Citations for
1TYK2
Kinase Inactive Tyrosine Kinase (Tyk2) Supports Differentiation of Brown Fat Cells.
Raje V, Derecka M, Cantwell M, Meier J, Szczepanek K, Sisler JD, Strobl B, Gamero A, Harris TE, Larner AC.
Endocrinology 158(1):148-157. doi: 10.1210/en.2015-2048. 2017
2GJA1, TYK2
Regulation of Connexin43 Function and Expression by Tyrosine Kinase 2.
Li H, Spagnol G, Zheng L, Stauch KL, Sorgen PL.
J Biol Chem 291(30):15867-80. doi: 10.1074/jbc.M116.727008. Epub 2016 May 27. 2016
3TYK2
Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway.
López-Isac E, Campillo-Davo D, Bossini-Castillo L, Guerra SG, Assassi S, Simeón CP, Carreira P, Ortego-Centeno N, García de la Peña P; Spanish Scleroderma Group, Beretta L, Santaniello A, Bellocchi C, Lunardi C, Moroncini G, Gabrielli A, Riemekasten G, Witte T, Hunzelmann N, Kreuter A, Distler JH, Voskuyl AE, de Vries-Bouwstra J, Herrick A, Worthington J, Denton CP, Fonseca C, Radstake TR, Mayes MD, Martín J.
Ann Rheum Dis 75(8):1521-6. doi: 10.1136/annrheumdis-2015-208154. Epub 2015 Sep 2. 2016
4HIES3, TYK2
Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome.
Kreins AY, Ciancanelli MJ, Okada S, Kong XF, Ramírez-Alejo N, Kilic SS, El Baghdadi J, Nonoyama S, Mahdaviani SA, Ailal F, Bousfiha A, Mansouri D, Nievas E, Ma CS, Rao G, Bernasconi A, Sun Kuehn H, Niemela J, Stoddard J, Deveau P, Cobat A, El Azbaoui S, Sabri A, Lim CK, Sundin M, Avery DT, Halwani R, Grant AV, Boisson B, Bogunovic D, Itan Y, Moncada-Velez M, Martinez-Barricarte R, Migaud M, Deswarte C, Alsina L, Kotlarz D, Klein C, Muller-Fleckenstein I, Fleckenstein B, Cormier-Daire V, Rose-John S, Picard C, Hammarstrom L, Puel A, Al-Muhsen S, Abel L, Chaussabel D, Rosenzweig SD, Minegishi Y, Tangye SG, Bustamante J, Casanova JL, Boisson-Dupuis S.
J Exp Med 212(10):1641-62. doi: 10.1084/jem.20140280. Epub 2015 Aug 24. 2015
5TYK2
Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).
Min X, Ungureanu D, Maxwell S, Hammarén H, Thibault S, Hillert EK, Ayres M, Greenfield B, Eksterowicz J, Gabel C, Walker N, Silvennoinen O, Wang Z.
J Biol Chem 290(45):27261-70. doi: 10.1074/jbc.M115.672048. Epub 2015 Sep 10. 2015
6TYK2
Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.
Tokarski JS, Zupa-Fernandez A, Tredup JA, Pike K, Chang C, Xie D, Cheng L, Pedicord D, Muckelbauer J, Johnson SR, Wu S, Edavettal SC, Hong Y, Witmer MR, Elkin LL, Blat Y, Pitts WJ, Weinstein DS, Burke JR.
J Biol Chem 290(17):11061-74. doi: 10.1074/jbc.M114.619502. Epub 2015 Mar 11. 2015
7IL22, STAT3, TYK2
Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis.
Hainzl E, Stockinger S, Rauch I, Heider S, Berry D, Lassnig C, Schwab C, Rosebrock F, Milinovich G, Schlederer M, Wagner M, Schleper C, Loy A, Urich T, Kenner L, Han X, Decker T, Strobl B, Müller M.
J Immunol 195(10):5011-24. doi: 10.4049/jimmunol.1402565. Epub 2015 Oct 2. 2015
8TYK2
Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition.
Lupardus PJ, Ultsch M, Wallweber H, Bir Kohli P, Johnson AR, Eigenbrot C.
Proc Natl Acad Sci U S A 111(22):8025-30. doi: 10.1073/pnas.1401180111. Epub 2014 May 19. 2014
9IFNAR1, TYK2
Structural basis of recognition of interferon-α receptor by tyrosine kinase 2.
Wallweber HJ, Tam C, Franke Y, Starovasnik MA, Lupardus PJ.
Nat Struct Mol Biol 21(5):443-8. doi: 10.1038/nsmb.2807. Epub 2014 Apr 6. 2014
10TYK2
Tyk2 is a therapeutic target for psoriasis-like skin inflammation.
Ishizaki M, Muromoto R, Akimoto T, Sekine Y, Kon S, Diwan M, Maeda H, Togi S, Shimoda K, Oritani K, Matsuda T.
Int Immunol 26(5):257-67. doi: 10.1093/intimm/dxt062. Epub 2013 Dec 17. 2014
11COPS5, IFNR, NEDD8, TYK2
Jun activation domain-binding protein 1 (JAB1) is required for the optimal response to interferons.
Muromoto R, Nakajima M, Hirashima K, Hirao T, Kon S, Shimoda K, Oritani K, Matsuda T.
J Biol Chem 288(43):30969-79. doi: 10.1074/jbc.M113.485847. Epub 2013 Sep 16. 2013
12TYK2
A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors.
Sohn SJ, Barrett K, Van Abbema A, Chang C, Kohli PB, Kanda H, Smith J, Lai Y, Zhou A, Zhang B, Yang W, Williams K, Macleod C, Hurley CA, Kulagowski JJ, Lewin-Koh N, Dengler HS, Johnson AR, Ghilardi N, Zak M, Liang J, Blair WS, Magnuson S, Wu LC.
J Immunol 191(5):2205-16. doi: 10.4049/jimmunol.1202859. Epub 2013 Jul 26. 2013
13IL13, IL4, STAT1, STAT6, TYK2
IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages.
Bhattacharjee A, Shukla M, Yakubenko VP, Mulya A, Kundu S, Cathcart MK.
Free Radic Biol Med ree Radic Biol Med. 2012 Nov 1. doi:pii: S0891-5849(12)01795-9. 10.1016/j.freeradbiomed.2012.10.553. [Epub ahead of print] 2012
14TYK2
Exome sequencing identifies a novel multiple sclerosis susceptibility variant in the TYK2 gene.
Dyment DA, Cader MZ, Chao MJ, Lincoln MR, Morrison KM, Disanto G, Morahan JM, De Luca GC, Sadovnick AD, Lepage P, Montpetit A, Ebers GC, Ramagopalan SV.
Neurology 79(5):406-11. doi: 10.1212/WNL.0b013e3182616fc4. Epub 2012 Jun 27. 2012
15TYK2
The role of Tyk2 in regulation of breast cancer growth.
Zhang Q, Sturgill JL, Kmieciak M, Szczepanek K, Derecka M, Koebel C, Graham LJ, Dai Y, Chen S, Grant S, Cichy J, Shimoda K, Gamero A, Manjili M, Bear H, Conrad D, Larner AC.
J Interferon Cytokine Res 31(9):671-7. doi: 10.1089/jir.2011.0023. Epub 2011 Aug 24. 2011
16MSSL6, TYK2
A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis.
Mero IL, Lorentzen AR, Ban M, Smestad C, Celius EG, Aarseth JH, Myhr KM, Link J, Hillert J, Olsson T, Kockum I, Masterman T, Oturai AB, Søndergaard HB, Sellebjerg F, Saarela J, Kemppinen A, Elovaara I, Spurkland A, Dudbridge F, Lie BA, Harbo HF.
Eur J Hum Genet 18(4):502-4. Epub 2009 Nov 4.PMID: 19888296 2010
17TYK2
A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis.
Mero IL, Lorentzen AR, Ban M, Smestad C, Celius EG, Aarseth JH, Myhr KM, Link J, Hillert J, Olsson T, Kockum I, Masterman T, Oturai AB, Søndergaard HB, Sellebjerg F, Saarela J, Kemppinen A, Elovaara I, Spurkland A, Dudbridge F, Lie BA, Harbo HF.
Eur J Hum Genet 18(4):502-4. Epub 2009 Nov 4.PMID: 19888296 2010
18SIVA1, TYK2
Tyrosine kinase 2 interacts with the proapoptotic protein Siva-1 and augments its apoptotic functions.
Shimoda HK, Shide K, Kameda T, Matsunaga T, Shimoda K.
Biochem Biophys Res Commun 400(2):252-7. Epub 2010 Aug 19. 2010
19MSSL6, TYK2
Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor.
Ban M, Goris A, Lorentzen AR, Baker A, Mihalova T, Ingram G, Booth DR, Heard RN, Stewart GJ, Bogaert E, Dubois B, Harbo HF, Celius EG, Spurkland A, Strange R, Hawkins C, Robertson NP, Dudbridge F, Wason J, De Jager PL, Hafler D, Rioux JD, Ivinson AJ, McCauley JL, Pericak-Vance M, Oksenberg JR, Hauser SL, Sexton D, Haines J, Sawcer S; Wellcome Trust Case-Control Consortium (WTCCC), Compston A.
Eur J Hum Genet 17(10):1309-13. Epub 2009 Mar 18.PMID: 19293837 2009
20HIES, HIES3, STAT3, TYK2
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome.
Minegishi Y, Saito M, Tsuchiya S, Tsuge I, Takada H, Hara T, Kawamura N, Ariga T, Pasic S, Stojkovic O, Metin A, Karasuyama H.
Nature 448(7157):1058-62. Epub 2007 Aug 5. 2007
21HIES3, TYK2
The hyper IgE syndrome and mutations in TYK2.
Woellner C, SchŠffer AA, Puck JM, Renner ED, Knebel C, Holland SM, Plebani A, Grimbacher B.
Immunity 26(5):535; author reply 536. No abstract available. 2007
22TYK2
Tyk2 mediates effects of urokinase on human vascular smooth muscle cell growth.
Patecki M, von Schaewen M, Tkachuk S, Jerke U, Dietz R, Dumler I, Kusch A.
Biochem Biophys Res Commun 359(3):679-84. Epub 2007 Jun 4. 2007
23IFNR, IFNAR1, TYK2
TYK2 activity promotes ligand-induced IFNAR1 proteolysis.
Marijanovic Z, Ragimbeau J, Kumar KG, Fuchs SY, Pellegrini S.
Biochem J 397(1):31-8. 2006
24HIES3, TYK2
Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity.
Minegishi Y, Saito M, Morio T, Watanabe K, Agematsu K, Tsuchiya S, Takada H, Hara T, Kawamura N, Ariga T, Kaneko H, Kondo N, Tsuge I, Yachie A, Sakiyama Y, Iwata T, Bessho F, Ohishi T, Joh K, Imai K, Kogawa K, Shinohara M, Fujieda M, Wakiguchi H, Pasic S, Abinun M, Ochs HD, Renner ED, Jansson A, Belohradsky BH, Metin A, Shimizu N, Mizutani S, Miyawaki T, Nonoyama S, Karasuyama H.
Immunity 25(5):745-55. 2006
25IFNAR1, IRF5, TYK2
Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.
Sigurdsson S, Nordmark G, Goring HH, Lindroos K, Wiman AC, Sturfelt G, Jonsen A, Rantapaa-Dahlqvist S, Moller B, Kere J, Koskenmies S, Widen E, Eloranta ML, Julkunen H, Kristjansdottir H, Steinsson K, Alm G, Ronnblom L, Syvanen AC.
Am J Hum Genet 76(3):528-37. Epub 2005 Jan 18. 2005
26JAKMIP1, JAK1, TYK2
Jamip1 (marlin-1) defines a family of proteins interacting with janus kinases and microtubules.
Steindler C, Li Z, Algarte M, Alcover A, Libri V, Ragimbeau J, Pellegrini S.
J Biol Chem 279(41):43168-77. Epub 2004 Jul 23. 2004
27TYK2, JAK1
Characterization of a class 3 tyrosine kinase.
Howard OMZ, et al.
Oncogene 7 : 895-900. 1992
28LTK, TYK2, FER
Identification and chromosomal mapping of new human tyrosine kinase genes.
Krolewski JJ, et al.
Oncogene 5 : 277-282. 1990
29TYK2
TYK2, prototype of a novel class of non-receptor tyrosine kinase genes.
Firmbach-Kraft I, et al.
Oncogene 5 : 1329-1336. 1990