Citations for
1EZH2, WHSC1
Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer.
Asangani IA, Ateeq B, Cao Q, Dodson L, Pandhi M, Kunju LP, Mehra R, Lonigro RJ, Siddiqui J, Palanisamy N, Wu YM, Cao X, Kim JH, Zhao M, Qin ZS, Iyer MK, Maher CA, Kumar-Sinha C, Varambally S, Chinnaiyan AM.
Mol Cell 49(1):80-93. doi: 10.1016/j.molcel.2012.10.008. Epub 2012 Nov 15. 2013
2H2AFX, MDC1, TP53BP1, WHSC1
MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites.
Pei H, Zhang L, Luo K, Qin Y, Chesi M, Fei F, Bergsagel PL, Wang L, You Z, Lou Z.
Nature 470(7332):124-8. 2011
3WHSC1
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD.
Blood 117(1):211-20. Epub 2010 Oct 25. 2011
4WHS, WHSC1
Wolf-Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage.
Hajdu I, Ciccia A, Lewis SM, Elledge SJ.
Proc Natl Acad Sci U S A 108(32):13130-4. Epub 2011 Jul 25. 2011
5WHSC1
MMSET is highly expressed and associated with aggressiveness in neuroblastoma.
Hudlebusch HR, Skotte J, Santoni-Rugiu E, Zimling ZG, Lees MJ, Simon R, Sauter G, Rota R, De Ioris MA, Quarto M, Johansen JV, Jørgensen M, Rechnitzer C, Maroun LL, Schrøder H, Petersen BL, Helin K.
Cancer Res 71(12):4226-35. Epub 2011 Apr 28. 2011
6NSD1, WHSC1, WHSC1L1
Structural insights into the regulation and the recognition of histone marks by the SET domain of NSD1.
Morishita M, di Luccio E.
Biochem Biophys Res Commun 412(2):214-9. Epub 2011 Jul 22. 2011
7WHSC1
NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming.
Kuo AJ, Cheung P, Chen K, Zee BM, Kioi M, Lauring J, Xi Y, Park BH, Shi X, Garcia BA, Li W, Gozani O.
Mol Cell 44(4):609-20. doi: 10.1016/j.molcel.2011.08.042. 2011
8WHSC1, WHSCR
Interstitial microdeletion of 4p16.3: contribution of WHSC1 haploinsufficiency to the pathogenesis of developmental delay in Wolf-Hirschhorn syndrome.
Izumi K, Okuno H, Maeyama K, Sato S, Yamamoto T, Torii C, Kosaki R, Takahashi T, Kosaki K.
Am J Med Genet A 152A(4):1028-32. No abstract available. PMID: 20358621 2010
9FGFRL1, WHSC1, WHSCR
Wolf-Hirschhorn syndrome facial dysmorphic features in a patient with a terminal 4p16.3 deletion telomeric to the WHSCR and WHSCR 2 regions.
Engbers H, van der Smagt JJ, van 't Slot R, Vermeesch JR, Hochstenbach R, Poot M.
Eur J Hum Genet 17(1):129-32. Epub 2008 Oct 1. 2009
10WHSC1
MMSET is overexpressed in cancers: link with tumor aggressiveness.
Kassambara A, Klein B, Moreaux J.
Biochem Biophys Res Commun 379(4):840-5. Epub 2008 Dec 31. 2009
11NKX2-5, WHSC1, WHSCR
A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome.
Nimura K, Ura K, Shiratori H, Ikawa M, Okabe M, Schwartz RJ, Kaneda Y.
Nature 460(7252):287-91. Epub 2009 May 31. 2009
12LETM1, NELFA, WHS, WHSC1
Genotype-phenotype correlation in 21 patients with Wolf-Hirschhorn syndrome using high resolution array comparative genome hybridisation (CGH).
Maas NM, Van Buggenhout G, Hannes F, Thienpont B, Sanlaville D, Kok K, Midro A, Andrieux J, Anderlid BM, Schoumans J, Hordijk R, Devriendt K, Fryns JP, Vermeesch JR.
J Med Genet 45(2):71-80. Epub 2007 Sep 14. 2008
13NSD1, WHSC1, WHSC1L1
NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.
Wang GG, Cai L, Pasillas MP, Kamps MP.
Nat Cell Biol 9(7):804-12. Epub 2007 Jun 24. 2007
14WHSC1, WHSC1L1
Evaluation of NSD2 and NSD3 in overgrowth syndromes.
Douglas J, Coleman K, Tatton-Brown K, Hughes HE, Temple IK, Cole TR, Rahman N; Childhood Overgrowth Collaboration.
Eur J Hum Genet 13(2):150-3. 2005
15LETM1, NELFA, WHS, WHSC1, WHSCR
The new Wolf-Hirschhorn syndrome critical region (WHSCR-2): A description of a second case.
Rodriguez L, Zollino M, Climent S, Mansilla E, Lopez-Grondona F, Martinez-Fernandez ML, Murdolo M, Martinez-Frias ML.
Am J Med Genet A 136(2):175-8. 2005
16NSD1, WHSC1, WHSC1L1
NSD1 mutations in Sotos syndrome.
Faravelli F.
Am J Med Genet C Semin Med Genet 137(1):24-31. 2005
17WHSC1, TACC3, FGFR3
Correlation of TACC3, FGFR3, MMSET and p21 expression with the t(4;14)(p16.3;q32) in multiple myeloma.
Stewart JP, Thompson A, Santra M, Barlogie B, Lappin TR, Shaughnessy J Jr.
Br J Haematol 126(1):72-6. 2004
18NSD1, WHSC1, WHSC1L1
NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines.
Angrand PO, Apiou F, Stewart AF, Dutrillaux B, Losson R, Chambon P.
Genomics 74(1):79-88. 2001
19WHSC1
A unique mRNA initiated within a middle intron of WHSC1/MMSET encodes a DNA binding protein that suppresses human IL-5 transcription.
Garlisi CG, Uss AS, Xiao H, Tian F, Sheridan KE, Wang L, Motasim Billah M, Egan RW, Stranick KS, Umland SP.
Am J Respir Cell Mol Biol 24(1):90-98. 2001
20WHSC1
Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by double-color fluorescent in situ hybridization.
Finelli P, et al.
Blood 94(2):724-32 1999
21WHS, WHSCR, WHSC1
WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma.
Stec I, et al.
Hum Mol Genet 7 : 1071-1082. 1998
22FGFR3, MSH6, WHSC1
The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts.
Chesi M, et al.
Blood 92 : 3025-3034. 1998
23BCL1, WHSC1
High incidence of translocations t(11;14)(q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies.
Avet-Loiseau H, et al.
Cancer Res 58 : 5640-5645. 1998
24KMT2D, MTM1, SETDB1, WHSC1
SET domain proteins modulate chromatin domains in eu- and heterochromatin.
Jenuwein T, et al.
Cell Mol Life Sci 54(1):80-93. Review. 1998