| 1 | TAF6, TRAF2, USP4
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| Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFα-induced cancer cell migration.
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| Xiao N, Li H, Luo J, Wang R, Chen H, Chen J, Wang P.
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| Biochem J 441(3):979-86.
2012
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| 2 | USP15, USP4
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| Ubiquitin removal in the TGF-β pathway.
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| Aggarwal K, Massagué J.
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| Nat Cell Biol 14(7):656-7. doi: 10.1038/ncb2534.
2012
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| 3 | PSMD11, USP4
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| The ubiquitin specific protease-4 (USP4) interacts with the S9/Rpn6 subunit of the proteasome.
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| Zhao B, Velasco K, Sompallae R, Pfirrmann T, Masucci MG, Lindsten K.
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| Biochem Biophys Res Commun 427(3):490-6. doi: 10.1016/j.bbrc.2012.09.075. Epub 2012 Sep 26.
2012
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| 4 | PDPK1, USP4
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| Ubiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1.
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| Uras IZ, List T, Nijman SM.
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| PLoS One 7(2):e31003. doi: 10.1371/journal.pone.0031003. Epub 2012 Feb 7.
2012
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| 5 | USP4
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| Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain.
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| Luna-Vargas MP, Faesen AC, van Dijk WJ, Rape M, Fish A, Sixma TK.
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| EMBO Rep 12(4):365-72. Epub 2011 Mar 18.
2011
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| 6 | HUWE1, USP4
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| USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1.
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| Zhang X, Berger FG, Yang J, Lu X.
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| EMBO J 30(11):2177-89. Epub 2011 Apr 26.
2011
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| 7 | MAP3K7, USP4
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| USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation.
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| Fan YH, Yu Y, Mao RF, Tan XJ, Xu GF, Zhang H, Lu XB, Fu SB, Yang J.
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| Cell Death Differ 18(10):1547-60. doi: 10.1038/cdd.2011.11. Epub 2011 Feb 18.
2011
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| 8 | PRPF19, PRPF3, USP4
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| The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.
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| Song EJ, Werner SL, Neubauer J, Stegmeier F, Aspden J, Rio D, Harper JW, Elledge SJ, Kirschner MW, Rape M.
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| Genes Dev 24(13):1434-47. 2010
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| 9 | USP4
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| The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathway.
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| Zhao B, Schlesiger C, Masucci MG, Lindsten K.
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| J Cell Mol Med 13(8B):1886-95.
2009
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| 10 | ACTN1, ADORA2A, CYTH2, TSNAX, USP4
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| The A(2A)-adenosine receptor: a GPCR with unique features?
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| Zezula J, Freissmuth M.
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| Br J Pharmacol 153 Suppl 1:S184-90. Epub 2008 Feb 4. Review.PMID: 18246094 2008
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| 11 | TRIM21, USP4
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| Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity.
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| Wada K, Tanji K, Kamitani T.
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| Biochem Biophys Res Commun 339(3):731-6. 2006
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| 12 | USP4
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| The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor.
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| Milojevic T, Reiterer V, Stefan E, Korkhov VM, Dorostkar MM, Ducza E, Ogris E, Boehm S, Freissmuth M, Nanoff C.
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| Mol Pharmacol 69(4):1083-94. Epub 2005 Dec 9.
2006
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| 13 | USP4
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| Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130.
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| Blanchette P, Gilchrist CA, Baker RT, Gray DA.
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| Oncogene 20(39):5533-7. 2001
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| 14 | USP4
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| The human UNP locus at 3p21.31 encodes two tissue-selective, cytoplasmic isoforms with deubiquitinating activity that have reduced expression in small cell lung carcinoma cell lines.
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| Frederick A, et al.
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| Oncogene 16 : 153-165. 1998
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| 15 | USP4
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| Elevated expression of Unph, a proto-oncogene at 3p21.3, in human lung tumors.
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| Gray DA, et al.
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| Oncogene 10 : 2179-2183. 1995
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