| 1 | MRXS30, UBE2A
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| A novel UBE2A mutation causes X-linked intellectual disability type Nascimento.
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| Tsurusaki Y, Ohashi I, Enomoto Y, Naruto T, Mitsui J, Aida N, Kurosawa K.
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| Hum Genome Var 4:17019. doi: 10.1038/hgv.2017.19. eCollection 2017.
2017
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| 2 | RNF20, UBE2A, WDR76
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| Subnuclear Relocalization of Structure-Specific Endonucleases in Response to DNA Damage.
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| Saugar I, Jiménez-Martín A, Tercero JA.
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| Cell Rep 20(7):1553-1562. doi: 10.1016/j.celrep.2017.07.059.
2017
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| 3 | UBE2A
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| An essential role for UBE2A/HR6A in learning and memory and mGLUR-dependent long-term depression.
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| Bruinsma CF, Savelberg SM, Kool MJ, Jolfaei MA, Van Woerden GM, Baarends WM, Elgersma Y.
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| Hum Mol Genet 25(1):1-8. doi: 10.1093/hmg/ddv436. Epub 2015 Oct 16.
2016
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| 4 | CBX5, UBE2A
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| RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1.
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| Chen S, Wang C, Sun L, Wang DL, Chen L, Huang Z, Yang Q, Gao J, Yang XB, Chang JF, Chen P, Lan L, Mao Z, Sun FL.
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| Mol Cell Biol 35(2):406-16. doi: 10.1128/MCB.01044-14. Epub 2014 Nov 10.
2015
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| 5 | ASF1A, MDM2, UBE2A, UBE2B
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| A conserved RAD6-MDM2 ubiquitin ligase machinery targets histone chaperone ASF1A in tumorigenesis.
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| Wang C, Chang JF, Yan H, Wang DL, Liu Y, Jing Y, Zhang M, Men YL, Lu D, Yang XM, Chen S, Sun FL.
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| Oncotarget 6(30):29599-613. doi: 10.18632/oncotarget.5011.
2015
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| 6 | MRXS30, UBE2A
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| UBE2A deficiency syndrome: a report of two unrelated cases with large Xq24 deletions encompassing UBE2A gene.
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| Thunstrom S, Sodermark L, Ivarsson L, Samuelsson L, Stefanova M.
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| Am J Med Genet A 167A(1):204-10. doi: 10.1002/ajmg.a.36800. Epub 2014 Oct 6.
2015
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| 7 | UBE2A
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| Human RAD6 promotes G1-S transition and cell proliferation through upregulation of cyclin D1 expression.
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| Cai F, Chen P, Chen L, Biskup E, Liu Y, Chen PC, Chang JF, Jiang W, Jing Y, Chen Y, Jin H, Chen S.
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| PLoS One 9(11):e113727. doi: 10.1371/journal.pone.0113727. eCollection 2014.
2014
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| 8 | RNF168, UBE2A, UBE2B
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| RNF168 forms a functional complex with RAD6 during the DNA damage response.
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| Liu C, Wang D, Wu J, Keller J, Ma T, Yu X.
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| J Cell Sci 126(Pt 9):2042-51. doi: 10.1242/jcs.122945. Epub 2013 Mar 22.
2013
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| 9 | UBE2A
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| Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy.
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| Haddad DM, Vilain S, Vos M, Esposito G, Matta S, Kalscheuer VM, Craessaerts K, Leyssen M, Nascimento RM, Vianna-Morgante AM, De Strooper B, Van Esch H, Morais VA, Verstreken P.
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| Mol Cell 50(6):831-43. doi: 10.1016/j.molcel.2013.04.012. Epub 2013 May 16.
2013
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| 10 | UBE2A, UBE2B
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| RAD6 regulates the dosage of p53 by a combination of transcriptional and posttranscriptional mechanisms.
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| Chen S, Wang DL, Liu Y, Zhao L, Sun FL.
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| Mol Cell Biol 32(2):576-87. doi: 10.1128/MCB.05966-11. Epub 2011 Nov 14.
2012
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| 11 | DELXQM, MRXS30, UBE2A
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| Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation.
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| Honda S, Orii KO, Kobayashi J, Hayashi S, Imamura A, Imoto I, Nakagawa E, Goto Y, Inazawa J.
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| J Hum Genet 55(4):244-7. Epub 2010 Mar 26. 2010
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| 12 | MRXS30, UBE2A
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| Novel missense mutations in the ubiquitination-related gene UBE2A cause a recognizable X-linked mental retardation syndrome.
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| Budny B, Badura-Stronka M, Materna-Kiryluk A, Tzschach A, Raynaud M, Latos-Bielenska A, Ropers HH.
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| Clin Genet 77(6):541-51. Epub 2010 Apr 19.PMID: 20412111 2010
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| 13 | HIST2H2BE, RNF20, UBE2A
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| RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells.
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| Kim J, Guermah M, McGinty RK, Lee JS, Tang Z, Milne TA, Shilatifard A, Muir TW, Roeder RG.
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| Cell 137(3):459-71.PMID: 19410543 2009
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| 14 | HLTF, UBE2V2, UBE2A, UBE2B, RAD18, UBE2N
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| Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination.
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| Unk I, Hajdś I, F‡tyol K, Hurwitz J, Yoon JH, Prakash L, Prakash S, Haracska L.
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| Proc Natl Acad Sci U S A 105(10):3768-73. Epub 2008 Mar 3. 2008
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| 15 | UBE2A
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| Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation.
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| Howard RA, Sharma P, Hajjar C, Caldwell KA, Caldwell GA, du Breuil R, Moore R, Boyd L.
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| BMC Cell Biol 8:32.PMID: 17663792 2007
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| 16 | UBE2A, UBE2B
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| Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification.
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| Notenboom V, Hibbert RG, van Rossum-Fikkert SE, Olsen JV, Mann M, Sixma TK.
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| Nucleic Acids Res 35(17):5819-30. Epub 2007 Aug 24.
2007
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| 17 | UBE2A, MRXS30
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| UBE2A, Which Encodes a Ubiquitin-Conjugating Enzyme, Is Mutated in a Novel X-Linked Mental Retardation Syndrome.
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| Nascimento RM, Otto PA, de Brouwer AP, Vianna-Morgante AM.
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| Am J Hum Genet 79(3):549-55. Epub 2006 Jul 3. 2006
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| 18 | HIST2H2BE, RNF20, UBE2A
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| Histone H2B ubiquitylation is associated with elongating RNA polymerase II.
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| Xiao T, Kao CF, Krogan NJ, Sun ZW, Greenblatt JF, Osley MA, Strahl BD.
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| Mol Cell Biol 25(2):637-51.PMID: 15632065 2005
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| 19 | UBE2A, UBE2B, RAD18, ZMYM2
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| ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins.
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| Kunapuli P, Somerville R, Still IH, Cowell JK.
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| Oncogene 22(22):3417-23. 2003
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| 20 | UBE2A, UBE2B
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| Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31.
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| Koken MHM, et al.
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| Genomics 12 : 447-453. 1992
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| 21 | UBE2A, UBE2B
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| cDNA cloning of a novel human ubiquitin carrier protein.
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| Liu Z, et al.
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| J Biol Chem 267 : 15829-15835. 1992
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| 22 | UBE2A, UBE2B
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| Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6.
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| Koken MH, et al.
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| Proc Natl Acad Sci U S A 88 : 8865-8869. 1991
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