1 | VGLL4
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| VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited Runx2 transcription
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| Suo J, Feng X, Li J, Wang J, Wang Z, Zhang L, Zou W.
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| Sci Adv. Oct 23;6(43):eaba4147. doi: 10.1126/sciadv.aba4147. 2020
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2 | VGLL1, VGLL2, VGLL3, VGLL4
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| Multiple Roles of Vestigial-Like Family Members in Tumor Development
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| Yamaguchi N.
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| Front Oncol. Jul 24;10:1266. doi: 10.3389/fonc.2020.01266. 2020
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3 | CD274, VGLL4, YAP1
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| Loss of VGLL4 suppresses tumor PD-L1 expression and immune evasion
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| Wu A, Wu Q, Deng Y, Liu Y, Lu J, Liu L, Li X, Liao C, Zhao B, Song H
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| EMBO J Jan 3;38(1):e99506. doi: 10.15252/embj.201899506. Epub 2018 Nov 5 2019
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4 | VGLL4
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| VGLL4 plays a critical role in heart valve development and homeostasis
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| Yu W, Ma X, Xu J, Heumüller AW, Fei Z, Feng X, Wang X, Liu K, Li J, Cui G, Peng G, Ji H, Li J, Jing N, Song H, Lin Z, Zhao Y, Wang Z, Zhou B, Zhang L.
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| PLoS Genet. Feb 21;15(2):e1007977. doi: 10.1371/journal.pgen.1007977. 2019
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5 | CTBP2, TEAD4, VGLL4
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| The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex
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| Zhang W, Xu J, Li J, Guo T, Jiang D, Feng X, Ma X, He L, Wu W, Yin M, Ge L, Wang Z, Ho MS, Zhao Y, Fei Z, Zhang L.
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| J Biol Chem. Nov 2;293(44):17119-17134. doi: 10.1074/jbc.RA118.003608. Epub 2018 Sep 12. 2018
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6 | VGLL4
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| VGLL4 is a transcriptional cofactor acting as a novel tumor suppressor via interacting with TEADs
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| Deng X, Fang L.
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| Am J Cancer Res. Jun 1;8(6):932-943. 2018
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7 | TEAD1, VGLL4, YAP1
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| VGLL4 Selectively Represses YAP-Dependent Gene Induction and Tumorigenic Phenotypes in Breast Cancer
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| Zhang Y, Shen H, Withers HG, Yang N, Denson KE, Mussell AL, Truskinovsky A, Fan Q, Gelman IH, Frangou C, Zhang J.
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| Sci Rep. Jul 21;7(1):6190. doi: 10.1038/s41598-017-06227-7. 2017
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8 | CDK1, VGLL4
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| Cyclin-dependent kinase 1 (CDK1)-mediated mitotic phosphorylation of the transcriptional co-repressor Vgll4 inhibits its tumor-suppressing activity
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| Zeng Y, Stauffer S, Zhou J, Chen X, Chen Y, Dong J.
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| J Biol Chem. Sep 8;292(36):15028-15038. doi: 10.1074/jbc.M117.796284. Epub 2017 Jul 24. 2017
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9 | TEAD1, VGLL4, YAP1
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| Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth
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| Lin Z, Guo H, Cao Y, Zohrabian S, Zhou P, Ma Q, VanDusen N, Guo Y, Zhang J, Stevens SM, Liang F, Quan Q, van Gorp PR, Li A, Dos Remedios C, He A, Bezzerides VJ, Pu WT.
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| Dev Cell. Nov 21;39(4):466-479. doi: 10.1016/j.devcel.2016.09.005. Epub 2016 Oct 6 2016
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10 | USP11, VGLL4
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| Ubiquitin-specific protease 11 (USP11) functions as a tumor suppressor through deubiquitinating and stabilizing VGLL4 protein
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| Zhang E, Shen B, Mu X, Qin Y, Zhang F, Liu Y, Xiao J, Zhang P, Wang C, Tan M, Fan Y.
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| Am J Cancer Res. Dec 1;6(12):2901-2909. 2016
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11 | VGLL4
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| Downregulation of VGLL4 in the progression of esophageal squamous cell carcinoma
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| Jiang W, Yao F, He J, Lv B, Fang W, Zhu W, He G, Chen J, He J.
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| Tumour Biol. Feb;36(2):1289-97. doi: 10.1007/s13277-014-2701-7. Epub 2014 Oct 30. 2015
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12 | VGLL4, YAP1
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| VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex
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| Zhang W, Gao Y, Li P, Shi Z, Guo T, Li F, Han X, Feng Y, Zheng C, Wang Z, Li F, Chen H, Zhou Z, Zhang L, Ji H
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| Cell Res. Mar;24(3):331-43. doi: 10.1038/cr.2014.10. Epub 2014 Jan 24. 2014
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13 | VGLL4
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| Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells. 2013
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| Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA
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| Stem Cells. Dec;31(12):2833-41. doi: 10.1002/stem.1445. 2013
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14 | BIRC2, BIRC3, VGLL4, XIAP
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| A novel inhibitor of apoptosis protein (IAP)-interacting protein, Vestigial-like (Vgl)-4, counteracts apoptosis-inhibitory function of IAPs by nuclear sequestration.
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| Jin HS, Park HS, Shin JH, Kim DH, Jun SH, Lee CJ, Lee TH.
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| Biochem Biophys Res Commun 412(3):454-9. Epub 2011 Aug 4.
2011
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15 | TEAD1, VGLL4
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| Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes.
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| Chen HH, Mullett SJ, Stewart AF.
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| J Biol Chem 279(29):30800-6. Epub 2004 May 12.
2004
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