Citations for
1UBE2N, ZNRF1
Structural insights into the nanomolar affinity of RING E3 ligase ZNRF1 for Ube2N and its functional implications.
Behera AP, Naskar P, Agarwal S, Banka PA, Poddar A, Datta AB.
Biochem J 475(9):1569-1582. doi: 10.1042/BCJ20170909. 2018
2BCL10, RNF168, RNF8, UBE2N
BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response.
Zhao H, Zhu M, Dou G, Zhao H, Zhu B, Li J, Liao J, Xu X.
Cell Cycle 13(11):1777-87. doi: 10.4161/cc.28707. Epub 2014 Apr 14. 2014
3PRKN, UBE2D2, UBE2D3, UBE2L3, UBE2N
The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy.
Geisler S, Vollmer S, Golombek S, Kahle PJ.
J Cell Sci 127(Pt 15):3280-93. doi: 10.1242/jcs.146035. Epub 2014 Jun 6. 2014
4RNF168, RNF8, UBE2N
Structural basis for role of ring finger protein RNF168 RING domain.
Zhang X, Chen J, Wu M, Wu H, Arokiaraj AW, Wang C, Zhang W, Tao Y, Huen MS, Zang J.
Cell Cycle 12(2):312-21. doi: 10.4161/cc.23104. Epub 2012 Jan 15. 2013
5OTUB1, UBE2D1, UBE2N
E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1.
Wiener R, DiBello AT, Lombardi PM, Guzzo CM, Zhang X, Matunis MJ, Wolberger C.
Nat Struct Mol Biol 20(9):1033-9. doi: 10.1038/nsmb.2655. Epub 2013 Aug 18. 2013
6OTUB1, UBE2N, UBE2V1, UBE2V2
Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitin-conjugating enzyme UBC13.
Sato Y, Yamagata A, Goto-Ito S, Kubota K, Miyamoto R, Nakada S, Fukai S.
J Biol Chem 287(31):25860-8. doi: 10.1074/jbc.M112.364752. Epub 2012 Jun 7. 2012
7CHUK, UBE2N
Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells.
Chang JH, Xiao Y, Hu H, Jin J, Yu J, Zhou X, Wu X, Johnson HM, Akira S, Pasparakis M, Cheng X, Sun SC.
Nat Immunol 13(5):481-90. doi: 10.1038/ni.2267. 2012
8GHR, STUB1, UBE2N
Ubc13 and COOH terminus of Hsp70-interacting protein (CHIP) are required for growth hormone receptor endocytosis.
Slotman JA, da Silva Almeida AC, Hassink GC, van de Ven RH, van Kerkhof P, Kuiken HJ, Strous GJ.
J Biol Chem 287(19):15533-43. doi: 10.1074/jbc.M111.302521. Epub 2012 Mar 20. 2012
9OTUB1, UBE2N, UBE2V1
The mechanism of OTUB1-mediated inhibition of ubiquitination.
Wiener R, Zhang X, Wang T, Wolberger C.
Nature 483(7391):618-22. doi: 10.1038/nature10911. 2012
10RNF8, UBE2L6, UBE2N
Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation.
Lok GT, Sy SM, Dong SS, Ching YP, Tsao SW, Thomson TM, Huen MS.
Nucleic Acids Res 40(1):196-205. doi: 10.1093/nar/gkr655. Epub 2011 Sep 12. 2012
11RNF168, RNF8, STUB1, TRAF6, UBE2N
Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.
Campbell SJ, Edwards RA, Leung CC, Neculai D, Hodge CD, Dhe-Paganon S, Glover JN.
J Biol Chem 287(28):23900-10. doi: 10.1074/jbc.M112.359653. Epub 2012 May 15. 2012
12C1orf86, RNF8, UBE2N
A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.
Yan Z, Guo R, Paramasivam M, Shen W, Ling C, Fox D 3rd, Wang Y, Oostra AB, Kuehl J, Lee DY, Takata M, Hoatlin ME, Schindler D, Joenje H, de Winter JP, Li L, Seidman MM, Wang W.
Mol Cell 47(1):61-75. doi: 10.1016/j.molcel.2012.05.026. Epub 2012 Jun 14. 2012
13TRIM5, UBE2N, UBE2V1
TRIM5 acts as more than a retroviral restriction factor.
de Silva S, Wu L.
Viruses 3(7):1204-9. doi: 10.3390/v3071204. Review. 2011
14OTUB1, RNF168, UBE2N
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.
Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D.
Nature 466(7309):941-6. doi: 10.1038/nature09297. 2010
15STUB1, UBE2D1, UBE2N
Insights into the conformational dynamics of the E3 ubiquitin ligase CHIP in complex with chaperones and E2 enzymes.
Graf C, Stankiewicz M, Nikolay R, Mayer MP.
Biochemistry 49(10):2121-9. doi: 10.1021/bi901829f. 2010
16UBE2N
Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13.
Wu X, Yamamoto M, Akira S, Sun SC.
Proc Natl Acad Sci U S A 106(49):20836-41. doi: 10.1073/pnas.0906547106. Epub 2009 Nov 19. 2009
17UBE2N
Control of p53 multimerization by Ubc13 is JNK-regulated.
Topisirovic I, Gutierrez GJ, Chen M, Appella E, Borden KL, Ronai ZA.
Proc Natl Acad Sci U S A 106(31):12676-81. doi: 10.1073/pnas.0900596106. Epub 2009 Jul 27. 2009
18MAP3K7, TRAF6, UBE2N, UBE2V1
Direct activation of protein kinases by unanchored polyubiquitin chains.
Xia ZP, Sun L, Chen X, Pineda G, Jiang X, Adhikari A, Zeng W, Chen ZJ.
Nature 461(7260):114-9. doi: 10.1038/nature08247. Epub 2009 Aug 12. 2009
19TRAF6, UBE2N
The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL.
Lamothe B, Campos AD, Webster WK, Gopinathan A, Hur L, Darnay BG.
J Biol Chem 283(36):24871-80. Epub 2008 Jul 10. 2008
20HLTF, UBE2V2, UBE2A, UBE2B, RAD18, UBE2N
Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination.
Unk I, Hajdś I, F‡tyol K, Hurwitz J, Yoon JH, Prakash L, Prakash S, Haracska L.
Proc Natl Acad Sci U S A 105(10):3768-73. Epub 2008 Mar 3. 2008
21UBE2N, UBE2V1
Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly.
Huen MS, Huang J, Yuan J, Yamamoto M, Akira S, Ashley C, Xiao W, Chen J.
Mol Cell Biol 28(19):6104-12. doi: 10.1128/MCB.00987-08. Epub 2008 Aug 4. 2008
22UBE2N
Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses.
Fukushima T, Matsuzawa S, Kress CL, Bruey JM, Krajewska M, Lefebvre S, Zapata JM, Ronai Z, Reed JC.
Proc Natl Acad Sci U S A 104(15):6371-6. Epub 2007 Apr 2. 2007
23UBE2N
A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination.
Zhao GY, Sonoda E, Barber LJ, Oka H, Murakawa Y, Yamada K, Ikura T, Wang X, Kobayashi M, Yamamoto K, Boulton SJ, Takeda S.
Mol Cell 25(5):663-75. 2007
24H2AFX, KAT5, UBE2N
DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics.
Ikura T, Tashiro S, Kakino A, Shima H, Jacob N, Amunugama R, Yoder K, Izumi S, Kuraoka I, Tanaka K, Kimura H, Ikura M, Nishikubo S, Ito T, Muto A, Miyagawa K, Takeda S, Fishel R, Igarashi K, Kamiya K.
Mol Cell Biol 27(20):7028-40. Epub 2007 Aug 20.PMID: 17709392 2007
25UBE2N, ZNRF2
The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation.
Plans V, Scheper J, Soler M, Loukili N, Okano Y, Thomson TM.
J Cell Biochem 97(3):572-82. 2006
26ISG15,UBE2N
ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity.
Takeuchi T, Yokosawa H.
Biochem Biophys Res Commun 336(1):9-13. 2005
27TRAF6, UBE2N
The TRAF6 RING finger domain mediates physical interaction with Ubc13.
Wooff J, Pastushok L, Hanna M, Fu Y, Xiao W.
FEBS Lett 566(1-3):229-33. 2004
28AURKA, UBE2N
Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human.
Ewart-Toland A, Briassouli P, de Koning JP, Mao JH, Yuan J, Chan F, MacCarthy-Morrogh L, Ponder BA, Nagase H, Burn J, Ball S, Almeida M, Linardopoulos S, Balmain A.
Nat Genet 34(4):403-12. 2003
29UBE2N
Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly ofnovel polyubiquitin chains for DNA repair.
Hofmann RM, Pickart CM.
Cell 96(5):645-53. 1999
30UBE2N
Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzymesimilar to the Drosophila bendless gene product.
Yamaguchi T, Kim NS, Sekine S, Seino H, Osaka F, Yamao F, Kato S.
J Biochem (Tokyo) 120(3):494-97. 1996