| 1 | NDEGH, UBR5, UBR7
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| UBR7 functions with UBR5 in the Notch signaling pathway and is involved in a neurodevelopmental syndrome with epilepsy, ptosis, and hypothyroidism 2021 PMID:
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| Li C, Beauregard-Lacroix E, Kondratev C, Rousseau J, Heo AJ, Neas K, Graham BH, Rosenfeld JA, Bacino CA, Wagner M, Wenzel M, Al Mutairi F, Al Deiab H, Gleeson JG, Stanley V, Zaki MS, Kwon YT, Leroux MR, Campeau PM.
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| Am J Hum Genet. Jan 7;108(1):134-147. doi: 10.1016/j.ajhg.2020.11.018. Epub 2020 Dec 18. 2021
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| 2 | OTUD5, UBR5
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| The OTUD5-UBR5 complex regulates FACT-mediated transcription at damaged chromatin.
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| de Vivo A, Sanchez A, Yegres J, Kim J, Emly S, Kee Y.
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| Nucleic Acids Res. Jan 25;47(2):729-746. doi: 10.1093/nar/gky1219. 2019
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| 3 | GKN1, UBR5
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| The E3 ligase UBR5 regulates gastric cancer cell growth by destabilizing the tumor suppressor GKN1.
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| Yang M, Jiang N, Cao QW, Ma MQ, Sun Q.
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| Biochem Biophys Res Commun. Sep 30;478(4):1624-9. doi: 10.1016/j.bbrc.2016.08.170. Epub 2016 Aug 31. 2016
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| 4 | ESR1, UBR5
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| Systems level-based RNAi screening by high content analysis identifies UBR5 as a regulator of estrogen receptor-α protein levels and activity.
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| Bolt MJ, Stossi F, Callison AM, Mancini MG, Dandekar R, Mancini MA.
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| Oncogene 34(2):154-64. doi: 10.1038/onc.2013.550. Epub 2014 Jan 20.
2015
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| 5 | ATMIN, UBR5
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| UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function.
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| Zhang T, Cronshaw J, Kanu N, Snijders AP, Behrens A.
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| Proc Natl Acad Sci U S A 111(33):12091-6. doi: 10.1073/pnas.1400230111. Epub 2014 Aug 4.
2014
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| 6 | DYRK2, NR1I2, UBR5
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| Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2.
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| Ong SS, Goktug AN, Elias A, Wu J, Saunders D, Chen T.
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| Biochem J 459(1):193-203. doi: 10.1042/BJ20130558.
2014
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| 7 | IGBP1, PPP2CA, UBR5
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| Progestin-inducible EDD E3 ubiquitin ligase binds to α4 phosphoprotein to regulate ubiquitination and degradation of protein phosphatase PP2Ac.
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| McDonald WJ, Thomas LN, Koirala S, Too CK.
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| Mol Cell Endocrinol 382(1):254-61. doi: 10.1016/j.mce.2013.09.033. Epub 2013 Oct 18.
2014
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| 8 | ACVRL1, UBR5
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| A functional genomic approach reveals the transcriptional role of EDD in the expression and function of angiogenesis regulator ACVRL1.
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| Chen HW, Yang CC, Hsieh CL, Liu H, Lee SC, Tan BC.
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| Biochim Biophys Acta 1829(12):1309-19. doi: 10.1016/j.bbagrm.2013.10.006. Epub 2013 Nov 2.
2013
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| 9 | UBR5
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| The E3 ubiquitin ligase UBR5 is recurrently mutated in mantle cell lymphoma.
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| Meissner B, Kridel R, Lim RS, Rogic S, Tse K, Scott DW, Moore R, Mungall AJ, Marra MA, Connors JM, Steidl C, Gascoyne RD.
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| Blood 121(16):3161-4. doi: 10.1182/blood-2013-01-478834. Epub 2013 Feb 13.
2013
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| 10 | DDB1, DYRK2, TERT, UBR5, VPRBP
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| Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation.
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| Jung HY, Wang X, Jun S, Park JI.
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| J Biol Chem 288(10):7252-62. doi: 10.1074/jbc.M112.416792. Epub 2013 Jan 28.
2013
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| 11 | MCRS1, UBR5
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| The novel interaction between microspherule protein Msp58 and ubiquitin E3 ligase EDD regulates cell cycle progression.
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| Benavides M, Chow-Tsang LF, Zhang J, Zhong H.
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| Biochim Biophys Acta 1833(1):21-32. doi: 10.1016/j.bbamcr.2012.10.007. Epub 2012 Oct 12.
2013
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| 12 | UBR5
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| Structure of the HECT C-lobe of the UBR5 E3 ubiquitin ligase.
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| Matta-Camacho E, Kozlov G, Menade M, Gehring K.
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| Acta Crystallogr Sect F Struct Biol Cryst Commun 68(Pt 10):1158-63. doi: 10.1107/S1744309112036937. Epub 2012 Sep 22.
2012
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| 13 | RNF168, TRIP12, UBR5
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| TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.
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| Gudjonsson T, Altmeyer M, Savic V, Toledo L, Dinant C, Grøfte M, Bartkova J, Poulsen M, Oka Y, Bekker-Jensen S, Mailand N, Neumann B, Heriche JK, Shearer R, Saunders D, Bartek J, Lukas J, Lukas C.
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| Cell 150(4):697-709. doi: 10.1016/j.cell.2012.06.039. Epub 2012 Aug 9. Erratum in: Cell. 2014 Dec 4;159(6):1476-7.
2012
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| 14 | TP53, UBR5
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| EDD induces cell cycle arrest by increasing p53 levels.
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| Smits VA.
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| Cell Cycle 11(4):715-20. doi: 10.4161/cc.11.4.19154.
2012
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| 15 | TP53, UBR5
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| EDD inhibits ATM-mediated phosphorylation of p53.
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| Ling S, Lin WC.
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| J Biol Chem 286(17):14972-82. doi: 10.1074/jbc.M110.182527. Epub 2011 Mar 7.
2011
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| 16 | EP300, PCK1, UBR5
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| Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase.
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| Jiang W, Wang S, Xiao M, Lin Y, Zhou L, Lei Q, Xiong Y, Guan KL, Zhao S.
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| Mol Cell. Jul 8;43(1):33-44. doi: 10.1016/j.molcel.2011.04.028 2011
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| 17 | MYOCD, UBR5
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| Modulation of myocardin function by the ubiquitin E3 ligase UBR5.
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| Hu G, Wang X, Saunders DN, Henderson M, Russell AJ, Herring BP, Zhou J.
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| J Biol Chem 285(16):11800-9. Epub 2010 Feb 18.PMID: 20167605 2010
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| 18 | IGBP1, PABPC1, PPP2CA, UBR5
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| alpha4 phosphoprotein interacts with EDD E3 ubiquitin ligase and poly(A)-binding protein.
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| McDonald WJ, Sangster SM, Moffat LD, Henderson MJ, Too CK.
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| J Cell Biochem 110(5):1123-9. doi: 10.1002/jcb.22624.
2010
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| 19 | UBR1, UBR2, UBR3, UBR4, UBR5, UBR7
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| The substrate recognition domains of the N-end rule pathway.
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| Tasaki T, Zakrzewska A, Dudgeon DD, Jiang Y, Lazo JS, Kwon YT.
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| J Biol Chem 284(3):1884-95. Epub 2008 Nov 13. 2009
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| 20 | UBR5
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| The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro.
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| O'Brien PM, Davies MJ, Scurry JP, Smith AN, Barton CA, Henderson MJ, Saunders DN, Gloss BS, Patterson KI, Clancy JL, Heinzelmann-Schwarz VA, Murali R, Scolyer RA, Zeng Y, Williams ED, Scurr L, Defazio A, Quinn DI, Watts CK, Hacker NF, Henshall SM, Sutherland RL.
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| Br J Cancer 98(6):1085-93. Epub 2008 Mar 18. Erratum in: Br J Cancer. 2008 Jun 3;98(11):1880. Murali, Rajmohan [added].
2008
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| 21 | UBR1, UBR2, UBR3, UBR4, UBR5, UBR7
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| Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway.
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| Lee MJ, Pal K, Tasaki T, Roy S, Jiang Y, An JY, Banerjee R, Kwon YT.
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| Proc Natl Acad Sci U S A 105(1):100-5. Epub 2007 Dec 27.
2008
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| 22 | UBR5
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| The E3 ubiquitin ligase EDD regulates S-phase and G(2)/M DNA damage checkpoints.
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| Munoz MA, Saunders DN, Henderson MJ, Clancy JL, Russell AJ, Lehrbach G, Musgrove EA, Watts CK, Sutherland RL.
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| Cell Cycle 6(24):3070-7. Epub 2007 Sep 7.PMID: 18073532 2007
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| 23 | UBR1, UBR2, UBR3, UBR4, UBR5
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| A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.
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| Tasaki T, Mulder LC, Iwamatsu A, Lee MJ, Davydov IV, Varshavsky A, Muesing M, Kwon YT.
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| Mol Cell Biol 25(16):7120-36.
2005
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| 24 | AREL1, C12orf51, HACE1, HECTD1, HECW2, HERC4, RAD23B, RAD23BL, UBE3B, UBE3C, UBR5
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| Characterization of the human UBE3B gene: structure, expression, evolution, and alternative splicing.
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| Gong TW, Huang L, Warner SJ, Lomax MI.
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| Genomics 82(2):143-52. 2003
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| 25 | UBR5
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| EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer.
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| Clancy JL, Henderson MJ, Russell AJ, Anderson DW, Bova RJ, Campbell IG, Choong DY, Macdonald GA, Mann GJ, Nolan T, Brady G, Olopade OI, Woollatt E, Davies MJ, Segara D, Hacker NF, Henshall SM, Sutherland RL, Watts CK.
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| Oncogene 22(32):5070-81. 2003
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| 26 | UBR5
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| EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response.
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| Henderson MJ, Russell AJ, Hird S, Munoz M, Clancy JL, Lehrbach GM, Calanni ST, Jans DA, Sutherland RL, Watts CK.
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| J Biol Chem 277(29):26468-78. Epub 2002 May 13. 2002
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| 27 | EBAG9,KCNV1,POLR2K,UBR5
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| An integrated physical map of 8q22-q24: use in positional cloning and deletion analysis of langer-giedion syndrome.
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| Hilton MJ, Gutierrez L, Zhang L, Moreno PA, Reddy M, Brown N, Tan Y, Hill A, Wells DE.
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| Genomics 71(2):192-9. 2001
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| 28 | UBR5
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| Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs.
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| Callaghan MJ, Russell AJ, Woollatt E, Sutherland GR, Sutherland RL, Watts CK.
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| Oncogene 17(26):3479-91. 1998
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