| 1 | PBX1, USP9X
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| Inhibition of the deubiquitinase USP9x induces pre-B cell homeobox 1 (PBX1) degradation and thereby stimulates prostate cancer cell apoptosis.
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| Liu Y, Xu X, Lin P, He Y, Zhang Y, Cao B, Zhang Z, Sethi G, Liu J, Zhou X, Mao X.
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| J Biol Chem 294(12):4572-4582. doi: 10.1074/jbc.RA118.006057. Epub 2019 Feb 4.
2019
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| 2 | EIF4A1, USP9X
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| USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1.
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| Li Z, Cheng Z, Raghothama C, Cui Z, Liu K, Li X, Jiang C, Jiang W, Tan M, Ni X, Pandey A, Liu JO, Dang Y.
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| Nucleic Acids Res. Jan 25;46(2):823-839. doi: 10.1093/nar/gkx1226. 2018
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| 3 | USP9X, ZBTB38
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| Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells.
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| Miotto B, Marchal C, Adelmant G, Guinot N, Xie P, Marto JA, Zhang L, Defossez PA.
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| Nucleic Acids Res. May 18;46(9):4392-4404. doi: 10.1093/nar/gky149. 2018
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| 4 | MRXS99F, USP9X
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| De Novo Loss-of-Function Mutations in USP9X Cause a Female-Specific Recognizable Syndrome with Developmental Delay and Congenital Malformations.
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| Reijnders MR, Zachariadis V, Latour B, Jolly L, Mancini GM, Pfundt R, Wu KM, van Ravenswaaij-Arts CM, Veenstra-Knol HE, Anderlid BM, Wood SA, Cheung SW, Barnicoat A, Probst F, Magoulas P, Brooks AS, Malmgren H, Harila-Saari A, Marcelis CM, Vreeburg M, Hobson E, Sutton VR, Stark Z, Vogt J, Cooper N, Lim JY, Price S, Lai AH, Domingo D, Reversade B; DDD Study, Gecz J, Gilissen C, Brunner HG, Kini U, Roepman R, Nordgren A, Kleefstra T.
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| Am J Hum Genet 98(2):373-81. doi: 10.1016/j.ajhg.2015.12.015. Epub 2016 Jan 28. 2016
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| 5 | PRKCB, USP9X, ZAP70
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| Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity.
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| Naik E, Dixit VM.
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| J Immunol 196(8):3438-51. doi: 10.4049/jimmunol.1403165. Epub 2016 Mar 2.
2016
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| 6 | MRX99, USP9X
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| Mutations in USP9X Are Associated with X-Linked Intellectual Disability and Disrupt Neuronal Cell Migration and Growth.
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| Homan CC, Kumar R, Nguyen LS, Haan E, Raymond FL, Abidi F, Raynaud M, Schwartz CE, Wood SA, Gecz J, Jolly LA.
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| Am J Hum Genet 94(3):470-8. doi: 10.1016/j.ajhg.2014.02.004. 2014
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| 7 | SMURF1, USP9X
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| Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.
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| Xie Y, Avello M, Schirle M, McWhinnie E, Feng Y, Bric-Furlong E, Wilson C, Nathans R, Zhang J, Kirschner MW, Huang SM, Cong F.
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| J Biol Chem 288(5):2976-85. doi: 10.1074/jbc.M112.430066. Epub 2012 Nov 26.
2013
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| 8 | USP9X
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| The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma.
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| Pérez-Mancera PA, Rust AG, van der Weyden L, Kristiansen G, Li A, Sarver AL, Silverstein KA, Grützmann R, Aust D, Rümmele P, Knösel T, Herd C, Stemple DL, Kettleborough R, Brosnan JA, Li A, Morgan R, Knight S, Yu J, Stegeman S, Collier LS, ten Hoeve JJ, de Ridder J, Klein AP, Goggins M, Hruban RH, Chang DK, Biankin AV, Grimmond SM; Australian Pancreatic Cancer Genome Initiative, Wessels LF, Wood SA, Iacobuzio-Donahue CA, Pilarsky C, Largaespada DA, Adams DJ, Tuveson DA.
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| Nature 486(7402):266-70. doi: 10.1038/nature11114.
2012
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| 9 | USP9X
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| Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR).
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| Agrawal P, Chen YT, Schilling B, Gibson BW, Hughes RE.
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| J Biol Chem 287(25):21164-75. Epub 2012 Apr 27.
2012
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| 10 | PEX5, USP9X
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| Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate.
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| Grou CP, Francisco T, Rodrigues TA, Freitas MO, Pinto MP, Carvalho AF, Domingues P, Wood SA, Rodríguez-Borges JE, Sá-Miranda C, Fransen M, Azevedo JE.
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| J Biol Chem 287(16):12815-27. doi: 10.1074/jbc.M112.340158. Epub 2012 Feb 27.
2012
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| 11 | HUWE1, MCL1, PMAIP1, USP9X
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| Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction.
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| Gomez-Bougie P, Ménoret E, Juin P, Dousset C, Pellat-Deceunynck C, Amiot M.
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| Biochem Biophys Res Commun. 413(3):460-4. 2011
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| 12 | USP9X
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| α-Synuclein fate is determined by USP9X-regulated monoubiquitination.
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| Rott R, Szargel R, Haskin J, Bandopadhyay R, Lees AJ, Shani V, Engelender S.
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| Proc Natl Acad Sci U S A 108(46):18666-71. Epub 2011 Nov 7.
2011
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| 13 | MCL1, USP9X
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| Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.
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| Schwickart M, Huang X, Lill JR, Liu J, Ferrando R, French DM, Maecker H, O'Rourke K, Bazan F, Eastham-Anderson J, Yue P, Dornan D, Huang DC, Dixit VM.
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| Nature 463(7277):103-7. Epub 2009 Dec 20.PMID: 20023629 2010
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| 14 | PSD, USP9X
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| USP9x-mediated deubiquitination of EFA6 regulates de novo tight junction assembly.
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| Théard D, Labarrade F, Partisani M, Milanini J, Sakagami H, Fon EA, Wood SA, Franco M, Luton F.
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| EMBO J 29(9):1499-509. Epub 2010 Mar 25.PMID: 20339350 2010
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| 15 | MCL1, USP9X
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| Mcl-1; the molecular regulation of protein function.
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| Thomas LW, Lam C, Edwards SW.
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| FEBS Lett 584(14):2981-9. Epub 2010 Jun 11. Review. 2010
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| 16 | SMAD4, TRIM33, USP9X
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| FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.
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| Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, Martello G, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Modena N, Argenton F, Newfeld SJ, Piccolo S.
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| Cell 136(1):123-35.
2009
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| 17 | USP9X
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| USP9X enhances the polarity and self-renewal of embryonic stem cell-derived neural progenitors.
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| Jolly LA, Taylor V, Wood SA.
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| Mol Biol Cell 20(7):2015-29. Epub 2009 Jan 28.
2009
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| 18 | MARCH7, USP7, USP9X
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| The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X.
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| Nathan JA, Sengupta S, Wood SA, Admon A, Markson G, Sanderson C, Lehner PJ.
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| Traffic 9(7):1130-45. Epub 2008 Apr 11.
2008
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| 19 | ITCH, USP9X
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| The ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme FAM/USP9X.
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| Mouchantaf R, Azakir BA, McPherson PS, Millard SM, Wood SA, Angers A.
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| J Biol Chem 281(50):38738-47. Epub 2006 Oct 12.
2006
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| 20 | DCX, USP9X
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| Doublecortin interacts with the ubiquitin protease DFFRX, which associates with microtubules in neuronal processes.
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| Friocourt G, Kappeler C, Saillour Y, Fauchereau F, Rodriguez MS, Bahi N, Vinet MC, Chafey P, Poirier K, Taya S, Wood SA, Dargemont C, Francis F, Chelly J.
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| Mol Cell Neurosci 28(1):153-64. 2005
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| 21 | USP9X, ADAM22
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| Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.
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| Fu GK, Wang JT, Yang J, Au-Young J, Stuve LL.
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| Genomics 84(1):205-10. 2004
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| 22 | CASK, CSNB1A, USP9X
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| Development of a 1.4-Mb BAC/PAC contig and physical map within the critical region for complete X-linked congenital stationary night blindness in xp11.4.
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| Sparkes RL, Summer CG, Boycott KM, Zahorchak RJ, Bech-Hansen NT.
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| Genomics 68(1):97-100. 2000
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| 23 | USP9X, USP9Y
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| The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2.
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| Jones MH, et al.
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| Hum Mol Genet 5 : 1695-1701. 1996
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