1 | IL22, UCP2
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| Interleukin-22 restored mitochondrial damage and impaired glucose-stimulated insulin secretion through down-regulation of uncoupling protein-2 in INS-1 cells.
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| Hu M, Lin H, Yang L, Cheng Y, Zhang H.
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| J Biochem 161(5):433-439. doi: 10.1093/jb/mvw084.
2017
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2 | GCG, UCP2
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| UCP2 regulates the glucagon response to fasting and starvation.
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| Allister EM, Robson-Doucette CA, Prentice KJ, Hardy AB, Sultan S, Gaisano HY, Kong D, Gilon P, Herrera PL, Lowell BB, Wheeler MB.
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| Diabetes 62(5):1623-33. doi: 10.2337/db12-0981. Epub 2013 Feb 22.
2013
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3 | GCK, UCP2
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| UCP2 mRNA expression is dependent on glucose metabolism in pancreatic islets.
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| Dalgaard LT.
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| Biochem Biophys Res Commun 417(1):495-500. doi: 10.1016/j.bbrc.2011.11.148. Epub 2011 Dec 8.
2012
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4 | UCP2, UCP3
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| Uncoupling protein 3 (UCP3) modulates the activity of Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) by decreasing mitochondrial ATP production.
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| De Marchi U, Castelbou C, Demaurex N.
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| J Biol Chem 286(37):32533-41. Epub 2011 Jul 20.
2011
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5 | LETM1, MICU1, UCP2, UCP3
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| Leucine zipper EF hand-containing transmembrane protein 1 (Letm1) and uncoupling proteins 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ uptake pathways.
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| Waldeck-Weiermair M, Jean-Quartier C, Rost R, Khan MJ, Vishnu N, Bondarenko AI, Imamura H, Malli R, Graier WF.
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| J Biol Chem 286(32):28444-55. Epub 2011 May 25. 2011
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6 | CYP11A1, UCP2
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| Abnormal expression of uncoupling protein-2 correlates with CYP11A1 expression in polycystic ovary syndrome.
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| Liu Y, Jiang H, He LY, Huang WJ, He XY, Xing FQ.
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| Reprod Fertil Dev 23(4):520-6. doi: 10.1071/RD10266.
2011
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7 | UCP2
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| Uncoupling protein-2 modulates myocardial excitation-contraction coupling.
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| Turner JD, Gaspers LD, Wang G, Thomas AP.
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| Circ Res 106(4):730-8. Epub 2010 Jan 7.
2010
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8 | UCP2
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| Uncoupling protein-2 decreases the lipogenic actions of ghrelin.
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| Andrews ZB, Erion DM, Beiler R, Choi CS, Shulman GI, Horvath TL.
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| Endocrinology 151(5):2078-86. Epub 2010 Feb 26.
2010
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9 | UCP2
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| Reduced expression of uncoupling protein 2 in adipose tissue in patients with hypothyroidism.
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| Gjedde S, Gormsen LC, Riis AL, Jørgensen JO, Rungby J, Møller N, Weeke J, Pedersen SB.
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| J Clin Endocrinol Metab 95(7):3537-41. Epub 2010 Apr 28.
2010
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10 | UCP2
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| The role of uncoupling protein 2 in the apoptosis induced by free fatty acid in rat cardiomyocytes.
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| Li N, Wang J, Gao F, Tian Y, Song R, Zhu SJ.
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| J Cardiovasc Pharmacol 55(2):161-7.
2010
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11 | UCP2, UCP3
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| Uncoupling protein 3 adjusts mitochondrial Ca(2+) uptake to high and low Ca(2+) signals.
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| Waldeck-Weiermair M, Duan X, Naghdi S, Khan MJ, Trenker M, Malli R, Graier WF.
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| Cell Calcium 48(5):288-301. Epub 2010 Nov 2.
2010
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12 | UCP1, UCP2
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| Identification and distribution of uncoupling protein isoforms in the normal and diabetic rat kidney.
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| Friederich M, Nordquist L, Olerud J, Johansson M, Hansell P, Palm F.
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| Adv Exp Med Biol 645:205-12. 2009
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13 | UCP2
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| Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content.
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| Tagen M, Elorza A, Kempuraj D, Boucher W, Kepley CL, Shirihai OS, Theoharides TC.
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| J Immunol 183(10):6313-9. Epub 2009 Oct 21.
2009
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14 | UCP2
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| Transcriptional upregulation of mitochondrial uncoupling protein 2 protects against oxidative stress-associated neurogenic hypertension.
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| Chan SH, Wu CA, Wu KL, Ho YH, Chang AY, Chan JY.
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| Circ Res 105(9):886-96. Epub 2009 Sep 17.
2009
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15 | UCP2
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| A common UCP2 polymorphism predisposes to stress hyperglycaemia in severe sepsis.
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| Pyle A, Ibbett IM, Gordon C, Keers SM, Walker M, Chinnery PF, Baudouin SV.
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| J Med Genet 46(11):773-5. Epub 2009 Jun 25.
2009
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16 | UCP2
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| UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis.
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| Elorza A, Hyde B, Mikkola HK, Collins S, Shirihai OS.
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| J Biol Chem 283(45):30461-70. Epub 2008 Aug 7.
2008
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17 | UCP2
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| Testicular aging involves mitochondrial dysfunction as well as an increase in UCP2 levels and proton leak.
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| Amaral S, Mota P, Rodrigues AS, Martins L, Oliveira PJ, Ramalho-Santos J.
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| FEBS Lett 582(30):4191-6. Epub 2008 Nov 28.
2008
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18 | UCP2
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| Uncoupling protein-2 accumulates rapidly in the inner mitochondrial membrane during mitochondrial reactive oxygen stress in macrophages.
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| Giardina TM, Steer JH, Lo SZ, Joyce DA.
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| Biochim Biophys Acta 1777(2):118-29. Epub 2007 Nov 22.PMID: 18082129 2008
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19 | UCP2
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| On the role of uncoupling protein-2 in pancreatic beta cells.
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| Affourtit C, Brand MD.
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| Biochim Biophys Acta 1777(7-8):973-9. Epub 2008 Apr 3. Review.
2008
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20 | UCP2
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| Uncoupling protein 2 protects testicular germ cells from hyperthermia-induced apoptosis.
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| Zhang K, Shang Y, Liao S, Zhang W, Nian H, Liu Y, Chen Q, Han C.
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| Biochem Biophys Res Commun 360(2):327-32. Epub 2007 Jun 21. 2007
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21 | UCP2
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| UCP2 is a mitochondrial transporter with an unusual very short half-life.
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| Rousset S, Mozo J, Dujardin G, Emre Y, Masscheleyn S, Ricquier D, Cassard-Doulcier AM.
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| FEBS Lett 581(3):479-82. Epub 2007 Jan 16. 2007
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22 | POMC, UCP2
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| Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.
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| Parton LE, Ye CP, Coppari R, Enriori PJ, Choi B, Zhang CY, Xu C, Vianna CR, Balthasar N, Lee CE, Elmquist JK, Cowley MA, Lowell BB.
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| Nature 449(7159):228-32. Epub 2007 Aug 29. 2007
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23 | UCP2
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| Role of uncoupling protein UCP2 in cell-mediated immunity: how macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes.
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| Emre Y, Hurtaud C, Karaca M, Nubel T, Zavala F, Ricquier D.
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| Proc Natl Acad Sci U S A 104(48):19085-90. Epub 2007 Nov 15. 2007
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24 | UCP2, UCP3
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| Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport.
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| Trenker M, Malli R, Fertschai I, Levak-Frank S, Graier WF.
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| Nat Cell Biol 9(4):445-52. Epub 2007 Mar 11. Erratum in: Nat Cell Biol. 2008 Nov;10(11):1371.
2007
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25 | SLC25A33, SLC25A34, SLC25A37, SLC25A38, SLC25A39, SLC25A40, SLC25A41, SLC25A41, SLC25A42, SLC25A43, SLC25A44, SLC25A45, SLC25A46, UCP2
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| Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.
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| Haitina T, Lindblom J, Renstrom T, Fredriksson R.
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| Genomics 88(6):779-90. Epub 2006 Sep 1. 2006
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26 | NFKBIL1, TNXB, NOTCH4, MRPL48, PAAF1, UCP2, OPTN, CCDC3, LTB4R2
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| Whole genome association study of rheumatoid arthritis using 27 039 microsatellites.
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| Tamiya G, Shinya M, Imanishi T, Ikuta T, Makino S, Okamoto K, Furugaki K, Matsumoto T, Mano S, Ando S, Nozaki Y, Yukawa W, Nakashige R, Yamaguchi D, Ishibashi H, Yonekura M, Nakami Y, Takayama S, Endo T, Saruwatari T, Yagura M, Yoshikawa Y, Fujimoto K, Oka A, Chiku S, Linsen SE, Giphart MJ, Kulski JK, Fukazawa T, Hashimoto H, Kimura M, Hoshina Y, Suzuki Y, Hotta T, Mochida J, Minezaki T, Komai K, Shiozawa S, Taniguchi A, Yamanaka H, Kamatani N, Gojobori T, Bahram S, Inoko H.
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| Hum Mol Genet 14(16):2305-21. Epub 2005 Jul 6. 2005
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27 | UCP2
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| The common -866 G/A polymorphism in the promoter of uncoupling protein 2 is associated with increased carbohydrate and decreased lipid oxidation in juvenile obesity.
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| Le Fur S, Le Stunff C, Dos Santos C, Bougneres P.
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| Diabetes 53(1):235-9. 2004
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28 | UCP2
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| A polymorphism in the promoter of UCP2 gene modulates lipid levels in patients with type 2 diabetes.
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| Reis AF, Dubois-Laforgue D, Bellanne-Chantelot C, Timsit J, Velho G.
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| Mol Genet Metab 82(4):339-44. 2004
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29 | UCP2
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| A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects.
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| Sesti G, Cardellini M, Marini MA, Frontoni S, D'Adamo M, Del Guerra S, Lauro D, De Nicolais P, Sbraccia P, Del Prato S, Gambardella S, Federici M, Marchetti P, Lauro R.
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| Diabetes 52(5):1280-3. 2003
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30 | UCP2
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| Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes.
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| Teshima Y, Akao M, Jones SP, Marban E.
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| Circ Res 93(3):192-200. Epub 2003 Jul 10. 2003
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31 | UCP2
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| Risk factors for neural tube defects: associations between uncoupling protein 2 polymorphisms and spina bifida.
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| Volcik KA, Shaw GM, Zhu H, Lammer EJ, Finnell RH.
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| Birth Defects Res A Clin Mol Teratol 67(3):158-61. 2003
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32 | UCP2, UCP3
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| Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone).
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| Echtay KS, Winkler E, Frischmuth K, Klingenberg M.
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| Proc Natl Acad Sci U S A 98(4):1416-21. 2001
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33 | UCP2
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| Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.
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| Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB.
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| Cell 105(6):745-55. 2001
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34 | UCP2
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| A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans.
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| Esterbauer H, Schneitler C, Oberkofler H, Ebenbichler C, Paulweber B, Sandhofer F, Ladurner G, Hell E, Strosberg AD, Patsch JR, Krempler F, Patsch W.
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| Nat Genet 28(2):178-83. 2001
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35 | UCP2, UCP3
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| Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family.
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| Pierrat B, Ito M, Hinz W, Simonen M, Erdmann D, Chiesi M, Heim J.
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| Eur J Biochem 267(9):2680-7. 2000
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36 | UCP2
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| Physiological relationships of uncoupling protein-2 gene expression in human adipose tissue in vivo.
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| Pinkney JH, Boss O, Bray GA, Bulmer K, Coppack SW, Mohamed-Ali V.
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| J Clin Endocrinol Metab 85(6):2312-7. 2000
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37 | SLC25A14, UCP1, UCP2, UCP3, SLC25A27
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| Specific sequence of motifs of mitochondrial uncoupling proteins.
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| Jezek P, Urbankova E.
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| IUBMB Life 49(1):63-70. 2000
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38 | UCP2
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| Structural organization and mutational analysis of the human uncoupling protein-2 (hUCP2) gene.
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| Tu N, et al.
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| Life Sci 64 :PL41-50. 1999
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39 | UCP1, UCP2, UCP3
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| Genomic organization and regulation by dietary fat of the uncoupling protein 3 and 2 genes.
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| Gong DW, et al.
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| Biochem Biophys Res Commun 256(1):27-32. 1999
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40 | UCP2, UCP3
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| Molecular cloning and functional characterization of the promoter region of the human uncoupling protein-2 gene.
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| Tu N, Chen H, Winnikes U, Reinert I, Marmann G, Pirke KM, Lentes KU.
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| Biochem Biophys Res Commun 265(2):326-34. 1999
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41 | UCP2, UCP3
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| Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima Indians.
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| Walder K, et al.
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| Hum Mol Genet 7 : 1431-1435. 1998
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42 | UCP2, UCP3
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| Reduced gene expression of UCP2 but not UCP3 in skeletal muscle of human obese subjects.
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| Nordfors L, et al.
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| Diabetologia 41 : 935-939. 1998
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43 | UCP2
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| Uncoupling protein-2 gene : reduced mRNA expression in intraperitoneal adipose tissue of obese humans.
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| Oberkofler H, et al.
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| Diabetologia 41 : 940-946. 1998
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44 | UCP2, UCP3
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| Expression of mRNAs encoding uncoupling proteins in human skeletal muscle : effects of obesity and diabetes.
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| Bao S, et al.
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| Diabetes 47 : 1935-1940. 1998
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45 | UCP1, UCP2, UCP3
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| Peroxisome proliferator-activated receptors gamma and alpha mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression.
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| Kelly LJ, et al.
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| Endocrinology 139 : 4920-4927. 1998
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46 | AGRP, CLU, CPE, MC4R, NPY5R, NPY6R, PCSK1, POMC, DIDAN, TUB, UCP2
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| Microsatellite marker content mapping of 12 candidate genes for obesity: assembly of seven obesity screening panels for automated genotyping.
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| Winick JD, Friedman JM.
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| Genome Res 8(9):985-94. 1998
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47 | UCP2
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| Uncoupling protein-2 : a novel gene linked to obesity and hyperinsulinemia.
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| Fleury C, et al.
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| Nat Genet 15 : 269-272. 1997
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48 | UCP2
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| Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans.
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| Bouchard C, Perusse L, Chagnon YC, Warden C, Ricquier D.
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| Hum Mol Genet 6(11):1887-9. 1997
|