| 1 | RMDN3, VAPB
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| The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity
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| Gómez-Suaga P, Pérez-Nievas BG, Glennon EB, Lau DHW, Paillusson S, Mórotz GM, Calě T, Pizzo P, Noble W, Miller CCJ.
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| Acta Neuropathol Commun. Mar 6;7(1):35. doi: 10.1186/s40478-019-0688-4 2019
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| 2 | RMDN3, VAPB
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| ER-mitochondria signaling regulates autophagy
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| Gomez-Suaga P, Paillusson S, Miller CCJ
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| Autophagy Jul 3;13(7):1250-1251. doi: 10.1080/15548627.2017.1317913. Epub 2017 May 26. 2017
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| 3 | RMDN3, VAPB
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| The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy
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| Gomez-Suaga P, Paillusson S, Stoica R, Noble W, Hanger DP, Miller CCJ.
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| Curr Biol. Feb 6;27(3):371-385. doi: 10.1016/j.cub.2016.12.038. Epub 2017 Jan 26 2017
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| 4 | COL4A3BP, OSBP, VAPA, VAPB
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| CARTS biogenesis requires VAP-lipid transfer protein complexes functioning at the endoplasmic reticulum-Golgi interface.
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| Wakana Y, Kotake R, Oyama N, Murate M, Kobayashi T, Arasaki K, Inoue H, Tagaya M.
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| Mol Biol Cell 26(25):4686-99. doi: 10.1091/mbc.E15-08-0599.
2015
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| 5 | ASNA1, FAF1, VAPB
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| VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase.
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| Baron Y, Pedrioli PG, Tyagi K, Johnson C, Wood NT, Fountaine D, Wightman M, Alexandru G.
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| BMC Biol 12:39. doi: 10.1186/1741-7007-12-39.
2014
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| 6 | RAB3GAP1, VAPB
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| VAP-B binds to Rab3GAP1 at the ER: its implication in nuclear envelope formation through the ER-Golgi intermediate compartment.
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| Hantan D, Yamamoto Y, Sakisaka T.
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| Kobe J Med Sci 60(3):E48-56.
2014
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| 7 | VAPA, VAPB
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| VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase.
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| Baron Y, Pedrioli PG, Tyagi K, Johnson C, Wood NT, Fountaine D, Wightman M, Alexandru G.
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| BMC Biol 12:39. doi: 10.1186/1741-7007-12-39.
2014
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| 8 | ALS8, VAPB
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| Investigating the contribution of VAPB/ALS8 loss of function in amyotrophic lateral sclerosis.
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| Kabashi E, El Oussini H, Bercier V, Gros-Louis F, Valdmanis PN, McDearmid J, Mejier IA, Dion PA, Dupre N, Hollinger D, Sinniger J, Dirrig-Grosch S, Camu W, Meininger V, Loeffler JP, René F, Drapeau P, Rouleau GA, Dupuis L.
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| Hum Mol Genet 22(12):2350-60. doi: 10.1093/hmg/ddt080. Epub 2013 Feb 26.
2013
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| 9 | VAPB, YIF1A
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| The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane delivery into dendrites.
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| Kuijpers M, Yu KL, Teuling E, Akhmanova A, Jaarsma D, Hoogenraad CC.
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| EMBO J. Jul 17;32(14):2056-72. doi: 10.1038/emboj.2013.131. Epub 2013 Jun 4 2013
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| 10 | VAPB
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| VAMP-associated protein B (VAPB) promotes breast tumor growth by modulation of Akt activity.
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| Rao M, Song W, Jiang A, Shyr Y, Lev S, Greenstein D, Brantley-Sieders D, Chen J.
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| PLoS One 7(10):e46281. doi: 10.1371/journal.pone.0046281. Epub 2012 Oct 1.
2012
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| 11 | ALS8, ALSFTD1, C9orf72, VAPB
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| VAPB and C9orf72 mutations in 1 familial amyotrophic lateral sclerosis patient.
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| van Blitterswijk M, van Es MA, Koppers M, van Rheenen W, Medic J, Schelhaas HJ, van der Kooi AJ, de Visser M, Veldink JH, van den Berg LH.
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| Neurobiol Aging 33(12):2950.e1-4. doi: 10.1016/j.neurobiolaging.2012.07.004. Epub 2012 Aug 9.
2012
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| 12 | ALS8, VAPB
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| A mutation in VAPB that causes amyotrophic lateral sclerosis also causes a nuclear envelope defect.
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| Tran D, Chalhoub A, Schooley A, Zhang W, Ngsee JK.
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| J Cell Sci 125(Pt 12):2831-6. doi: 10.1242/jcs.102111. Epub 2012 Mar 27.
2012
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| 13 | RMDN3, VAPB
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| VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis
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| De Vos KJ, Mórotz GM, Stoica R, Tudor EL, Lau KF, Ackerley S, Warley A, Shaw CE, Miller CC.
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| Hum Mol Genet. Mar 15;21(6):1299-311. doi: 10.1093/hmg/ddr559. Epub 2011 Nov 30. 2012
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| 14 | VAPA, VAPB
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| Human VAPA and the yeast VAP Scs2p with an altered proline distribution can phenocopy amyotrophic lateral sclerosis-associated VAPB(P56S).
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| Nakamichi S, Yamanaka K, Suzuki M, Watanabe T, Kagiwada S.
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| Biochem Biophys Res Commun 404(2):605-9. Epub 2010 Dec 7.
2011
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| 15 | ALS8, VAPB
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| Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients.
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| Mitne-Neto M, Machado-Costa M, Marchetto MC, Bengtson MH, Joazeiro CA, Tsuda H, Bellen HJ, Silva HC, Oliveira AS, Lazar M, Muotri AR, Zatz M.
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| Hum Mol Genet 20(18):3642-52. doi: 10.1093/hmg/ddr284. Epub 2011 Jun 17.
2011
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| 16 | ALS8, VAPB
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| Novel splice variants of the amyotrophic lateral sclerosis-associated gene VAPB expressed in human tissues.
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| Nachreiner T, Esser M, Tenten V, Troost D, Weis J, Krüttgen A.
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| Biochem Biophys Res Commun 394(3):703-8. Epub 2010 Mar 17.
2010
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| 17 | ALS1, ALS10, ALS6, ALS8, ALS9, ANG, FUS, SOD1, TARDBP, VAPB
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| SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations.
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| Millecamps S, Salachas F, Cazeneuve C, Gordon P, Bricka B, Camuzat A, Guillot-Noël L, Russaouen O, Bruneteau G, Pradat PF, Le Forestier N, Vandenberghe N, Danel-Brunaud V, Guy N, Thauvin-Robinet C, Lacomblez L, Couratier P, Hannequin D, Seilhean D, Le Ber I, Corcia P, Camu W, Brice A, Rouleau G, LeGuern E, Meininger V.
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| J Med Genet 47(8):554-60. Epub 2010 Jun 24.PMID: 20577002 2010
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| 18 | ALS8, VAPB
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| Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis.
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| Chen HJ, Anagnostou G, Chai A, Withers J, Morris A, Adhikaree J, Pennetta G, de Belleroche JS.
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| J Biol Chem 285(51):40266-81. Epub 2010 Oct 12.
2010
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| 19 | VAPB, ALS8, VAPA
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| hVAPB, the causative gene of a heterogeneous group of motor neuron diseases in humans, is functionally interchangeable with its Drosophila homologue DVAP-33A at the neuromuscular junction.
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| Chai A, Withers J, Koh YH, Parry K, Bao H, Zhang B, Budnik V, Pennetta G.
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| Hum Mol Genet 17(2):266-80. Epub 2007 Oct 18. 2008
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| 20 | VAPA, VAPB
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| VAPB interacts with and modulates the activity of ATF6.
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| Gkogkas C, Middleton S, Kremer AM, Wardrope C, Hannah M, Gillingwater TH, Skehel P.
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| Hum Mol Genet 17(11):1517-26. Epub 2008 Feb 8. 2008
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| 21 | ALS8, VAPB
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| The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors.
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| Tsuda H, Han SM, Yang Y, Tong C, Lin YQ, Mohan K, Haueter C, Zoghbi A, Harati Y, Kwan J, Miller MA, Bellen HJ.
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| Cell 133(6):963-77. 2008
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| 22 | VAPB
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| New VAPB deletion variant and exclusion of VAPB mutations in familial ALS.
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| Landers JE, Leclerc AL, Shi L, Virkud A, Cho T, Maxwell MM, Henry AF, Polak M, Glass JD, Kwiatkowski TJ, Al-Chalabi A, Shaw CE, Leigh PN, Rodriguez-Leyza I, McKenna-Yasek D, Sapp PC, Brown RH Jr.
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| Neurology 70(14):1179-85. Epub 2008 Mar 5.
2008
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| 23 | VAPA, VAPB
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| Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates.
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| Teuling E, Ahmed S, Haasdijk E, Demmers J, Steinmetz MO, Akhmanova A, Jaarsma D, Hoogenraad CC.
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| J Neurosci 27(36):9801-15.
2007
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| 24 | VAPB, ALS8
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| Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8).
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| Kanekura K, Nishimoto I, Aiso S, Matsuoka M.
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| J Biol Chem 281(40):30223-33. Epub 2006 Aug 4. 2006
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| 25 | VAPA, VAPB
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| Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B.
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| Hamamoto I, Nishimura Y, Okamoto T, Aizaki H, Liu M, Mori Y, Abe T, Suzuki T, Lai MM, Miyamura T, Moriishi K, Matsuura Y.
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| J Virol 79(21):13473-82. 2005
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| 26 | VAPB, ALS8, SMAPA
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| A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis.
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| Nishimura AL, Mitne-Neto M, Silva HC, Richieri-Costa A, Middleton S, Cascio D, Kok F, Oliveira JR, Gillingwater T, Webb J, Skehel P, Zatz M.
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| Am J Hum Genet 75(5):822-31. Epub 2004 Sep 15. 2004
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| 27 | VAPA, VAPB
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| Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins.
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| Nishimura Y, Hayashi M, Inada H, Tanaka T.
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| Biochem Biophys Res Commun 254(1):21-6. 1999
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| 28 | SMAPA, VAPB
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| Autosomal dominant late adult spinal muscular atrophy, type Finkel.
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| Richieri-Costa A, Rogatko A, Levisky R, Finkel N, Frota-Pessoa O.
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| Am J Med Genet 9(2):119-28. 1981
|