1 | TRPM8
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| Cold/menthol TRPM8 receptors initiate the cold-shock response and protect germ cells from cold-shock-induced oxidation.
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| Borowiec AS, Sion B, Chalmel F, Rolland AD, Lemonnier L, De Clerck T, Bokhobza A, Derouiche S, Dewailly E, Slomianny C, Mauduit C, Benahmed M, Roudbaraki M, Jégou B, Prevarskaya N, Bidaux G.
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| FASEB J ASEB J. 2016 Jun 17. pii: fj.201600257R. [Epub ahead of print]
2016
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2 | TRPA1, TRPM8
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| Activation of Cold-Sensitive Channels TRPM8 and TRPA1 Inhibits the Proliferative Airway Smooth Muscle Cell Phenotype.
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| Zhang L, An X, Wang Q, He M.
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| Lung ung. 2016 May 28. [Epub ahead of print]
2016
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3 | TRPM8
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| Implications of Human Transient Receptor Potential Melastatin 8 (TRPM8) Channel Gating from Menthol Binding Studies of the Sensing Domain.
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| Rath P, Hilton JK, Sisco NJ, Van Horn WD.
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| Biochemistry 55(1):114-24. doi: 10.1021/acs.biochem.5b00931. Epub 2015 Dec 23.
2016
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4 | TRPM8
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| Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner.
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| Bidaux G, Borowiec AS, Gordienko D, Beck B, Shapovalov GG, Lemonnier L, Flourakis M, Vandenberghe M, Slomianny C, Dewailly E, Delcourt P, Desruelles E, Ritaine A, Polakowska R, Lesage J, Chami M, Skryma R, Prevarskaya N.
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| Proc Natl Acad Sci U S A 112(26):E3345-54. doi: 10.1073/pnas.1423357112. Epub 2015 Jun 15.
2015
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5 | TRPM8
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| TRPM8 is a neuronal osmosensor that regulates eye blinking in mice.
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| Quallo T, Vastani N, Horridge E, Gentry C, Parra A, Moss S, Viana F, Belmonte C, Andersson DA, Bevan S.
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| Nat Commun 6:7150. doi: 10.1038/ncomms8150.
2015
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6 | TRPM8
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| TRPM8 channel as a novel molecular target in androgen-regulated prostate cancer cells.
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| Asuthkar S, Velpula KK, Elustondo PA, Demirkhanyan L, Zakharian E.
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| Oncotarget 6(19):17221-36.
2015
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7 | TRPM8
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| The TRPM8 protein is a testosterone receptor: I. Biochemical evidence for direct TRPM8-testosterone interactions.
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| Asuthkar S, Elustondo PA, Demirkhanyan L, Sun X, Baskaran P, Velpula KK, Thyagarajan B, Pavlov EV, Zakharian E.
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| J Biol Chem 290(5):2659-69. doi: 10.1074/jbc.M114.610824. Epub 2014 Dec 5.
2015
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8 | TCAF1, TCAF2, TRPM8
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| TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity.
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| Gkika D, Lemonnier L, Shapovalov G, Gordienko D, Poux C, Bernardini M, Bokhobza A, Bidaux G, Degerny C, Verreman K, Guarmit B, Benahmed M, de Launoit Y, Bindels RJ, Fiorio Pla A, Prevarskaya N.
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| J Cell Biol 208(1):89-107. doi: 10.1083/jcb.201402076.
2015
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9 | CALCA, TRPM8
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| TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP.
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| de Jong PR, Takahashi N, Peiris M, Bertin S, Lee J, Gareau MG, Paniagua A, Harris AR, Herdman DS, Corr M, Blackshaw LA, Raz E.
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| Mucosal Immunol 8(3):491-504. doi: 10.1038/mi.2014.82. Epub 2014 Oct 1.
2015
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10 | TRPA1, TRPM8, TRPV1, ZBTB20
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| ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons.
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| Ren AJ, Wang K, Zhang H, Liu A, Ma X, Liang Q, Cao D, Wood JN, He DZ, Ding YQ, Yuan WJ, Xie Z, Zhang WJ.
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| Nat Commun 5:4984. doi: 10.1038/ncomms5984.
2014
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11 | TRPM8
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| Temperature and voltage coupling to channel opening in transient receptor potential melastatin 8 (TRPM8).
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| Raddatz N, Castillo JP, Gonzalez C, Alvarez O, Latorre R.
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| J Biol Chem 289(51):35438-54. doi: 10.1074/jbc.M114.612713. Epub 2014 Oct 28.
2014
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12 | TRPM8
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| The region adjacent to the C-end of the inner gate in transient receptor potential melastatin 8 (TRPM8) channels plays a central role in allosteric channel activation.
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| Taberner FJ, López-Córdoba A, Fernández-Ballester G, Korchev Y, Ferrer-Montiel A.
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| J Biol Chem 289(41):28579-94. doi: 10.1074/jbc.M114.577478. Epub 2014 Aug 25.
2014
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13 | TRPA1, TRPM8, TRPV1
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| TRPV1, TRPA1, and TRPM8 channels in inflammation, energy redirection, and water retention: role in chronic inflammatory diseases with an evolutionary perspective.
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| Straub RH.
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| J Mol Med (Berl) 92(9):925-37. doi: 10.1007/s00109-014-1175-9. Epub 2014 May 29. Review.
2014
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14 | TRPM8, UCP1
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| Human white adipocytes express the cold receptor TRPM8 which activation induces UCP1 expression, mitochondrial activation and heat production.
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| Rossato M, Granzotto M, Macchi V, Porzionato A, Petrelli L, Calcagno A, Vencato J, De Stefani D, Silvestrin V, Rizzuto R, Bassetto F, De Caro R, Vettor R.
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| Mol Cell Endocrinol 383(1-2):137-46. doi: 10.1016/j.mce.2013.12.005. Epub 2013 Dec 14.
2014
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15 | OPRM1, TRPM8
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| Opiates modulate thermosensation by internalizing cold receptor TRPM8.
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| Shapovalov G, Gkika D, Devilliers M, Kondratskyi A, Gordienko D, Busserolles J, Bokhobza A, Eschalier A, Skryma R, Prevarskaya N.
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| Cell Rep 4(3):504-15. doi: 10.1016/j.celrep.2013.07.002. Epub 2013 Aug 1.
2013
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16 | PIRT, TRPM8, TRPV1
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| Pirt functions as an endogenous regulator of TRPM8.
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| Tang Z, Kim A, Masuch T, Park K, Weng H, Wetzel C, Dong X.
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| Nat Commun 4:2179. doi: 10.1038/ncomms3179.
2013
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17 | TRPM8
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| TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain.
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| Liu B, Fan L, Balakrishna S, Sui A, Morris JB, Jordt SE.
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| Pain 154(10):2169-77. doi: 10.1016/j.pain.2013.06.043. Epub 2013 Jun 29.
2013
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18 | TRPM8
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| Regulation of activity of transient receptor potential melastatin 8 (TRPM8) channel by its short isoforms.
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| Bidaux G, Beck B, Zholos A, Gordienko D, Lemonnier L, Flourakis M, Roudbaraki M, Borowiec AS, Fernández J, Delcourt P, Lepage G, Shuba Y, Skryma R, Prevarskaya N.
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| J Biol Chem 287(5):2948-62. doi: 10.1074/jbc.M111.270256. Epub 2011 Nov 28.
2012
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19 | TRPM8
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| Short isoforms of the cold receptor TRPM8 inhibit channel gating by mimicking heat action rather than chemical inhibitors.
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| Fernández JA, Skryma R, Bidaux G, Magleby KL, Scholfield CN, McGeown JG, Prevarskaya N, Zholos AV.
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| J Biol Chem 287(5):2963-70. doi: 10.1074/jbc.M111.272823. Epub 2011 Nov 28.
2012
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20 | TRPM2, TRPM8
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| Importance of a conserved sequence motif in transmembrane segment S3 for the gating of human TRPM8 and TRPM2.
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| Winking M, Hoffmann DC, Kühn C, Hilgers RD, Lückhoff A, Kühn FJ.
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| PLoS One 7(11):e49877. doi: 10.1371/journal.pone.0049877. Epub 2012 Nov 21.
2012
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21 | TRPA1, TRPM8, TRPV1
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| Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura.
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| Huang D, Li S, Dhaka A, Story GM, Cao YQ.
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| Mol Pain 8:66. doi: 10.1186/1744-8069-8-66.
2012
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22 | TRPM8
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| N-glycosylation of TRPM8 ion channels modulates temperature sensitivity of cold thermoreceptor neurons.
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| Pertusa M, Madrid R, Morenilla-Palao C, Belmonte C, Viana F.
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| J Biol Chem 287(22):18218-29. doi: 10.1074/jbc.M111.312645. Epub 2012 Apr 5.
2012
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23 | CHRM3, TRPM8
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| Complex regulation of the TRPM8 cold receptor channel: role of arachidonic acid release following M3 muscarinic receptor stimulation.
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| Bavencoffe A, Kondratskyi A, Gkika D, Mauroy B, Shuba Y, Prevarskaya N, Skryma R.
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| J Biol Chem 286(11):9849-55. Epub 2011 Jan 18.
2011
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24 | CRISP1, CRISP3, TRPM8
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| Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function.
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| Gibbs GM, Orta G, Reddy T, Koppers AJ, Martínez-López P, Luis de la Vega-Beltràn J, Lo JC, Veldhuis N, Jamsai D, McIntyre P, Darszon A, O'Bryan MK.
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| Proc Natl Acad Sci U S A 108(17):7034-9. Epub 2011 Apr 11.
2011
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25 | TRPM8
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| Exploring the activation mechanism of TRPM8 channel by targeted MD simulations.
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| Pedretti A, Labozzetta A, Lo Monte M, Beccari AR, Moriconi A, Vistoli G.
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| Biochem Biophys Res Commun 414(1):14-9. Epub 2011 Sep 6.
2011
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26 | KLK3, TRPM8
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| PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression.
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| Gkika D, Flourakis M, Lemonnier L, Prevarskaya N.
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| Oncogene 29(32):4611-6. Epub 2010 Jun 7. 2010
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27 | TRPM8
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| Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers.
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| Zakharian E, Cao C, Rohacs T.
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| J Neurosci 30(37):12526-34.PMID: 20844147 2010
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28 | TRPM8
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| Topical application of TRPM8 agonists accelerates skin permeability barrier recovery and reduces epidermal proliferation induced by barrier insult: role of cold-sensitive TRP receptors in epidermal permeability barrier homoeostasis.
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| Denda M, Tsutsumi M, Denda S.
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| Exp Dermatol 19(9):791-5. Epub 2010 Jul 16.PMID: 20636355 2010
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29 | TRPM8
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| Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma.
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| Yee NS, Zhou W, Lee M.
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| Cancer Lett 297(1):49-55. Epub 2010 Jun 1.PMID: 20605675 2010
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30 | TRPM8
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| Expression of the TRPM8-immunoreactivity in dorsal root ganglion neurons innervating the rat urinary bladder.
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| Hayashi T, Kondo T, Ishimatsu M, Yamada S, Nakamura K, Matsuoka K, Akasu T.
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| Neurosci Res 65(3):245-51. Epub 2009 Jul 19.PMID: 19622375 2009
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31 | TRPM8
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| TRPM8, a versatile channel in human sperm.
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| De Blas GA, Darszon A, Ocampo AY, Serrano CJ, Castellano LE, Hernández-González EO, Chirinos M, Larrea F, Beltrán C, Treviño CL.
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| PLoS One 4(6):e6095.PMID: 19582168 2009
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32 | TRPM8
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| Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone.
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| Johnson CD, Melanaphy D, Purse A, Stokesberry SA, Dickson P, Zholos AV.
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| Am J Physiol Heart Circ Physiol 296(6):H1868-77. Epub 2009 Apr 10.PMID: 19363131 2009
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33 | TRPM8
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| Lipid raft segregation modulates TRPM8 channel activity.
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| Morenilla-Palao C, Pertusa M, Meseguer V, Cabedo H, Viana F.
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| J Biol Chem 284(14):9215-24. Epub 2009 Jan 27.PMID: 19176480 2009
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34 | TRPM8
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| TRPM8 mechanism of autonomic nerve response to cold in respiratory airway.
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| Xing H, Ling JX, Chen M, Johnson RD, Tominaga M, Wang CY, Gu J.
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| Mol Pain 4:22.PMID: 18534015 2008
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35 | TRPA1, TRPM8
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| Role of TRPM8 and TRPA1 for cold allodynia in patients with cold injury.
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| Namer B, Kleggetveit IP, Handwerker H, Schmelz M, Jorum E.
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| Pain 139(1):63-72. Epub 2008 Apr 25.PMID: 18440147 2008
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36 | TRPM8
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| Human lung epithelial cells express a functional cold-sensing TRPM8 variant.
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| Sabnis AS, Shadid M, Yost GS, Reilly CA.
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| Am J Respir Cell Mol Biol 39(4):466-74. Epub 2008 May 5.
2008
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37 | TRPM8
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| TRPM8-independent menthol-induced Ca2+ release from endoplasmic reticulum and Golgi.
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| Mahieu F, Owsianik G, Verbert L, Janssens A, De Smedt H, Nilius B, Voets T.
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| J Biol Chem 282(5):3325-36. Epub 2006 Dec 1. 2007
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38 | TRPM8
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| TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli.
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| Voets T, Owsianik G, Janssens A, Talavera K, Nilius B.
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| Nat Chem Biol 3(3):174-82. Epub 2007 Feb 11.
2007
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39 | TRPM8
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| TRPM8 protein localization in trigeminal ganglion and taste papillae.
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| Abe J, Hosokawa H, Okazawa M, Kandachi M, Sawada Y, Yamanaka K, Matsumura K, Kobayashi S.
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| Brain Res Mol Brain Res 136(1-2):91-8. Epub 2005 Mar 2. 2005
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40 | TRPM8
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| Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells.
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| Thebault S, Lemonnier L, Bidaux G, Flourakis M, Bavencoffe A, Gordienko D, Roudbaraki M, Delcourt P, Panchin Y, Shuba Y, Skryma R, Prevarskaya N.
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| J Biol Chem 280(47):39423-35. Epub 2005 Sep 20. 2005
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41 | TRPM8
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| A TRP channel that senses cold stimuli and menthol.
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| Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson DA, Story GM, Earley TJ, Dragoni I, McIntyre P, Bevan S, Patapoutian A.
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| Cell 108(5):705-15. 2002
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42 | TRPM8
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| Identification of a cold receptor reveals a general role for TRP channels in thermosensation.
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| McKemy DD, Neuhausser WM, Julius D.
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| Nature 416(6876):52-8. 2002
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43 | TRPM1, TRPM2, TRPM3, TRPM5, TRPM6, TRPM7, TRPM8, TRPV1, TRPV4, TRPV5, TRPV6
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| The TRP channels, a remarkably functional family.
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| Montell C, Birnbaumer L, Flockerzi V.
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| Cell 108(5):595-8. Review. 2002
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44 | TRPM8
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| Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins.
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| Tsavaler L, Shapero MH, Morkowski S, Laus R.
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| Cancer Res 61(9):3760-9. 2001
|