| 1 | VCAN, WGN1
|
| Homozygous Recessive Versican Missense Variation Is Associated With Early Teeth Loss in a Pakistani Family.
|
| Bigoni S, Neri M, Scotton C, Farina R, Sabatelli P, Jiang C, Zhang J, Falzarano MS, Rossi R, Ognibene D, Selvatici R, Gualandi F, Bosshardt D, Perri P, Campa C, Brancati F, Salvatore M, De Stefano MC, Taruscio D, Trombelli L, Fang M, Ferlini A.
|
| Front Genet 9:723. doi: 10.3389/fgene.2018.00723. eCollection 2018.
2019
|
| 2 | VCAN, WGN1
|
| VCAN Canonical Splice Site Mutation is Associated With Vitreoretinal Degeneration and Disrupts an MMP Proteolytic Site.
|
| Tang PH, Velez G, Tsang SH, Bassuk AG, Mahajan VB.
|
| Invest Ophthalmol Vis Sci 60(1):282-293. doi: 10.1167/iovs.18-25624.
2019
|
| 3 | PAPSSS2, SNAI1, VCAN
|
| Enhanced PAPSS2/VCAN sulfation axis is essential for Snail-mediated breast cancer cell migration and metastasis.
|
| Zhang Y, Zou X, Qian W, Weng X, Zhang L, Zhang L, Wang S, Cao X, Ma L, Wei G, Wu Y, Hou Z.
|
| Cell Death Differ 26(3):565-579. doi: 10.1038/s41418-018-0147-y. Epub 2018 Jun 28.
2019
|
| 4 | VCAN
|
| Identification of critical genes to predict recurrence and death in colon cancer: integrating gene expression and bioinformatics analysis.
|
| Long X, Deng Z, Li G, Wang Z.
|
| Cancer Cell Int 18:139. doi: 10.1186/s12935-018-0640-x. eCollection 2018.
2018
|
| 5 | VCAN, WGN1
|
| Is exon 8 the most critical or the only dispensable exon of the VCAN gene? Insights into VCAN variants and clinical spectrum of Wagner syndrome.
|
| Ankala A, Jain N, Hubbard B, Alexander JJ, Shankar SP.
|
| Am J Med Genet A 176(8):1778-1783. doi: 10.1002/ajmg.a.38855. Epub 2018 Jul 28.
2018
|
| 6 | VCAN
|
| Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs.
|
| Chang MY, Kang I, Gale M Jr, Manicone AM, Kinsella MG, Braun KR, Wigmosta T, Parks WC, Altemeier WA, Wight TN, Frevert CW.
|
| Am J Physiol Lung Cell Mol Physiol 313(6):L1069-L1086. doi: 10.1152/ajplung.00353.2017. Epub 2017 Sep 14.
2017
|
| 7 | VCAN
|
| Versican Promotes Tumor Progression, Metastasis and Predicts Poor Prognosis in Renal Carcinoma.
|
| Mitsui Y, Shiina H, Kato T, Maekawa S, Hashimoto Y, Shiina M, Imai-Sumida M, Kulkarni P, Dasgupta P, Wong RK, Hiraki M, Arichi N, Fukuhara S, Yamamura S, Majid S, Saini S, Deng G, Dahiya R, Nakajima K, Tanaka Y.
|
| Mol Cancer Res 15(7):884-895. doi: 10.1158/1541-7786.MCR-16-0444. Epub 2017 Feb 27.
2017
|
| 8 | VCAN
|
| Role of Versican and ADAMTS-1 in Polycystic Ovary Syndrome.
|
| Özler S, Öztaş E, Tokmak A, Ergin M, Kuru Pekcan M, Gümüş Güler B, Yakut Hİ, Yılmaz N.
|
| J Clin Res Pediatr Endocrinol 9(1):24-30. doi: 10.4274/jcrpe.3414. Epub 2016 Dec 2.
2017
|
| 9 | VCAN
|
| G1 Domain of Versican Regulates Hyaluronan Organization and the Phenotype of Cultured Human Dermal Fibroblasts.
|
| Merrilees MJ, Zuo N, Evanko SP, Day AJ, Wight TN.
|
| J Histochem Cytochem 64(6):353-63. doi: 10.1369/0022155416643913. Epub 2016 Apr 28.
2016
|
| 10 | VCAN
|
| Versican: a novel modulator of hepatic fibrosis.
|
| Bukong TN, Maurice SB, Chahal B, Schaeffer DF, Winwood PJ.
|
| Lab Invest 96(3):361-74. doi: 10.1038/labinvest.2015.152. Epub 2016 Jan 11.
2016
|
| 11 | VCAN
|
| Versican localizes to the nucleus in proliferating mesenchymal cells.
|
| Carthy JM, Abraham T, Meredith AJ, Boroomand S, McManus BM.
|
| Cardiovasc Pathol 24(6):368-74. doi: 10.1016/j.carpath.2015.07.010. Epub 2015 Aug 7.
2015
|
| 12 | VCAN
|
| A role for versican in the development of leiomyosarcoma.
|
| Keire PA, Bressler SL, Lemire JM, Edris B, Rubin BP, Rahmani M, McManus BM, van de Rijn M, Wight TN.
|
| J Biol Chem 289(49):34089-103. doi: 10.1074/jbc.M114.607168. Epub 2014 Oct 15.
2014
|
| 13 | VCAN
|
| Versican regulates metastasis of epithelial ovarian carcinoma cells and spheroids.
|
| Desjardins M, Xie J, Gurler H, Muralidhar GG, Sacks JD, Burdette JE, Barbolina MV.
|
| J Ovarian Res 7:70. doi: 10.1186/1757-2215-7-70. eCollection 2014.
2014
|
| 14 | ADAMTS5, SMAD2, VCAN
|
| Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves.
|
| Dupuis LE, Osinska H, Weinstein MB, Hinton RB, Kern CB.
|
| J Mol Cell Cardiol 60:50-9. doi: 10.1016/j.yjmcc.2013.03.010. Epub 2013 Mar 24.
2013
|
| 15 | VCAN
|
| Versican V2 isoform enhances angiogenesis by regulating endothelial cell activities and fibronectin expression.
|
| Yang W, Yee AJ.
|
| FEBS Lett 587(2):185-92. doi: 10.1016/j.febslet.2012.11.023. Epub 2012 Nov 28.
2013
|
| 16 | DSPP, MEPE, OGN, VCAN
|
| Developmental changes and regional localization of Dspp, Mepe, Mimecan and Versican in postnatal developing mouse teeth.
|
| Hou C, Liu ZX, Tang KL, Wang MG, Sun J, Wang J, Li S.
|
| J Mol Histol 43(1):9-16. doi: 10.1007/s10735-011-9368-9. Epub 2011 Nov 1.
2012
|
| 17 | ADAMTS1, FBLN1, VCAN
|
| Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation.
|
| Cooley MA, Fresco VM, Dorlon ME, Twal WO, Lee NV, Barth JL, Kern CB, Iruela-Arispe ML, Argraves WS.
|
| Dev Dyn 241(2):303-14. doi: 10.1002/dvdy.23716. Epub 2011 Dec 19.
2012
|
| 18 | VCAN
|
| Inhibition of hyaluronan synthesis reduces versican and fibronectin levels in trabecular meshwork cells.
|
| Keller KE, Sun YY, Vranka JA, Hayashi L, Acott TS.
|
| PLoS One 7(11):e48523. doi: 10.1371/journal.pone.0048523. Epub 2012 Nov 5.
2012
|
| 19 | VCAN, WGN1
|
| A new VCAN/versican splice acceptor site mutation in a French Wagner family associated with vascular and inflammatory ocular features.
|
| Brézin AP, Nedelec B, Barjol A, Rothschild PR, Delpech M, Valleix S.
|
| Mol Vis. 17:1669-78. 2011
|
| 20 | VCAN
|
| Versican facilitates chondrocyte differentiation and regulates joint morphogenesis.
|
| Choocheep K, Hatano S, Takagi H, Watanabe H, Kimata K, Kongtawelert P, Watanabe H.
|
| J Biol Chem. 285(27):21114-25. 2010
|
| 21 | VCAN
|
| Structure and regulation of the versican promoter: the versican promoter is regulated by AP-1 and TCF transcription factors in invasive human melanoma cells.
|
| Domenzain-Reyna C, Hernández D, Miquel-Serra L, Docampo MJ, Badenas C, Fabra A, Bassols A.
|
| J Biol Chem 284(18):12306-17. Epub 2009 Mar 6.
2009
|
| 22 | VCAN
|
| Association analysis of genes involved in the maintenance of the integrity of the extracellular matrix with intracranial aneurysms in a Japanese cohort.
|
| Ruigrok YM, Rinkel GJ, Wijmenga C, Kasuya H, Tajima A, Takahashi T, Hata A, Inoue I, Krischek B.
|
| Cerebrovasc Dis 28(2):131-4. Epub 2009 Jun 5.
2009
|
| 23 | VCAN
|
| Versican overexpression in cutaneous malignant melanoma.
|
| Gambichler T, Kreuter A, Grothe S, Altmeyer P, Brockmeyer NH, Rotterdam S.
|
| Eur J Med Res 13(11):500-4.
2008
|
| 24 | VCAN
|
| Versican, a major hyaluronan-binding component in the dermis, loses its hyaluronan-binding ability in solar elastosis.
|
| Hasegawa K, Yoneda M, Kuwabara H, Miyaishi O, Itano N, Ohno A, Zako M, Isogai Z.
|
| J Invest Dermatol 127(7):1657-63. Epub 2007 Mar 15.
2007
|
| 25 | VCAN
|
| Versican expression in human cervical cancer.
|
| Kodama J, Hasengaowa, Kusumoto T, Seki N, Matsuo T, Nakamura K, Hongo A, Hiramatsu Y.
|
| Eur J Cancer 43(9):1460-6. Epub 2007 Apr 18.
2007
|
| 26 | WGN1, VCAN
|
| Erosive vitreoretinopathy and wagner disease are caused by intronic mutations in CSPG2/Versican that result in an imbalance of splice variants.
|
| Mukhopadhyay A, Nikopoulos K, Maugeri A, de Brouwer AP, van Nouhuys CE, Boon CJ, Perveen R, Zegers HA, Wittebol-Post D, van den Biesen PR, van der Velde-Visser SD, Brunner HG, Black GC, Hoyng CB, Cremers FP.
|
| Invest Ophthalmol Vis Sci 47(8):3565-72. 2006
|
| 27 | WGN1, VCAN
|
| Identification of the genetic defect in the original Wagner syndrome family.
|
| Kloeckener-Gruissem B, Bartholdi D, Abdou MT, Zimmermann DR, Berger W.
|
| Mol Vis 12:350-5. 2006
|
| 28 | VCAN
|
| Versican mediates mesenchymal-epithelial transition.
|
| Sheng W, Wang G, La Pierre DP, Wen J, Deng Z, Wong CK, Lee DY, Yang BB.
|
| Mol Biol Cell 17(4):2009-20. Epub 2006 Feb 1. 2006
|
| 29 | VCAN, WGN1
|
| Identification of a novel splice site mutation of the CSPG2 gene in a Japanese family with Wagner syndrome.
|
| Miyamoto T, Inoue H, Sakamoto Y, Kudo E, Naito T, Mikawa T, Mikawa Y, Isashiki Y, Osabe D, Shinohara S, Shiota H, Itakura M.
|
| Invest Ophthalmol Vis Sci 46(8):2726-35. 2005
|
| 30 | VCAN
|
| Versican splice variants in human trabecular meshwork and ciliary muscle.
|
| Zhao X, Russell P.
|
| Mol Vis 11:603-8. 2005
|
| 31 | ADAMTS4, VCAN
|
| ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein.
|
| Westling J, Gottschall PE, Thompson VP, Cockburn A, Perides G, Zimmermann DR, Sandy JD.
|
| Biochem J 377(Pt 3):787-95. 2004
|
| 32 | VCAN
|
| PG-M/versican binds to P-selectin glycoprotein ligand-1 and mediates leukocyte aggregation.
|
| Zheng PS, Vais D, Lapierre D, Liang YY, Lee V, Yang BL, Yang BB.
|
| J Cell Sci. 117(Pt 24):5887-95. 2004
|
| 33 | VCAN
|
| Distinct interaction of versican/PG-M with hyaluronan and link protein.
|
| Matsumoto K, Shionyu M, Go M, Shimizu K, Shinomura T, Kimata K, Watanabe H.
|
| J Biol Chem. 278(42):41205-12. 2003
|
| 34 | VCAN
|
| Versican interacts with fibrillin-1 and links extracellular microfibrils to other connective tissue networks.
|
| Isogai Z, Aspberg A, Keene DR, Ono RN, Reinhardt DP, Sakai LY.
|
| J Biol Chem. 277(6):4565-72. 2002
|
| 35 | VCAN
|
| beta 1-Integrin-mediated glioma cell adhesion and free radical-induced apoptosis are regulated by binding to a C-terminal domain of PG-M/versican.
|
| Wu Y, Chen L, Zheng PS, Yang BB.
|
| J Biol Chem. 277(14):12294-301 2002
|
| 36 | VCAN
|
| Versican interacts with chemokines and modulates cellular responses.
|
| Hirose J, Kawashima H, Yoshie O, Tashiro K, Miyasaka M
|
| J Biol Chem. 276(7):5228-34. 2001
|
| 37 | VCAN
|
| The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding.
|
| Olin AI, Mörgelin M, Sasaki T, Timpl R, Heinegĺrd D, Aspberg A.
|
| J Biol Chem. 276(2):1253-61. 2001
|
| 38 | VCAN
|
| Binding of a large chondroitin sulfate/dermatan sulfate proteoglycan, versican, to L-selectin, P-selectin, and CD44.
|
| Kawashima H, Hirose M, Hirose J, Nagakubo D, Plaas AH, Miyasaka M.
|
| J Biol Chem. 275(45):35448-56. 2000
|
| 39 | HAPLN1, VCAN, WVR, WGN1
|
| Refined genetic and physical localization of the Wagner disease (WGN1) locus and the genes CRTL1 and CSPG2 to a 2- to 2.5-cM region of chromosome 5q14.3.
|
| Perveen R, et al.
|
| Genomics 57(2):219-26. 1999
|
| 40 | VRD1, WGN1, VCAN
|
| A novel hereditary developmental vitreoretinopathy with multiple ocular abnormalities localizing to a 5-cM region of chromosome 5q13-q14.
|
| Black GC, Perveen R, Wiszniewski W, Dodd CL, Donnai D, McLeod D.
|
| Ophthalmology 106(11):2074-81 1999
|
| 41 | VCAN
|
| Fibulin-1 is a ligand for the C-type lectin domains of aggrecan and versican.
|
| Aspberg A, Adam S, Kostka G, Timpl R, Heinegĺrd D.
|
| J Biol Chem. 274(29):20444-9. 1999
|
| 42 | VCAN
|
| Distribution of the large aggregating proteoglycan versican in adult human tissues.
|
| Bode-Lesniewska B, Dours-Zimmermann MT, Odermatt BF, Briner J, Heitz PU, Zimmermann DR.
|
| J Histochem Cytochem. 44(4):303-12. 1996
|
| 43 | WVR, SET, WGN1, VCAN
|
| Genetic linkage of Wagner disease and erosive vitreoretinopathy to chromosome 5q13-14.
|
| Brown DM, et al.
|
| Arch Ophthalmol 113 : 671-675. 1995
|
| 44 | VCAN
|
| Expression of PG-M(V3), an alternatively spliced form of PG-M without a chondroitin sulfate attachment in region in mouse and human tissues.
|
| Zako M, Shinomura T, Ujita M, Ito K, Kimata K.
|
| J Biol Chem 270(8):3914-8. 1995
|
| 45 | VCAN
|
| A novel glycosaminoglycan attachment domain identified in two alternative splice variants of human versican.
|
| Dours-Zimmermann MT, Zimmermann DR.
|
| J Biol Chem 269(52):32992-8. 1994
|
| 46 | VCAN
|
| Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter.
|
| Naso MF, Zimmermann DR, Iozzo RV.
|
| J Biol Chem 269(52):32999-3008. 1994
|
| 47 | VCAN
|
| Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14).
|
| Iozzo RV, et al.
|
| Genomics 14 : 845-851. 1992
|
| 48 | VCAN
|
| Multiple domains of the large fibroblast proteoglycan, versican.
|
| Zimmermann DR, Ruoslahti E.
|
| EMBO J 8(10):2975-81. 1989
|
| 49 | VCAN
|
| A fibroblast chondroitin sulfate proteoglycan core protein contains lectin-like and growth factor-like sequences.
|
| Krusius T, Gehlsen KR, Ruoslahti E.
|
| J Biol Chem 262(27):13120-5. 1987
|