| 1 | UBE2N, ZNRF1
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| Structural insights into the nanomolar affinity of RING E3 ligase ZNRF1 for Ube2N and its functional implications.
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| Behera AP, Naskar P, Agarwal S, Banka PA, Poddar A, Datta AB.
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| Biochem J 475(9):1569-1582. doi: 10.1042/BCJ20170909.
2018
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| 2 | BCL10, RNF168, RNF8, UBE2N
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| BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response.
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| Zhao H, Zhu M, Dou G, Zhao H, Zhu B, Li J, Liao J, Xu X.
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| Cell Cycle 13(11):1777-87. doi: 10.4161/cc.28707. Epub 2014 Apr 14.
2014
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| 3 | PRKN, UBE2D2, UBE2D3, UBE2L3, UBE2N
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| The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy.
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| Geisler S, Vollmer S, Golombek S, Kahle PJ.
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| J Cell Sci 127(Pt 15):3280-93. doi: 10.1242/jcs.146035. Epub 2014 Jun 6.
2014
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| 4 | RNF168, RNF8, UBE2N
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| Structural basis for role of ring finger protein RNF168 RING domain.
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| Zhang X, Chen J, Wu M, Wu H, Arokiaraj AW, Wang C, Zhang W, Tao Y, Huen MS, Zang J.
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| Cell Cycle 12(2):312-21. doi: 10.4161/cc.23104. Epub 2012 Jan 15.
2013
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| 5 | OTUB1, UBE2D1, UBE2N
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| E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1.
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| Wiener R, DiBello AT, Lombardi PM, Guzzo CM, Zhang X, Matunis MJ, Wolberger C.
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| Nat Struct Mol Biol 20(9):1033-9. doi: 10.1038/nsmb.2655. Epub 2013 Aug 18.
2013
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| 6 | OTUB1, UBE2N, UBE2V1, UBE2V2
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| Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitin-conjugating enzyme UBC13.
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| Sato Y, Yamagata A, Goto-Ito S, Kubota K, Miyamoto R, Nakada S, Fukai S.
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| J Biol Chem 287(31):25860-8. doi: 10.1074/jbc.M112.364752. Epub 2012 Jun 7. 2012
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| 7 | CHUK, UBE2N
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| Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells.
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| Chang JH, Xiao Y, Hu H, Jin J, Yu J, Zhou X, Wu X, Johnson HM, Akira S, Pasparakis M, Cheng X, Sun SC.
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| Nat Immunol 13(5):481-90. doi: 10.1038/ni.2267.
2012
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| 8 | GHR, STUB1, UBE2N
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| Ubc13 and COOH terminus of Hsp70-interacting protein (CHIP) are required for growth hormone receptor endocytosis.
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| Slotman JA, da Silva Almeida AC, Hassink GC, van de Ven RH, van Kerkhof P, Kuiken HJ, Strous GJ.
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| J Biol Chem 287(19):15533-43. doi: 10.1074/jbc.M111.302521. Epub 2012 Mar 20.
2012
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| 9 | OTUB1, UBE2N, UBE2V1
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| The mechanism of OTUB1-mediated inhibition of ubiquitination.
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| Wiener R, Zhang X, Wang T, Wolberger C.
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| Nature 483(7391):618-22. doi: 10.1038/nature10911.
2012
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| 10 | RNF8, UBE2L6, UBE2N
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| Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation.
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| Lok GT, Sy SM, Dong SS, Ching YP, Tsao SW, Thomson TM, Huen MS.
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| Nucleic Acids Res 40(1):196-205. doi: 10.1093/nar/gkr655. Epub 2011 Sep 12.
2012
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| 11 | RNF168, RNF8, STUB1, TRAF6, UBE2N
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| Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.
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| Campbell SJ, Edwards RA, Leung CC, Neculai D, Hodge CD, Dhe-Paganon S, Glover JN.
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| J Biol Chem 287(28):23900-10. doi: 10.1074/jbc.M112.359653. Epub 2012 May 15.
2012
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| 12 | C1orf86, RNF8, UBE2N
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| A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.
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| Yan Z, Guo R, Paramasivam M, Shen W, Ling C, Fox D 3rd, Wang Y, Oostra AB, Kuehl J, Lee DY, Takata M, Hoatlin ME, Schindler D, Joenje H, de Winter JP, Li L, Seidman MM, Wang W.
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| Mol Cell 47(1):61-75. doi: 10.1016/j.molcel.2012.05.026. Epub 2012 Jun 14.
2012
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| 13 | TRIM5, UBE2N, UBE2V1
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| TRIM5 acts as more than a retroviral restriction factor.
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| de Silva S, Wu L.
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| Viruses 3(7):1204-9. doi: 10.3390/v3071204. Review.
2011
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| 14 | OTUB1, RNF168, UBE2N
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| Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.
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| Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D.
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| Nature 466(7309):941-6. doi: 10.1038/nature09297.
2010
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| 15 | STUB1, UBE2D1, UBE2N
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| Insights into the conformational dynamics of the E3 ubiquitin ligase CHIP in complex with chaperones and E2 enzymes.
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| Graf C, Stankiewicz M, Nikolay R, Mayer MP.
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| Biochemistry 49(10):2121-9. doi: 10.1021/bi901829f.
2010
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| 16 | UBE2N
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| Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13.
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| Wu X, Yamamoto M, Akira S, Sun SC.
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| Proc Natl Acad Sci U S A 106(49):20836-41. doi: 10.1073/pnas.0906547106. Epub 2009 Nov 19.
2009
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| 17 | UBE2N
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| Control of p53 multimerization by Ubc13 is JNK-regulated.
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| Topisirovic I, Gutierrez GJ, Chen M, Appella E, Borden KL, Ronai ZA.
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| Proc Natl Acad Sci U S A 106(31):12676-81. doi: 10.1073/pnas.0900596106. Epub 2009 Jul 27.
2009
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| 18 | MAP3K7, TRAF6, UBE2N, UBE2V1
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| Direct activation of protein kinases by unanchored polyubiquitin chains.
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| Xia ZP, Sun L, Chen X, Pineda G, Jiang X, Adhikari A, Zeng W, Chen ZJ.
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| Nature 461(7260):114-9. doi: 10.1038/nature08247. Epub 2009 Aug 12.
2009
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| 19 | TRAF6, UBE2N
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| The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL.
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| Lamothe B, Campos AD, Webster WK, Gopinathan A, Hur L, Darnay BG.
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| J Biol Chem 283(36):24871-80. Epub 2008 Jul 10.
2008
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| 20 | HLTF, UBE2V2, UBE2A, UBE2B, RAD18, UBE2N
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| Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination.
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| Unk I, Hajdś I, F‡tyol K, Hurwitz J, Yoon JH, Prakash L, Prakash S, Haracska L.
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| Proc Natl Acad Sci U S A 105(10):3768-73. Epub 2008 Mar 3. 2008
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| 21 | UBE2N, UBE2V1
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| Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly.
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| Huen MS, Huang J, Yuan J, Yamamoto M, Akira S, Ashley C, Xiao W, Chen J.
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| Mol Cell Biol 28(19):6104-12. doi: 10.1128/MCB.00987-08. Epub 2008 Aug 4. 2008
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| 22 | UBE2N
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| Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses.
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| Fukushima T, Matsuzawa S, Kress CL, Bruey JM, Krajewska M, Lefebvre S, Zapata JM, Ronai Z, Reed JC.
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| Proc Natl Acad Sci U S A 104(15):6371-6. Epub 2007 Apr 2. 2007
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| 23 | UBE2N
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| A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination.
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| Zhao GY, Sonoda E, Barber LJ, Oka H, Murakawa Y, Yamada K, Ikura T, Wang X, Kobayashi M, Yamamoto K, Boulton SJ, Takeda S.
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| Mol Cell 25(5):663-75.
2007
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| 24 | H2AFX, KAT5, UBE2N
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| DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics.
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| Ikura T, Tashiro S, Kakino A, Shima H, Jacob N, Amunugama R, Yoder K, Izumi S, Kuraoka I, Tanaka K, Kimura H, Ikura M, Nishikubo S, Ito T, Muto A, Miyagawa K, Takeda S, Fishel R, Igarashi K, Kamiya K.
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| Mol Cell Biol 27(20):7028-40. Epub 2007 Aug 20.PMID: 17709392 2007
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| 25 | UBE2N, ZNRF2
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| The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation.
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| Plans V, Scheper J, Soler M, Loukili N, Okano Y, Thomson TM.
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| J Cell Biochem 97(3):572-82.
2006
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| 26 | ISG15,UBE2N
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| ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity.
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| Takeuchi T, Yokosawa H.
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| Biochem Biophys Res Commun 336(1):9-13. 2005
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| 27 | TRAF6, UBE2N
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| The TRAF6 RING finger domain mediates physical interaction with Ubc13.
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| Wooff J, Pastushok L, Hanna M, Fu Y, Xiao W.
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| FEBS Lett 566(1-3):229-33. 2004
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| 28 | AURKA, UBE2N
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| Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human.
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| Ewart-Toland A, Briassouli P, de Koning JP, Mao JH, Yuan J, Chan F, MacCarthy-Morrogh L, Ponder BA, Nagase H, Burn J, Ball S, Almeida M, Linardopoulos S, Balmain A.
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| Nat Genet 34(4):403-12. 2003
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| 29 | UBE2N
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| Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly ofnovel polyubiquitin chains for DNA repair.
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| Hofmann RM, Pickart CM.
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| Cell 96(5):645-53. 1999
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| 30 | UBE2N
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| Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzymesimilar to the Drosophila bendless gene product.
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| Yamaguchi T, Kim NS, Sekine S, Seino H, Osaka F, Yamao F, Kato S.
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| J Biochem (Tokyo) 120(3):494-97. 1996
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