Citations for
1BRCA1, FANCR, FANCS, FANCT, FANCU, FANCV, MAD2L2, RAD51, RAD51B, RAD51C, RAD51D, REV3L, UBE2T, XRCC2
Recent discoveries in the molecular pathogenesis of the inherited bone marrow failure syndrome Fanconi anemia.
Mamrak NE, Shimamura A, Howlett NG.
Blood Rev lood Rev. 2016 Oct 13. pii: S0268-960X(16)30054-6. doi: 10.1016/j.blre.2016.10.002. Review. 2016
2FANCT, UBE2T
Mutations in the Gene Encoding the E2 Conjugating Enzyme UBE2T Cause Fanconi Anemia.
Hira A, Yoshida K, Sato K, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Shimamoto A, Tahara H, Ito E, Kojima S, Kurumizaka H, Ogawa S, Takata M, Yabe H, Yabe M.
Am J Hum Genet 96(6):1001-7. doi: 10.1016/j.ajhg.2015.04.022. 2015
3FANCM, UBE2T
The Fanconi anaemia components UBE2T and FANCM are functionally linked to nucleotide excision repair.
Kelsall IR, Langenick J, MacKay C, Patel KJ, Alpi AF.
PLoS One 7(5):e36970. Epub 2012 May 15. 2012
4FANCD2, FANCI, FANCL, UBE2T
Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway.
Hodson C, Cole AR, Lewis LP, Miles JA, Purkiss A, Walden H.
J Biol Chem 286(37):32628-37. Epub 2011 Jul 20. 2011
5UBE2T
Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T.
Ramaekers CH, van den Beucken T, Meng A, Kassam S, Thoms J, Bristow RG, Wouters BG.
Radiother Oncol 101(1):190-7. Epub 2011 Jun 29. 2011
6FANCD2, FANCI, FANCL, UBE2T
FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL.
Longerich S, San Filippo J, Liu D, Sung P.
J Biol Chem 284(35):23182-6. Epub 2009 Jul 8. 2009
7FANCD2, FANCL, UBE2T
Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI.
Alpi AF, Pace PE, Babu MM, Patel KJ.
Mol Cell 32(6):767-77. 2008
8FANCD2, UBE2T
UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination.
Alpi A, Langevin F, Mosedale G, Machida YJ, Dutta A, Patel KJ.
Mol Cell Biol 27(24):8421-30. Epub 2007 Oct 15.PMID: 17938197 2007
9UBE2T
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation.
Machida YJ, Machida Y, Chen Y, Gurtan AM, Kupfer GM, D'Andrea AD, Dutta A.
Mol Cell 23(4):589-96. 2006