| 1 | NTN1, UNC5A, UNC5B, UNC5C, UNC5D
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| Growth cone repulsion to Netrin-1 depends on lipid raft microdomains enriched in UNC5 receptors.
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| Hernaiz-Llorens M, Roselló-Busquets C, Durisic N, Filip A, Ulloa F, Martínez-Mármol R, Soriano E.
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| Cell Mol Life Sci. Mar;78(6):2797-2820. doi: 10.1007/s00018-020-03663-z. Epub 2020 Oct 23. 2021
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| 2 | UNC5A, UNC5B, UNC5C, UNC5D
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| O-GlcNAcylation Links Nutrition to the Epigenetic Downregulation of UNC5A during Colon Carcinogenesis.
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| Decourcelle A, Very N, Djouina M, Loison I, Thévenet J, Body-Malapel M, Lelièvre E, Coqueret O, Leprince D, El Yazidi-Belkoura I, Dehennaut V.
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| Cancers (Basel) Oct 28;12(11):3168. doi: 10.3390/cancers12113168 2020
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| 3 | NTN1, TUBB3, UNC5C
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| Disease-associated mutations in human TUBB3 disturb netrin repulsive signaling.
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| Shao Q, Yang T, Huang H, Majumder T, Khot BA, Khouzani MM, Alarmanazi F, Gore YK, Liu G.
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| PLoS One. Jun 21;14(6):e0218811. doi: 10.1371/journal.pone.0218811. 2019
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| 4 | NTN1, TUBB3, UNC5C
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| Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.
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| Shao Q, Yang T, Huang H, Alarmanazi F, Liu G.
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| J Neurosci. Jun 7;37(23):5620-5633. doi: 10.1523/JNEUROSCI.2617-16.2017. Epub 2017 May 8. 2017
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| 5 | ADGRL3, FLRT3, UNC5A, UNC5B, UNC5C, UNC5D
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| Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion.
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| Lu YC, Nazarko OV, Sando R 3rd, Salzman GS, Li NS, Südhof TC, Araç D.
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| Structure. Sep 1;23(9):1678-1691. doi: 10.1016/j.str.2015.06.024. Epub 2015 Jul 30. 2015
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| 6 | DCC, NTN1, UNC5C
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| Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation.
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| Srivatsa S, Parthasarathy S, Britanova O, Bormuth I, Donahoo AL, Ackerman SL, Richards LJ, Tarabykin V.
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| Nat Commun 5:3708. doi: 10.1038/ncomms4708.
2014
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| 7 | DCC, NTN1, UNC5C
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| Netrin 1 and Dcc signalling are required for confinement of central axons within the central nervous system.
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| Laumonnerie C, Da Silva RV, Kania A, Wilson SI.
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| Development 141(3):594-603. doi: 10.1242/dev.099606.
2014
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| 8 | DCC, DSCAM, MAPK8, NTN1, UNC5C
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| c-Jun N-terminal kinase 1 (JNK1) is required for coordination of netrin signaling in axon guidance.
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| Qu C, Li W, Shao Q, Dwyer T, Huang H, Yang T, Liu G.
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| J Biol Chem 288(3):1883-95. doi: 10.1074/jbc.M112.417881. Epub 2012 Dec 6.
2013
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| 9 | DCC, UNC5C
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| unc5c haploinsufficient phenotype: striking similarities with the dcc haploinsufficiency model.
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| Auger ML, Schmidt ER, Manitt C, Dal-Bo G, Pasterkamp RJ, Flores C.
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| Eur J Neurosci 38(6):2853-63. doi: 10.1111/ejn.12270. Epub 2013 Jun 5.
2013
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| 10 | DCC, DSCAM, NTN1, UNC5C
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| Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.
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| Purohit AA, Li W, Qu C, Dwyer T, Shao Q, Guan KL, Liu G.
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| J Biol Chem 287(32):27126-38. doi: 10.1074/jbc.M112.340174. Epub 2012 Jun 8.
2012
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| 11 | UNC5C
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| Methylation of the UNC5C gene is frequently detected in hepatocellular carcinoma.
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| Hibi K, Sakuraba K, Shirahata A, Goto T, Saito M, Ishibashi K, Kigawa G, Nemoto H, Sanada Y.
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| Hepatogastroenterology 59(120):2573-5. doi: 10.5754/hge10616.
2012
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| 12 | UNC5C
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| The UNC5C netrin receptor regulates dorsal guidance of mouse hindbrain axons.
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| Kim D, Ackerman SL.
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| J Neurosci 31(6):2167-79. doi: 10.1523/JNEUROSCI.5254-10.2011.
2011
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| 13 | NTN1, UNC5A, UNC5B, UNC5C, UNC5D
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| Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression.
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| Paradisi A, Maisse C, Coissieux MM, Gadot N, Lépinasse F, Delloye-Bourgeois C, Delcros JG, Svrcek M, Neufert C, Fléjou JF, Scoazec JY, Mehlen P.
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| Proc Natl Acad Sci U S A 106(40):17146-51. Epub 2009 Aug 31.PMID: 19721007 2009
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| 14 | UNC5C
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| Aberrant methylation of the UNC5C gene is frequently detected in advanced colorectal cancer.
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| Hibi K, Mizukami H, Shirahata A, Goto T, Sakata M, Saito M, Ishibashi K, Kigawa G, Nemoto H, Sanada Y.
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| Anticancer Res 29(1):271-3.
2009
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| 15 | UNC5C, RHOXF1, RHOXF2
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| The RHOX5 homeodomain protein mediates transcriptional repression of the netrin-1 receptor gene Unc5c.
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| Hu Z, Shanker S, MacLean JA 2nd, Ackerman SL, Wilkinson MF.
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| J Biol Chem 283(7):3866-76. Epub 2007 Dec 11. 2008
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| 16 | UNC5C
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| Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer.
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| Shin SK, Nagasaka T, Jung BH, Matsubara N, Kim WH, Carethers JM, Boland CR, Goel A.
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| Gastroenterology 133(6):1849-57. Epub 2007 Sep 5. 2007
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| 17 | UNC5C
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| UNC5C is required for spinal accessory motor neuron development.
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| Dillon AK, Jevince AR, Hinck L, Ackerman SL, Lu X, Tessier-Lavigne M, Kaprielian Z.
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| Mol Cell Neurosci 35(3):482-9. Epub 2007 May 6.
2007
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| 18 | RORA, UNC5C
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| RAR-related orphan receptor A isoform 1 (RORa1) is disrupted by a balanced translocation t(4;15)(q22.3;q21.3) associated with severe obesity.
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| Klar J, Asling B, Carlsson B, Ulvsback M, Dellsen A, Strom C, Rhedin M, Forslund A, Anneren G, Ludvigsson JF, Dahl N.
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| Eur J Hum Genet 13(8):928-34. 2005
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| 19 | UNC5A, UNC5B, UNC5C, UNC5D
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| The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase.
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| Llambi F, Loureno FC, Gozuacik D, Guix C, Pays L, Del Rio G, Kimchi A, Mehlen P.
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| EMBO J 24(6):1192-201. Epub 2005 Feb 24. 2005
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| 20 | NTN1, UNC5A, UNC5B, UNC5C, UNC5D
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| Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.
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| Mazelin L, Bernet A, Bonod-Bidaud C, Pays L, Arnaud S, Gespach C, Bredesen DE, Scoazec JY, Mehlen P.
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| Nature 431(7004):80-4. 2004
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| 21 | UNC5A, UNC5B, UNC5C, UNC5D
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| The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment.
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| Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, Saurin JC, Romeo G, Mehlen P.
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| Proc Natl Acad Sci U S A 100(7):4173-8. Epub 2003 Mar 24. 2003
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| 22 | DCC, NTN1, UNC5C
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| Netrin-1 acts as a survival factor via its receptors UNC5H and DCC.
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| Llambi F, Causeret F, Bloch-Gallego E, Mehlen P.
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| EMBO J 20(11):2715-2722. 2001
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| 23 | DCC, NTN1, UNC5C
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| Attraction versus repulsion: modular receptors make the difference in axon guidance.
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| Seeger MA, Beattie CE.
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| Cell 97(7):821-4. Review. No abstract available 1999
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| 24 | UNC5C
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| Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23.
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| Ackerman SL, et al.
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| Genomics 52 : 205-208. 1998
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