Citations for
1SEC31A, STAM, USP8
Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion.
Kawaguchi K, Endo A, Fukushima T, Madoka Y, Tanaka T, Komada M.
Biochem Biophys Res Commun 499(3):635-641. doi: 10.1016/j.bbrc.2018.03.202. Epub 2018 Mar 31. 2018
2BACE1, USP8
The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation.
Yeates EF, Tesco G.
J Biol Chem 291(30):15753-66. doi: 10.1074/jbc.M116.718023. Epub 2016 Jun 14. 2016
3MET, USP8
USP8/UBPy-regulated sorting and the development of sperm acrosome: the recruitment of MET.
Berruti G, Paiardi C.
Reproduction eproduction. 2015 Mar 5. pii: REP-14-0671. [Epub ahead of print] 2015
4BIRC6, MCPH1, USP8
BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1.
Ge C, Che L, Ren J, Pandita RK, Lu J, Li K, Pandita TK, Du C.
Proc Natl Acad Sci U S A 112(11):E1210-9. doi: 10.1073/pnas.1418335112. Epub 2015 Mar 2. 2015
5USP8
Recurrent gain-of-function USP8 mutations in Cushing's disease.
Ma ZY, Song ZJ, Chen JH, Wang YF, Li SQ, Zhou LF, Mao Y, Li YM, Hu RG, Zhang ZY, Ye HY, Shen M, Shou XF, Li ZQ, Peng H, Wang QZ, Zhou DZ, Qin XL, Ji J, Zheng J, Chen H, Wang Y, Geng DY, Tang WJ, Fu CW, Shi ZF, Zhang YC, Ye Z, He WQ, Zhang QL, Tang QS, Xie R, Shen JW, Wen ZJ, Zhou J, Wang T, Huang S, Qiu HJ, Qiao ND, Zhang Y, Pan L, Bao WM, Liu YC, Huang CX, Shi YY, Zhao Y.
Cell Res 25(3):306-17. doi: 10.1038/cr.2015.20. Epub 2015 Feb 13. 2015
6USP8
Mutations in the deubiquitinase gene USP8 cause Cushing's disease.
Reincke M, Sbiera S, Hayakawa A, Theodoropoulou M, Osswald A, Beuschlein F, Meitinger T, Mizuno-Yamasaki E, Kawaguchi K, Saeki Y, Tanaka K, Wieland T, Graf E, Saeger W, Ronchi CL, Allolio B, Buchfelder M, Strom TM, Fassnacht M, Komada M.
Nat Genet 47(1):31-8. doi: 10.1038/ng.3166. Epub 2014 Dec 8. 2015
7PRKN, USP8
USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin.
Durcan TM, Tang MY, Pérusse JR, Dashti EA, Aguileta MA, McLelland GL, Gros P, Shaler TA, Faubert D, Coulombe B, Fon EA.
EMBO J 33(21):2473-91. doi: 10.15252/embj.201489729. Epub 2014 Sep 12. 2014
8USP8
USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin.
Durcan TM, Tang MY, Pérusse JR, Dashti EA, Aguileta MA, McLelland GL, Gros P, Shaler TA, Faubert D, Coulombe B, Fon EA.
EMBO J 33(21):2473-91. doi: 10.15252/embj.201489729. Epub 2014 Sep 12. 2014
9USP8
USP8 controls the trafficking and sorting of lysosomal enzymes.
MacDonald E, Urbé S, Clague MJ.
Traffic 15(8):879-88. doi: 10.1111/tra.12180. Epub 2014 Jul 3. 2014
10ARL6IP1, ARSI, ERLIN1, FLRT1, KIF1C, PGAP1, RAB3GAP2, SPAX2, SPG59, SPG60, SPG61, SPG62, SPG66, SPG67, SPG68, SPG69, SPG71, USP8, WDR48, ZFR
Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.
Novarino G, Fenstermaker AG, Zaki MS, Hofree M, Silhavy JL, Heiberg AD, Abdellateef M, Rosti B, Scott E, Mansour L, Masri A, Kayserili H, Al-Aama JY, Abdel-Salam GMH, Karminejad A, Kara M, Kara B, Bozorgmehri B, Ben-Omran T, Mojahedi F, El Din Mahmoud IG, Bouslam N, Bouhouche A, Benomar A, Hanein S, Raymond L, Forlani S, Mascaro M, Selim L, Shehata N, Al-Allawi N, Bindu PS, Azam M, Gunel M, Caglayan A, Bilguvar K, Tolun A, Issa MY, Schroth J, Spencer EG, Rosti RO, Akizu N, Vaux KK, Johansen A, Koh AA, Megahed H, Durr A, Brice A, Stevanin G, Gabriel SB, Ideker T, Gleeson JG.
Science 343(6170):506-511. doi: 10.1126/science.1247363. 2014
11SCNN1A, USP8
Ubiquitin-specific peptidase 8 (USP8) regulates endosomal trafficking of the epithelial Na+ channel.
Zhou R, Tomkovicz VR, Butler PL, Ochoa LA, Peterson ZJ, Snyder PM.
J Biol Chem 288(8):5389-97. doi: 10.1074/jbc.M112.425272. Epub 2013 Jan 7. 2013
12RNF41, USP8
Reciprocal cross-regulation between RNF41 and USP8 controls cytokine receptor sorting and processing.
De Ceuninck L, Wauman J, Masschaele D, Peelman F, Tavernier J.
J Cell Sci 126(Pt 16):3770-81. doi: 10.1242/jcs.131250. Epub 2013 Jun 7. 2013
13USP8
The Usp8 deubiquitination enzyme is post-translationally modified by tyrosine and serine phosphorylation.
Meijer IM, Kerperien J, Sotoca AM, van Zoelen EJ, van Leeuwen JE.
Cell Signal 25(4):919-30. doi: 10.1016/j.cellsig.2013.01.003. Epub 2013 Jan 17. 2013
14SMO, USP8
USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization.
Xia R, Jia H, Fan J, Liu Y, Jia J.
PLoS Biol 10(1):e1001238. doi: 10.1371/journal.pbio.1001238. Epub 2012 Jan 10. 2012
15KCNN4, USP8
Role of ubiquitylation and USP8-dependent deubiquitylation in the endocytosis and lysosomal targeting of plasma membrane KCa3.1.
Balut CM, Loch CM, Devor DC.
FASEB J 25(11):3938-48. doi: 10.1096/fj.11-187005. Epub 2011 Aug 9. 2011
16HGS, ITCH, STAM, USP8
The deubiquitinating enzyme USP8 promotes trafficking and degradation of the chemokine receptor 4 at the sorting endosome.
Berlin I, Higginbotham KM, Dise RS, Sierra MI, Nash PD.
J Biol Chem 285(48):37895-908. Epub 2010 Sep 27. 2010
17F2RL1, STAMBP, USP8
Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2.
Hasdemir B, Murphy JE, Cottrell GS, Bunnett NW.
J Biol Chem 284(41):28453-66. Epub 2009 Aug 14.PMID: 19684015 2009
18USP8
14-3-3-dependent inhibition of the deubiquitinating activity of UBPY and its cancellation in the M phase.
Mizuno E, Kitamura N, Komada M.
Exp Cell Res 313(16):3624-34. Epub 2007 Aug 2.PMID: 17720156 2007
19CHMP1A, CHMP1B, CHMP7, STAMBP, USP8
The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.
Row PE, Liu H, Hayes S, Welchman R, Charalabous P, Hofmann K, Clague MJ, Sanderson CM, Urbé S.
J Biol Chem 282(42):30929-37. Epub 2007 Aug 21. Erratum in: J Biol Chem. 2009 Mar 20;284(12):8207. PMID: 17711858 2007
20STAM, STAMBP, USP8
The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation.
Row PE, Prior IA, McCullough J, Clague MJ, Urbé S.
J Biol Chem 281(18):12618-24. Epub 2006 Mar 6. 2006
21USP8
A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes.
Mizuno E, Kobayashi K, Yamamoto A, Kitamura N, Komada M.
Traffic 7(8):1017-31. Epub 2006 Jun 12.PMID: 16771824 2006
22RNF41, USP8
Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8).
Avvakumov GV, Walker JR, Xue S, Finerty PJ Jr, Mackenzie F, Newman EM, Dhe-Paganon S.
J Biol Chem 281(49):38061-70. Epub 2006 Oct 11. 2006
23USP8, RNF41
Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8.
Wu X, Yen L, Irwin L, Sweeney C, Carraway KL 3rd.
Mol Cell Biol 24(17):7748-57. 2004
24USP8
Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1.
Gnesutta N, Ceriani M, Innocenti M, Mauri I, Zippel R, Sturani E, Borgonovo B, Berruti G, Martegani E.
J Biol Chem 276(42):39448-54. Epub 2001 Aug 10. 2001
25USP8
Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 (supplement).
Nomura N, et al.
DNA Res 1 : 251-262. 1994