Citations for
1SNDC, VAC14
Biallelic Mutations of VAC14 in Pediatric-Onset Neurological Disease.
Lenk GM, Szymanska K, Debska-Vielhaber G, Rydzanicz M, Walczak A, Bekiesinska-Figatowska M, Vielhaber S, Hallmann K, Stawinski P, Buehring S, Hsu DA, Kunz WS, Meisler MH, Ploski R.
Am J Hum Genet 99(1):188-94. doi: 10.1016/j.ajhg.2016.05.008. Epub 2016 Jun 9. 2016
2FIG4, PIKFYVE, VAC14
The Vac14-interaction network is linked to regulators of the endolysosomal and autophagic pathway.
Schulze U, Vollenbröker B, Braun DA, Van Le T, Granado D, Kremerskothen J, Fränzel B, Klosowski R, Barth J, Fufezan C, Wolters DA, Pavenstädt H, Weide T.
Mol Cell Proteomics 13(6):1397-411. doi: 10.1074/mcp.M113.034108. Epub 2014 Feb 27. 2014
3PIKFYVE, VAC14
Vac14 protein multimerization is a prerequisite step for Fab1 protein complex assembly and function.
Alghamdi TA, Ho CY, Mrakovic A, Taylor D, Mao D, Botelho RJ.
J Biol Chem 288(13):9363-72. doi: 10.1074/jbc.M113.453712. Epub 2013 Feb 6. 2013
4PIKFYVE, VAC14
In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.
Zolov SN, Bridges D, Zhang Y, Lee WW, Riehle E, Verma R, Lenk GM, Converso-Baran K, Weide T, Albin RL, Saltiel AR, Meisler MH, Russell MW, Weisman LS.
Proc Natl Acad Sci U S A 109(43):17472-7. doi: 10.1073/pnas.1203106109. Epub 2012 Oct 9. 2012
5VAC14
Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P₂ and PI(5)P.
Zhang Y, McCartney AJ, Zolov SN, Ferguson CJ, Meisler MH, Sutton MA, Weisman LS.
EMBO J 31(16):3442-56. doi: 10.1038/emboj.2012.200. Epub 2012 Jul 27. 2012
6CMT4J, FIG4, VAC14
ArPIKfyve regulates Sac3 protein abundance and turnover: disruption of the mechanism by Sac3I41T mutation causing Charcot-Marie-Tooth 4J disorder.
Ikonomov OC, Sbrissa D, Fligger J, Delvecchio K, Shisheva A.
J Biol Chem 285(35):26760-4. Epub 2010 Jul 14.PMID: 20630877 2010
7FIG4, PIKFYVE, VAC14
PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis.
Ikonomov OC, Sbrissa D, Fenner H, Shisheva A.
J Biol Chem 284(51):35794-806. Epub .PMID: 19840946 2009
8FIG4, PIKFYVE, VAC14
VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.
Jin N, Chow CY, Liu L, Zolov SN, Bronson R, Davisson M, Petersen JL, Zhang Y, Park S, Duex JE, Goldowitz D, Meisler MH, Weisman LS.
EMBO J 27(24):3221-34. Epub 2008 Nov 27.PMID: 19037259 2008
9VAC14
Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex.
Sbrissa D, Ikonomov OC, Fu Z, Ijuin T, Gruenberg J, Takenawa T, Shisheva A.
J Biol Chem 282(33):23878-91. Epub 2007 Jun 7. 2007
10PIKFYVE, VAC14
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.
Zhang Y, Zolov SN, Chow CY, Slutsky SG, Richardson SC, Piper RC, Yang B, Nau JJ, Westrick RJ, Morrison SJ, Meisler MH, Weisman LS.
Proc Natl Acad Sci U S A 104(44):17518-23. Epub 2007 Oct 23. 2007
11NOS1, VAC14
Binding of Vac14 to neuronal nitric oxide synthase: Characterisation of a new internal PDZ-recognition motif.
Lemaire JF, McPherson PS.
FEBS Lett 580(30):6948-54. Epub 2006 Dec 4. 2006
12VAC14
Isolation of a cDNA clone, TRX encoding a human T-cell lymphotrophic virus type-I Tax1 binding protein.
Mireskandari A, Reid RL, Kashanchi F, Dittmer J, Li WB, Brady JN.
Biochim Biophys Acta 1306(1):9-13. 1996