| 1 | UBE2B, UBR1, UBR2
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| UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination.
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| An JY, Kim EA, Jiang Y, Zakrzewska A, Kim DE, Lee MJ, Mook-Jung I, Zhang Y, Kwon YT.
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| Proc Natl Acad Sci U S A 107(5):1912-7. Epub 2010 Jan 11. 2010
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| 2 | UBR1, UBR2, UBR3, UBR4, UBR5, UBR7
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| The substrate recognition domains of the N-end rule pathway.
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| Tasaki T, Zakrzewska A, Dudgeon DD, Jiang Y, Lazo JS, Kwon YT.
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| J Biol Chem 284(3):1884-95. Epub 2008 Nov 13. 2009
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| 3 | JBS, UBR1
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| Johanson-Blizzard syndrome: report of a novel mutation and severe liver involvement.
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| Al-Dosari MS, Al-Muhsen S, Al-Jazaeri A, Mayerle J, Zenker M, Alkuraya FS.
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| Am J Med Genet A 146A(14):1875-9. 2008
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| 4 | JBS, UBR1
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| Johanson-Blizzard syndrome caused by identical UBR1 mutations in two unrelated girls, one with a cardiomyopathy.
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| Elting M, Kariminejad A, de Sonnaville ML, Ottenkamp J, Bauhuber S, Bozorgmehr B, Zenker M, Cobben JM.
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| Am J Med Genet A 146A(23):3058-61.
2008
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| 5 | UBR1, UBR2, UBR3, UBR4, UBR5, UBR7
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| Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway.
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| Lee MJ, Pal K, Tasaki T, Roy S, Jiang Y, An JY, Banerjee R, Kwon YT.
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| Proc Natl Acad Sci U S A 105(1):100-5. Epub 2007 Dec 27.
2008
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| 6 | ISG15,UBR1
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| Negative regulation of ISG15 E3 ligase EFP through its autoISGylation.
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| Zou W, Wang J, Zhang DE.
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| Biochem Biophys Res Commun 354(1):321-7. Epub 2007 Jan 8. 2007
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| 7 | MAPK7, UBR1
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| Spatiotemporal regulation of c-Fos by ERK5 and the E3 ubiquitin ligase UBR1, and its biological role.
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| Sasaki T, Kojima H, Kishimoto R, Ikeda A, Kunimoto H, Nakajima K.
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| Mol Cell 24(1):63-75.
2006
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| 8 | JBS, UBR1, UBR2
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| Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome).
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| Zenker M, Mayerle J, Lerch MM, Tagariello A, Zerres K, Durie PR, Beier M, Hulskamp G, Guzman C, Rehder H, Beemer FA, Hamel B, Vanlieferinghen P, Gershoni-Baruch R, Vieira MW, Dumic M, Auslender R, Gil-da-Silva-Lopes VL, Steinlicht S, Rauh M, Shalev SA, Thiel C, Winterpacht A, Kwon YT, Varshavsky A, Reis A.
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| Nat Genet 37(12):1345-50. Epub 2005 Nov 20. 2005
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| 9 | UBR1, UBR2, UBR3, UBR4, UBR5
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| A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.
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| Tasaki T, Mulder LC, Iwamatsu A, Lee MJ, Davydov IV, Varshavsky A, Muesing M, Kwon YT.
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| Mol Cell Biol 25(16):7120-36.
2005
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| 10 | RECQL4, RAPADILINO, UBR1, UBR2, RTS
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| RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.
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| Yin J, Kwon YT, Varshavsky A, Wang W.
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| Hum Mol Genet 13(20):2421-30. Epub 2004 Aug 18. 2004
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| 11 | ABLIM1, ARGLU1, BRPF1, BTAF1, CCNYL1, CCNYL1, CYTH4, DIP2B, EIF2D, EXO5, HOMEZ, KIAA1429, PHC2, POGZ, RRBP1, SCFD1, SEMA5A, SLC41A3, SMTN, UBR1, UNK, USP19, WDHD1, YEATS2, ZMYND8, ZNF224
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| Large-scale characterization of HeLa cell nuclear phosphoproteins.
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| Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP.
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| Proc Natl Acad Sci U S A 101(33):12130-5. Epub 2004 Aug 9. 2004
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| 12 | UBR1
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| The mouse and human genes encoding the recognition component of the N-end rulepathway.
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| Kwon YT, Reiss Y, Fried VA, Hershko A, Yoon JK, Gonda DK, Sangan P,Copeland NG, Jenkins NA, Varshavsky A.
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| Proc Natl Acad Sci U S A 95(14):7898-903. 1998
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| 13 | UBR1
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| The mouse and human genes encoding the recognition component of the N-end rule pathway.
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| Kwon YT, Reiss Y, Fried VA, Hershko A, Yoon JK, Gonda DK, Sangan P, Copeland NG, Jenkins NA, Varshavsky A.
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| Proc Natl Acad Sci U S A 95(14):7898-903. 1998
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