| 1 | BAIAP2L1, BAIAP2L2, EPS8, RHOF, WASF2
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| The Rho GTPase Rif signals through IRTKS, Eps8 and WAVE2 to generate dorsal membrane ruffles and filopodia
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| Sudhaharan T, Sem KP, Liew HF, Yu YH, Goh WI, Chou AM, Ahmed S.
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| J Cell Sci. Jul 15;129(14):2829-40. doi: 10.1242/jcs.179655. Epub 2016 Jun 8. 2016
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| 2 | CTTN, WASF2, WASL
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| Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens.
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| Han SP, Gambin Y, Gomez GA, Verma S, Giles N, Michael M, Wu SK, Guo Z, Johnston W, Sierecki E, Parton RG, Alexandrov K, Yap AS.
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| J Biol Chem 289(11):7764-75. doi: 10.1074/jbc.M113.544478. Epub 2014 Jan 27.
2014
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| 3 | WASF2
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| Decreased expression of Wiskott-Aldrich syndrome protein family verprolin-homologous protein 2 may be involved in the development of pre-eclampsia.
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| Li J, Luo X, Xiao X, Zhang X, Qi H, Liu X, Zhang H, Gao L, Yang Z.
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| Reprod Biomed Online 28(1):70-9. doi: 10.1016/j.rbmo.2013.07.015. Epub 2013 Aug 27.
2014
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| 4 | WASF2
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| Decreased expression of Wiskott-Aldrich syndrome protein family verprolin-homologous protein 2 may be involved in the development of pre-eclampsia.
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| Li J, Luo X, Xiao X, Zhang X, Qi H, Liu X, Zhang H, Gao L, Yang Z.
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| Reprod Biomed Online 28(1):70-9. doi: 10.1016/j.rbmo.2013.07.015. Epub 2013 Aug 27.
2014
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| 5 | WAS, WASF2
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| WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site.
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| Pauker MH, Reicher B, Joseph N, Wortzel I, Jakubowicz S, Noy E, Perl O, Barda-Saad M.
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| J Biol Chem 289(50):34503-19. doi: 10.1074/jbc.M114.591685. Epub 2014 Oct 23.
2014
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| 6 | CTTN, SKAP2, WASF2
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| The Src substrate SKAP2 regulates actin assembly by interacting with WAVE2 and cortactin proteins.
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| Shimamura S, Sasaki K, Tanaka M.
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| J Biol Chem 288(2):1171-83. doi: 10.1074/jbc.M112.386722. Epub 2012 Nov 16.
2013
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| 7 | WASF2
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| WAVE2 regulates epithelial morphology and cadherin isoform switching through regulation of Twist and Abl.
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| Bryce NS, Reynolds AB, Koleske AJ, Weaver AM.
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| PLoS One 8(5):e64533. doi: 10.1371/journal.pone.0064533. Print 2013.
2013
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| 8 | BAIAP2, DIAPH1, DIAPH2, DIAPH3, WASF2
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| mDia1 and WAVE2 proteins interact directly with IRSp53 in filopodia and are involved in filopodium formation.
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| Goh WI, Lim KB, Sudhaharan T, Sem KP, Bu W, Chou AM, Ahmed S.
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| J Biol Chem 287(7):4702-14. doi: 10.1074/jbc.M111.305102. Epub 2011 Dec 17.
2012
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| 9 | EXOC7, WASF2
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| Exo70 stimulates the Arp2/3 complex for lamellipodia formation and directional cell migration.
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| Liu J, Zhao Y, Sun Y, He B, Yang C, Svitkina T, Goldman YE, Guo W.
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| Curr Biol 22(16):1510-5. doi: 10.1016/j.cub.2012.05.055. Epub 2012 Jun 28.
2012
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| 10 | ACTR2, ACTR3, CDH1, WASF2
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| A WAVE2-Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens.
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| Verma S, Han SP, Michael M, Gomez GA, Yang Z, Teasdale RD, Ratheesh A, Kovacs EM, Ali RG, Yap AS.
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| Mol Biol Cell 23(23):4601-10. doi: 10.1091/mbc.E12-08-0574. Epub 2012 Oct 10.
2012
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| 11 | PRKACA, WASF2
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| WAVE2 forms a complex with PKA and is involved in PKA enhancement of membrane protrusions.
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| Yamashita H, Ueda K, Kioka N.
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| J Biol Chem 286(5):3907-14. Epub 2010 Nov 30.
2011
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| 12 | MAPK1, WASF2
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| ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex.
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| Mendoza MC, Er EE, Zhang W, Ballif BA, Elliott HL, Danuser G, Blenis J.
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| Mol Cell 41(6):661-71.
2011
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| 13 | ENAH, PDGFA, WASF2, WASL
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| WAVE2, N-WASP, and Mena facilitate cell invasion via phosphatidylinositol 3-kinase-dependent local accumulation of actin filaments.
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| Takahashi K, Suzuki K.
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| J Cell Biochem 112(11):3421-9. doi: 10.1002/jcb.23276.
2011
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| 14 | WASF2
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| WAVE2 regulates meiotic spindle stability, peripheral positioning and polar body emission in mouse oocytes.
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| Sun SC, Xu YN, Li YH, Lee SE, Jin YX, Cui XS, Kim NH.
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| Cell Cycle 10(11):1853-60. Epub 2011 Jun 1.
2011
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| 15 | WASF2, WASL
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| IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.
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| Orange JS, Roy-Ghanta S, Mace EM, Maru S, Rak GD, Sanborn KB, Fasth A, Saltzman R, Paisley A, Monaco-Shawver L, Banerjee PP, Pandey R.
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| J Clin Invest 121(4):1535-48. doi: 10.1172/JCI44862. Epub 2011 Mar 7.
2011
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| 16 | WAS, WASF1, WASF2, WASF3
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| Relative actin nucleation promotion efficiency by WASP and WAVE proteins in endothelial cells.
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| Kang H, Wang J, Longley SJ, Tang JX, Shaw SK.
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| Biochem Biophys Res Commun 400(4):661-6. Epub 2010 Sep 9.
2010
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| 17 | WASF2
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| Activation of the WAVE complex by coincident signals controls actin assembly.
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| Lebensohn AM, Kirschner MW.
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| Mol Cell 36(3):512-24.PMID: 19917258 2009
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| 18 | ARHGEF7, GIT1, WASF2
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| BetaPIX and GIT1 regulate HGF-induced lamellipodia formation and WAVE2 transport.
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| Morimura S, Suzuki K, Takahashi K.
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| Biochem Biophys Res Commun 382(3):614-9. Epub 2009 Mar 19.PMID: 19303398 2009
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| 19 | WASF2
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| WAVE2 is regulated by multiple phosphorylation events within its VCA domain.
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| Pocha SM, Cory GO.
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| Cell Motil Cytoskeleton 66(1):36-47.PMID: 19012317 2009
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| 20 | WASF2
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| Requirement of kinesin-mediated membrane transport of WAVE2 along microtubules for lamellipodia formation promoted by hepatocyte growth factor.
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| Takahashi K, Suzuki K.
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| Exp Cell Res 314(11-12):2313-22. Epub 2008 May 2.PMID: 18514191 2008
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| 21 | WASF2
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| Phosphorylation of WAVE2 by MAP kinases regulates persistent cell migration and polarity.
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| Danson CM, Pocha SM, Bloomberg GB, Cory GO.
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| J Cell Sci 120(Pt 23):4144-54.PMID: 18032787 2007
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| 22 | WASF2
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| Expression of the WASP verprolin-homologues (WAVE members) in human breast cancer.
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| Fernando HS, Davies SR, Chhabra A, Watkins G, Douglas-Jones A, Kynaston H, Mansel RE, Jiang WG.
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| Oncology 73(5-6):376-83. Epub 2008 May 29.PMID: 18509249 2007
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| 23 | WASF2
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| Increased expression of Wiskott-Aldrich syndrome protein family verprolin-homologous protein 2 correlated with poor prognosis of hepatocellular carcinoma.
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| Yang LY, Tao YM, Ou DP, Wang W, Chang ZG, Wu F.
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| Clin Cancer Res 12(19):5673-9. 2006
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| 24 | SORBS3, WASF2
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| Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin.
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| Mitsushima M, Sezaki T, Akahane R, Ueda K, Suetsugu S, Takenawa T, Kioka N.
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| Genes Cells 11(3):281-92. 2006
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| 25 | WASF2, ABL1
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| c-Abl interacts with the WAVE2 signaling complex to induce membrane ruffling and cell spreading.
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| Stuart JR, Gonzalez FH, Kawai H, Yuan ZM.
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| J Biol Chem 281(42):31290-7. Epub 2006 Aug 9. 2006
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| 26 | CD9, WASF2
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| MRP-1/CD9 gene transduction regulates the actin cytoskeleton through the downregulation of WAVE2.
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| Huang CL, Ueno M, Liu D, Masuya D, Nakano J, Yokomise H, Nakagawa T, Miyake M.
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| Oncogene 25(49):6480-8. Epub 2006 May 8.
2006
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| 27 | ABL1, ABI1, WASF2
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| Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation.
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| Leng Y, Zhang J, Badour K, Arpaia E, Freeman S, Cheung P, Siu M, Siminovitch K.
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| Proc Natl Acad Sci U S A 102(4):1098-103. Epub 2005 Jan 18. 2005
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| 28 | WASF2
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| WAVE2 is required for directed cell migration and cardiovascular development.
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| Yamazaki D, Suetsugu S, Miki H, Kataoka Y, Nishikawa S, Fujiwara T, Yoshida N, Takenawa T.
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| Nature 424(6947):452-6. 2003
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| 29 | WASF1, WASF2, WASF3
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| Genomic organization and expression profile of the human and mouse WAVE gene family.
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| Sossey-Alaoui K, Head K, Nowak N, Cowell JK.
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| Mamm Genome 14(5):314-22. 2003
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| 30 | WASF2
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| WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility.
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| Yan C, Martinez-Quiles N, Eden S, Shibata T, Takeshima F, Shinkura R, Fujiwara Y, Bronson R, Snapper SB, Kirschner MW, Geha R, Rosen FS, Alt FW.
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| EMBO J 22(14):3602-12. 2003
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| 31 | WASF1, WASF2, WASF3
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| Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex.
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| Suetsugu S, et al.
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| Biochem Biophys Res Commun 260(1):296-302 1999
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| 32 | WASF2
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| SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development.
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| Bear JE, et al.
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| J Cell Biol 142(5):1325-35 1998
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