1 | LRP6, UBA2
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| Comprehensive clinical and molecular studies in split-hand/foot malformation: identification of two plausible candidate genes (LRP6 and UBA2).
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| Yamoto K, Saitsu H, Nishimura G, Kosaki R, Takayama S, Haga N, Tonoki H, Okumura A, Horii E, Okamoto N, Suzumura H, Ikegawa S, Kato F, Fujisawa Y, Nagata E, Takada S, Fukami M, Ogata T.
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| Eur J Hum Genet ur J Hum Genet. 2019 Jul 22. doi: 10.1038/s41431-019-0473-7. [Epub ahead of print]
2019
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2 | UBA2
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| Identifying UBA2 as a proliferation and cell cycle regulator in lung cancer A549 cells.
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| Jiang B, Fan X, Zhang D, Liu H, Fan C.
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| J Cell Biochem 120(8):12752-12761. doi: 10.1002/jcb.28543. Epub 2019 Mar 8.
2019
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3 | ACCDA, UBA2
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| Aplasia cutis congenita associated with a heterozygous loss-of-function UBA2 variant.
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| Wang Y, Dupuis L, Jobling R, Kannu P.
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| Br J Dermatol r J Dermatol. 2019 Oct 6. doi: 10.1111/bjd.18594. [Epub ahead of print] 2019
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4 | UBA2
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| Ubiquitin-like modifier activating enzyme 2 promotes cell migration and invasion through Wnt/β-catenin signaling in gastric cancer.
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| Li J, Sun X, He P, Liu WQ, Zou YB, Wang Q, Meng XW.
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| World J Gastroenterol 24(42):4773-4786. doi: 10.3748/wjg.v24.i42.4773.
2018
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5 | UBA2
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| UBA2 promotes proliferation of colorectal cancer.
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| He P, Sun X, Cheng HJ, Zou YB, Wang Q, Zhou CL, Liu WQ, Hao YM, Meng XW.
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| Mol Med Rep 18(6):5552-5562. doi: 10.3892/mmr.2018.9613. Epub 2018 Oct 30.
2018
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6 | UBA2, WTIP
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| Identification of the UBA2-WTIP fusion gene in acute myeloid leukemia.
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| Lu X, Zhuang H, Yu Q, Zhang X, Wu Z, Zhang L, Xu Y, Wu B, Yang L, Ma A, Gan X, Yu X, Shen J, Xu R.
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| Exp Cell Res 371(2):409-416. doi: 10.1016/j.yexcr.2018.08.035. Epub 2018 Sep 1.
2018
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7 | PIAS1, RANBP2, SAE1, UBA2, UBE2I
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| Localization Patterns of Sumoylation Enzymes E1, E2 and E3 in Ocular Cell Lines Predict Their Functional Importance.
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| Gong X, Nie Q, Xiao Y, Xiang JW, Wang L, Liu F, Fu JL, Liu Y, Yang L, Gan Y, Chen H, Luo Z, Qi R, Chen Z, Tang X, Li DW.
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| Curr Mol Med 18(8):516-522. doi: 10.2174/1566524019666190112144436.
2018
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8 | ACCDA, UBA2
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| Missense variant in UBA2 associated with aplasia cutis congenita, duane anomaly, hip dysplasia and other anomalies: A possible new disorder involving the SUMOylation pathway.
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| Marble M, Guillen Sacoto MJ, Chikarmane R, Gargiulo D, Juusola J.
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| Am J Med Genet A 173(3):758-761. doi: 10.1002/ajmg.a.38078. Epub 2017 Jan 22.
2017
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9 | DPP8, DPP9, SUMO1, SUMO2, UBA2
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| A novel SUMO1-specific interacting motif in dipeptidyl peptidase 9 (DPP9) that is important for enzymatic regulation.
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| Pilla E, Möller U, Sauer G, Mattiroli F, Melchior F, Geiss-Friedlander R.
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| J Biol Chem 287(53):44320-9. doi: 10.1074/jbc.M112.397224. Epub 2012 Nov 14.
2012
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10 | SAE1, UBA2
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| Sumoylation of SAE2 C terminus regulates SAE nuclear localization.
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| Truong K, Lee TD, Li B, Chen Y.
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| J Biol Chem 287(51):42611-9. doi: 10.1074/jbc.M112.420877. Epub 2012 Oct 24.
2012
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11 | SAE1, UBA2
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| A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis.
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| Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, Bernardi RJ, Yu B, Hsu T, Golding I, Luo J, Osborne CK, Creighton CJ, Hilsenbeck SG, Schiff R, Shaw CA, Elledge SJ, Westbrook TF.
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| Science 335(6066):348-53. doi: 10.1126/science.1212728. Epub 2011 Dec 8.
2012
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12 | UBA2
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| Importin α/β mediates nuclear import of individual SUMO E1 subunits and of the holo-enzyme.
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| Moutty MC, Sakin V, Melchior F.
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| Mol Biol Cell 22(5):652-60. doi: 10.1091/mbc.E10-05-0461. Epub 2011 Jan 5.
2011
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13 | APOBEC3G, UBA2
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| APOBEC3G-UBA2 fusion as a potential strategy for stable expression of APOBEC3G and inhibition of HIV-1 replication.
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| Li L, Liang D, Li JY, Zhao RY.
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| Retrovirology 5:72.
2008
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14 | UBA2
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| Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1.
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| Lois LM, Lima CD.
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| EMBO J 24(3):439-51. Epub 2005 Jan 20. 2005
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15 | SAE1, UBA2
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| Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1.
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| Lois LM, Lima CD.
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| EMBO J 24(3):439-51. Epub 2005 Jan 20.
2005
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16 | UBA2
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| A mechanism for inhibiting the SUMO pathway.
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| Boggio R, Colombo R, Hay RT, Draetta GF, Chiocca S.
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| Mol Cell 16(4):549-61. 2004
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17 | SAE1, UBA2, SUMO1
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| Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1.
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| Desterro JM, et al.
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| J Biol Chem 274(15):10618-24. 1999
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18 | SAE1, UBA2, SUMO1
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| Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex.
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| Gong L, et al.
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| FEBS Lett 448(1):185-9. 1999
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19 | SAE1, UBA2
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| In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2.
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| Okuma T, Honda R, Ichikawa G, Tsumagari N, Yasuda H.
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| Biochem Biophys Res Commun 254(3):693-8. 1999
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20 | UBA2, SUMO1, RANBP2, RANGAP1
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| A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.
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| Mahajan R, et al.
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| Cell 88(1):97-107. 1997
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