| 1 | VAV1, VAV2, VAV3
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| The C1 domain of Vav3, a novel potential therapeutic target.
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| Kelsey JS, Géczy T, Kaler CJ, Blumberg PM.
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| Cell Signal 40:133-142. doi: 10.1016/j.cellsig.2017.09.008. Epub 2017 Sep 18.
2017
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| 2 | VAV1, VAV3
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| Involvement of the guanine nucleotide exchange factor Vav3 in central nervous system development and plasticity.
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| Ulc A, Gottschling C, Schäfer I, Wegrzyn D, van Leeuwen S, Luft V, Reinhard J, Faissner A.
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| Biol Chem 398(5-6):663-675. doi: 10.1515/hsz-2016-0275. Review.
2017
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| 3 | NCF2, VAV1
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| Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase.
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| Jacob CO, Eisenstein M, Dinauer MC, Ming W, Liu Q, John S, Quismorio FP Jr, Reiff A, Myones BL, Kaufman KM, McCurdy D, Harley JB, Silverman E, Kimberly RP, Vyse TJ, Gaffney PM, Moser KL, Klein-Gitelman M, Wagner-Weiner L, Langefeld CD, Armstrong DL, Zidovetzki R.
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| Proc Natl Acad Sci U S A 109(2):E59-67. doi: 10.1073/pnas.1113251108. Epub 2011 Dec 27. 2012
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| 4 | PLCG1, VAV1
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| Vav1 oncogenic mutation inhibits T cell receptor-induced calcium mobilization through inhibition of phospholipase Cγ1 activation.
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| Knyazhitsky M, Moas E, Shaginov E, Luria A, Braiman A.
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| J Biol Chem 287(23):19725-35. doi: 10.1074/jbc.M111.309799. Epub 2012 Apr 3.
2012
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| 5 | LIME1, VAV1
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| LIME mediates immunological synapse formation through activation of VAV.
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| Son M, Park I, Lee OH, Rhee I, Park C, Yun Y.
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| Mol Cells. Apr;33(4):407-14. doi: 10.1007/s10059-012-0011-8. Epub 2012 Mar 5. 2012
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| 6 | VAV1
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| The distinct role of guanine nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells.
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| Yin J, Wan YJ, Li SY, Du MJ, Zhang CZ, Zhou XL, Cao YJ.
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| Acta Pharmacol Sin 32(1):99-107. Epub 2010 Dec 13.PMID: 21151158 2011
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| 7 | VAV1
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| Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity.
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| Lazer G, Pe'er L, Farago M, Machida K, Mayer BJ, Katzav S.
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| J Biol Chem 285(30):23075-85. Epub 2010 May 10.PMID: 20457609 2010
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| 8 | IDO1, VAV1
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| IDO inhibits T-cell function through suppressing Vav1 expression and activation.
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| Li R, Wei F, Yu J, Li H, Ren X, Hao X.
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| Cancer Biol Ther 8(14):1402-8. Epub 2009 Jul 30.PMID: 19597340 2009
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| 9 | VAV1
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| A role for VAV1 in experimental autoimmune encephalomyelitis and multiple sclerosis.
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| Jagodic M, Colacios C, Nohra R, Dejean AS, Beyeen AD, Khademi M, Casemayou A, Lamouroux L, Duthoit C, Papapietro O, Sjöholm L, Bernard I, Lagrange D, Dahlman I, Lundmark F, Oturai AB, Soendergaard HB, Kemppinen A, Saarela J, Tienari PJ, Harbo HF, Spurkland A, Ramagopalan SV, Sadovnick DA, Ebers GC, Seddighzadeh M, Klareskog L, Alfredsson L, Padyukov L, Hillert J, Clanet M, Edan G, Fontaine B, Fournié GJ, Kockum I, Saoudi A, Olsson T.
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| Sci Transl Med 1(10):10ra21.PMID: 20368159 2009
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| 10 | ARHGEF19, ARHGEF5, NGEF, VAV1
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| Role of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteins.
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| Yohe ME, Rossman K, Sondek J.
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| Biochemistry 47(26):6827-39. Epub 2008 Jun 7.PMID: 18537266 2008
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| 11 | KHDRBS1, VAV1
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| The association of Sam68 with Vav1 contributes to tumorigenesis.
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| Lazer G, Pe'er L, Schapira V, Richard S, Katzav S.
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| Cell Signal 19(12):2479-86. Epub 2007 Aug 8.PMID: 17855053 2007
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| 12 | DNM2, VAV1
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| Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse.
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| Gomez TS, Hamann MJ, McCarney S, Savoy DN, Lubking CM, Heldebrant MP, Labno CM, McKean DJ, McNiven MA, Burkhardt JK, Billadeau DD.
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| Nat Immunol 6(3):261-70. Epub 2005 Feb 6. 2005
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| 13 | CD4, LCK, VAV1
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| CD4-Lck through TCR and in the absence of Vav exchange factor induces Bax increase and mitochondrial damage.
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| Tuosto L, Marinari B, Piccolella E.
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| J Immunol 168(12):6106-12. 2002
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| 14 | VAV1, VAV2, VAV3
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| Genomic organization and regulation of the vav proto-oncogene.
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| Denkinger DJ, Borges CR, Butler CL, Cushman AM, Kawahara RS.
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| Biochim Biophys Acta 1491(1-3):253-62. 2000
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| 15 | VAV1
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| The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways.
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| Costello PS, et al.
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| Proc Natl Acad Sci U S A 96(6):3035-3040. 1999
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| 16 | VAV1
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| The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization.
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| Adams JM, et al.
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| Oncogene 7 : 611-618. 1992
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| 17 | VAV1
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| The human VAV proto-oncogene maps to chromosome region 19p12-19p13.2.
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| Martinerie C, et al.
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| Hum Genet 86 : 65-68. 1990
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| 18 | VAV1
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| vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.
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| Katvav S, et al.
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| EMBO J 8 : 2283-2290. 1989
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