| 1 | ISG15, USP18
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| Structural basis of the specificity of USP18 toward ISG15.
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| Basters A, Geurink PP, Röcker A, Witting KF, Tadayon R, Hess S, Semrau MS, Storici P, Ovaa H, Knobeloch KP, Fritz G.
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| Nat Struct Mol Biol 24(3):270-278. doi: 10.1038/nsmb.3371. Epub 2017 Feb 6.
2017
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| 2 | IFNA2, IRS4, USP18
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| Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway.
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| Jiao B, Shi X, Chen Y, Ye H, Yao M, Hong W, Li S, Duan X, Li Y, Wang Y, Chen L.
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| Oncotarget Nov 18;8(62):105923-105935. doi: 10.18632/oncotarget.22510. eCollection 2017 Dec 1. 2017
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| 3 | USP18, USP20
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| USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA.
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| Zhang M, Zhang MX, Zhang Q, Zhu GF, Yuan L, Zhang DE, Zhu Q, Yao J, Shu HB, Zhong B.
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| Cell Res 26(12):1302-1319. doi: 10.1038/cr.2016.125. Epub 2016 Nov 1.
2016
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| 4 | USP18, WT1
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| Ubiquitin specific protease 18 (Usp18) is a WT1 transcriptional target.
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| Shahidul Makki M, Cristy Ruteshouser E, Huff V.
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| Exp Cell Res xp Cell Res. 2013 Jan 2. doi:pii: S0014-4827(12)00498-3. 10.1016/j.yexcr.2012.12.021. [Epub ahead of print]
2013
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| 5 | CCND1, ISG15, USP18
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| Evidence for the ubiquitin protease UBP43 as an antineoplastic target.
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| Guo Y, Chinyengetere F, Dolinko AV, Lopez-Aguiar A, Lu Y, Galimberti F, Ma T, Feng Q, Sekula D, Freemantle SJ, Andrew AS, Memoli V, Dmitrovsky E.
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| Mol Cancer Ther 11(9):1968-77. doi: 10.1158/1535-7163.MCT-12-0248. Epub 2012 Jul 2.
2012
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| 6 | USP18
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| USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis.
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| Santin I, Moore F, Grieco FA, Marchetti P, Brancolini C, Eizirik DL.
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| Cell Death Dis 3:e419. doi: 10.1038/cddis.2012.158.
2012
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| 7 | ISG15, USP18
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| High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion system.
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| Basters A, Ketscher L, Deuerling E, Arkona C, Rademann J, Knobeloch KP, Fritz G.
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| BMC Biotechnol 12:56. doi: 10.1186/1472-6750-12-56.
2012
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| 8 | USP18
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| Usp18 promotes conventional CD11b+ dendritic cell development.
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| Cong XL, Lo MC, Reuter BA, Yan M, Fan JB, Zhang DE.
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| J Immunol 188(10):4776-81. doi: 10.4049/jimmunol.1101609. Epub 2012 Apr 9.
2012
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| 9 | USP18
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| The mitochondrial pathway and reactive oxygen species are critical contributors to interferon-α/β-mediated apoptosis in Ubp43-deficient hematopoietic cells.
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| Yim HY, Yang Y, Lim JS, Lee MS, Zhang DE, Kim KI.
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| Biochem Biophys Res Commun 423(2):436-40. doi: 10.1016/j.bbrc.2012.05.154. Epub 2012 Jun 5.
2012
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| 10 | ITGAM, USP18
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| Usp18 promotes conventional CD11b+ dendritic cell development.
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| Cong XL, Lo MC, Reuter BA, Yan M, Fan JB, Zhang DE.
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| J Immunol 188(10):4776-81. doi: 10.4049/jimmunol.1101609. Epub 2012 Apr 9.
2012
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| 11 | EGFr, USP18
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| Usp18 regulates epidermal growth factor (EGF) receptor expression and cancer cell survival via microRNA-7.
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| Duex JE, Comeau L, Sorkin A, Purow B, Kefas B.
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| J Biol Chem 286(28):25377-86. doi: 10.1074/jbc.M111.222760. Epub 2011 May 18.
2011
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| 12 | USP18
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| Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARα and inhibits the growth of acute promyelocytic leukemia.
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| Guo Y, Dolinko AV, Chinyengetere F, Stanton B, Bomberger JM, Demidenko E, Zhou DC, Gallagher R, Ma T, Galimberti F, Liu X, Sekula D, Freemantle S, Dmitrovsky E.
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| Cancer Res 70(23):9875-85. Epub 2010 Oct 8.
2010
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| 13 | USP18
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| Identification of USP18 as an important regulator of the susceptibility to IFN-alpha and drug-induced apoptosis.
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| Potu H, Sgorbissa A, Brancolini C.
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| Cancer Res 70(2):655-65. doi: 10.1158/0008-5472.CAN-09-1942. Epub 2010 Jan 12.
2010
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| 14 | USP18
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| Epstein-Barr virus independent dysregulation of UBP43 expression alters interferon-stimulated gene expression in Burkitt lymphoma.
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| Ruf IK, Houmani JL, Sample JT.
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| PLoS One 4(6):e6023. doi: 10.1371/journal.pone.0006023.
2009
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| 15 | EGFR, USP18
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| RNA interference screen identifies Usp18 as a regulator of epidermal growth factor receptor synthesis.
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| Duex JE, Sorkin A.
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| Mol Biol Cell 20(6):1833-44. doi: 10.1091/mbc.E08-08-0880. Epub 2009 Jan 21.
2009
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| 16 | USP18
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| The level of hepatitis B virus replication is not affected by protein ISG15 modification but is reduced by inhibition of UBP43 (USP18) expression.
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| Kim JH, Luo JK, Zhang DE.
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| J Immunol 181(9):6467-72.
2008
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| 17 | USP18
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| Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling.
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| Yan M, Luo JK, Ritchie KJ, Sakai I, Takeuchi K, Ren R, Zhang DE.
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| Blood 110(1):305-12. Epub 2007 Mar 20. 2007
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| 18 | ISG15, USP18
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| Ubp43 gene expression is required for normal Isg15 expression and fetal development.
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| Rempel LA, Austin KJ, Ritchie KJ, Yan M, Shen M, Zhang DE, Henkes LE, Hansen TR.
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| Reprod Biol Endocrinol 5:13.
2007
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| 19 | USP18
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| Silencing of USP18 potentiates the antiviral activity of interferon against hepatitis C virus infection.
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| Randall G, Chen L, Panis M, Fischer AK, Lindenbach BD, Sun J, Heathcote J, Rice CM, Edwards AM, McGilvray ID.
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| Gastroenterology 131(5):1584-91. Epub 2006 Aug 22.
2006
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| 20 | ISG15, USP18
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| UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity.
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| Malakhova OA, Kim KI, Luo JK, Zou W, Kumar KG, Fuchs SY, Shuai K, Zhang DE.
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| EMBO J 25(11):2358-67. Epub 2006 May 18.
2006
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| 21 | ISG15, USP18
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| Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection.
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| Ritchie KJ, Hahn CS, Kim KI, Yan M, Rosario D, Li L, de la Torre JC, Zhang DE.
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| Nat Med 10(12):1374-8. Epub 2004 Dec. 2004
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| 22 | USP18
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| Cloning and characterization of human ubiquitin-processing protease-43 from terminally differentiated human melanoma cells using a rapid subtraction hybridization protocol RaSH.
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| Kang D, Jiang H, Wu Q, Pestka S, Fisher PB.
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| Gene 267(2):233-42. 2001
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| 23 | USP18
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| Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18).
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| Schwer H, Liu LQ, Zhou L, Little MT, Pan Z, Hetherington CJ, Zhang DE.
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| Genomics 65(1):44-52. 2000
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