KIAA0319, KIAA0323, KIAA0355, KIAA0379, KIAA0391, KIF3B, KMT2B, LBA1, MADD, MAST4, MCF2L, MDN1, MTMR3, MYO6, N4BP3, NACAD, NRCAM, PCDH9, PCDHGA8, PCDHGC3, PDZD2, PER2, PFAS, PLEKHM1, PLXNB2, PRUNE2, PTPRN2, RAPGEF2, RIMBP2, RIMS1, RUSC2, SALL2, SEC16A, SEMA3C, SEMA3E, SETD1A, SFRS14, SNPH, SPECC1L, SPTBN2, SR140, SRCAP, SRRM2, SYNJ2, TECPR2, TLN2, TRIM66, TTC37, UBR2, WNK1, XPO6, ZBTB39, ZBTB5, ZFYVE16, ZFYVE26, ZMYM3, ZNF518A, ZNF609, ZNF629, ZNF646
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A,Kotani H, Nomura N, Ohara O.
DNA Res 4(2):141-50. 1997