| 1 | UCP1
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| CPEB2-dependent translation of long 3'-UTR Ucp1 mRNA promotes thermogenesis in brown adipose tissue.
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| Chen HF, Hsu CM, Huang YS.
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| EMBO J MBO J. 2018 Sep 3. pii: e99071. doi: 10.15252/embj.201899071. [Epub ahead of print]
2018
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| 2 | UCP1, UCP3
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| Inhibition of mitochondrial UCP1 and UCP3 by purine nucleotides and phosphate.
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| Macher G, Koehler M, Rupprecht A, Kreiter J, Hinterdorfer P, Pohl EE.
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| Biochim Biophys Acta Biomembr 1860(3):664-672. doi: 10.1016/j.bbamem.2017.12.001. Epub 2017 Dec 5.
2018
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| 3 | CLK2, UCP1
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| Adipose Tissue CLK2 Promotes Energy Expenditure during High-Fat Diet Intermittent Fasting.
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| Hatting M, Rines AK, Luo C, Tabata M, Sharabi K, Hall JA, Verdeguer F, Trautwein C, Puigserver P.
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| Cell Metab 25(2):428-437. doi: 10.1016/j.cmet.2016.12.007. Epub 2017 Jan 12.
2017
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| 4 | MAP2K6, UCP1
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| MKK6 controls T3-mediated browning of white adipose tissue.
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| Matesanz N, Bernardo E, Acín-Pérez R, Manieri E, Pérez-Sieira S, Hernández-Cosido L, Montalvo-Romeral V, Mora A, Rodríguez E, Leiva-Vega L, Lechuga-Vieco AV, Ruiz-Cabello J, Torres JL, Crespo-Ruiz M, Centeno F, Álvarez CV, Marcos M, Enríquez JA, Nogueiras R, Sabio G.
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| Nat Commun 8(1):856. doi: 10.1038/s41467-017-00948-z.
2017
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| 5 | UCP1
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| Specific Interaction of the Human Mitochondrial Uncoupling Protein 1 with Free Long-Chain Fatty Acid.
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| Zhao L, Wang S, Zhu Q, Wu B, Liu Z, OuYang B, Chou JJ.
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| Structure 25(9):1371-1379.e3. doi: 10.1016/j.str.2017.07.005. Epub 2017 Aug 3.
2017
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| 6 | CCAR2, SIRT1, UCP1
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| Inflammation Downregulates UCP1 Expression in Brown Adipocytes Potentially via SIRT1 and DBC1 Interaction.
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| Nøhr MK, Bobba N, Richelsen B, Lund S, Pedersen SB.
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| Int J Mol Sci 18(5). pii: E1006. doi: 10.3390/ijms18051006.
2017
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| 7 | TENM2, UCP1
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| Teneurin-2 (TENM2) deficiency induces UCP1 expression in differentiating human fat cells.
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| Tews D, Fromme T, Keuper M, Hofmann SM, Debatin KM, Klingenspor M, Wabitsch M, Fischer-Posovszky P.
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| Mol Cell Endocrinol 443:106-113. doi: 10.1016/j.mce.2017.01.015. Epub 2017 Jan 11.
2017
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| 8 | UCP1
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| The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism.
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| Crichton PG, Lee Y, Kunji ER.
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| Biochimie 134:35-50. doi: 10.1016/j.biochi.2016.12.016. Epub 2017 Jan 3. Review.
2017
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| 9 | UCP1
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| UCP1, the mitochondrial uncoupling protein of brown adipocyte: A personal contribution and a historical perspective.
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| Ricquier D.
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| Biochimie 134:3-8. doi: 10.1016/j.biochi.2016.10.018. Epub 2016 Dec 2. Review.
2017
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| 10 | UCP1
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| The complementary and divergent roles of uncoupling proteins 1 and 3 in thermoregulation.
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| Riley CL, Dao C, Kenaston MA, Muto L, Kohno S, Nowinski SM, Solmonson AD, Pfeiffer M, Sack MN, Lu Z, Fiermonte G, Sprague JE, Mills EM.
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| J Physiol 594(24):7455-7464. doi: 10.1113/JP272971. Epub 2016 Nov 13.
2016
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| 11 | UCP1
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| Human and Mouse Brown Adipose Tissue Mitochondria Have Comparable UCP1 Function.
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| Porter C, Herndon DN, Chondronikola M, Chao T, Annamalai P, Bhattarai N, Saraf MK, Capek KD, Reidy PT, Daquinag AC, Kolonin MG, Rasmussen BB, Borsheim E, Toliver-Kinsky T, Sidossis LS.
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| Cell Metab 24(2):246-55. doi: 10.1016/j.cmet.2016.07.004.
2016
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| 12 | KDM1A, UCP1, ZNF512
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| LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program.
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| Sambeat A, Gulyaeva O, Dempersmier J, Tharp KM, Stahl A, Paul SM, Sul HS.
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| Cell Rep 15(11):2536-49. doi: 10.1016/j.celrep.2016.05.019. Epub 2016 Jun 2.
2016
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| 13 | UCP1, UCP3
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| The expression of UCP3 directly correlates to UCP1 abundance in brown adipose tissue.
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| Hilse KE, Kalinovich AV, Rupprecht A, Smorodchenko A, Zeitz U, Staniek K, Erben RG, Pohl EE.
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| Biochim Biophys Acta 1857(1):72-78. doi: 10.1016/j.bbabio.2015.10.011. Epub 2015 Oct 27.
2016
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| 14 | MED1, PRDM16, UCP1
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| PRDM16 enhances nuclear receptor-dependent transcription of the brown fat-specific Ucp1 gene through interactions with Mediator subunit MED1.
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| Iida S, Chen W, Nakadai T, Ohkuma Y, Roeder RG.
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| Genes Dev 29(3):308-21. doi: 10.1101/gad.252809.114.
2015
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| 15 | UCP1
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| Post-transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity.
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| Takahashi A, Adachi S, Morita M, Tokumasu M, Natsume T, Suzuki T, Yamamoto T.
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| Cell Rep 13(12):2756-67. doi: 10.1016/j.celrep.2015.11.056. Epub 2015 Dec 17.
2015
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| 16 | UCP1
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| Uncoupling protein 1 binds one nucleotide per monomer and is stabilized by tightly bound cardiolipin.
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| Lee Y, Willers C, Kunji ER, Crichton PG.
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| Proc Natl Acad Sci U S A 112(22):6973-8. doi: 10.1073/pnas.1503833112. Epub 2015 May 18.
2015
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| 17 | SESN2, UCP1
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| Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species.
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| Ro SH, Nam M, Jang I, Park HW, Park H, Semple IA, Kim M, Kim JS, Park H, Einat P, Damari G, Golikov M, Feinstein E, Lee JH.
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| Proc Natl Acad Sci U S A 111(21):7849-54. doi: 10.1073/pnas.1401787111. Epub 2014 May 13.
2014
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| 18 | TRPM8, UCP1
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| Human white adipocytes express the cold receptor TRPM8 which activation induces UCP1 expression, mitochondrial activation and heat production.
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| Rossato M, Granzotto M, Macchi V, Porzionato A, Petrelli L, Calcagno A, Vencato J, De Stefani D, Silvestrin V, Rizzuto R, Bassetto F, De Caro R, Vettor R.
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| Mol Cell Endocrinol 383(1-2):137-46. doi: 10.1016/j.mce.2013.12.005. Epub 2013 Dec 14.
2014
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| 19 | RARA, UCP1
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| Retinoic acid has different effects on UCP1 expression in mouse and human adipocytes.
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| Murholm M, Isidor MS, Basse AL, Winther S, Sørensen C, Skovgaard-Petersen J, Nielsen MM, Hansen AS, Quistorff B, Hansen JB.
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| BMC Cell Biol 14:41. doi: 10.1186/1471-2121-14-41.
2013
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| 20 | IGF2, MYOD1, PRDM16, UCP1
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| Double Myod and Igf2 inactivation promotes brown adipose tissue development by increasing Prdm16 expression.
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| Borensztein M, Viengchareun S, Montarras D, Journot L, Binart N, Lombès M, Dandolo L.
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| FASEB J 26(11):4584-91. doi: 10.1096/fj.12-208496. Epub 2012 Aug 2.
2012
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| 21 | UCP1
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| Fatty acids change the conformation of uncoupling protein 1 (UCP1).
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| Divakaruni AS, Humphrey DM, Brand MD.
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| J Biol Chem 287(44):36845-53. doi: 10.1074/jbc.M112.381780. Epub 2012 Sep 5.
2012
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| 22 | CKMT1A, CKMT1B, KCNK3, UCP1
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| Gene expression in human brown adipose tissue.
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| Svensson PA, Jernås M, Sjöholm K, Hoffmann JM, Nilsson BE, Hansson M, Carlsson LM.
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| Int J Mol Med 27(2):227-32. doi: 10.3892/ijmm.2010.566. Epub 2010 Dec 1. 2011
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| 23 | UCP1
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| Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue.
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| Shore A, Karamitri A, Kemp P, Speakman JR, Lomax MA.
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| Diabetologia 53(6):1164-73. Epub 2010 Mar 18.
2010
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| 24 | KLF11, KLF15, UCP1
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| Transcriptional regulation of a brown adipocyte-specific gene, UCP1, by KLF11 and KLF15.
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| Yamamoto K, Sakaguchi M, Medina RJ, Niida A, Sakaguchi Y, Miyazaki M, Kataoka K, Huh NH.
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| Biochem Biophys Res Commun 400(1):175-80. Epub 2010 Aug 13.
2010
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| 25 | UCP1
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| Uncoupling protein 1 decreases superoxide production in brown adipose tissue mitochondria.
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| Oelkrug R, Kutschke M, Meyer CW, Heldmaier G, Jastroch M.
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| J Biol Chem 285(29):21961-8. Epub 2010 May 13.
2010
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| 26 | UCP1
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| The role of UCP 1 in production of reactive oxygen species by mitochondria isolated from brown adipose tissue.
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| Dlasková A, Clarke KJ, Porter RK.
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| Biochim Biophys Acta 1797(8):1470-6. Epub 2010 Apr 21.
2010
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| 27 | UCP1, UCP2
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| Identification and distribution of uncoupling protein isoforms in the normal and diabetic rat kidney.
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| Friederich M, Nordquist L, Olerud J, Johansson M, Hansell P, Palm F.
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| Adv Exp Med Biol 645:205-12. 2009
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| 28 | UCP1
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| Muscle mitochondrial uncoupling dismantles neuromuscular junction and triggers distal degeneration of motor neurons.
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| Dupuis L, Gonzalez de Aguilar JL, Echaniz-Laguna A, Eschbach J, Rene F, Oudart H, Halter B, Huze C, Schaeffer L, Bouillaud F, Loeffler JP.
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| PLoS One 4(4):e5390. Epub 2009 Apr 30.
2009
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| 29 | UCP1
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| Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria.
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| Parker N, Crichton PG, Vidal-Puig AJ, Brand MD.
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| J Bioenerg Biomembr 41(4):335-42. Epub 2009 Aug 25.
2009
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| 30 | BMP7, PRDM16, UCP1
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| New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.
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| Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR.
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| Nature 454(7207):1000-4.
2008
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| 31 | NR4A2, UCP1
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| Orphan nuclear receptor NOR-1 enhances 3',5'-cyclic adenosine 5'-monophosphate-dependent uncoupling protein-1 gene transcription.
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| Kumar N, Liu D, Wang H, Robidoux J, Collins S.
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| Mol Endocrinol 22(5):1057-64. Epub 2008 Jan 31.PMID: 18238829 2008
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| 32 | UCP1
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| Identification of serine phosphorylation in mitochondrial uncoupling protein 1.
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| Carroll AM, Porter RK, Morrice NA.
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| Biochim Biophys Acta 1777(7-8):1060-5. Epub 2008 Apr 30.
2008
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| 33 | ADRB2, ADRB3, UCP1
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| Common variants in beta2- and beta3-adrenergic receptor genes and uncoupling protein 1 as predictors of the risk for type 2 diabetes and body weight changes. The Finnish Diabetes Prevention Study.
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| Salopuro T, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M.
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| Clin Genet 66(4):365-7. No abstract available. 2004
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| 34 | UCP1
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| A polymorphism in the 5' untranslated region and a Met229-->Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus.
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| Mori H, Okazawa H, Iwamoto K, Maeda E, Hashiramoto M, Kasuga M.
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| Diabetologia 44(3):373-6. 2001
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| 35 | UCP1
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| Coenzyme Q is an obligatory cofactor for uncoupling protein function.
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| Echtay KS, Winkler E, Klingenberg M.
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| Nature 408(6812):609-13. 2000
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| 36 | UCP1
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| Uncoupling protein-1 mRNA expression in lipomas from patients bearing pathogenic mitochondrial DNA mutations.
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| Vila MR, Gamez J, Solano A, Playan A, Schwartz S, Santorelli FM, Cervera C, Casali C, Montoya J, Villarroya F.
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| Biochem Biophys Res Commun 278(3):800-2. 2000
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| 37 | SLC25A14, UCP1, UCP2, UCP3, SLC25A27
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| Specific sequence of motifs of mitochondrial uncoupling proteins.
|
| Jezek P, Urbankova E.
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| IUBMB Life 49(1):63-70. 2000
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| 38 | UCP1, UCP2, UCP3
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| Genomic organization and regulation by dietary fat of the uncoupling protein 3 and 2 genes.
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| Gong DW, et al.
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| Biochem Biophys Res Commun 256(1):27-32. 1999
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| 39 | UCP1
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| Structural and functional study of a conserved region in the uncoupling protein UCP1: the three matrix loops are involved in the control of transport.
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| Gonzalez-Barroso MM, Fleury C, Jimenez MA, Sanz JM, Romero A, Bouillaud F, Rial E.
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| J Mol Biol 292(1):137-49 1999
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| 40 | UCP1
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| Frequency and significance of the A-->G (-3826) polymorphism in the promoter of the gene for uncoupling protein-1 with regard to metabolic parameters and adipocyte transcription factor binding in a large population-based Caucasian cohort.
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| Schaffler A, Palitzsch KD, Watzlawek E, Drobnik W, Schwer H, Scholmerich J, Schmitz G.
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| Eur J Clin Invest 29(9):770-9 1999
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| 41 | UCP1, UCP2, UCP3
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| Peroxisome proliferator-activated receptors gamma and alpha mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression.
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| Kelly LJ, et al.
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| Endocrinology 139 : 4920-4927. 1998
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| 42 | UCP1
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| DNA polymorphism in the uncoupling protein (UCP) gene and human body fat.
|
| Oppert JM, et al.
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| Int J Obes 18 : 526-531. 1994
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| 43 | UCP1
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| Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4.
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| Cassard AM, et al.
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| J Cell Biochem 43 : 255-264. 1990
|