| 1 | APOL1, UBD
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| UBD modifies APOL1-induced kidney disease risk.
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| Zhang JY, Wang M, Tian L, Genovese G, Yan P, Wilson JG, Thadhani R, Mottl AK, Appel GB, Bick AG, Sampson MG, Alper SL, Friedman DJ, Pollak MR.
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| Proc Natl Acad Sci U S A 115(13):3446-3451. doi: 10.1073/pnas.1716113115. Epub 2018 Mar 12.
2018
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| 2 | ISG15, UBD
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| Newly translated proteins are substrates for ubiquitin, ISG15, and FAT10.
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| Spinnenhirn V, Bitzer A, Aichem A, Groettrup M.
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| FEBS Lett 591(1):186-195. doi: 10.1002/1873-3468.12512. Epub 2016 Dec 20.
2017
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| 3 | EEF1A1, UBD
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| The ubiquitin-like protein FAT10 stabilizes eEF1A1 expression to promote tumor proliferation in a complex manner.
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| Liu X, Chen L, Ge J, Yan C, Huang Z, Hu J, Wen C, Li M, Huang D, Qiu Y, Hao H, Yuan R, Lei J, Yu X, Shao J.
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| Cancer Res ancer Res. 2016 Jun 16. pii: canres.3118.2015. [Epub ahead of print]
2016
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| 4 | DDX58, UBD
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| Ubiquitin-like modifier FAT10 attenuates RIG-I mediated antiviral signaling by segregating activated RIG-I from its signaling platform.
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| Nguyen NT, Now H, Kim WJ, Kim N, Yoo JY.
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| Sci Rep 6:23377. doi: 10.1038/srep23377.
2016
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| 5 | UBA6, UBD, UBE2Z
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| Structure of UBE2Z Enzyme Provides Functional Insight into Specificity in the FAT10 Protein Conjugation Machinery.
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| Schelpe J, Monté D, Dewitte F, Sixma TK, Rucktooa P.
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| J Biol Chem 291(2):630-9. doi: 10.1074/jbc.M115.671545. Epub 2015 Nov 10.
2016
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| 6 | LMO2, UBA6, UBD, USE1
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| LMO2 blocks the UBA6-USE1 interaction and downstream FAT10ylation by targeting the ubiquitin fold domain of UBA6.
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| Wu C, Liu Y, Gu X, Zhu T, Yang S, Sun W.
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| Biochem Biophys Res Commun 478(3):1442-8. doi: 10.1016/j.bbrc.2016.08.143. Epub 2016 Aug 26.
2016
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| 7 | UBA1, UBD
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| Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation.
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| Bialas J, Groettrup M, Aichem A.
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| PLoS One 10(3):e0120329. doi: 10.1371/journal.pone.0120329. eCollection 2015.
2015
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| 8 | UBD
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| The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection.
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| Buerger S, Herrmann VL, Mundt S, Trautwein N, Groettrup M, Basler M.
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| J Immunol 195(9):4106-16. doi: 10.4049/jimmunol.1500592. Epub 2015 Sep 23.
2015
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| 9 | STAT3, UBD
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| NFκB and STAT3 synergistically activate the expression of FAT10, a gene counteracting the tumor suppressor p53.
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| Choi Y, Kim JK, Yoo JY.
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| Mol Oncol 8(3):642-55. doi: 10.1016/j.molonc.2014.01.007. Epub 2014 Jan 24.
2014
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| 10 | UBD
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| Increased FAT10 expression is related to poor prognosis in pancreatic ductal adenocarcinoma.
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| Sun GH, Liu YD, Yu G, Li N, Sun X, Yang J.
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| Tumour Biol 35(6):5167-71. doi: 10.1007/s13277-014-1670-1. Epub 2014 Feb 4.
2014
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| 11 | UBD
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| FAT10 protects cardiac myocytes against apoptosis.
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| Peng X, Shao J, Shen Y, Zhou Y, Cao Q, Hu J, He W, Yu X, Liu X, Marian AJ, Hong K.
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| J Mol Cell Cardiol 59:1-10. doi: 10.1016/j.yjmcc.2013.01.018. Epub 2013 Feb 13.
2013
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| 12 | UBD
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| Structure of a compact conformation of linear diubiquitin.
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| Rohaim A, Kawasaki M, Kato R, Dikic I, Wakatsuki S.
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| Acta Crystallogr D Biol Crystallogr 68(Pt 2):102-8. Epub 2012 Jan 13.
2012
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| 13 | UBD
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| FAT10 is a proteasomal degradation signal that is itself regulated by ubiquitination.
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| Buchsbaum S, Bercovich B, Ciechanover A.
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| Mol Biol Cell 23(1):225-32. Epub 2011 Nov 9.
2012
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| 14 | NUB1, PSMD4, UBD
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| FAT10 and NUB1L bind to the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis.
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| Rani N, Aichem A, Schmidtke G, Kreft SG, Groettrup M.
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| Nat Commun 3:749. doi: 10.1038/ncomms1752.
2012
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| 15 | AIPL1, NUB1, UBD
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| The inherited blindness protein AIPL1 regulates the ubiquitin-like FAT10 pathway.
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| Bett JS, Kanuga N, Richet E, Schmidtke G, Groettrup M, Cheetham ME, van der Spuy J.
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| PLoS One 7(2):e30866. doi: 10.1371/journal.pone.0030866. Epub 2012 Feb 7.
2012
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| 16 | UBA6, UBD
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| Mechanistic studies on activation of ubiquitin and di-ubiquitin-like protein, FAT10, by ubiquitin-like modifier activating enzyme 6, Uba6.
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| Gavin JM, Chen JJ, Liao H, Rollins N, Yang X, Xu Q, Ma J, Loke HK, Lingaraj T, Brownell JE, Mallender WD, Gould AE, Amidon BS, Dick LR.
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| J Biol Chem 287(19):15512-22. doi: 10.1074/jbc.M111.336198. Epub 2012 Mar 15.
2012
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| 17 | LRRFIP2, TLR4, TOR1AIP2, UBD
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| Modification of the inflammatory mediator LRRFIP2 by the ubiquitin-like protein FAT10 inhibits its activity during cellular response to LPS.
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| Buchsbaum S, Bercovich B, Ziv T, Ciechanover A.
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| Biochem Biophys Res Commun 428(1):11-6. doi: 10.1016/j.bbrc.2012.09.110. Epub 2012 Oct 1.
2012
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| 18 | TNF, UBD
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| FAT10 mediates the effect of TNF-α in inducing chromosomal instability.
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| Ren J, Wang Y, Gao Y, Mehta SB, Lee CG.
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| J Cell Sci 124(Pt 21):3665-75. Epub 2011 Oct 24.
2011
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| 19 | UBD
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| FAT10 protein binds to polyglutamine proteins and modulates their solubility.
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| Nagashima Y, Kowa H, Tsuji S, Iwata A.
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| J Biol Chem 286(34):29594-600. Epub 2011 Jul 8.
2011
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| 20 | UBD
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| FAT10 modifies p53 and upregulates its transcriptional activity.
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| Li T, Santockyte R, Yu S, Shen RF, Tekle E, Lee CG, Yang DC, Chock PB.
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| Arch Biochem Biophys 509(2):164-9. Epub 2011 Mar 9.
2011
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| 21 | UBD
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| The ubiquitin-like protein FAT10 mediates NF-kappaB activation.
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| Gong P, Canaan A, Wang B, Leventhal J, Snyder A, Nair V, Cohen CD, Kretzler M, D'Agati V, Weissman S, Ross MJ.
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| J Am Soc Nephrol 21(2):316-26. Epub 2009 Dec 3.
2010
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| 22 | UBD, USE1
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| USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis.
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| Aichem A, Pelzer C, Lukasiak S, Kalveram B, Sheppard PW, Rani N, Schmidtke G, Groettrup M.
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| Nat Commun 1:13. doi: 10.1038/ncomms1012.
2010
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| 23 | NUB1, UBD
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| Degradation of FAT10 by the 26S proteasome is independent of ubiquitylation but relies on NUB1L.
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| Schmidtke G, Kalveram B, Groettrup M.
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| FEBS Lett 583(3):591-4. Epub 2009 Jan 21.
2009
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| 24 | UBD
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| FAT10 level in human gastric cancer and its relation with mutant p53 level, lymph node metastasis and TNM staging.
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| Ji F, Jin X, Jiao CH, Xu QW, Wang ZW, Chen YL.
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| World J Gastroenterol 15(18):2228-33.
2009
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| 25 | HDAC6, UBD
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| The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition.
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| Kalveram B, Schmidtke G, Groettrup M.
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| J Cell Sci 121(Pt 24):4079-88. Epub 2008 Nov 25.
2008
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| 26 | UBD
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| Proinflammatory cytokines cause FAT10 upregulation in cancers of liver and colon.
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| Lukasiak S, Schiller C, Oehlschlaeger P, Schmidtke G, Krause P, Legler DF, Autschbach F, Schirmacher P, Breuhahn K, Groettrup M.
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| Oncogene 27(46):6068-74. Epub 2008 Jun 23.
2008
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| 27 | UBD
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| Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease.
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| Ross MJ, Wosnitzer MS, Ross MD, Granelli B, Gusella GL, Husain M, Kaufman L, Vasievich M, D'Agati VD, Wilson PD, Klotman ME, Klotman PE.
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| J Am Soc Nephrol 17(4):996-1004. Epub 2006 Feb 22. 2006
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| 28 | UBD
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| FAT10 plays a role in the regulation of chromosomal stability.
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| Ren J, Kan A, Leong SH, Ooi LL, Jeang KT, Chong SS, Kon OL, Lee CG.
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| J Biol Chem 281(16):11413-21. Epub 2006 Feb 22. 2006
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| 29 | NUB1, UBD
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| The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10.
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| Schmidtke G, Kalveram B, Weber E, Bochtler P, Lukasiak S, Hipp MS, Groettrup M.
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| J Biol Chem 281(29):20045-54. Epub 2006 May 17.
2006
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| 30 | UBD
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| FAT10, a ubiquitin-independent signal for proteasomal degradation.
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| Hipp MS, Kalveram B, Raasi S, Groettrup M, Schmidtke G.
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| Mol Cell Biol 25(9):3483-91. 2005
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| 31 | UBD
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| Expression of the FAT10 gene is highly upregulated in hepatocellular carcinoma and other gastrointestinal and gynecological cancers.
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| Lee CG, Ren J, Cheong IS, Ban KH, Ooi LL, Yong Tan S, Kan A, Nuchprayoon I, Jin R, Lee KH, Choti M, Lee LA.
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| Oncogene 22(17):2592-603. 2003
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| 32 | UBD, MAD2L1
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| A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2.
|
| Liu YC, et al.
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| Proc Natl Acad Sci U S A 96(8):4313-8. 1999
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| 33 | UBD
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| Identification and analysis of a novel member of the ubiquitin family expressed in dendritic cells and mature B cells.
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| Bates EE, Ravel O, Dieu MC, Ho S, Guret C, Bridon JM, Ait-Yahia S, Briere F, Caux C, Banchereau J, Lebecque S.
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| Eur J Immunol 27(10):2471-7. 1997
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| 34 | BSN, GNL1, HFEC@, MOG, QMR1, RAN, TRAM2, TRIM15, TRIM27, TRNAS2, TRNAS3, TUBB, UBD
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| A transcription map of the major histocompatibility complex (MHC) class I region.
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| Gruen JR, Nalabolu SR, Chu TW, Bowlus C, Fan WF, Goei VL, Wei H, Sivakamasundari R, Liu Y, Xu HX, Parimoo S, Nallur G, Ajioka R, Shukla H, Bray-Ward P, Pan J, Weissman SM.
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| Genomics 36(1):70-85. 1996
|