| 1 | VKORC1, VKORC1L1
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| Conserved Loop Cysteines of Vitamin K Epoxide Reductase Complex Subunit 1-like 1 (VKORC1L1) Are Involved in Its Active Site Regeneration.
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| Tie JK, Jin DY, Stafford DW.
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| J Biol Chem 289(13):9396-407. doi: 10.1074/jbc.M113.534446. Epub 2014 Feb 13.
2014
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| 2 | VKORC1
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| miR-133a regulates vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1), a key protein in the vitamin K cycle.
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| Pérez-Andreu V, Teruel R, Corral J, Roldán V, García-Barberá N, Salloum-Asfar S, Gómez-Lechón MJ, Bourgeois S, Deloukas P, Wadelius M, Vicente V, González-Conejero R, Martínez C.
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| Mol Med 18:1466-72. doi: 10.2119/molmed.2012.00062.
2013
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| 3 | VKORC1
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| The influence of VKORC1 and CYP2C9 gene sequence variants on the stability of maintenance phase warfarin treatment.
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| Skov J, Bladbjerg EM, Leppin A, Jespersen J.
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| Thromb Res 131(2):125-9. doi: 10.1016/j.thromres.2012.11.004. Epub 2012 Nov 16.
2013
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| 4 | VKORC1
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| Brief Report: Single-nucleotide polymorphisms in VKORC1 are risk factors for systemic lupus erythematosus in Asians.
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| Kaiser R, Taylor KE, Deng Y, Zhao J, Li Y, Nititham J, Chang M, Catanese J, Begovich AB, Brown EE, Edberg JC, McGwin G, Alarcón GS, Ramsey-Goldman R, Reveille JD, Vila LM, Petri M, Kimberly RP, Feng X, Sun L, Shen N, Li W, Lu JX, Wakeland EK, Li QZ, Yang W, Lau YL, Liu FL, Chang DM, Yu CY, Song YW, Tsao BP, Criswell LA; Hwee Siew Howe and the Tan Tock Seng Hospital Systemic Lupus Erythematosus Study Group.
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| Arthritis Rheum 65(1):211-5. doi: 10.1002/art.37751.
2013
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| 5 | VKORC1
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| VKORC1 rs2359612C allele is associated with increased risk of coronary artery disease in the presence of coronary calcification.
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| Wang Y, Chen J, Zhang Y, Bin L, Sun K, Yu W, Liu J, Zhang C, Shen H, Hou Z, Yu F, Hui R.
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| Hum Genet 132(1):29-37. doi: 10.1007/s00439-012-1222-y. Epub 2012 Aug 23.
2013
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| 6 | VKORC1, VKORC1L1
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| VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.
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| Hammed A, Matagrin B, Spohn G, Prouillac C, Benoit E, Lattard V.
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| J Biol Chem 288(40):28733-42. doi: 10.1074/jbc.M113.457119. Epub 2013 Aug 8. 2013
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| 7 | VKORC1
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| Positive selection in the chromosome 16 VKORC1 genomic region has contributed to the variability of anticoagulant response in humans.
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| Patillon B, Luisi P, Blanché H, Patin E, Cann HM, Génin E, Sabbagh A.
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| PLoS One 7(12):e53049. doi: 10.1371/journal.pone.0053049. Epub 2012 Dec 28.
2012
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| 8 | CYP2C9, VKORC1
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| Influence of CYP2C9 and VKORC1 on patient response to warfarin: a systematic review and meta-analysis.
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| Jorgensen AL, FitzGerald RJ, Oyee J, Pirmohamed M, Williamson PR.
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| PLoS One 7(8):e44064. doi: 10.1371/journal.pone.0044064. Epub 2012 Aug 29. Review.
2012
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| 9 | VKORC1
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| Biochemical characterization of spontaneous mutants of rat VKORC1 involved in the resistance to antivitamin K anticoagulants.
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| Hodroge A, Longin-Sauvageon C, Fourel I, Benoit E, Lattard V.
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| Arch Biochem Biophys 515(1-2):14-20. doi: 10.1016/j.abb.2011.08.010. Epub 2011 Aug 31.
2011
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| 10 | SERP1, VKORC1
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| Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation.
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| Schaafhausen A, Rost S, Oldenburg J, Müller CR.
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| Thromb Haemost 105(2):285-94. doi: 10.1160/TH10-07-0483. Epub 2010 Nov 23.
2011
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| 11 | SERP1, VKORC1
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| Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation.
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| Schaafhausen A, Rost S, Oldenburg J, Müller CR.
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| Thromb Haemost 105(2):285-94. doi: 10.1160/TH10-07-0483. Epub 2010 Nov 23.
2011
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| 12 | VKORC1
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| Vitamin K epoxide reductase (VKORC1) gene mutations in osteoporosis: A pilot study.
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| Holzer G, Grasse AV, Zehetmayer S, Bencur P, Bieglmayer C, Mannhalter C.
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| Transl Res 156(1):37-44. doi: 10.1016/j.trsl.2010.05.005. Epub 2010 May 27.
2010
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| 13 | VKORC1
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| VKORC1 pharmacogenomics summary.
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| Owen RP, Gong L, Sagreiya H, Klein TE, Altman RB.
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| Pharmacogenet Genomics 20(10):642-4. doi: 10.1097/FPC.0b013e32833433b6. No abstract available.
2010
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| 14 | CYP2C9, CYP4F2, VKORC1
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| A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.
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| Takeuchi F, McGinnis R, Bourgeois S, Barnes C, Eriksson N, Soranzo N, Whittaker P, Ranganath V, Kumanduri V, McLaren W, Holm L, Lindh J, Rane A, Wadelius M, Deloukas P.
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| PLoS Genet 5(3):e1000433. Epub 2009 Mar 20.
2009
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| 15 | VKORC1
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| VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding.
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| Spohn G, Kleinridders A, Wunderlich FT, Watzka M, Zaucke F, Blumbach K, Geisen C, Seifried E, Müller C, Paulsson M, Brüning JC, Oldenburg J.
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| Thromb Haemost 101(6):1044-50.
2009
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| 16 | CYP2C9, VKORC1
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| Warfarin pharmacogenetics: CYP2C9 and VKORC1 genotypes predict different sensitivity and resistance frequencies in the Ashkenazi and Sephardi Jewish populations.
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| Scott SA, Edelmann L, Kornreich R, Desnick RJ.
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| Am J Hum Genet 82(2):495-500. Epub 2008 Jan 17. 2008
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| 17 | AGPS, ARSE, CDPX1, CDPX2A, CHILD, DHAPAT, EBP, GGCX, HEMSK, KES, LBR, MGP, NSHDL, PEX7, RCDP1, RCDP2, RCDP3, VKCFD2, VKORC1
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| Chondrodysplasia punctata: a clinical diagnostic and radiological review.
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| Irving MD, Chitty LS, Mansour S, Hall CM.
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| Clin Dysmorphol 17(4):229-41.
2008
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| 18 | CYP2C9, VKORC1
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| Polymorphisms in the VKORC1 gene are strongly associated with warfarin dosage requirements in patients receiving anticoagulation.
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| Li T, Lange LA, Li X, Susswein L, Bryant B, Malone R, Lange EM, Huang TY, Stafford DW, Evans JP.
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| J Med Genet 43(9):740-4. Epub 2006 Apr 12. 2006
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| 19 | VKORC1
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| A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity.
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| Yuan HY, Chen JJ, Lee MT, Wung JC, Chen YF, Charng MJ, Lu MJ, Hung CR, Wei CY, Chen CH, Wu JY, Chen YT.
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| Hum Mol Genet 14(13):1745-51. Epub 2005 May 11. 2005
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| 20 | VKORC1
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| The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen.
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| Sconce EA, Khan TI, Wynne HA, Avery P, Monkhouse L, King BP, Wood P, Kesteven P, Daly AK, Kamali F.
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| Blood 106(7):2329-33. Epub 2005 Jun 9. 2005
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| 21 | VKORC1
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| A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin.
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| D'Andrea G, D'Ambrosio RL, Di Perna P, Chetta M, Santacroce R, Brancaccio V, Grandone E, Margaglione M.
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| Blood 105(2):645-9. Epub 2004 Sep 9. 2005
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| 22 | VKORC1, VKCFD2
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| Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
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| Rost S, Fregin A, Ivaskevicius V, Conzelmann E, Hortnagel K, Pelz HJ, Lappegard K, Seifried E, Scharrer I, Tuddenham EG, Muller CR, Strom TM, Oldenburg J.
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| Nature 427(6974):537-41. 2004
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| 23 | VKORC1, VKCFD2
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| Identification of the gene for vitamin K epoxide reductase.
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| Li T, Chang CY, Jin DY, Lin PJ, Khvorova A, Stafford DW.
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| Nature 427(6974):541-4. 2004
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| 24 | GGCX, GGCXD, VKCFD2, VKORC1
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| Homozygosity mapping of a second gene locus for hereditary combined deficiency of vitamin K-dependent clotting factors to the centromeric region of chromosome 16.
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| Fregin A, Rost S, Wolz W, Krebsova A, Muller CR, Oldenburg J.
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| Blood 100(9):3229-32. 2002
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