| 1 | PIAS1, RANBP2, SAE1, UBA2, UBE2I
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| Localization Patterns of Sumoylation Enzymes E1, E2 and E3 in Ocular Cell Lines Predict Their Functional Importance.
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| Gong X, Nie Q, Xiao Y, Xiang JW, Wang L, Liu F, Fu JL, Liu Y, Yang L, Gan Y, Chen H, Luo Z, Qi R, Chen Z, Tang X, Li DW.
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| Curr Mol Med 18(8):516-522. doi: 10.2174/1566524019666190112144436.
2018
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| 2 | FYB1, RAC1, RAP1A, RASSF5, UBE2I
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| Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion.
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| Xiong Y, Ye C, Yang N, Li M, Liu H.
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| J Immunol 199(12):4142-4154. doi: 10.4049/jimmunol.1700572. Epub 2017 Nov 10.
2017
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| 3 | CANX, UBE2I
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| UBC9-dependent association between calnexin and protein tyrosine phosphatase 1B (PTP1B) at the endoplasmic reticulum.
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| Lee D, Kraus A, Prins D, Groenendyk J, Aubry I, Liu WX, Li HD, Julien O, Touret N, Sykes BD, Tremblay ML, Michalak M.
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| J Biol Chem 290(9):5725-38. doi: 10.1074/jbc.M114.635474. Epub 2015 Jan 13.
2015
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| 4 | PIAS1, SUMO1, UBE2I
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| Identification of a non-covalent ternary complex formed by PIAS1, SUMO1, and UBC9 proteins involved in transcriptional regulation.
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| Mascle XH, Lussier-Price M, Cappadocia L, Estephan P, Raiola L, Omichinski JG, Aubry M.
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| J Biol Chem 288(51):36312-27. doi: 10.1074/jbc.M113.486845. Epub 2013 Oct 30.
2013
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| 5 | RANBP2, RANGAP1, SUMO1, SUMO2, UBE2I
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| Determinants of small ubiquitin-like modifier 1 (SUMO1) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin RanBP2.
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| Gareau JR, Reverter D, Lima CD.
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| J Biol Chem 287(7):4740-51. doi: 10.1074/jbc.M111.321141. Epub 2011 Dec 22. 2012
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| 6 | UBE2I
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| Ubc9 negatively regulates BMP-mediated osteoblastic differentiation in cultured cells.
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| Yukita A, Hosoya A, Ito Y, Katagiri T, Asashima M, Nakamura H.
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| Bone 50(5):1092-9. doi: 10.1016/j.bone.2012.02.008. Epub 2012 Feb 17.
2012
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| 7 | MDM2, RWDD3, SKI, SRSF1, UBE2I
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| Overexpression of SKI oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylation.
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| Ding B, Sun Y, Huang J.
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| J Biol Chem 287(18):14621-30. doi: 10.1074/jbc.M111.301523. Epub 2012 Mar 12.
2012
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| 8 | IPO13, UBE2I
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| Structure of Importin13-Ubc9 complex: nuclear import and release of a key regulator of sumoylation.
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| Grünwald M, Bono F.
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| EMBO J 30(2):427-38. Epub 2010 Dec 7.
2011
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| 9 | EGR2, UBE2I
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| The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators.
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| García-Gutiérrez P, Juárez-Vicente F, Gallardo-Chamizo F, Charnay P, García-Domínguez M.
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| EMBO Rep 12(10):1018-23. doi: 10.1038/embor.2011.152.
2011
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| 10 | SETD8, UBE2I
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| The UBC9 E2 SUMO conjugating enzyme binds the PR-Set7 histone methyltransferase to facilitate target gene repression.
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| Spektor TM, Congdon LM, Veerappan CS, Rice JC.
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| PLoS One 6(7):e22785. doi: 10.1371/journal.pone.0022785. Epub 2011 Jul 29.
2011
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| 11 | BRCA1, UBE2I
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| Ubc9 mediates nuclear localization and growth suppression of BRCA1 and BRCA1a proteins.
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| Qin Y, Xu J, Aysola K, Begum N, Reddy V, Chai Y, Grizzle WE, Partridge EE, Reddy ES, Rao VN.
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| J Cell Physiol 226(12):3355-67. doi: 10.1002/jcp.22695.
2011
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| 12 | TCERG1, UBE2I
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| Differential effects of sumoylation on transcription and alternative splicing by transcription elongation regulator 1 (TCERG1).
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| Sánchez-Alvarez M, Montes M, Sánchez-Hernández N, Hernández-Munain C, Suñé C.
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| J Biol Chem 285(20):15220-33. Epub 2010 Mar 9.PMID: 20215116 2010
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| 13 | UBE2I
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| Role of UBC9 in the regulation of the adipogenic program in 3T3-L1 adipocytes.
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| Cignarelli A, Melchiorre M, Peschechera A, Conserva A, Renna LA, Miccoli S, Natalicchio A, Perrini S, Laviola L, Giorgino F.
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| Endocrinology 151(11):5255-66. doi: 10.1210/en.2010-0417. Epub 2010 Sep 29.
2010
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| 14 | UBE2I
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| Expression analysis of Ubc9, the single small ubiquitin-like modifier (SUMO) E2 conjugating enzyme, in normal and malignant tissues.
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| Moschos SJ, Jukic DM, Athanassiou C, Bhargava R, Dacic S, Wang X, Kuan SF, Fayewicz SL, Galambos C, Acquafondata M, Dhir R, Becker D.
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| Hum Pathol 41(9):1286-98. doi: 10.1016/j.humpath.2010.02.007. Epub 2010 Jun 18.
2010
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| 15 | CDC42, CXCR4, UBE2I
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| Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner.
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| Zhu S, Sachdeva M, Wu F, Lu Z, Mo YY.
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| Oncogene 29(12):1763-72. doi: 10.1038/onc.2009.459. Epub 2009 Dec 21.
2010
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| 16 | RASD2, UBE2I
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| Rhes, a physiologic regulator of sumoylation, enhances cross-sumoylation between the basic sumoylation enzymes E1 and Ubc9.
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| Subramaniam S, Mealer RG, Sixt KM, Barrow RK, Usiello A, Snyder SH.
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| J Biol Chem 285(27):20428-32. doi: 10.1074/jbc.C110.127191. Epub 2010 Apr 27.
2010
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| 17 | FOXL2, STAR, UBE2I
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| Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the Steroidogenic Acute Regulatory gene.
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| Kuo FT, Bentsi-Barnes IK, Barlow GM, Bae J, Pisarska MD.
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| Cell Signal 21(12):1935-44. Epub 2009 Sep 8.PMID: 19744555 2009
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| 18 | UBE2I
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| Ubc9 gene polymorphisms and late-onset Alzheimer's disease in the Korean population: a genetic association study.
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| Ahn K, Song JH, Kim DK, Park MH, Jo SA, Koh YH.
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| Neurosci Lett 465(3):272-5. doi: 10.1016/j.neulet.2009.09.017. Epub 2009 Sep 17.
2009
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| 19 | PIAS1, UBE2I, ZMYND11
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| BS69 undergoes SUMO modification and plays an inhibitory role in muscle and neuronal differentiation.
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| Yu B, Shao Y, Zhang C, Chen Y, Zhong Q, Zhang J, Yang H, Zhang W, Wan J.
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| Exp Cell Res 315(20):3543-53. doi: 10.1016/j.yexcr.2009.09.011. Epub 2009 Sep 18.
2009
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| 20 | PLAGL2, UBE2I
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| Modulation of PLAGL2 transactivation activity by Ubc9 co-activation not SUMOylation.
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| Guo Y, Yang MC, Weissler JC, Yang YS.
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| Biochem Biophys Res Commun 374(3):570-5. Epub 2008 Jul 23.
2008
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| 21 | IRF1, UBE2I
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| Ubc9-mediated sumoylation leads to transcriptional repression of IRF-1.
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| Kim EJ, Park JS, Um SJ.
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| Biochem Biophys Res Commun 377(3):952-6. Epub 2008 Oct 26.PMID: 18955028 2008
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| 22 | UBE2I
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| UBE2I (UBC9), a SUMO-conjugating enzyme, localizes to nuclear speckles and stimulates transcription in mouse oocytes.
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| Ihara M, Stein P, Schultz RM.
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| Biol Reprod 79(5):906-13. doi: 10.1095/biolreprod.108.070474. Epub 2008 Aug 13.
2008
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| 23 | RANGAP1, UBE2I
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| Ubc9 sumoylation regulates SUMO target discrimination.
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| Knipscheer P, Flotho A, Klug H, Olsen JV, van Dijk WJ, Fish A, Johnson ES, Mann M, Sixma TK, Pichler A.
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| Mol Cell 31(3):371-82. doi: 10.1016/j.molcel.2008.05.022.
2008
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| 24 | UBE2I, UIMC1
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| RAP80 interacts with the SUMO-conjugating enzyme UBC9 and is a novel target for sumoylation.
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| Yan J, Yang XP, Kim YS, Joo JH, Jetten AM.
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| Biochem Biophys Res Commun 362(1):132-8. Epub 2007 Aug 8. 2007
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| 25 | UBE2I
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| Regulation of nuclear receptor and coactivator functions by the carboxyl terminus of ubiquitin-conjugating enzyme 9.
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| Chang YL, Huang CJ, Chan JY, Liu PY, Chang HP, Huang SM.
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| Int J Biochem Cell Biol 39(5):1035-46. Epub 2007 Feb 6.
2007
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| 26 | UBE2I
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| Coactivation of the N-terminal transactivation of mineralocorticoid receptor by Ubc9.
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| Yokota K, Shibata H, Kurihara I, Kobayashi S, Suda N, Murai-Takeda A, Saito I, Kitagawa H, Kato S, Saruta T, Itoh H.
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| J Biol Chem 282(3):1998-2010. Epub 2006 Nov 14.
2007
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| 27 | UBE2I
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| Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway.
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| Woeller CF, Anderson DD, Szebenyi DM, Stover PJ.
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| J Biol Chem 282(24):17623-31. Epub 2007 Apr 19.
2007
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| 28 | SOX4, UBE2I
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| Ubc9 interacts with SOX4 and represses its transcriptional activity.
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| Pan X, Li H, Zhang P, Jin B, Man J, Tian L, Su G, Zhao J, Li W, Liu H, Gong W, Zhou T, Zhang X.
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| Biochem Biophys Res Commun 344(3):727-34. Epub 2006 Apr 17.
2006
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| 29 | FHL2, PIAS1, UBE2I
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| FHL2, UBC9, and PIAS1 are novel estrogen receptor alpha-interacting proteins.
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| Kobayashi S, Shibata H, Yokota K, Suda N, Murai A, Kurihara I, Saito I, Saruta T.
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| Endocr Res 30(4):617-21. 2004
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| 30 | UBE2I, SMAD4
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| SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4.
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| Lin X, Liang M, Liang YY, Brunicardi FC, Feng XH.
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| J Biol Chem 278(33):31043-8. Epub 2003 Jun 17. 2003
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| 31 | RANGAP1, UBE2I
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| Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1.
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| Bernier-Villamor V, Sampson DA, Matunis MJ, Lima CD.
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| Cell 108(3):345-56. 2002
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| 32 | RANBP2, UBE2I
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| Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358.
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| Saitoh H, Pizzi MD, Wang J.
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| J Biol Chem 277(7):4755-63. 2002
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| 33 | FHIT, UBE2I
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| Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9.
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| Shi Y, Zou M, Farid NR, Paterson MC.
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| Biochem J 352 Pt 2:443-8. 2000
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| 34 | ETV6, UBE2I, SUMO1
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| Posttranslational modification of TEL and TEL/AML1 by SUMO-1 and cell-cycle-dependent assembly into nuclear bodies.
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| Chakrabarti SR, Sood R, Nandi S, Nucifora G.
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| Proc Natl Acad Sci U S A 97(24):13281-5. 2000
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| 35 | UBE2I
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| Cloning, expression, and mapping of UBE2I, a novel gene encoding a humanhomologue of yeast ubiquitin-conjugating enzymes which are critical for regulating the cell cycle.
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| Watanabe TK, et al.
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| Cytogenet Cell Genet 72 : 86-89. 1996
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| 36 | UBE2I
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| Associations of UBE21 with RAD52, UBL1, p53, and RAD51 proteins in a yeast two-hybrid system.
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| Shen Z, et al.
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| Genomics 37 : 183-186. 1996
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| 37 | UBE2I
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| Molecular cloning of the cDNA and chromosome localization of the gene for human ubiquitin-conjugating enzyme 9.
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| Wang ZY, et al.
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| J Biol Chem 271 : 24811-24816. 1996
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| 38 | UBE2I
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| Assignment of the gene for a ubiquitin-conjugating enzyme (UBE2I) to human chromosome band 16p13.3 by in situ hybridization.
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| Tachibana M, et al.
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| Cytogenet Cell Genet 75 : 222-223. 1996
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| 39 | UBE2I
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| Identification of the structural and functional human homolog of the yeast ubiquitin conjugating enzyme UBC9.
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| Yasugi T, Howley PM.
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| Nucleic Acids Res 24(11):2005-10.
1996
|